Material properties and tensile strength prediction model of traditional Chinese medicine tablets based on PCA-RBF neural network / 中国中药杂志

This paper constructs a prediction model of material attribute-tensile strength based on principal component analysis-radial basis neural network( PCA-RBF),in order to predict the formability of traditional Chinese medicine tablets. Firstly,design Expert8. 0 software was used to design the dosage of different types of extracts,the mixture of traditional Chinese medicine with different physical properties was obtained,the powder properties of each extract and the tensile strength of tablets were determined,the correlation of the original input layer data was eliminated by PCA,the new variables unrelated to each other were trained as the input data of RBF neural network,and the tensile strength of the tablets was predicted. The experimental results showed that the PCA-RBF model had a good predictive effect on the tensile strength of the tablet,the minimum relative error was 0. 25%,the maximum relative error was2. 21%,and the average error was 1. 35%,which had a high fitting degree and better network prediction accuracy. This study initially constructed a prediction model of material properties-tensile strength of Chinese herbal tablets based on PCA-RBF,which provided a reference for the establishment of effective quality control methods for traditional Chinese medicine preparations.

Study on forming technique of maxing antitussive and antiasthmatic grannule / 中草药

Objective: To optimize the processing conditions of Maxing Antitussive and Antiasthmatic Grannule (MAAG). Methods: The influence of different excipients including lactose, soluble amylum, and dextrine, and usage amount of soluble amylum to hygroscopicity of powdered extract was investigated; Processing conditions were optimized by orthogonal test, flowability, and hygroscopicity were investigated. Taking forming rate, solubility, and absorption rate as indexes, the materials added prescription varieties, ratio, and optimum molding process were screened. Results: The particles sugar plus dextrin as excipients were superior to dextrin or sugar or soluble starch as excipient particles; The optimized conditions were obtained with: main drug-accessories (1:2), accessories for the dextrin-powdered sugar (1:1), with 80% ethanol as wetting agent which accounted for 14% of the main drug. Conclusion: The selected accessories in MAAG is reasonable and forming process is feasible. This research provides the basis for the establishment of forming technique and control of production environment of MAAG.

Study on modeling process for golden gel / 中草药

Objective: To study the preparation process of golden gel. Methods: Taking the gel forming properties, stability, water loss rate, and pH value as investigation indexes, the influences of gel matrix, humectants, and binder dosage on gel forming were studied by single factor experiments. Results: The optimal conditions of preparation process were as follows: 1 g carbopol static swelling for 4 h, adding 10 g glycerol and 4 g drug powder, stirring after adding 1 g triethanolamine, adding water to 100 g, stirring well to obtain the gel. Conclusion: The method provides the evaluation criterion and basis for the further optimization of the golden gel forming process.

Correlations between physical properties of raw materials and formability of Panax notoginseng saponins pellets / 中草药

Objective: To investigate the correlations between raw material powders, wetting mass and the formability of Panax notoginseng saponins (PNS) pellets. Methods: PNS powder mixed with different proportions of microcrystalline cellulose (MCC), lactose, and starch were made into the pellets by extrusion-spheronization. Particle size, span, density, compressibility, Hausner ratio, specific surface area, pore volume, hygroscopicity, critical relative moisture, and angle of repose were used to evaluate the properties of mixing powders. Liquid solid ratio, plasticity index, liquid point, plastic point, and consistence were used to evaluate the properties of wetting mass. Feret diameter, aspect ratio, yield, density, and friability were used to evaluate the properties of the PNS Pellets. The correlations between the raw materials and the formability of their pellets were analyzed by cluster analysis, principal component analysis, and partial least squares regression analysis. Results: The properties of PNS pellets had no direct correlation with the properties of material powders; The liquid solid ratio, liquid points were positively correlated with the pore volume of powders and were negatively correlated with density, diffusion rate, and span of material powders; The density of the pellets was positively correlated with water content of wetting mass; The dissolution rate was positively correlated with PV and was negatively correlated with the constant ka. Conclusion: There are certain correlations between the formability of PNS Pellets and the physical properties of raw materials.

Optimization of damp-proof excipients for Gushuling Granules / 中草药

Objective: To evaluate the effect of the excipients on hygroscopicity of Gushuling Granules and optimize the damp-proof excipients. Methods: Moisture absorption rate was used to optimize the type and ratio of materials; The concentration of ethanol, moisture absorption rate, formability, angle of repose, and appearance of Gushuling Granules were used to optimize the molding technology. Results: The best damp-proofing excipients were as follows: the hybrid materials were lactose-mannitol 4:1, medicine-auxiliary ratio of 1:2, and with 85% ethanol to granulate. Gushuling Granules were good uniform, damp-proofing, and formability, the critical relative humidity was 76%. Conclusion: The preparation technology is stable. The study provides the experimental evidences for the research and development of Gushuling Granules.

Preliminary study on formalizing process of Changle Granule / 中成药

Objective:To screen better excipient and better ratio of the excipients and to improve the formability of the compound Chinese medicine Changle (Saliva Miltiorrhiza) and resistant to moisture of the granules. Methods: Through measuring the distribution of the size and the absorption of moisture of the granule the formability was determined. Under high moisture for a moment, the amount of absorption of moisture and the flowability of the granule was measured and the appearance was observed as to determine the nature of resistant to moiture of the granules. Results: The better excipients was soluble starch and avicel. It was better that the combined excipients of starch: avicel in a ratio of 1∶1 was mixed with the extract powder in a ratio of 2∶3. Conclusion: When the combined excipients of starch: avicel in a rato of 1∶1 was used, the extract powder was easy to be formed and the granule made was moisture-resistant.