ABSTRACT
The mechanism of hypercholesterolemia effect of Cu2+ deficiency was studied in rats. There was increased activity of hepatic hydroxymethylglutaryl-coenzyme A reductase and increased incorporation of labelled acetate into free cholesterol of liver in the Cu2+ deficient rats. Incorporation of label into ester cholesterol was however decreased in the liver. Concentration of bile acids in the liver was not significantly altered. Increase in the incorporation of labelled acetate into serum cholesterol and increase in the concentration of cholesterol and apo B in the low density lipoproteins + very low density lipoproteins fractions were observed. Activity of lipoprotein lipase of the extrahepatic tissues decreased in the Cu 2+ deficient rats.
ABSTRACT
The mechanism of hypocholesterolemic action of glucagon was studied in rats. A single injection of glucagon resulted in decreased synthesis of hepatic cholesterol, decreased release of lipoproteins into the circulation and increased degradation of cholesterol to bile acids in the liver. Lipoprotein lipase activity of the extrahepatic tissues was not affected.