Research Progress on Animal Models of Menopausal Syndrome： A Review / 中国实验方剂学杂志

In order to explore the pathological mechanism of perimenopausal syndrome and seek prevention and treatment measures， it is necessary to establish animal models that similar to human perimenopausal syndrome， so as to provide reference for drug research， new drug development and clinical application. In this paper， the keywords of "perimenopausal period" "perimenopausal syndrome" "menopause" "menopausal syndrome""menopausal period" "menopausal syndrome" and "animal" were searched in China National Knowledge Infrastructure （CNKI）， Chongqing Weipu， China Biomedical Literature Database （CBM） and Pubmed. In addition， the selection of domestic peripheral menopausal syndrome model animals in recent years and the advantages and disadvantages of corresponding models were summarized. A total of 673 studies were identified， of which 61 were included in the analysis. The most common animal model of perimenopausal syndrome is castration model， while the immunodeficiency model is less used. With the aging of the population and the rapid increase of psychosocial stress， the incidence of perimenopausal syndrome is high. Therefore， it is particularly important to explore the mechanism of perimenopausal syndrome. According to the experimental purpose， experimental period， experimental technology and other factors， the selection of appropriate model animals and modeling methods is the key of the success of the experiment of perimenopausal syndrome.

Effect of modified Sanjia-Fumai decoction on the endocrine and immune function of patients with climacteric syndrome / 国际中医中药杂志

Objective To observe the effect of modified SanJia-Fumai decoction with hormone replacement therapy on the endocrine and immune function of patients with climacteric syndrome. Methods A total of 84 patients with climacteric syndrome were divided into two groups according to the random number table, 42 cases in each group. The control group was treated with hormone replacement therapy. While the observation group was treated with modified Sanjia-Fumai decoction on the basis of the control grop. Both groups were treated for 4 weeks. The efficacy by scoring the changes of the patients clinical symptoms and signs was evaluated, and the serum hormones (LH, FSH, E2) levels were detected by radioimmunoassay, and the immune function index (CD3+, CD4+, CD8+) levels by immunofluorescence method, and the IL-2 by ELLSA. Results After treatment, the total efficiency of observation group was 92.8％ (39/42), while the control group was 73.8％ (31/42), and the difference was statistically significant (Z=-2.736, P=0.003). After treatment, the scores of hot flashes, menstrual disorders, insomnia and dreaminess, hot sweating, restlessness and dry mouth constipation in the observation group were significantly lower than those in the control group (t were 7.745, 10.364, 11.201, 16.765, 18.442, 18.625 respectively, P<0.001); the Serum LH and FSH levels in observation group were significantly lower than those in control group (t were 4.837, 5.016 respectively, P<0.01); the E2 level was significantly higher than that of control group (t=7.309, P<0.01). The levels of CD3+, CD4+, CD4+/CD8+, IL-2 in the observation group were significantly higher than those in the control group (t were 5.139, 6.083, 6.158, 5.932 respectively, P<0.01); The level of CD8+ was significantly lower than that of the control group (t=5.994, P<0.01). Conclusions The modified SanJia-Fumai decoction with hormone replacement therapy can regulate the endocrine function, improve the body's immunity and improve clinical symptoms of climacteric syndrome patients.

Effect of Ziyin-Jianghuo formula on the neuroendocrine system of menopausal caused by Yin deficiency generating intrinsic heat type of rats / 国际中医中药杂志

Objective To observe the effect of Ziyin-Jianghuo formula in treatment of Yin deficiency generating intrinsic heat type of the levels of monoamine neurotransmitters and estrogens in rats, and investigate its intervention in the neuroendocrine system. Methods There were 7 groups, which were sham operation group, model control group, estrogen tablet group, Gengnian capsule group, Ziyin-Jianghuo formula low, medium and high dose groups. Castration was performed by castration (extraction of ovaries) plus hot traditional Chinese medicine. The rats in the treatment group were given the above drugs 24 hours after the last administration of the hot Chinese medicine, once a day for 30 consecutive days. The sham operation group and the model control group were given an equal volume of purified water by simultaneous intragastric administration. The serum estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL) levels,uterine coefficient and monoamine neurotransmitters dopamine (DA), norepinephrine (NE), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) content in the hypothalamus were detected after 12 hours of the last treatment. Results Compared with the model group, the levels of serum FSH (4.39 ± 0.22 IU/L, 2.89 ± 0.91 IU/L, 2.84 ± 0.98 IU/L vs. 5.51 ± 0.24 IU/L), LH (14.48 ± 0.24 IU/L, 11.46 ± 0.33 IU/L, 5.28 ± 1.31 IU/L vs. 15.02 ± 0.37 IU/L) in the low, middle and high doses of Ziyin-Jianghuo formula significantly decreased (P<0.05), the levels of serum E2 (39.84 ± 6.08 pmol/L, 48.65 ± 6.77 pmol/L, 64.96 ± 7.97 pmol/L vs. 33.16 ± 4.62 pmol/L) significantly increased (P<0.05). The content of DA, 5-HT, 5-HIAA in the hypothalamus and the 5-HT/NE (0.48 ± 0.02, 0.43 ± 0.03, 0.27 ± 0.02 vs. 0.67 ± 0.02), 5-HIAA/5-HT (1.74 ± 0.09, 1.71 ± 0.10, 1.80 ± 0.17 vs. 2.00 ± 0.10) in the low, middle and high doses of Ziyin-Jianghuo formula significantly decreased ( P<0.05), the content of NE (663.34 ± 9.81 ng/kg, 695.94 ± 10.54 ng/kg, 790.76 ± 16.35 ng/kg vs. 602.95 ± 13.24 ng/kg) in the hypothalamus in the low, middle and high doses of Ziyin-Jianghuo formula significantly increased (P<0.05). The levels of serum PRL (10.16 ± 1.26 μg/L, 7.22 ± 1.26 μg/L vs. 14.80 ± 1.64 μg/L) in the middle and high doses of Ziyin-Jianghuo formula significantly decreased (P<0.05). Conclusions The Ziyin-Jianghuo formula has a significant positive regulation effect on the neuroendocrine system of menopausal Yin deficiency generating intrinsic heat type of rats, and this process is dose-dependent and can improve a series of symptoms caused by autonomic dysfunction.

Effect of Heshi-Gejiugao on neuroendocrine immune network in women with perimenopausal syndrome / 国际中医中药杂志

Objective@#To study the mechanism of Heshi-Gejiugao on the nerve endocrine immune network in the treatment of perimenopausal syndrome.@*Methods@#A total of 100 patients with perimenopausal syndrome were randomly divided into treatment group and control group, 50 cases in each group. The control group was only given general treatment, while the treatment group was treated with Heshi-Gejiugao on the basis of general treatment for 30 days. The clinical efficacy, Kupperman score, nerve, endocrine and immune related indexes of the two groups before and after treatment were observed.@*Results@#The total effective rate was 96.0% (48/50) in the treatment group and 50.0% (25/50) in the control group. There was significant difference between the two groups (χ2=37.639, P<0.01). The Kupperman score (17.52 ± 2.73 vs. 24.22 ± 6.87, t=6.409) in the treatment group was significantly lower than that in the control group (P<0.01). After treatment, NE (1 878.08 ± 931.57 ng/m vs. 1 278.43 ± 866.32 ng/ml, t=3.331), DA (1 568.56 ± 597.15 ng/ml vs. 1 183.62 ± 798.72 ng/ml, t=2.729) in the treatment group were significantly higher than those in the control group (P<0.05); E2 (42.12 ± 9.77 pg/ml vs. 35.91 ± 12.55 pg/ml, t=2.761), FSH (62.70 ± 15.96 mIU/ml vs. 72.67 ± 30.18 mIU/ml, t=2.065), LH (33.88 ± 12.18 mIU/ml vs. 42.93 ± 9.83 mIU/ml, t=4.089) were significantly lower than those of the control group (P<0.05). CD3+ (1 087.34/μl ± 432.19/μl vs. 918.27/μl ± 199.72/μl, t=2.511), CD4+ (738.16/μl ± 326.75/μl vs. 588.43/μl ± 212.55/μl, t=2.716) and CD4/CD8 (1.87 ± 0.56 vs. 1.16 ± 0.55), t=6.483) were significantly higher than those of the control group (P<0.05); CD8+ (788.32/μl ± 214.56/μl vs. 976.37/μl ± 318.62/μl, t=3.462) was significantly lower than that of the control group (P<0.05).@*Conclusions@#Heshi-Gejiugao can reduce the symptoms and improve the quality of life by regulating the multi target and multi direction of the neuroendocrine immune network of perimenopausal patients.

Ten Cases Successfully Treated with kuoketsuzai （Drugs for Overcoming oketsu）and Yokukansankachimpihange for Climacteric Women / 日本東洋医学雑誌

In the treatment of climacteric disorders, evaluation of menopausal women based on personal and overall aspects of their sho condition has been found to be useful. This form of treatment is considered particularly useful for patients who cannot, or do not wish to use hormone replacement therapy (HRT). In this paper, we present the cases of patients who were assessed using sho and the Kampo medical index, and given successful treatment using kuoketsuzai (drugs for overcoming oketsu) and yokukansankachinpihange.

Síndrome climatérico en mujeres de edad mediana / Climacteric syndrome in women of middle age

introducción: Es evidente que el síndrome climatérico puede manifestarse de formas diferentes, con un mayor o menor grado de intensidad, de acuerdo a las condiciones sociales y ambientales de cada mujer, esto puede afectar el patrón biológico y variar su estado de salud.Objetivos: Caracterizar a las mujeres de edad mediana en virtud de la intensidad del síndrome climatérico y un conjunto de características biológicas, psicológicas y sociales, así como identificar entre las variables evaluadas, aquellas que constituyen factores de riesgo para los niveles más intensos del síndrome climatérico en las mujeres de edad mediana Métodos: La investigación clasifica como observacional, que transita del nivel descriptivo al analítico, con una muestra de 532 mujeres de edad entre 40 a 59 años del municipio Plaza de la Revolución durante el primer semestre de 2017. Las variables estudiadas fueron edad en años, edad de aparición de los síntomas, apoyo familiar y cantidad de enfermedades. Resultados: La intensidad del síndrome climatérico en mujeres de edad mediana, de manera global, mostró ser menos intenso en aquellas que no han tenido la menopausia, con una tendencia decreciente con la edad en este segmento poblacional. Conclusiones: La intensidad del síndrome climatérico está asociada con la edad cronológica de la mujer de edad mediana, la edad de aparición de la menopausia, el apoyo familiar y la cantidad de enfermedades relacionadas(AU)

Introduction: The climacteric syndrome can evidently manifest itself in different ways, with a greater or lower degree of intensity. According to the social and environmental conditions of each woman, this can affect the biological pattern and vary the woman's state of health. Objectives: To characterize women of middle age based on the intensity of the climacteric syndrome and a set of biological, psychological and social characteristics, as well as to identify, among the variables evaluated, those that constitute risk factors for the most intense levels of the climacteric syndrome in women of middle age. Methods: The research was classified as observational, which moves from the descriptive to the analytical level, with a sample of 532 women aged 40-59 years of Plaza de la Revolución Municipality during the first semester of 2017. The variables studied were age in years, age of symptoms onset, family support and number of diseases. Results: The intensity of the climacteric syndrome in women of middle age showed to be globally less intense in those that have not had menopause, with a tendency that decreases with age in this population segment. Conclusions: The intensity of the climacteric syndrome is associated with the chronological age of the woman of middle age, the age of menopause onset, family support and the number of associated diseases(AU)

Impacto del síndrome climatérico en la función sexual / Impact of climateric syndrome on sexual function

Introducción: El síndrome climatérico se puede definir como el conjunto de signos y síntomas que se presentan en la perimenopausia y postmenopausia, incluye síntomas vasomotores, alteraciones del sueño, alteraciones psicológicas y atrofia genital. Objetivo: Conocer el impacto del síndrome climatérico sobre la función sexual y calidad de vida de las mujeres que atraviesan esta etapa de la vida. Métodos: Se trata de una revisión bibliográfica. Los artículos revisados fueron obtenidos de fuentes como Google Académico, Pubmed, LILACS; la selección de la bibliografía comprendió artículos publicados entre 2011 y 2018. Conclusiones: La sexualidad en este periodo y la vejez es un tema de vital importancia para la salud pública. La disfunción sexual como resultado del síndrome climatérico desencadena sentimientos de baja autoestima, desapego y frustración, lo que ocasiona en la mujer que lo padece desinterés por el sexo y un impacto negativo muy claro en su calidad de vida.

The climacteric syndrome can be defined as a set of signs and symptoms that appear in perimenopause and postmenopause, including vasomotor symptoms, sleep disturbances, psychological alterations and genital atrophy. Objective: To know the impact of the climacteric syndrome on the sexual function and quality of life of the women going through this stage of life. Methods: The present work is literature review. Reviewed articles were obtained from sources such as Google Scholar, Pubmed, LILACS; the selection of literature included articles published between 2011 and 2018. Conclusions: Sexuality in this period and old age is a topic of vital importance for public health. Sexual dysfuntion as a result of climateric syndrome originates feelings of low self­esteem, detachment and frustration, causing disinterest in sex, having a clear negative impact on women quality of life.

Intensidad y evolución del síndrome climatérico y su relación con los factores de riesgo para aterosclerosis / Intensity and Evolution of the Climacteric Syndrome and Its Relation with Atherosclerosis Risk Factors

Introducción: el estudio del climaterio y la menopausia tiene gran importancia y vigencia por su morbilidad asociada. Objetivo: determinar la presencia de factores de riesgo ateroscleróticos con la intensidad y evolución del síndrome climatérico en este grupo. Métodos: estudio prospectivo y de intervención en mujeres de 40 a 59 años con síndrome climatérico a las que se les aplicó terapia hormonal -previo consentimiento informado- y se observó la respuesta evolutiva al mismo. Resultados: las variables estudiadas: sobrepeso, obesidad, sedentarismo, hábito de fumar, circunferencia de cintura, hipertensión arterial y diabetes mellitus tipo 2; así como la sobrecarga de género que tenían dichas mujeres, tuvieron relación con la presencia y evolución desfavorable del síndrome climatérico. La obesidad y el sobrepeso son las de mayor influencia sobre la evolución de este síndrome. La otra variable de mayor importancia fue el hábito de fumar. En orden de importancia le siguió el sedentarismo. Conclusiones: los factores de riesgo para aterosclerosis estudiados se asociaron con síndrome climatérico más intenso y con una evolución desfavorable del mismo, aporte científico de esta investigación, lo que también ocurrió con la sobrecarga de género. El aumento de la circunferencia de cintura, el índice de masa corporal elevado y el tabaquismo fueron los factores de riesgo de mayor importancia en la evolución desfavorable de dicho síndrome(AU)

Introduction: The study of climacteric and menopause has great importance and validity due to its associated morbidity. Objective: Determine the presence of atherosclerotic risk factors with the intensity and evolution of the climacteric syndrome in this group. Methods: A prospective and interventional study was carried out in women aged 40 to 59 years with climacteric syndrome who received hormone therapy - previous informed consent. The evolutionary response was observed. Results: The variables studied (overweight, obesity, sedentary lifestyle, smoking habits, waist circumference, arterial hypertension and type 2 diabetes mellitus), these women gender overload were related to the presence and unfavorable evolution of the climacteric syndrome. Obesity and overweight are the most influential on this syndrome evolution. The other major variable was smoking. In order of importance, sedentary followed. Conclusions: The atherosclerosis risk factors studied were associated with a more intense climacteric syndrome and with an unfavorable evolution of them, which is the scientific contribution of this research. Increased waist circumference, high body mass index and smoking habits were the most important risk factors for the unfavorable evolution of this syndrome(AU)

Curative efficacy of dydrogesterone in treatment of Climacteric syndrome and its effects on sex hormone and blood fat / 中国生化药物杂志

Objective To study the curative efficacy of dydrogesterone in treatment of Climacteric syndrome and its effects on sex hormone, blood fat.Methods104 patients of Climacteric syndrome who received therapy from February 2014 to November 2016 in our hospital were selected as research objects, according to different divided into observation group and control group, treatment group used to bend progesterone therapy, the control group using a placebo.one month after treatment to observe the two groups of clinical curative effect, compare two groups before and after the treatment and testing level of estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH),total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C).ResultsAfter treatment, the clinical total effective rate in the two groups to compare have no significant difference;Compared with before treatment, the control group in estrogen level and blood lipid levels in patients with no significant change, the observation group of patients with E2 and HDL-C level increased significantly, and significantly higher than the control group (P<0.05);FSH, LH, TC, TG, LDL levels significantly decreased, and significantly lower than the control group (P<0.05).ConclusionUsing of dydrogesterone short time the clinical curative effect of treatment of menopausal syndrome with placebo, but can effectively improve patient sex hormone levels, adjust blood lipid levels, to reduce the incidence of cardiovascular disease (CVD) patients, improve their quality of life.

Recognition of Pathogenesis of Climacteric Syndrome / 世界科学技术-中医药现代化

At present,most of the scholars of traditional Chinese medicine (TCM) considered that climacteric syndrome was caused by yin-deficiency,as the therapy of nourishing yin and clearing heat was the most common treatment,neglecting the pathologic role of yang-deficiency in climacteric syndrome.This paper redefined the pathogensis of climacteric syndrome and its syndromes based on differentiation in Gynecology of Traditional Chinese Medicine of various versions and in accordance with previous syndrome epidemiological results over it.The emerge of hot flushes and sweating,forgetful and hyposexuality was prevalent.The inaccurate description of hot flash and sweating in climacteric syndrome was rectified.The therapeutic effects of nourishing yin therapy on vasomotion were discussed based on the understanding of etiology,pathology and treatment of climacteric syndrome in ancient Chinese medical books.The phytoestrogens action of warming kidney-yang drugs was summarized from the aspect of modern pharmacology for exploring the significance of the role of yang-deficiency in climacteric syndrome.The treatment against yang-deficiency would be an innovative clinical pathway of climacteric syndrome.

Analysis of 80 cases of climacteric syndrome treated by Tai pill and Qinghao Biejia Decoction / 中国生化药物杂志

Objective To study the clinical effect analysis of Thailand pill and Qinghao Biejia Decoction in treating climacteric syndrome. Methods 80 cases of climacteric syndrome treated in our hospital from February 2015 to October 2016 were selected and randomly divided into the control group and the experimental group, with 40 patients in each group. Patients in the control group were given conventional treatment, including vitamins and 1 mg estradiol valerate, 1 times per day. Patients in the experimental group were given Thailand pill and Qinghao Biejia decoction, two times a day to take water for 30min, the two groups were treated for 40 days. The therapeutic effects of the patients in the experimental group and the control group were compared and analyzed. Results After the corresponding treatment, the effective rate of treatment in the experimental group (95.0 %) was significantly higher than that in the control group (75.0 %), the difference was statistically significant (P<0.05). After treatment, there were no serious adverse reactions in the experimental group and the control group, and the safety was better. Two groups of patients before and after treatment of liver and kidney test, as well as feces, blood and urine test results are not unusual, and related adverse reactions. The irritable and Fanre signs disappeared rate in the experimental group were 75.0 % and 80.0 %,the disappearance rate in the control group were 50.0 % and 60.0 %. Conclusion The clinical effect of Thailand pill and Qinghao Biejia.0 Decoction in treating climacteric syndrome, good safety, with further clinical promotion and application significance.

Research on Traditional Chinese Medicine Professor Niu Jianzhao's Medication Rule in Prescriptions with Climacteric Syndrome Based on Data Mining / 世界科学技术-中医药现代化

This study was aimed to explore traditional Chinese medicine (TCM) professor Niu Jianzhao's medication rule in prescription with climacteric syndrome.Prescriptions treating climacteric syndrome that built by professor Niu were collected to build a database based on TCM Inheritance Assist System.The method of association rules with apriori algorithm was used to achieve frequency of single medicine,nature,taste and channel tropism of herbs,frequency of drug combination,association rules between herbs and core herb combinations.The data mining results showed 22 types of herbs used with high frequency,28 pairs of herb combination with most frequency,20 groups of herb association rules with the confidence of more than 0.95,52 herb pairs with high association,32 groups of three herbs as the core combinations,and 7 new prescriptions.It was concluded that in professor Niu Jianzhao's treatment of climacteric syndrome,the drugs were commonly used to invigorate the kidney,liver and spleen,and in combination with promoting blood circulation and calming the nerves.The medicinal properties of used herbs were even,warm or slightly cold.The tastes of used herbs were sweet,bitter and spicy.The channel tropisms of used herbs were the liver,kidney and lung meridian.This study highlighted data mining as an important tool for expedited analysis of TCM professor Niu Jianzhao's medication rules in prescriptions with climacteric syndrome.

Effects of liver-soothing therapy on the expression of estrogen receptors mRNA in perimenopausal syndrome rats with liver qi stagnation / 国际中医中药杂志

Objective To explore the effect of liver-soothing therapy on the expression of estrogen receptors mRNA in perimenopausal syndrome (PMS) rats with liver qi stagnation. Methods A total of 30 nature aging rats are assigned into control groups (n=8), model groups (n=8),Chaihu-Shugan San (CHSGS group,n=8) andDanzhi-Xiaoyao San (DZXYS group, n=8), according to the random number table. The PMS liver-Qi stagnation syndrome rat models were established by the methods of isolation raised and chronic bondage in all the groups except the control group. CHSGS group were administered 4.0 g/kg water decoctions ofChaihu ShuganSan, and DZXYS group 4.9 g/kg water decoctions ofDanzhi XiaoyaoSan respectively for 3 weeks after the rat models established. The model group and control group were administered with equal volume of normal saline. The open field test was used for the behavior test. The serum E2, FSH, LH level were measured by radioimmunoassay. The ERα, ERβ in ovary were measured by quantitative real-time PCR. Results Compared with model group on the 21st days, the CHSGS and DZXYS groups showed a significantly increase in crossings (49.6 ± 6.0, 51.6 ± 5.8vs. 40.0 ± 4.6,P0.05) increaed in the DZXYS group, but there was no remarkable difference. Conclusion The Liver-soothing therapy can improve the behavior of PMS rats with liver-Qi stagnation, and the mechanism may be related to the regulation of endocrine and ovarian estrogen receptors.

Therapeutic ComparisonBetween Acupuncture and Chinese Medication in Improving the Quality of Life in Post-menopausal Women / 上海针灸杂志

ObjectiveTo observe the effect of acupuncture and Chinese medication in improving the quality of life in post-menopausal women.MethodThe menopause Rating Scale (MRS) was adopted to evaluate the quality of life in post-menopausal women. Thirty post-menopausal women of MRS≥20 were randomized into an acupuncture group and a Chinese medication group to respectively receive 4-week treatment. They were scored again by using MRS at the end of intervention and during the follow-up study to compare with the pre-treatment scores.ResultThe decrease of MRS score was more significant in the acupuncture group than that in the Chinese medication group, and the intra-group comparisons between pre-treatment and post-treatment scores showed significant differences (P<0.001), and the intra-group comparisons also showed differences between pre-treatment and follow-up results (P<0.05).ConclusionThe effect of acupuncture in improving the quality of life in post-menopausal women is more significant than that of Chinese medication.

The general situation of climacteric syndrome treated with traditional Chinese medicine / 国际中医中药杂志

Climacteric syndrome is a common clinical disease with high incidence.The understanding of the disease is progressing in recent years.This article collects thirty-seven documents in this field in recent eight years.The pathogenesis of climacteric syndrome is divided into two aspects as the deficiency of the kidney and the imbalance of the liver, the spleen and the heart.It also sums up the therapy of climacteric syndrome from this two aspects.At last, the authors propose that we should pay attention to the importance of the liver, the spleen and the heart in both the pathogenesis and the therapy.

Clinical Observation of Acupuncture plus Medication for Perimenopausal Syndrome / 上海针灸杂志

ObjectiveTo compare the therapeutic efficacy of acupuncture plus medication versus using Chinese medication or acupuncture alone in treating perimenopausal syndrome.MethodNinety patients with perimenopausal syndrome were randomized into 3 groups, 30 in each group, to respectively receive acupuncture plus Chinese medication, Chinese medication alone, and acupuncture alone, totally for 3 months. Modified Kupperman index was adopted to evaluate therapeutic efficacy.ResultAfter intervention, the Kupperman scores decreased significantly in all three groups (P<0.01). The Kupperman score of the acupuncture-medication group was markedly superior to that ofthe medication group and acupuncture group (P<0.05).Conclusion Combination of acupuncture and medication can significantly improve the symptoms of perimenopausal syndrome, and is valuablein clinic.

The efifcacy and safety assessment of estradiol for treatment of women with perimenopausal syndrome / 中国生化药物杂志

Objective To investigate the clinical efifcacy of estradiol on perimenopausal syndrome,and evaluate its safety. Methods 64 cases with perimenopausal syndrome collected in our hospital from January 2010 to January 2011 were used as observation group, and treated with Estradiol valerate. Another 64 cases during the same period were used as control group, and treated with conventional therapy. After treatment, the symptom improvement of both groups were evaluated by the scoring criteria of HAMD and Kupperman, and the related hormone levels were detected and recorded. Adverse reactions after treatment were also observed. Results Clinical results showed that the HAMD and Kupperman score of both groups in end of treatment were better than before treatment, and the improvement degree in observation group were better than control in. The differences were signiifcant (P<0.05). Test results showed that the improvement of various hormonal indicators in observation group were also better than that in control group, the diffierences were significant (P<0.05). 8 cases of adverse reactions were observed in observation group after treatment, 12 cases in control group. Adverse reactions included breast tenderness, vaginal bleeding and gastrointestinal discomfort. The side effects between both groups had no signiifcant difference. Conclusion The efifcacy of Estradiol on perimenopausal syndrome was obvious, it can improve the menopausal symptoms, with less adverse reactions, and improve the life quality of perimenopausal women.

Yiyuan Shengjing Decoction Treat Similar Climacteric Syndrome of Breast Cancer after Treated with Tamoxifen / 浙江中医药大学学报

Objective] To observe the clinical effect of Yiyuan Shengjing Decoction on similar climacteric syndrome of breast cancer after treated with tamoxifen. [Method] Choose 60 cases of breast cancer, randomly divide them into control group 30 cases and treatment group 30 cases, the control one were treated with tamoxifen and oryzanol, the treatment one, with tamoxifen and Yiyuan Shengjing Decoction. After 4w, evaluate the efficacy, compare their clinical symptoms score, hormone levels and endometrium thickness, and calculate the clinical relieving rate. [Result] After treatment, both groups clinical symptoms were relieved more than before treatment, with difference of statistical meaning; comparing on clinical symptoms scores, the treatment was much less than control one, with statistical meaning; on clinical relieving rates, the treatment group reached 83.33%, while 26.67% for control one, both had difference of statistical meaning. The comparison of reproductive hormone levels and endometrium thickness, the difference had no statistical meaning. [Conclusion] Yiyuan Shengjing Decoction treating breast cancer similar climacteric syndrome after treated with tamoxifen had marked cure effect, without influencing reproductive hormone level and endometrium thickness.

Efficacy of Venlafaxine Hydrochloride Extended Release for the Treatment of Perimenopausal Depressive Women with Vasomotor Symptoms: Open-Label Observation Study / 대한정신약물학회지

OBJECTIVE: During the transition to menopause, various symptoms including vasomotor symptoms and depressed mood lead to low quality of life. We investigated the effect of low-dose venlafaxine hydrochloride extended release on depressed mood and vasomotor symptoms of perimenopausal women. METHODS: 33 perimenopausal women fulfilling Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria for a depressive episode were enrolled between January 2014 and May 2014. Subjects were prescribed 37.5 mg/day or 75 mg/day venlafaxine hydrochloride according to clinician's judgement, and the dosages were maintained for 8 weeks. Depressed mood and other psychological difficulties were evaluated by using Hamilton Rating Scale for Depression (HAMD), Hamilton Rating Scale for Anxiety (HAMA), Clinical Global Impression-Severity. Climacteric symptoms including vasomotor symptoms were evaluated by using Greene Climacteric Scale (GCS). For statistical analysis, paired t-test was used. RESULTS: Significant decreases in HAMD, HAMA, GCS scores were observed after 2 weeks of treatment and the trends continued until the end of the study. The scores of HAMD significantly decreased, 28 of them reached remission (HAMD < or =7). The scores on vasomotor symptoms of GCS after 8 week treatment significantly decreased compared to baseline (13.1+/-5.0, p<0.01). CONCLUSION: These results suggest that venlafaxine hydrochloride is effective and tolerable treatment option for vasomotor symptoms and depressed mood in perimenopausal women. To validate our results, furthur studies with double-blind, placebo controlled will be needed.

Clinical Research on Treatment of Climacteric Syndrome by Combination of Yi-Shen Yang-Xin Shu-Gan Decoction and Acupuncture Therapy / 世界科学技术-中医药现代化

This study was aimed to explore the clinical effect on treatment of climacteric syndrome by the combina-tion of Yi-Shen Yang-Xin Shu-Gan (YSYXSG) decoction and acupuncture therapy. A total of 78 female patients suffering from climacteric syndrome were selected and randomly divided into two groups, with 39 cases in each group. The control group was treated with oral administration of estradiol valerate. The treatment group was treated with the combination of YSYXSG decoction and acupuncture therapy on basis of western medicine treatment. Four-week was one treatment course. The treatment was continued for three treatment courses. Improvement state of both groups were compared by the integration of clinical symptoms before and after treatment as well as the Hamilton's Depression Scale (HAMD)/(HAMA). The results showed that according to the clinical symptoms, both groups had im-provements in varying degrees (P< 0.05, P< 0.01), in which HAMD, HAMA, FSH decreased (P< 0.05), and E2 in-creased (P< 0.05). The treatment group had more obvious superiority compared to the control group. There was sta-tistical significance between two groups (P < 0.05). The total efficiency rate of the treatment group was obviously higher than the control group with statistical significance (P < 0.05). It was concluded that combination of YSYXSG decoction, acupuncture therapy with hormonotherapy had more superiority in improving clinical symptoms, remitting emotion of anxiety-depression and controlling patient's condition compared with pure hormonotherapy, which had su-periority.