ABSTRACT
The objective of this study is to develop a new-type biodegradable, biocompatible curcumin-loaded nanoerythrosomes (Cur-RBC-NPs) by means of the sonication method. The size of Cur-RBC-NPs was optimized by varying drug loading parameters. The morphology, size distribution, stability, in vitro release pattern, cellular uptake of nanoparticles and in vitro anti-tumor effects were evaluated, respectively. The results showed the prepared Cur-RBC-NPs were nearly uniform spheres, with an average diameter of (245.7 ± 1.3) nm. Encapsulation efficiency (EE) and load efficiency (LE) of Cur-RBC-NPs were 50.65% ± 1.36% and 6.27% ± 0.29%. And the nanoparticles had a good sustained release property. According to the in vitro experiment, Cur-RBC-NPs were effectively taken in by tumor cells, and exhibited a significant anti-tumor effect. In conclusion, the method for preparing Cur-RBC-NPs is convenient, with a good sustained release behavior and anti-tumor efficacy, and so expected to be a new-type nano-drug delivery system in clinical practice.
ABSTRACT
Objective: Taking mesoporous silica nanoparticle (MSN) as carrier, to prepare curcumin (Cur)-MSN-solid dispersion (SD) for study on its effect on the dissolution rate and solubility of Cur. Methods: MSN was prepared by condensation method and Cur-MSN-SD was obtained using solvent evaporation method. Then, Cur-MSN-SD was characterized with scanning electron microscope, nitrogen adsorption test, infrared spectrum analysis, and differential scanning calorimetry. Then the dissolution rate and solubility between Cur and Cur-MSN-SD were compared. Results: The average pore diameter of prepared MSN was 2.737 nm, with the feature of typical mesoporous structure, and Cur was distributed in the channel. The cumulative dissolution rate and solubility of the drug were the best as the mass ratio of Cur to MSN was 1∶4. Conclusion: The Cur-MSN-SD prepared with the MSN as carrier could improve the cumulative dissolution rate and solubility of Cur, which provides an effective method for solving the water non-solubility of Cur.