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@#AIM: To evaluate the differences of macular vascular network measured by optical coherence tomography angiography(OCTA)between severe non-proliferative diabetic retinopathy(S-NPDR)eyes and health eyes, and explore the changes of these OCTA characteristics in patients with S-NPDR before and after panretinal photocoagulation(PRP).<p>METHODS: This was a prospective study including 31 eyes from 18 consecutive patients with S-NPDR and 31 eyes of healthy subjects. We measured macular vascular density and foveal avascular zone(FAZ)area and volume by an OCTA device.<p>RESULTS: Compared to the normal control group, in superficial retinal capillary plexus(SCP), macular vascular density decreased in S-NPDR group, except foveal vascular density unchanged. Consistently, in deep retinal capillary plexus(DCP), macular vascular density was also lower in S-NPDR group. In addition, FAZ area and volume expanded in S-NPDR eyes. At 6mo post-PRP in S-NPDR eyes, foveal SCP and DCP densities increased significantly, while FAZ area and volume decreased. At 3mo post-PRP, only foveal vascular density in DCP increased. The changes of foveal SCP and DCP densities as well as FAZ area and volume were not statically significant at 1mo post-PRP.<p>CONCLUSION: Macular vascular network was impaired in S-NPDR assessed by OCTA. Although OCTA parameters were not significantly affected by PRP in 1 and 3mo period, at 6mo follow-up parameters became significant after PRP.
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@#AIM: To evaluate the value of OCTA in the diagnosis and treatment of retinal vein occlusion.<p>METHODS: A retrospective case-control study was conducted to select 38 patients(38 eyes)with retinal vein occlusion diagnosed in ophthalmology clinic of Dalian Third People's Hospital from January to October 2018. The affected eyes were group A and the contralateral healthy eyes were group B. All patients underwent OCTA mode scanning of macular retina in the range of 3 mm×3 mm. Four layers of macular blood flow density maps were obtained, including surface retina, deep retina, outer retina and choroidal capillary layer. The area of vascularized area(FAZ)in the central fovea of the surface retina was measured. Image J software was used to calculate four layers of macular blood. Flow density(MVD)and OCT were used to measure the horizontal and vertical fovea thickness(CFT). <p>RESULTS: There were differences in FAZ measurements in superficial retina between group A and group B(<i>P</i><0.01), and in horizontal and vertical CFT measurements(<i>P</i><0.01). There were differences in MVD between group A and group B(<i>P</i><0.01). There was no difference in MVD results in outer retina(<i>P</i>=0.542)and choroidal capillary layer(<i>P</i>=0.489). BCVA was positively correlated with surface retinal FAZ, horizontal CFT and vertical CFT, and negatively correlated with surface retinal MVD and deep retinal MVD, respectively(<i>r</i>=-0.486, -0.465,all <i>P</i><0.01).<p>CONCLUSION: The application of OCTA examination has important guiding significance in indicating macular retinal microcirculation disorder and visual prognosis in patients with retinal vein occlusion.
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Objective To observe the early changes in the area of the foveal avascular zone (FAZ) and macular vascular density (MVD) in diabetic patients using optical coherence tomography angiography (OCTA) and its clinical significance.Methods This was a retrospective study.Totally 33 patients with diabetes mellitus were enrolled,including 13 patients with no-diabetic retinopathy (NDR group) and 20 patients with nonproliferative diabetic retinopathy (NPDR group) according to the international clinical grading criteria of diabetic retinopathy.Additional 26 healthy subjects with matched age were enrolled in the control group.All the subjects underwent the 3 mm ×3 mm scanning of macular retina by OCTA for obtaining 4 levels of macular vascular density map.And the area of the FAZ and the MVD were measured.Results The area of FAZ was(0.392 ± 0.028) mm2 in the NDR group and (0.410 ± 0.019) mm2 in the NPDR group,respectively,and the difference was statistically significant compared with the control group (0.314 ± 0.025) mm2 (all P =0.000),and there was statistically significant difference between the NDR group and NPDR group (P =0.010).The MVD in the superficial retinal layer,deep retinal layer,outer retinal layer and choroidal capillary layer was 0.500 ±0.012,0.553 ±0.007,0.393 ±0.005,0.651 ±0.006 in the NDR group,and 0.484 ± 0.012,0.522 ± 0.007,0.397 ± 0.007,0.642 ± 0.007 in the NPDR group,respectively,and the difference was statistically significant compared with the control group (0.518 ±0.014,0.572 ±0.008,0.385 ±0.005,0.666 ±0.007) (all P =0.000);there were statistically significant differences in MVD between the NDR group and NPDR group in the superficial retinal layer,deep retinal layer and choroidal capillary layer (all P =0.000),but not in the outer retinal layer (P =0.065).Conclusion OCTA suggested that the early retinal microcirculation impairment in the macula in patients with diabetes,which changes with the progression of the disease.
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Objective To investigate the macular vascular density after successful repair of rhegmatogenous retinal detachment (RRD) for one year using optical coherence tomography angiography (OCTA),and discuss the correlation between the macular vascular density and visual acuity.Methods Totally 42 patients of the RRD (42 eyes),their contralateral eyes (A group) and 42 patients of the normal eyes (B group) were recruited into this study.All participants underwent examination with best corrected visual acuity (BCVA) and OCTA.The difference in macular vascular density was compared and the correlation between BCVA and the vascular density was analyzed.Results The macular vascular density of superficial layer,deep layer and choroidal capillary layer was 0.422 4 ±0.089 3,0.4836 ±0.0748,0.527 1 ±0.039 0 in RRD group,respectively,0.469 3 ±0.112 5,0.550 0 ±0.074 0,0.546 2 ±0.034 3 in A group,respectively,0.5619 ±0.053 7,0.611 2 ±0.035 2,0.562 6 ±0.030 4 in B group,respectively.The macular vascular density was significantly decreased in RRD group when compared with A and B groups (all P ＜ 0.05).There was a positive correlation between BCVA and the macular vascular density in the deep layer and choroidal capillaries layer (r =0.629,0.654,both P =0.000).However,there's no correlation between the macular vascular density of superficial layer and BCVA (P =0.103).Conclusion All the macular vascular densities are decreased in patients of RRD after successful repair of retinal detachment one year later,which indicated that the blood flow does not completely recover.And there is a positive correlation between BCVA and macular vascular densities in deep layer and choroidal capillaries layer.And meanwhile,OCTA can objectively and effectively quantify the status of macular region blood flow.