ABSTRACT
When eukaryotic cells face various environment stimulation,eukaryotic cells form some dense granules in hyalomitome,that are stress granules(SGs).They have antioxidant and inhibit apoptosis. Interaction between mRNA-binding proteins promotes stress granule formation. Assembly and disassembly of stress granules are modulated by va-rious post-translational modifications as well as numerous ATP-dependent RNP or protein remodeling complexes.Stress granules have the ability of liquidity,and energy input is required to maintain their dynamic state.Stress granule for-mation can regulate the process of stress reaction,virus infection and the signal transduction.The formation of constant and the abnormal stress granules result in neurodegenerative diseases and certain types of cancer.
ABSTRACT
When eukaryotic cells face various environment stimulation,eukaryotic cells form some dense granules in hyalomitome,that are stress granules(SGs).They have antioxidant and inhibit apoptosis. Interaction between mRNA-binding proteins promotes stress granule formation. Assembly and disassembly of stress granules are modulated by va-rious post-translational modifications as well as numerous ATP-dependent RNP or protein remodeling complexes.Stress granules have the ability of liquidity,and energy input is required to maintain their dynamic state.Stress granule for-mation can regulate the process of stress reaction,virus infection and the signal transduction.The formation of constant and the abnormal stress granules result in neurodegenerative diseases and certain types of cancer.
ABSTRACT
The purpose of this study was to investigate the identification of distinct characteristics of postural control during transition from a dynamic into a static state in young and older adults. We tested 8 healthy elderly (mean age of 67 yr±0.8) and 8 healthy young (mean age of 23 yr±1.2) adult subjects. After the consent session, all trial participants gave written informed consent if they agreed voluntarily to participate. The subject transitioned from a dynamic state into a static state on the force platform during a step maximally. Center of pressure (COP) from the force platform were recorded during 15s from both feet on the force plat with a sampling frequency of 100 Hz.The anterior-posterior (A-P) and medial-lateral (M-L) direction mean of COP of older adult subjects produced different postural sway and presented significant difference on the distributed value of COP in the quiet standing after the dynamic task, in comparison to the young adult subjects. A-P direction and M-L direction mean of COP was significant difference during the seconds from 0 to 2 (p＜0.05), and 1.5 to 2.5 (p＜0.05), respectively, between young and old subjects. The difference in the mean distance of COP and distributed value of COP between younger and older subjects were revealed by this study. These findings indicate that the development of a simple, non-stressful technique to analyze postural control in older adults is highly useful.
ABSTRACT
The purpose of this study is to develop a new system for measuring leg motions using a portable three-dimensional accelerometer. The measuring system is composed of acceleration sensors (MicroStone, MA3-10Ac), a data logger, a data reader, and a personal computer. The personal computer draws a graph of the acceleration of movements (i.e., accelerogram) from the output signals of the acceleration sensors. We then calculated the average acceleration to evaluate leg motions. We drew the accelerograms from 19 young subjects and 36 elderly subjects during the performance of physical fitness activities and walking. Different accelerograms were obtained from two subjects for different walking styles. The average accelerations at the lumbar, ankle and toe points were higher at all axes during movements from the physical fitness activities in the elderly subjects. The accelerations of leg motion at the knee point were, however, lower in the up and down axis in the elderly subjects than in the young subjects, although they were higher in the back and forth and the right and left axes. The new instrument has enabled us to evaluate leg motions by measuring three-dimensional acceleration during the performance of physical fitness activities and walking. The average accelerations of leg motions showed age-related changes. Thus, the average acceleration of leg motions may be used as a new index for evaluating leg motions at the dynamic state.
Subject(s)
Lower Extremity , Walking , Physical Fitness , Aged , MotionABSTRACT
The purpose of this study is to develop a new system for measuring leg motions using a portable three-dimensional accelerometer. The measuring system is composed of acceleration sensors (Micro Stone, MA3-10Ac), a data logger, a data reader, and a personal computer. The personal computer draws a graph of the acceleration of movements (i.e., accelerogram) from the output signals of the acceleration sensors. We then calculated the average acceleration to evaluate leg motions. We drew the accelerograms from 19 young subjects and 36 elderly subjects during the performance of physical fitness activities and walking. Different accelerograms were obtained from two subjects for different walking styles. The average accelerations at the lumbar, ankle and toe points were higher at all axes during movements from the physical fitness activities in the elderly subjects. The accelerations of leg motion at the knee point were, however, lower in the up and down axis in the elderly subjects than in the young subjects, although they were higher in the back and forth and the right and left axes. The new instrument has enabled us to evaluate leg motions by measuring three-dimensional acceleration during the performance of physical fitness activities and walking. The average accelerations of leg motions showed age-related changes. Thus, the average acceleration of leg motions may be used as a new index for evaluating leg motions at the dynamic state.