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To evaluate the efficacy and safety of Compound Glycyrrhizin Injection(CGI) in improving liver damage in chronic hepatitis B(CHB). PubMed, Web of Science, SinoMed, CNKI, Wanfang and VIP databases were retrieved from their inception to February 10, 2020. The randomized controlled trial(RCT) of CGI in the treatment of CHB was included. Data were independently extracted by two authors, and the methodological quality was evaluated using the Cochrane bias risk assessment tool by other two authors. Statistical analysis was performed using RevMan 5.3 software. A total of 18 two-armed RCTs were included, involving 1 915 participants. The methodological quality of all studies included was generally low. In the comparison between CGI and diammonium glycyrrhizinate, the results showed that CGI was superior to the control group in improving the overall clinical effectiveness, but there was no statistical difference between the two groups in increasing ALT normalization rate, reducing ALT and AST level. In the comparison between CGI and diammonium glycyrrhizinate+other general hepatoprotective drugs, the results showed that CGI was superior to the control group in reducing AST level, while there was no statistical difference between the two groups in reducing ALT level and increasing overall clinical effectiveness. In the comparison between CGI+other commonly used drugs(including energy mixture, glutathione, vitamins, potassium magnesium aspartate) and diammonium glycyrrhizinate+other commonly used drugs, the results showed that CGI combined with other commonly used drugs was better than the control group in reducing ALT and AST level and improving the clinical total effective rate, and there was no statistical difference between the two groups in increasing the rate of ALT normalization. In the comparison between CGI+other commonly used drugs and other commonly used drugs, the results showed that CGI combined with other commonly used drugs was superior to the control group in reducing ALT and AST level and improving the overall clinical effectiveness. In the comparison between CGI+vitamins and diammonium glycyrrhizinate+potassium magnesium aspartate+vitamins, the results showed no statistical difference between the two groups in reducing AST level. A small number of studies included reported that CGI caused mild adverse reactions when used alone or in combination with other drugs. Based on the results, CGI has a certain effect in improving CHB liver damage, but the evidence is not enough to prove that CGI would cause serious adverse events. In the future, more well-designed and strictly-enforced RCT with an adequate sample size are needed to further evaluate the effect CGI in alleviating CHB liver damage.
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Humans , Drugs, Chinese Herbal/adverse effects , Glycyrrhizic Acid , Hepatitis B, Chronic/drug therapyABSTRACT
Objective To evaluate the clinical efficacy of compound glycyrrhizin injection in the treatment of melasma.Methods A total of 30 melasma patients with blood vessel scores of ++ or +++ and melanin scores of ++ or +++,which were evaluated by dermoscopy and reflectance confocal microscopy (RCM) respectively,were collected from the Department of Dermatology of Hangzhou Third Hospital between May 2015 and July 2016.All the patients were randomly divided into 2 groups by drawing lots:treatment group treated with intravenous drips of compound glycyrrhizin injection at a dose of 40 ml once every three days for 8 sessions,oral vitamin C tablets at a dose of 0.2 g thrice a day,and oral vitamin E tablets at a dose of 0.1 g once a day,and control group treated with oral vitamin C and vitamin E tablets at the same dose as the treatment group.Three months after starting the treatment,the therapeutic effect was evaluated using melasma area and severity index (MASI).Meanwhile,RCM,dermoscopy and VISIA skin detector were used to detect skin lesions,and the melanin score,blood vessel score and brown spot and erythema indices were calculated.Results For the treatment group,the melanin score and blood vessel score were both significantly decreased at 3 months after starting the treatment compared with those before the treatment (Z =2.773,3.135,P =0.006,0.002,respectively),so were the brown spot index (38.3 ± 3.1 vs.43.9 ± 5.8,Z =3.091,P =0.002)and erythema index (26.5 ± 5.6 vs.33.3 ± 7.7,t =2.752,P =0.010).For the control group,the melanin score significantly decreased at 3 months after starting the treatment compared with those before the treatment (P =0.023),while no significant differences were observed in the blood vessel score or VISIA indices (P ＞ 0.05).Three months after starting the treatment,9 cases showed marked improvement,and 6 showed improvement in the treatment group;3 cases showed marked improvement,11 improvement,and 1 showed no improvement in the control group.The therapeutic effect in the treatment group was significantly superior to that in the control group (Z =2.276,P =0.029).Conclusion Compound glycyrrhizin injection is effective for the treatment of melasma,and RCM,dermoscopy and VISIA skin detector can be used to assist efficacy evaluation in melasma.
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OBJECTIVE:To observe therapeutic efficacy and safety of Calcipotriol betamethasone ointment combined with Compound glycyrrhizin injection in the treatment of erythrodermic psoriasis. METHODS:120 cases of erythrodermic psoriasis were randomly divided into observation group and control group,60 cases in each. Control group received Calcipotriol betamethasone ointment topical,2 times a day,for 6 weeks. Observation group was additionally given Compound glycyrrhizin injection 80 ml add-ed into 250 ml Glucose solution intravenously,once a day,on the basis of control group. PASI score,VAS score,DLQI score, Clinical efficacy and ADR of 2 groups were observed. RESULTS:Two groups of patients after treatment,PASI score,VAS score, lesion area and DLQI score were significantly decreased,the observation group decreased more significantly,the difference was sta-tistically significant (P0.05). CONCLUSIONS:Calcipotriol betamethasone ointment combined with Compound glycyrrhizin injection can effectively alleviate the clinical symptoms of psoriasis erythrodermic,improve their quality of life,has a definite curative effect and ADR.
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OBJECTIVE:To observe the curative effects and safety of compound glycyrrhizin injection combined with chemotherapy in the treatment of enteron malignant tumor at intermediate and advanced stage.METHODS:100patients were randomized into treatment and control group,the treatment group were given compound glycyrrhizin injection combined with chemotherapy,while the control group was treated with only chemotherapy,the curative effects and side effects were observed and compared between2groups.RESULTS:The short-term effective rates in the treatment group and the control group were58%and36%respectively(P
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0.05),but there were significant differences in liver function and prothrombin activity between the two groups(P
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OBJECTIVE:To observe the short-term curative effect of treating malignant tumor with compound glycyrrhizin injection plus chemotherapy and the effect of the combined therapy on liver function.METHODS:A total of62patients with malignant tumor were randomly divided into two groups:the treatment group was assigned to receive compound glycyrrhizin injection(60ml)combined with chemotherapy,and control group receive single conventional chemotherapy,the short-term curative effect and the impact on liver function between groups were compared.RESULTS:The total effective rates were51.6%and32.8%,respectively for the treatment group and the control group(P
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0.05),however,adverse reactions in trial group were obviously less than those in control group.CONCLUSION:CG is effecacious and safe in the treatment of CHB and other damage of liver and its clinical efficacy is better than that of DG.
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OBJECTIVE:To summarize the effects of compound glycyrrhizin injection(GL)on hormone withdrawal syndrome(HWS)in SARS patients.METHODS:Using contrast design,the HWS of 134 cases of SARS who had received hormone theropy was retrospectively analysed.RESULTS:Administration of GL could descend the incidence rate of symptoms of HWS,of which the incidence rates of short breath and chest distress,the main symptoms of SARS patients,dropped from 24.5%and 22.6%to 3.6%(P≤0.01)and 7.1%(P≤0.05)and the incidence of asthenia,musculoarthragia and headache decreased from 13.2%,15.1%and 10.4%to 7.2%,14.3%and 0%respectively.The number of patients with elevated ALT reduced(P≤0.01).CONCLUSION:GL can decrease the incidence of HWS.