ABSTRACT
Objective To compare differences of SRS-22 scores between male and female AIS patients.Methods From October 2007 to April 2009,298 AIS patients from 7 spine centers completed simplified Chinese edition of SRS-22 questionnaire,including 62 males and 236 females with an average age of 15.7 years old,and the average Cobb angle was 52.8°.Of 62 male patients,34 were from urban areas and 28 rural areas.Among 236 female patients,132 were from urban areas and 104 rural areas.A comparison was conducted in terms of age,Cobb angle,the ratio of urban population to rural population,and the scores of all domains and the subtotal scores of SRS-22 questionnaire between male and female patients.Results There was no difference of age,Cobb angle and the ratio of urban population to rural population between male and female patients(P＞0.05).The scores of four domains and subtotal scores of SRS-22 questionnaire were significantly higher in male patients when compared with female patients(P＜0.05).Conclusion Gender difference should be taken into the consideration when estimating the quality of life in AIS patients by SRS-22 questionnaire.The quality of life in male patients with AIS was better than that of female patients.
ABSTRACT
Objective: To investigate the influence of gender difference on the activation of platelets in septic rats. Methods: Totally 20 female and 20 male SD rats were randomly divided into four groups: male sham-operated group, female sham-operated group, female septic group, and male septic group, with each group containing 10 rats. Sepsis model in the last two groups was produced by cecal ligation and puncture (CLP); rats in the sham-operated group received no CLP. The rats were sacrificed 24 hours after surgery; the blood samples were collected for blood routine test; and the serum β-TG levels were detected by ELISA assay. Serum estrogen (E2) levels were detected by radioimmunoassay. Results: The blood platelet counts were decreased in both septic rats of both genders; the count in female rats was significantly higher than in the male rats (P< 0.01). The serum β-TG levels were increased in septic rats of both genders; the level in the female rats was significantly lower than that in the male rats (P<0.01). The blood platelets count in female or male septic rats was significantly positive correlation with the level of serum estrogen and the β-TG expression in female or male septic rats was significantly negative correlation with the level of serum estrogen(P<0.05). Conclusion: There is a gender difference in the activation of platelets in septic rats, and the endogenous estrogen may have protective effect on the platelets of female septic rats.
ABSTRACT
Objective:To investigate the influence of gender difference on the activation of platelets in septic rats.Methods: Totally 20 female and 20 male SD rats were randomly divided into four groups: male sham-operated group,female sham-operated group,female septic group,and male septic group,with each group containing 10 rats.Sepsis model in the last two groups was produced by cecal ligation and puncture(CLP);rats in the sham-operated group received no CLP.The rats were sacrificed 24 hours after surgery;the blood samples were collected for blood routine test;and the serum ?-TG levels were detected by ELISA assay.Serum estrogen(E2) levels were detected by radioimmunoassay.Results: The blood platelet counts were decreased in both septic rats of both genders;the count in female rats was significantly higher than in the male rats(P