Pharmacokinetics of lyophilization of toad venom-loaded solid lipid nanoparticles / 中成药

AIM: To investigate the pbarmacokinetics of lyophilization of toad venom(Venenum Bufouis)-loaded solid lipid nanoparticles(Vs-SLN). METHODS: Cinobufagin and resibufogenin plasma concentration in rat was determined by RP-HPLC. RESULTS: Statistic test showed that there was significant difference between lyophilization of Vs-SLN and Vs-injection for C_(max)、 AUC_(extra)、 MRT. CONCLUSION: As the circulating time of the drug in blood was markedly prolonged,Vs-SLN can be developed to a novel preparation for controlled release of lipophilic drugs.