ABSTRACT
Introduction: Paraphynylenediamine (PPD) in hair dye causes angioneurotic edema leading to acute respiratory distress, rhabdomyolysis, i.e. necrosis of skeletal muscle resulting in acute renal failure and liver injury upon ingestion. We studied the time course of treatment on organ damage markers such as plasma Creatine phosphokinase (CPK), Lactate dehydrogenase (LDH) and Total leukocyte count (TLC) of these patients till discharge. Materials and methods: We reviewed the case records of 10 Patients of suicidal hair dye poisoning. Data was collected in pre-specified data collection forms regarding WBC count, CPK levels, age, gender, time to index admission, ventilator support, the volume of ingestion and outcome. We followed the values of CPK and TLC of these patients till discharge. Results: The average age was 25.8±10.5, the mean volume of consumption of hair die was 102.5±17.5, and time to reach emergency room was 7.6±3.2 hours. On arrival, all patients were intubated and received gastric lavage, antihistamines, parenteral steroids, and sodium bicarbonate. Duration of ventilator support was 2.9±0.7 days and length of hospital stay was 10.1±2.7 days. At admission, CPK, TLC, and LDH were elevated, during hospital stay values CPK, LDH and TLC gradually decreased by day-5 after that they showed a marginal increase by day-7. Conclusion: We observed significantly elevated levels of CPK, LDH and TLC at index admission after oral ingestion of hair dye suggesting muscle, hepatic and hematological injury. The rate of decline of these values (recovery) is parallel.
ABSTRACT
SUMMARY: A 21-year-old healthy Korean man worked on a building construction site every day for almost 2 months and exercised every day for 1 or 2 hours after working hard. He felt dizziness, nausea, and experienced vomiting and body aches immediately after exercise and immediately took cold medicines including acetaminophen, cimetidine, bepotastine, and Codenal? complex for the common cold symptoms for 2 days because he was scheduled to participate in navy training at that time. He complained of severe trapezius pain and aches in his left calf 3 days after joining the Navy training. Testing revealed creatine phosphokinase (CPK) 6260 U/L, myogloblin 176 mcg/L in the urine, liver enzymes increased, and oliguria, suggesting rhabdomyolysis. He recovered with intravenous fluids without any complications.
Subject(s)
Humans , Young Adult , Acetaminophen , Cimetidine , Common Cold , Creatine Kinase , Dizziness , Liver , Nausea , Oliguria , Rhabdomyolysis , Superficial Back Muscles , VomitingABSTRACT
The use of teicoplanin is increasing with increase in the incidence of wound infections caused by methicillin-resistant Staphylococcus aureus. Teicoplanin has longer half-life than vancomycin, so it can be administerd once daily, whereas vancomycin has to be administered 3~4 times daily. Teicoplanin is known to have lesser side effect profiles than vancomycin, such as skin eruptions, ototoxicity and nephrotoxicity. A 27-year old women in vegetative state had a grade 3 pressure sore at coccyx area. We prescribe teicoplanin to manage wound infected by methicillin-resistant Staphylococcus aureus. Plasma creatine phosphokinase (CPK) was elevated abruptly at 9th day of teicoplanin therapy. Five days after discontinuation of teicoplanin, CPK was normalized. We experienced a case of elevation of plasma creatine phosphokinase associated with teicoplanin.
Subject(s)
Female , Humans , Coccyx , Creatine , Creatine Kinase , Half-Life , Incidence , Methicillin-Resistant Staphylococcus aureus , Persistent Vegetative State , Plasma , Pressure Ulcer , Skin , Teicoplanin , Vancomycin , Wound InfectionABSTRACT
Object To study the protective effect of Rodobryum roseum (Hedw) Limpr. on acute myocardial ischemia. Methods Rat acute myocardial ischemia models were prepared by ligating their left coronary arteries. Changes of their S-T segment was observed on lead Ⅱ dynamic ECG. Degree of ischemia was assessed by the extent of S-T segment elevation. Lactic dehydrogenase (LDH), creative phosphokinase (CPK), superoxide dismutase (SOD) and malondialdehyde (MDA) were determined at the same time. Results R. roseum can significantly alleviate S-T segment elevation, being most evident at the dose of 2 g/kg (P
ABSTRACT
We performed a electrophoresis to determine the serum level of isoenzyme of creatine phosphokinase in 30 patients with head injuries. The present study was undertaken to examine whether the measurement of serum level of brain type isoenzyme(CPK-BB) and heart type isoenzyme(CPKMB) were valuable in evaluating the clinical status of head injuries. All patients were diagnosed by Glasgow coma scale score, CT scan and then we performed a serial blood sampling during the first 7days. Brain type creatine phosphokinase(CPK-BB) was detected in the serum in 4 of 30 patientts(13.3%) and heart type creatine phosphokinase(CPK-MB) was detected in the serum in 8 of 30 patients(26.7%). These findings were seen within 48 hours after head injuries. The higher level were associated with severe brain damage; hemorrhagic contusion, subdural hemorrhage, subarachnoid hemorrhage and pneumocephalus.