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AIM To investigate the effects of Tongxinluo Capsules (Ginseng Radix et Rhizoma,Hirudo,Scorpio,etc.) combined with routine treatment on fibrinogen (Fib) and mean platelet volume (MPV) levels in appropriate patients for coronary artery bypass graft (CABG) surgery.METHODS One hundred and six patients were randomly assigned into control group (n =50) for routine treatment and observation group (n =56) for combination therapy of Tongxinluo Capsules and routine treatment.Both groups had their Fib and MPV levels evaluated,and safety compared.RESULTS Thirty,ninety days after the treatment,the two groups reported less incidence of composite cardiovascular events (refractory angina pectoris,relapsing myocardial infarction or death) (P ＜ 0.01),and the observation group had an even more obviously reduced plasma Fib level (P ＜0.01).The significantly decreased after-treatment MPV levels in the two groups were observed (P ＜ 0.05),and a most distinct decrease extent was found in the observation group after 90 d (P ＜ 0.05).For the bleeding events,the incidence rates of the observation group and the control group were 5.4％ and 4.0％,respectively.CONCLUSION For appropriate candidates of CABG surgery,Tongxinluo Capsules shows its efficacy in dissolving thrombus and improving clinical symptoms without serious bleeding risk.
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Fundamentos: Performance cirúrgica depende de condições pré e pós-operatórias. Eventos que ocorrem no período intraoperatório também podem estas associados à evolução. Objetivo: Avaliar a associação de fatores intraoperatórios com época de óbito de pacientes submetidos à cirurgia de revascularização miocárdica (RVM), em quatro hospitais públicos da cidade do Rio de Janeiro, entre janeiro 1999 e dezembro 2001. Métodos: Selecionadas, em quatro hospitais públicos da cidde do Rio de Janeiro, amostras aleatórias e ponderadas de 150 prontuários de pacientes, entre sobreviventes e óbitos. Informações sobre características intraoperatórias e época do óbito foram coletadas retrospectivamente dos prontuários e das declarações de óbitos. Estimaram-se taxas de letalidade em diversas faixas de tempo até um ano após cirurgia. Resultados: Na sala de operações ocorreram 7,4 por cento dos ópbitos; até o terceiro dia, 40,3 por cento; e até o 15º dia, 69 por cento dos óbitos do primeiro ano. Ao final do primeiro ano, 14,9 por cento dos pacientes faleceram. Tempos mais elevados de circulação extracorporea ou de clampeamento aórtico ocorreram naqueles que morreram durante acirurgia. Baixo débito, parada cardiorrespiratória (PCR) e arritmia ventricular grave intraoperatórios se associaram significativamente com o óbito precoce. Fibrilação atrialintraoperatória se associou com óbito mais frequente nos segundo e terceiro dias de pós-operatório. Conclusão: Fatores intraoperatórios favoreceram aocorrência de óbitos precoces, representando 2/3 das mortes do primeiro ano.
Background: Although surgical performance depends largely on pre- and post-operative conditions, intraoperative events may also be associated with these outcomes.Objective: To evaluate the association between intraoperative factors and times of death among patientsundergoing CABG surgery in four government hospitals in the City of Rio de Janeiro, between January 1999 andDecember 2003. Methods: Random weighted samples of 150 patient records with survivors and deaths were selected at four government hospitals in the City of Rio de Janeiro. Information on intra-operative characteristics and timesof death was collected retrospectively from the medical records and declarations of death. The lethality rates were estimated for several timeframes extending up to a year after the operation. Results: 7.4% of the deaths occurred in the operating theater; 40.3% by Day 3 and by Day 15, 69% of the deaths occurring during the first year. By the end of the first year, 14.9% of the patients were deceased. Longerextracorporeal circulation or aortic clamping times were found among patients who died during surgery. Low debit, cardio-respiratory failure (CRF) and severe intra-operative ventricular arrhythmia were significantly associated with early death. Intra-operative atrialfibrillation was associated more frequently with death on the second and third days after surgery. Conclusion: Intra-operative factors contributed to theoccurrence of early deaths, representing two thirds of deaths during the first year after surgery.
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Humans , Risk Factors , Myocardial Revascularization/adverse effects , Myocardial Revascularization/mortality , Extracorporeal Circulation/mortality , Atrial Fibrillation/complications , Atrial Fibrillation/mortalityABSTRACT
OBJECTIVE:To analyze the utilization and cost of three kinds antibiotics in patients undergoing coronary artery bypass graft (CABG). METHODS:Eight four CABG patients were divided into three groups:Mezlocillin Sodium group (n=28),Cefuroxime Sodium group (n=28) and Ciprofloxacin group (n=28). The postoperative infection rate,changes in body temperature WBC count and the cost of antibiotics were compared among the 3 groups. RESULTS:No postoperative infection case was noted in all the 3 groups. The duration for breathing machine used in Cefuroxime sodium group was the shortest at (14.21?5.45) hours,and the average cost for antibiotics in this group was also the lowest at (678.28?256.74) yuan,showing significance as compared with the other two groups (P
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PURPOSE: The purpose of this study was to investigate the stages of change in smoking cessation after a Coronary Artery Bypass Graft(CABG) and to identify the related factors. METHODS: The subjects (n=157) were patients who underwent a CABG in a university hospital from March 1998 to October 2005 and were smokers before the CABG. Data was collected viachart review and a telephone interview, and analyzed with descriptive statistics, Chi2 test, one-way ANOVA, and Kruskal-Wallis procedure by the SPSS/PC win 12.0 program. RESULTS: The subjects smoked for an average of 34 years (21 cigarettes per day) before surgery. Eleven percent of the subjects were in pre-contemplation, 6.4% in contemplation, 13.5% in preparation, 4.5% in action, and 64.5% in the maintenance stage. Nicotine dependence and selfefficacy were different among the groups with different stages of change in smoking cessation. Nicotine dependence was the lowest (p=0.00) and self-efficacy was the highest (p=0.00) in the maintenance stage. The number of subjects in pre-contemplation and contemplation significantly increased 6 years after surgery(p=0.05). CONCLUSIONS: To implement effective smoking cessation interventions for CABG patients, the intervention should be developed to accommodate individual readiness for smoking cessation, especially so for those who had a CABG more than 6 years previously.