Dor musculoesquelética relacionada com o trabalho e características dos trabalhadores de cervejaria no sudoeste da Nigéria - Um estudo-piloto / Work-related musculoskeletal pain and characteristics of brewery workers in southwest Nigeria- a pilot study

A dor osteoarticular relacionada ao trabalho (DORT) é um sintoma comum associado a perturbações musculoesqueléticas relacionadas com o trabalho. É agravada por más técnicas de elevação, ergonomia inadequada, movimentos repetitivos e postura incômoda durante o exercício das suas funções. Variáveis como a idade, o estado civil, a experiência profissional, o álcool, o tabagismo e os hábitos de exercício têm desempenhado um papel importante na prevalência das DORT entre as diferentes categorias de trabalhadores. OBJETIVOS: este estudo centrou-se na prevalência ao longo da vida, de 12 meses e pontos das WMSP em associação com as características sociodemográficas, de estilo de vida e de trabalho dos trabalhadores da indústria cervejeira no Estado de Osun, sudoeste, Nigéria. MÉTODO: um design de pesquisa descritiva foi utilizado, e um total de oitenta e nove (89) participantes foram recrutados com estrita adesão aos critérios de inclusão. Foi desenvolvido um questionário de 28 itens para obter informações específicas sobre a prevalência e o padrão de DORT, enquanto medições antropométricas (peso e altura) de cada participante foram medidas. Os dados coletados foram organizados e analisados usando estatísticas descritivas e teste de Qui quadrado. RESULTADOS: A prevalência de DORT ao longo da vida, 12 meses e pontos entre os participantes foi de 96,6%, 93,3% e 57,3%, respectivamente. As costas baixas eram a região corporal mais afetada. Existem associações significativas entre cada uma das idades, a prevalência de 12 meses e pontos das DORT e o estado civil dos participantes. Além disso, existe uma associação significativa entre a prevalência pontual de DORT e a idade dos participantes. CONCLUSÃO: concluiu-se que havia uma elevada prevalência de DORT entre os trabalhadores da cervejaria no Estado de Osun, sudoeste, Nigéria.

Work-related musculoskeletal pain (WMSP) is a common symptom associated with workrelated musculoskeletal disorders. It is aggravated by poor lifting techniques, inappropriate ergonomics, repetitive movements and awkward posture during the course of performing one's duties. Variables such as age, marital status, work experience, alcohol, smoking and exercise habits have been found to play major roles in WMSP prevalence among different categories of workers. OBJECTIVES: This study focused on the lifetime, 12-month and point prevalence of WMSP in association with the socio-demographics, lifestyle and work-related characteristics of brewery workers in Osun state, Southwest, Nigeria. METHOD: A descriptive research design was utilized, and a total of eightynine (89) participants were recruited with strict adherence to the inclusion criteria. A 28-item questionnaire was developed to obtain specific information on the prevalence and pattern of WMSP, while anthropometric measurements (weight and height) of each participant were measured. Collected data were organized and analyzed using descriptive statistics and Chi square test. RESULTS: The lifetime, 12-month and point prevalence of WMSP among the participants were 96.6%, 93.3%, and 57.3% respectively. The low back was the mostly affected body region. Significant associations exist between each of the lifetime, 12-month and point prevalence of WMSP and participants' marital status. Furthermore, a significant association exists between the point prevalence of WMSP and participants' age. CONCLUSION: It was concluded that there was a high prevalence of WMSP among brewery workers in Osun state, Southwest, Nigeria.

Evaluation of Zinc, Vitamin C and Vitamin E Levels in Male Subjects with Type 2 Diabetes Mellitus

Aim: The aim of this study was to determine the serum/plasma levels of zinc, vitamin C and E in male subjects with type 2 diabetes mellitus to establish their concentration pattern.Place and Duration of Study: Medical outpatient clinic, Chemical Pathology Laboratory of Enugu State University of Science and Technology Teaching Hospital, between January and December 2016.Methodology: This prospective cohort study enrolled 40 male individuals with type 2 diabetes mellitus and 40 apparently healthy control, within the age range of 45-75 years. Zinc, vitamin C, vitamin E, and fasting blood glucose levels were determined at pre-treatment, six months and 12 months into treatment. Results: The mean values of zinc, vitamin E and fasting blood glucose were significantly higher at pre-treatment compared to apparently healthy control values (147. 76 +/-32.95 vs 114.31+/-15.58 μg/dl,11.88+/-3.13 vs 3.42+/-0.21mg/dl and 8.08 +/-3.22vs 5.25+/-0.35 mmol/l respectively) (p=<0.001, <0.001, and <0.001 respectively). At 6 month into treatment in comparison to pre-treatment values, there were significant decreases in vitamin C (3.90+/-0.97 vs 5.15+/-1.43 mg/dl) (p= 0.04). At 12 month into treatment in comparison to pre-treatment values, there were significant decreases in vitamin C (3.25+/-0.16 vs 5.15+/-1.43 mg/dl) (p= <0.001). At pre-treatment, vitamin C significantly decrease from 6.49+/-0.96mg/dl in age group 45-64 years to 4.10+/-0.76mg/dl in age >65 years (p=0.01).Conclusion:The levels of vitamin C were lower at six months, but lowest at 12 month into treatment. Also vitamin C levels were found to be lower in age >65 years.

Phytotoxicity in two sugarcane cultivars in the initial development as affected by selectivity to herbicides / Fitotoxidez em dois cultivares de cana-de-açúcar no desenvolvimento inicial em função da seletividade a herbicidas

Sugarcane is a crop of great importance for human consumption, either for the production of sucrose or for the production of ethanol fuel. The objective of this work was to evaluate the phytotoxicity caused by the herbicides, the agronomic components in two sugarcane cultivars, at five evaluation times, during the 12-month and 18-month cultivation periods. The experimental design was randomized blocks with four replicates, in a 10 x 2 factorial scheme, with nine herbicides (tembotrione, mesotrione, clomazone, saflufenacil, 2,4 dichlorophenoxyacetic, fluroxypyr + picloram, metribuzin, isoxaflutole, sulfentrazone), two sugarcane cultivars (RB006995 and RB036153), and five evaluation times (7, 14, 21, 28 and 35 days after application ­ DAA). The most phytotoxic herbicides for the 12-month cultivation period in the cultivars RB036153 and RB006995 were clomazone and sulfentrazone. For 18-month cultivation period, the herbicides isoxaflutole, clomazone and sulfentrazone were the most phytotoxic, mainly for the cultivar RB006995. For most herbicides, phytotoxicity decreased along the days after application. The most selective herbicides for both cultivars and cultivation periods were tembotrione, mesotrione and fluroxypyr + picloram.(AU)

A cana-de-açúcar é uma cultura de grande importância para alimentação humana, tanto para a produção de sacarose quanto para a produção de combustível etanol. O objetivo deste trabalho foi avaliar a fitotoxidade causada pelos herbicidas, nos períodos de cultivo de cana de ano e cana de ano-e-meio durante o estádio de brotação e perfilhamento de dois cultivares de cana-de-açúcar. O delineamento experimental utilizado foi de blocos casualizados com quatro repetições, em um esquema fatorial 10 x 2, sendo os fatores compostos por nove herbicidas (tembotriona, mesotriona, clomazona, saflufenacil, 2,4 diclorofenoxiacético, fluroxipir + picloram, metribuzin, isoxaflutol, sulfentrazona) mais uma testemunha, dois cultivares de cana-de-açúcar (RB006995, RB036153) e cinco épocas de avaliação (7, 14, 21, 28 e 35 DAA). Os herbicidas mais fitotóxicos para a cana de ano nos cultivares RB036153 e RB006995 foram clomazona e sulfentrazona. Para a cana de ano-e-meio, os herbicidas isoxaflutol, clomazona e sulfentrazona foram os mais fitotóxicos, principalmente no cultivar RB006995. Para a maioria dos herbicidas houve decréscimo da fitotoxidez com o passar dos dias após a aplicação. Os herbicidas mais seletivos para ambos os cultivares e períodos de cultivo foram tembotriona, mesotriona e fluroxipir + picloram.(AU)

Cell Membrane Stability and Relative Water Content of Cymbopogon citratus (Lemon Grass)

In this research the cell membrane stability (CMS), relative water content (RWC) and effect of different water interval on Cymbopogon citratus (lemon grass) was assessed. The cell membrane stability and relative water content of the plant shows the physiological activity of the plant. The plant sample was subjected to three different watering regimes viz: one, two- and three-days intervals with a control sample irrigated daily for a period of twelve months. Uniform stalk of lemon grass plants were planted into a depth of 7.5 cm composted soil, each treatment was made in triplicate. The evaluated growth parameters where height of the plant, number of leaves and tillers, which were taken weekly for period of twelve months (year). The height shows a significant difference from first to twelfth month after planting. The height of the plant increases simultaneous with the age of the plant. First month after planting show significant difference in height of sample watered daily and treated samples. The results shows that the RWC (07.14%) and CMS (52.58%) was low in samples under water stress respectively when compared to well-watered samples (55.41%). No significant difference was observed between samples under one, two and three days interval. The number of leaves differs significantly in the first MAP except in the samples watered daily and three days interval. Maximum number of leaves was achieved at twelfth MAP under one day interval (137.33) followed by samples watered daily (126) and two days interval, while three days interval has the least number of leaves (leaf number). The number of tillers shows significant differences between the means at fifth and sixth MAP, (fifth MAP = 73.33 and sixth MAP = 126) and the treatments under one day intervals (fifth MAP = 18.33 and sixth MAP = 35.67). In the research, samples watered daily and under one day intervals shows high productivity when compared to the remaining treatment.

A study to assess nutritional status and related factors among children of 6 months to 5 years in residing at field practice area of B. J. Medical Collage, Ahmedabad

Background: Under nutrition continues to be an important public health problem, inspite of several nutrition intervention programs in India. The present study was carried out to know the prevalence of underweight, stunting and wasting among 6 months to 5 years children and to assess nutrition status and related factors among study population.Methods: A community based cross sectional study using stratified random sampling. Total 165 samples were taken from 5 field practice area of B. J. Medical College, Ahmedabad. From each area 33 random samples were taken.Results: Out of 165 children 80 and 85 were male and female. The prevalence of underweight, stunting and wasting was 45%, 46% and 29% respectively. SE class IV and V, low birth weight, higher birth order, late age of starting complementary feeding, parents education were significantly associated with undernutrition.Conclusions: The risk of undernutrition is higher in field practice area of B. J. Medical College, Ahmedabad. There is a need to strengthen promotion of maternal nutrition; maternal education and improving household socio-economic condition along with health care services may improve nutritional status of children.

Nutritional assessment for 0-6-month old infant / 中国实用儿科杂志

Accurate nutritional assessment is the premise to get nutritional diagnosis,nutritional treatment,and optimal clinical outcomes. Traditional nutritional assessment "ABCDE" approach includes anthropometry,biochemistry,clinical assessment,dietary assessment,and environment and family information,which need to be comprehensively evaluated by the pediatricians or clinical dietitians with clinical experience. For 0-6-month old infants,nutritional assessment should be made based on "ABCDE" approach,focusing on the individual longitudinal growth curve change according to the WHO growth charts. If possible,body composition measurements may provide a more accurate evaluation.

Comparison of Polysaccharide and Dendrobine Content in Hejiang Dendrobium nobile at Different Harvesting Time / 中国药房

OBJECTIVE:To determine quality indexes of Hejiang Dendrobium nobile at different harvesting time and months,and to provide scientific reference for reasonable harvesting period of Hejiang D.nobile.METHODS:The stem of annual,biennial and triennial D.nobile were collected.The drying rate,the contents of polysaccharides (colorimetry),dendrobine (GC) and total alkaloids (colorimetry),effective component total rate (dendrobine×drying rate) were measured.Biennial D.nobile were collected in autumn and winter (Oct.of the second year-Mar.of the third year,15th day a month) to determine drying rate,the contents of polysaccharides and dendrobine.RESULTS:The drying rate,the contents of polysaccharides and effective component total rate were higher than annual and triennial D.nobile.The content of total alkaloids and dendrobine were in descending order:annual D.nobile (0.52％,0.48％) ＞biennial D.nobile(0.48％,0.44％) ＞triennial D.nobile (0.32％,0.22％).From Oct.of the second year to Mar.of the third year,the drying rate of biennial D.nobile was increasing month by month;the contents of polysaccharides and dendrobine increased firstly and then decreased;the content of polysaccharide was the highest in Feb.(17.32％),and the content of dendrobine reached the highest level in Dec.(0.51％).CONCLUSIONS:The optimal harvesting period is biennial Hejiang D.nobile in Dec.and Jan.(third years before flowering),considering flowering characteristics,drying rate,the contents of polysaccharide and dendrobine.

An observational study of trigeminal neuralgia patients taking carbamazepine during the fasting month of Ramadan

Introduction: Trigeminal neuralgia is an agonising orofacial pain affecting unilaterally the distribution of the trigeminal nerve and it usually occurs in the middle and older age groups. Carbamazepine which is an anti-neuralgic as well as an anti-convulsant medication is the first line drug for treatment of trigeminal neuralgia. It is commonly taken as one tablet (200 mg) three times a day. Materials and Methods: This is an observational study carried out from April to September 2014 to determine how Muslim patients on carbamazepine treatment for trigeminal neuralgia cope with their neuralgic pain. The pattern of how the medication was taken during the fasting month of Ramadan was also observed. Results: A total of 29 patients participated in this study and 27(93%) observed the fast. Ten of them adjusted the carbamazepine dose from three times pre-Ramadan to twice daily during the fasting month. Three patients continued fasting despite feeling the pain during the daytime while five patients had their pain under control with the newly adjusted dose. Conclusion: Medical professionals should advise trigeminal neuralgia patients on how to take and adjust their carbamazepine dose during the fasting month.

Research on Month Rhythm Change of Plasma Metabolic Markers of Rat with Wei Qi Deficiency / 中国中医药信息杂志

Objective To use metabonomics method to study the change of the basic materials of month rhythm of wei qi deficiency syndrome; To find the potential markers so as to provides a new way for the essence of the wei qi deficiency syndrome research.Methods Based on the autumnal equinox in lunar calendar month, the beginning of a month (the first day of lunar August), the middle of a month (the 15th day of lunar August), and the end of a month (the 30th day of lunar August) were set as the three days to draw experimental materials. Two weeks before drawing materials, 20 rats were randomly divided into control group and model group, 10 rats in each group. The model rats were modeled by the stimulus of fatigue combined with coldness and hotness. Control group rats received conventional breeding. The rats in the both groups during the three experiments received decollation and the blood was taken at the 12 o’clock at noon. HPLC-MS was used to detect plasma metabolites, and partial least squares were used to make statistical analysis on the data for comparing plasma metabonomics original data of control group and model group. Possible metabolic markers of wei qi deficiency syndrome were explored, and the potential makers of month rhythm change of wei qi deficiency syndrome were deduced.Results Oleamide, phosphatidyl glycerol, cortisol, proline, dimethyl fumarate, and eicosapentaenoic acid may be potential markers of wei qi deficiency syndrome in the beginning of a month. Sphingosine-1-phosphate, malic acid, cortisol, oleamide, carnitine, eicosapentaenoic acid and dimethyl fumarate may be potential markers of wei qi deficiency syndrome in the middle of a month. Cholesteryl acetate, threonine, cortisol, dimethyl fumarate, oleamide, eicosapentaenoic acid and pyroglutamate may be potential markers of wei qi deficiency syndrome in the end of a month.Conclusion Month rhythm change of wei qi deficiency syndrome may be influenced by oleamide, cortisol, eicosapentaenoic acid, dimethyl fumarate, and aconitic acid, and may be closely related to energy metabolism, meanwhile accompanied by regulation of cell, hormone and nerves.

Perioperative morbidity and mortality in the first year of life: a systematic review (1997-2012) / Morbimortalidade perioperatória no primeiro ano de idade: revisão sistemática (1997-2012)

ABSTRACTBACKGROUND AND OBJECTIVES: Although many recognize that the first year of life and specifically the neonatal period are associated with increased risk of anesthetic morbidity and mortality, there are no studies directed to these pediatric subpopulations. This systematic review of the scientific literature including the last 15 years aimed to analyze the epidemiology of morbidity and mortality associated with general anesthesia and surgery in the first year of life and particularly in the neonatal (first month) period.CONTENT: The review was conducted by searching publications in Medline/PubMed databases, and the following outcomes were evaluated: early mortality in the first year of life (<1 year) and in subgroups of different vulnerability in this age group (0-30 days and 1-12 months) and the prevalence of cardiac arrest and perioperative critical/adverse events of various types in the same subgroups.CONCLUSIONS: The current literature indicates great variability in mortality and morbidity in the age group under consideration and in its subgroups. However, despite the obvious methodological heterogeneity and absence of specific studies, epidemiological profiles of morbidity and mortality related to anesthesia in children in the first year of life show higher frequency of morbidity and mortality in this age group, with the highest peaks of incidence in the neonates' anesthesia.

RESUMOJUSTIFICATIVA E OBJETIVOS: Embora muitos reconheçam que a idade inferior a um ano e especificamente o período neonatal estejam associados a maior risco de morbimortalidade anestésica, não existem estudos dirigidos a essas subpopulações pediátricas. Esta revisão sistemática das publicações científicas dos últimos 15 anos teve como objetivo analisar o perfil epidemiológico da morbimortalidade relacionada com a anestesia geral e cirurgia no primeiro ano de idade e em particular no período neonatal (primeiro mês de idade).CONTEúDO: A revisão foi conduzida por pesquisa de publicações nas bases de dados Medline/PubMed. Foram avaliados os seguintes desfechos: mortalidade precoce no primeiro ano de idade (< 1A) e em subgrupos de diferente vulnerabilidade nesta faixa etária (0-30 dias e 1-12 meses) e prevalência de parada cardíaca e eventos críticos/adversos perioperatórios de diversos tipos nos mesmos subgrupos.CONCLUSÕES: A literatura corrente indica grande variabilidade nos índices de mortalidade e morbidade na faixa etária em análise, bem como nos seus subgrupos. No entanto, apesar da óbvia heterogeneidade metodológica e da ausência de estudos específicos, os perfis epidemiológicos de morbimortalidade relacionada com a anestesia de crianças no primeiro ano de idade mostram frequência mais alta de morbimortalidade nessa faixa etária, com os maiores picos de incidência na anestesia de neonatos.

Physicochemical and antioxidant properties of kiwifruit as a function of cultivar and fruit harvested month

The present study was carried out to find the effect of fruit harvesting stage (October, November and December) on the physicochemical and antioxidant properties in five kiwi cultivars (Abbot, Bruno, Allison, Hayward, Monty). Results showed that soluble solid content (SSC) and pH increased while ascorbic acid (Vit C), titrated acidity (TAD) and SSC/TAD decreased in all the cultivars with delay in harvesting. Total polyphenols (TP) were decreased while total flavonoids (TF) increased in all tested cultivars with delay in harvesting. The highest concentration of TP (2.02 mg gallic acid equivalent/g fresh weight) and TF (51.12 mg catechin equivalent/100g FW) were found in cultivar 'Allison' in the month of October and December, respectively. Antioxidant activities (AA) were genotype depended and no trend was observed with month of harvesting. Principal component analysis (PCA) showed strong correlation between Vit C, TP and antioxidant activities. Two major clusters were computed using agglomerative hierarchical clustering (AHC). All the studied important traits may be used in the breeding programmes to increase the variability for different physiochemical and antioxidative characteristics and to make suitable selections that could be acceptable to consumers.

Prognostic factors of survival in patients with metastatic renal cell carcinoma treated with sunitinib / 中华泌尿外科杂志

Objective To study the prognostic factors of survival in patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib.Methods From May 2008 to Dec 2012,the clinical data of 82 cases with mRCC adminstered by sunitinib were reviewed retrospectively.The study included 60 male patients and 22 female patients,whose age ranged from 29 to 82 years [mean (56.1±11.3) years].Among them,52 cases presented hematuria,flank pain and palpable mass.The size of renal tumor ranged from 2.0 to 18.0 cm [mean (8.0±3.0) cm].The location of tumor included 41 in left kidney,37 in right kidney and 4 in bilateral kidney.The pathological tissue obtained from the operation in 69 cases and from biopsy in 13 cases.The pathological results demonstrated renal cell carcinoma in 75 cases,papillary cell carcinoma in 2 cases,chromophobe cell carcinoma in 2 cases,sarcomatoid carcinoma in 2 cases,collecting duct carcinoma in one case.The site of metastasis included lung in 50 cases,liver in 11 cases,bone in 14 cases,pancrease in 3 cases,retroperitoneal lymph node in 31 cases.In 52 cases,the ECOG scores ranged from 1 to 2.The others scores were more than 3.The average level of hemoglobin,AKP,LDH and leukocyte were (132±24)g/L,(90±65) U/L,(168±114) U/L and (6.4±2.0)×109/L,respectively.Before treatment,the abnormal cases in those parameters were 59,9,6 and 2,respectively.According to the MSKCC risk model,14 cases were classified into the high risk group and 68 cases into medium risk group.74 cases were accepted the sunitinb therapy within one year after diagnosis and 8 cases were accepted same therapy until one year after diagnosis.The overall survival (OS) rates were calculated by Kaplan-Meier method and Cox regression model was used to analyze the relationship between the influencing factors and the prognosis.Results The average OS was (21.6± 14.1) months (ranged 2.8 to 64.1 months).The survival rate at 1 st,2nd and 3rd year were 71％,64％ and 58％,respectively.Single factor analysis showed that significant prognostic factors were as follows:ECOG performance status ≥ 2 (P =0.005),clinical symptom during first clinic visiting (P =0.031),without nephrectomy (P =0.012),the number of metastatic sites ≥ 2 (P =0.015),hemoglobin before treatment (P=0.005),serum AKP level before treatment (＞126 U/L) (P=0.007),MSKCC score≥ 3 (P =0.000),the presence of liver metastases (P =0.000) and bone metastases (P =0.000) and relative dose intensity in the first month (1M-RDI) of sunitinib ≥ 50％ (P=0.000).Cox regression model showed that the beneficial predictive factors were ECOG performance status＜2 (P=0.136),no symptom during the first clinic visiting (P=0.801),serum AKP ＜126 U/L (P=0.618) before treatment,the absence of bone (P =0.068) and pancreas metastases (P =0.265).Sunitinib 1M-RDI ≥ 50％ was the independent predictive factor (P=0.000).Conclusions In targeted therapy era,there is some change in the prognostic factors for mRCC and target drug play an important role in the prognosis of mRCC.Sunitinib 1M-RDI ≥50％ is the independent predictive factor for the prognosis of renal carcinoma.

Right sided congenital diaphragmatic defect with liver hernia: A case report.

Congenital diaphragmatic hernia is a rare entity occurring in 1 in 2000-4000 live births and accounts for 8% of all major congenital anomalies. Congenital diaphragmatic hernia (CDH) is a major surgical emergency in new-borns because the key to survival depends on the prompt diagnosis and treatments. We reported here a case of right sided congenital diaphragmatic defect with liver hernia in a 7 month old baby, who came to seek medical care at a tertiary care centre in Navi Mumbai for on and off cold and cough with breathlessness after feeds. The baby was tachypneic on examination. Immediately chest X-ray and CT scan of thorax and abdomen was done to assess symptomatically and clinically suspected case of congenital diaphragmatic hernia. It was a case of right sided congenital diaphragmatic hernia.

Breastfeeding Self-efficacy of Mothers and the Affecting Factors / La autoeficacia de las madres en cuanto a la lactancia y los factores que la afectan / A autoeficacia das mães quanto à lactancia e os fatores que a afetam

Objectives: The purpose of this study was to determine the breastfeeding self-efficacy of mothers in the 0-3 month period and the affecting factors. Material and methods: The study was conducted between January-April 2011. The universe of the study consisted of all the mothers who were living in the center of Sakarya province and had infants ages 0-3 months. The sample used in the study consisted of 152 mothers who agreed to participate. The data were collected through face-to-face interviews with the mothers, using the "Personal Information Form" developed by the researchers and the "Breast-feeding Self-efficacy Scale-Short Form / BSES-SF" developed by Dennis. Turkish validity and reliability of the scale were done by Tokat et al. (2010). The data were evaluated with the SPSS program, using percentages, averages, the t-test, chi-square and ANOVA. Results: The average total score from the "taken BSES-SF" was determined as 58.61 ± 8.93, min = 16, max = 70. No significant differences were found between the scale score and maternal age (F = 0.437, p = 0.781), maternal education (F = 0.625, p = 0.645), economic status (F = 0.253, p = 0.777) and mode of delivery (t = 0.922, p = 0.358). The mean scores were determined as being higher for mothers who indicated having received training for breastfeeding compared to others who indicated having received no such training, and the difference between the scale score was statistically significant (X2 = 50.848, p = 0.010). Conclusions: Requirements for developing breastfeeding adequacy among mothers were determined. Nurses can give the necessary support to low breast-feeding mothers by assessing and identifying those requirements with help of this scale.

Objetivos: el objetivo de este estudio fue determinar la autoeficacia de las madres en cuanto a la lactancia durante el período de 0-3 meses y los factores que la afectan. Materiales y métodos: el estudio se realizó entre enero y abril de 2011. El universo del estudio estuvo compuesto por todas las madres que vivían en el centro de la provincia de Sakarya y tenían niños lactantes de 0-3 meses. La muestra utilizada en el estudio estuvo conformada por 152 madres que aceptaron participar. Los datos fueron recolectados a través de entrevistas cara a cara con las madres, utilizando el "Formulario de Información Personal" desarrollado por los investigadores y el "Formulario de Escala de Autoeficacia en Lactancia - versión abreviada/ BSES-SF" desarrollado por Dennis. La validez y confiabilidad de la escala usada en Turquía fueron medidas por Tokat et al. (2010). Los datos fueron evaluados a través del programa SPSS, utilizando los porcentajes, los promedios, la prueba t, el chi-cuadrado y ANOVA. Resultados: el puntaje total promedio de la "BSES-SF tomada" se determinó como 58,61 ± 8,93, min. = 16, máx. = 70. No se hallaron diferencias significativas entre el puntaje de la escala y la edad materna (F = 0,437, p = 0,781), la educación materna (F = 0,625, p = 0,645), la situación económica (F = 0,253, p = 0,777) y el tipo de parto (t = 0,922, p = 0,358). Los puntajes promedio fueron mayores para las madres que indicaron haber recibido capacitación para la lactancia materna en comparación con otras que indicaron no haber recibido dicha formación, y la diferencia entre el puntaje de la escala fue estadísticamente significativa (X2 = 50,848, p = 0,010). Conclusiones: los requisitos para el desarrollo de un nivel adecuado de lactancia materna entre las madres fueron identificados. Las enfermeras pueden dar el apoyo necesario a las madres con bajo nivel de lactancia mediante la evaluación y la identificación de los requisitos con la ayuda de esta escala.

Objetivos: o objetivo deste estudo foi determinar a autoeficácia das mães quanto à lactancia durante o período de 0-3 meses e os fatores que a afetam. Materiais e métodos: o estudo foi realizado entre janeiro e abril de 2011. O universo do estudo esteve composto por todas as mães que moravam no centro da província de Sakarya e tinham crianças lactantes de 0-3 meses. A amostra utilizada no estudo esteve conformada por 152 mães que aceitaram participar. Os dados foram coletados por meio de entrevistas cara a cara com as mães, utilizando o "Formulário de Informação Pessoal" desenvolvido pelos pesquisadores e pelo "Formulário de Escala de Autoeficácia em Lactancia - versão abreviada BSES-SF" desenvolvido por Dennis. A validade e confiabilidade da escala usada na Turquia foram medidas por Tokat et al. (2010). Os dados foram avaliados por meio do programa SPSS, utilizando as porcentagens, as médias, a prova t, o qui-quadrado e Anova. Resultados: a pontuação total média da "BSES-SF tomada" foi determinada como 58,61 ± 8,93, min. = 16, máx. = 70. Não se constataram diferenças significativas entre a pontuação da escala e a da idade materna (F = 0,437, p = 0,781), da educação materna (F = 0,625, p = 0,645), da situação econômica (F = 0,253, p = 0,777) e do tipo de parto (t = 0,922, p = 0,358). As pontuações médias foram maiores para as mães que indicaram ter recebido capacitação para a lactancia materna em comparação com outras que indicaram não ter recebido essa formação, e a diferença entre a pontuação da escala foi estatisticamente significativa (X2 = 50,848, p = 0,010). Conclusões: os requisitos para o desenvolvimento de um nível adequado de lactancia materna entre as mães foram identificados. As enfermeiras podem dar o apoio necessário às mães com baixo nível de lactancia mediante a avaliação e a identificação dos requisitos com a ajuda dessa escala.

Seasonal Variation in Months of Birth and Symptom Flares in Korean Patients with Inflammatory Bowel Disease

BACKGROUND/AIMS: Seasonal variation may influence the development and exacerbation of inflammatory bowel disease (IBD). However, most epidemiologic studies on this topic have been conducted in Western countries. The purpose of this study was to determine whether birth dates and symptom flares follow a seasonal pattern in Korean patients with IBD. METHODS: Patients with a diagnosis of IBD established between January 2003 and December 2010 were investigated at six university hospitals in Korea. The expected births and flares, with a uniform distribution during the year and considering differences in the number of days in the months of 1 year, were calculated. RESULTS: A total of 411 patients with ulcerative colitis (UC) and 316 patients with Crohn disease (CD) were included in the study. Birth during the winter period, and especially in January and February, was associated with an increased risk of IBD, especially in UC patients. The symptom flares of CD patients occurred most frequently in the spring, with a nadir in the autumn. However, no disease flare seasonality was noted for UC patients. CONCLUSIONS: Our data suggest that seasonally varying environmental factors during pregnancy and the postpartum period are associated with a susceptibility to IBD later in life and that exacerbations of CD are influenced by seasonal factors.

Clinical characteristics of 16 fatality cases of hand foot and mouth disease caused by enterovirus 71 / 中国小儿急救医学

ObjectiveTo explore clinical characteristics of fatality cases of hand foot and mouth disease caused by enterovirus 71 (EV71),and to improve the diagnosis and treatment of the disease.Methods Sixteen children infected with EV71 were retrospectively reviewed.Clinical manifestation,laboratory data and death causes were analyzed.ResultsAll cases were younger than four years,and the mean age was 18.9 months.Seasonal variations in incidence were observed,with a peak in incidence during the summer season.These cases typically presented with a brief duration of febrile illness,nonspecific neurological signs including headache,vomiting,limb tremor and convulsions.After two to four days,they all got sudden deterioration,manifested with tachycardia,poor peripheral perfusion,tachypnea and transient hypertension.After intubation,they all had pink frothy or blood from the endotracheal.Tweleve of them died from pulmonary edema or pulmonary hemorrhage,and acute refractory cardiac dysfunction.The other four of cases died from brain stem encephalitis.Atypical presentation such as absence of skin rash should alert the physician.Total white cell count,blood glucose and cardiac troponin I were raised significantly.The protein raised in cerebrospinal fluid.ConclusionHand foot and mouth disease caused by EV71 progresses rapidly.The primary site of attack is the central nervous system,particularly the brainstem,and the cause of death are neurogenic pulmonary edema and/or hemorrhage,acute refractory cardiac dysfunction.

Isolation and cultivation of goat temporomandibular joint disc cells / 实用口腔医学杂志

Objective:To study the isolation, culture and identification of the TMJ cells and to observe the biological characteristics of cultured fibrochondrocytes. Methods:The TMJ discs were dissected from two 1 month goats under sterile conditions and were digested with collagenase. The cells were collected. Morphological changes and attachment efficiency were constantly observed under phase-contrast microscope. Immunohistochemical staining for type I collagen as well as toluidine blue staining were performed. Ultrastructures of the TMJ cells were observed under transmission electron microscope. Results: Most of the primary fibrochondrocytes presented a short spindle-shape while the rest showed polygon-shape. On the 7th day, the perliferating fibrochondrocytes started to contact each other to form a monolayer covering the bottom of the incubation disc. Immunohistochemical staining of type I and toluidine blue staining exhibited positive results. The fibrochondrocytes cytoplasms were rich in mictochondria and endoplasm reticulum. Conclusion: The fibrochondrcytes isolated from one-month-old goat TMJ disc have good proliferation ability in vitro and cells from passage 1 to 3 might be used as seed cells for TMJ disc tissue engineering.

The Factors Implicated When an Individual Starts to Smoke Again After a 6 Month Cessation / 예방의학회지

OBJECTIVES: This study was conducted to examine the factors implicated when people start smoking again after a 6 month cessation, and was carried out at the smoking cessation clinic of a public health center. METHODS: The study subjects were 191 males who had attended the smoking cessation clinic of a public health center for 6 months in an attempt to quit smoking. Data was collected, by phone interview, regarding individual smoking habits, if any, over the 6 month study period. The factors which may have caused an individual to smoke again were examined. This study employed a health belief model as it theoretical basis. RESULTS: Following a 6 month cessation, 24.1% of the study group began to smoke again during the 6 month test period. In a simple analysis, the factors related to individuals relapsing and smoking again included barriers of stress reduction, body weight gain and induction of smoking by surroundings among perceived barriers factor of our health belief model (p<0.05). In multiple logistic regression analysis for relapsed smoking, significant factors included barriers of stress reduction and induction of smoking by surroundings (p<0.05). The most important reason of for an individual to relapse into smoking was stress (60.9%) and the most likely place for a relapse to occur was a drinking establishment (39.1%). CONCLUSIONS: Our results indicate that both regular consultations and a follow-up management program are important considerations in a public health center program geared towards maintaining smoking cessation.

Long-Term Results of Intravitreal Bevacizumab Injection for Macular Edema: Retinal Vein Obstruction and Diabetic Retinopathy

PURPOSE: To evaluate the long-term results of intravitreal bevacizumab injection for macular edema (ME) due to retinal vein obstruction (RVO) and diabetic retinopathy (DR). METHODS: The objects of study were patients with decreased visual acuity due to ME with RVO and DR for whom intravitreal injections of 1.25 mg (0.05 ml) bevacizumab were repeated three times with an interval of six weeks and who were available for a follow-up period of more than 12 months. The patients underwent additional bevacizumab injections if ME increased as assessed by optical coherence tomography (OCT). Best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measured at baseline and follow-up visits. RESULTS: There were 16 patients with RVO and 18 patients with DR. In the RVO group, the mean length of follow-up was 12.4+/-1.1 months, the mean baseline BCVA was 0.75+/-0.32 and the final BCVA was 0.42+/-0.25, a difference that was statistically significant (p0.05). The mean CMT at baseline was 462.0+/-195.0 microm and decreased to a mean of 282.2+/-177.3 microm at the end of the follow-up period (p<0.05). CONCLUSIONS: In RVO and DR, three injections of intravitreal bevacizumab with an interval of six weeks and additional injections as indicated were effective in reducing ME and showed especially good results in improvement of visual acuity for ME due to RVO.

Usefulness of delta MELD/month for Prediction of the Mortality in the First Episode of Variceal Bleeding Patients with Liver Cirrhosis: Comparison with CTP, MELD score and delta CTP/month / 대한간학회지

BACKGROUND/AIMS: There are many models for predicting prognosis of liver cirrhosis including Child Turcotte Pugh (CTP), the model for end-stage liver disease (MELD) score and its changes over time (delta CTP and delta MELD/month). We investigated the ability of these models to predict the mortality of liver cirrhosis patients with the first episode of variceal bleeding and which model can be usefully applied in practice. METHODS: Seventy-one liver cirrhosis patients hospitalized for the first episode of esophageal variceal bleeding were retrospectively analyzed. The predictive power of initial CTP, MELD score, delta CTP and delta MELD/month was compared through c-statistics and multiple logistic regression. RESULTS: All of the prognostic predictors measured higher in patients who survived than in those who died. The area under the receiver operating characteristic (ROC) curve for delta MELD/month in 6 months was 1, a higher value than 0.81 for initial CTP, 0.75 for initial MELD, and 0.84 for delta CTP/month; the area of delta MELD/month in 12 months was 0.81, also showing a higher value than others. delta MELD/month >0.27 was a strong significant prognostic predictor in 6 (odds ratio: 40.1, p=0.001) and 12 months (odds ratio: 14.1, p<0.001). Only the delta MELD/month was an independent prognostic predictor with a risk ratio of 1.604 (95% CI: 1.119-2.302, p=0.01) in 6 months and 1.627 (95% CI: 1.294-2.047, p<0.001) in 12 months. CONCLUSIONS: The delta MELD/month is superior to initial CTP, MELD and delta CTP/month to predict 6 and 12 months mortality in liver cirrhosis patients with the first episode of variceal bleeding.