Prevalence of non-cancer chronic morbidity in tobacco users among adults in Kolar district: community-based study

Background: Tobacco contains many chemicals which causes cancer and chronic morbidities as evidenced from number of studies. Information regarding the chronic morbidities resulting from tobacco use was lacking in Indian setting. This study was conducted with the objective to find the prevalence of chronic morbidities other than cancer and oral conditions in tobacco users among adults in Kolar district.Methods: This is a community based, cross sectional study conducted in Kolar district among selected sample size of 1534 from six taluks during December 2018 to March 2019. The structured questionnaire was used to collect information at different geographical and social meeting places to represent the sample. The questionnaire contained information about sociodemographic, tobacco use and self-declared morbidity conditions.Results: Study subjects were aged between 18 to 80 years and the mean age was 53.7±18.2 years. The prevalence of chronic morbidity was 14.4% in 1534 subjects and 24.2% in 521 tobacco users. Diabetes mellitus and cardiovascular diseases accounted for 80 percent of morbidities followed by respiratory and other systems. The odd ratio (OR) was 3.4 for tobacco users and chronic morbidities, OR for diabetes mellitus and cardiovascular diseases was 5-19 and 5-22 respectively.Conclusions: The prevalence of diabetes mellitus, cardiovascular diseases and other conditions are high among any form of tobacco use or consumption, illiterates, aged above 51 years and agriculture related workers compared to no tobacco users. There is a need of awareness about early detection of chronic morbidities to reduce the premature deaths and economic loss to the community.

Bioinformatics analysis and functional prediction of potential lung cancer associated genes in female non-smokers / 中国肿瘤生物治疗杂志

@#[Abstract] Objective: To explore the pathogenosis and prognostic markers for non-smoking female lung cancer patients with bioinfor‐ matics analysis and functional prediction of potential lung cancer associated genes in female non-smokers. Methods: Data for nonsmoking female patients with lung cancer were downloaded from the Gene Expression Omnibus (GEO) database and the differentially expressed genes (DEGs) were identified using GEO2R. DAVID online data base was used to perform gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG), and STRING online software was used to perform protein-protein interaction (PPI) analysis; then the plug-in (M-CODE) was used to screen the key DEGs; finally, GEPIA and Kaplan-Meier plotter were used to perform function prediction and prognosis analysis of key DEGs. Results: A total of 160 DEGs were screened, including 54 up-regulated and 106 down-regulated genes; GO enrichment analysis showed that these DEGs were mainly related to neovascularization, single cell adhesion, positive regulation of GTPase activity and signal transduction (all P<0.05). KEGG pathway analysis revealed that DEGs were mainly involved in cell adhesion molecules (CAMs), leukocyte transendothelial migration, tight junction and endocytosis (all P<0.05); PPI network analysis revealed 8 key DEGs, including TIE1, PECAM1, CLDN5, VEGFD, ICAM2, ESAM, EMCN and ROBO4. Conclusion: TIE1, CLDN5, ICAM2, ESAM, VEGFD and ROBO4 may be the research targets of the pathogenesis of non-smoking female lung cancer patients. PECAM1 and EMCN may be the new bio-markers to predict the progression and prognosis of nonsmoking female lung cancer patients.

Determinants of Voluntary Smoke- Free Home Among Non- Smoking Women in Alor Gajah, Melaka

Abstract@#Introduction: Second hand smoke exposure to cigarette smoke leads to many medical conditions including asthma and lung cancer. Women are the most vulnerable adults of passive smoking at home. Even though Malaysia had its own smoke- free policy, the smoke- free home is voluntary in nature. Thus, this study was aimed to explore the practice of voluntary smoke- free- home among women in Alor Gajah and its determinants. Methods: A cross-sectional study based on multistage sampling was conducted among 180 non- smoking women in areas implemented Community Intervention Program (KOSPEN), which emphasized on healthy lifestyle, in Alor Gajah, Melaka from April 2018 to May 2018. Data on sociodemographic characteristic, characteristic of second hand smoke (SHS) exposure at home, knowledge, attitude and avoidance behaviour from SHS were collected using questionnaires. The data were then analysed using IBM Statistical Package for Social Science (SPSS) version 24.0 involving descriptive and inferential statistics. Results: Majority of the respondents practised smoke- free home (72.8%). The predictors of smoke- free home were those who attained higher education (AOR= 11.939, 95% CI 1.175- 121.277), did not live with any children (AOR= 3.546, 95% CI 0.985- 12.765) and lived with smokers other than their husband (AOR= 3.793, 95% CI 1.192- 12.076). Conclusion: Education level and household factors were significant predictors of smoke- free home. Thus, few measures were suggested to increase tobacco bans at home among women including periodic health programs, community empowerment programs and creating smoke- free housing.

Screening of lncRNAs in female non-smoking lung cancer patients based on TCGA data / 临床检验杂志

Objective@#To screen the differentially expressed long non-coding RNAs(lncRNAs) by analyzing the related gene sequencing data of female non-smoking lung cancer patients in the database of The Cancer Genome Atlas (TCGA). @*Methods@#The gene expression data and the corresponding clinical information of female non-smoking lung cancer patients were downloaded from the TCGA database. Then, the data were processed, integrated and analyzed with the R software package, and the differentially expressed genes were screened out. The prognosis was analyzed by the Survival package. @*Results@#A total of 354 differentially expressed lncRNAs associated with female non-smoking lung cancer were obtained, of which 45 were down-regulated and 309 were up-regulated in tumor tissues. The prognosis analysis showed that the expression level of LINC01863 was positively correlated with the prognosis of female non-smoking lung cancer patients (P＜0.05), and that the expression levels of LINC02487, LINC01419 and DSCAM-AS1 were negatively correlated with the prognosis of female non-smoking lung cancer patients (P＜0.05). @*Conclusion@#The re-analysis on the high-throughput sequencing data in TCGA database obtains a large number of lncRNAs related to the development of female non-smoking lung cancer, which provides the potential new targets for the diagnosis and prognosis assessment of female non-smoking lung cancer.

Redução do número de cigarros durante internação psiquiátrica: intervenção ou punição? / Reducción del número de cigarrillos durante la hospitalización psiquiátrica: ¿intervención o sanción? / The decreasing number of cigarettes during psychiatric hospitalization: intervention or punishment?

A restrição do fumo durante internação psiquiátrica provoca mudanças pessoais e institucionais. Objetivo: Identificar a percepção dos portadores de transtorno mental, fumantes, sobre a redução do número de cigarros durante a internação psiquiátrica. Método: Estudo exploratório com 96 portadores de transtorno mental, fumantes, internados em hospital geral: G1 (34 sujeitos quando permitido um cigarro/hora) e G2 (62 sujeitos quando reduzido para oito cigarros/dia). Questionário semiestruturado. Análise temática do conteúdo. Resultados: O G1 declarou-se satisfeito com a restrição – fumo na internação como direito. O G2 resiste à mudança da restrição que ocorreu sem diálogo ou apoio. Apesar das dificuldades, constataram-se algumas mudanças de atitudes sobre o cigarro tais como aumento responsabilidade, descoberta de capacidade em reduzir o fumo e ressignificação do seu papel. Conclusão: Alguns sujeitos entendem a mudança na política de saúde do tabagismo como punição, enquanto outros como oportunidade de repensar o papel do cigarro em sua vida. .

La restricción al tabaquismo durante la hospitalización psiquiátrica promueve cambios personales e institucionales. Objetivo: Identificar la percepción de portadores de trastorno mental, fumadores, sobre la reducción del número de cigarrillos durante la internación psiquiátrica. Método: Estudio exploratorio con 96 portadores de trastorno mental, tabaquistas, internados en hospital general: GI (34 sujetos cuando permitido un cigarrillo/hora) y G2 (62 sujetos cuando reducido para ocho cigarrillo/día). Cuestionario semi-estructurado. Análisis temática del contenido. Resultados: El GI se declaró satisfecho con la restricción – tabaco en la hospitalización como directo. El G2 resiste al cambio de la restricción que ocurrió sin dialogo o ayuda. Aunque las dificultades, se constató algunos cambios de actitudes sobre el tabaco como el aumento de responsabilidad, descubierta de la capacidad de reducir el fumo y re-significación de su papel. Conclusión: Algunos de los sujetos comprenden el cambio en la política de salud del tabaquismo como sanción, mientras otros como una oportunidad de replantear el papel del cigarrillo en su vida. .

The smoking ban during psychiatric hospitalization provokes personal and institutional changes. Objective: To identify the mental disorders carriers’ perception, the smokers ones, about the decreasing number of cigarettes during psychiatric hospitalization. Method: Exploratory study with 96 hospitalized carriers of mental disorders who are smokers: G1 (34 subjects hospitalized when was allowed one cigarette by hour) and G2 (62 subjects hospitalized when it was reduced to eight cigarette by day). Semi-structured questionnaire. Thematic content analysis. Results: The G1 admitted satisfaction with the restriction – smoking during hospitalization as entitlement. The G2 resists the restriction change occurred without dialogue or support. In spite of the difficulties, some attitude changes about the cigarette were noticed such as increase of the responsibility, discovery of the ability to reduce smoking and the meaning of its role. Conclusion: Some subjects understand the smoking health policy change as punishment, while others as opportunity to think about the role of cigarette in their life. .

Anthropometric, Biochemical Characteristics, Nutrient Intakes and Bone Density by Smoking Period in Elderly Male Smokers: Analysis of Data from Korea National Health and Nutrition Examination Survey (KNHANES), 2008~2011

This study investigated anthropometric and biochemical characteristics, nutrient intakes, and bone density of Korean elderly men (over 65 yrs). Data on bone density and anthropometric (height, weight, waist circumference, body mass index and blood pressure) and biochemical (total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, triglyceride and hemoglobin) characteristics, nutrient intakes, and nutrient density were obtained from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES, 2008~2011). Subjects were categorized into smoking and non-smoking groups, and smoking groups were divided into three groups by smoking period (under 20 yrs, 21~40 yrs and over 41 yrs). Serum triglyceride concentrations of the smoking group aged 21~40 yrs were higher than those of other groups (P<0.01), whereas other biochemical factors were not different. Intake ratios of energy, protein, phosphorus and sodium in subjects were over 100% of Dietary Reference Intake for Koreans (KDRI). Nutrient densities according to intakes of thiamin, riboflavin, and niacin per 1,000 kcal were significantly different among the groups (P<0.05). Bone density of subjects decreased according to smoking period (T-score of total femur in non-smoking group -0.3108, and -0.2918, -0.4941, -0.6847 in smoking group, respectively). Ratio of osteoporosis was 38.1% in the non-smoking group and 44.4%, 51.1%, and 64.0% in the smoking group, respectively. The findings of the present study show that smoking may be associated with bone health, higher ratio of osteoporosis, and low nutrient density in elderly men. Therefore, practical and systematic non-smoking programs are required to improve the bone density of elderly men as well as maintain healthy bone levels and desirable lifestyle.

The opinion of patients with mental disorder about tobacco and its prohibition in psychiatric hospitalization / Opinião dos portadores de transtorno mental sobre o fumo e sua proibição na internação psiquiátrica / Opinión de los portadores de trastorno mental sobre el tabaco y su prohibición en la hospitalización psiquiátrica

Objective: To identify the opinion of patients with mental disorder about tobacco and its prohibition during psychiatric hospitalization. Method: An exploratory study with 96 patients smokers with mental disorders hospitalized in a psychiatric ward of a general hospital. The interviews were conducted individually, using an instrument designed for this study. The content from the interviews was recorded, transcribed and submitted to a thematic content analysis. Results: The patients with mental disorder were identified as perceiving smoking during the psychiatric hospitalization as a help to support the difficulties in socialization and in the lack of activities. The permission for smoking is seen as a signal of respect to their needs. The subjects mentioned to not accept the total smoking prohibition. Conclusion: Tobacco helps to face difficulties and conflicts in the psychiatric hospitalization. There is resistance regarding the possibility to totally withdraw the smoking permission during hospitalization.

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Objetivo:Construir un modelo teórico que configure la vivencia del apoyo de la red social por las personas en cuidado domiciliario. Método: Estudio de abordaje cualitativa, con la utilización del método Teoría Fundamentada en los Datos. La recopilación y el análisis concomitante de los datos hizo viable la interpretación del significado del fenómeno La vivencia del apoyo de la red social por las personas implicadas en el cuidado domiciliario. Resultados: Se destacó la postura pasiva de la población en la construcción de su bienestar. Reconociendo que debe existir una responsabilidad compartida entre las partes implicadas, población y Estado. Conclusión: Se sugiere que los enfermeros sean estimulados a ampliar el cuidado que realizan en el domicilio para atender las demandas de los cuidadores; y que sean elaborados nuevos estudios con distintas poblaciones, con el fin de validar o complementar el modelo teórico propuesto.
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Objetivo: Identificar a opinião dos portadores de transtorno mental sobre o fumo e sua proibição durante a internação psiquiátrica. Método: Estudo exploratório com 96 portadores de transtorno mental, tabagistas, internados em enfermaria psiquiátrica de hospital geral. As entrevistas foram realizadas individualmente, utilizando-se o instrumento elaborado para este estudo. O conteúdo verbalizado nas entrevistas foi gravado, transcrito e submetido à análise de conteúdo temático. Resultados: Identificou-se que os portadores de transtorno mental veem o tabagismo na internação psiquiátrica como ajuda para suportar a dificuldade de convívio e a falta de atividades. A permissão do tabagismo é vista como sinal de respeito às suas necessidades. Os sujeitos relatam não aceitar a proibição total do tabagismo. Conclusão: O tabagismo ajuda a enfrentar dificuldades e conflitos na internação psiquiátrica. Existe resistência quanto à possibilidade de retirar totalmente a permissão para fumar na internação.


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A case -control study on risk factors of lung cancer among non -smoking women / 预防医学

Objective To explore the risk factors of lung cancer among non -smoking women.Methods A total of 229 new cases of lung cancer among non -smoking women from 2005 to 2008 were collected.The design method of 1 to 2 matching case -control study was used controlling age,sex and smoking conditions.The data was analyzed by univariate and multivariate conditional logistic regression analysis.Results Single factor analysis identified 13 risk factors (all P <0.05).The multivariate conditional logistic regression and factor analysis showed that respiratory disease history,family history of cancer,poor interpersonal relationship,psychological problems,feeling heavy smoke when cooking,consumption of salty and dry food,later menarche and passive smoking were risk factors (OR =24.427,5.539,3.041,2.622,1.856, 1.724,1.565 and 1.598 respectively),high income level and high consumption of vegetables were protective factors (OR =0.650 and 0.683 ).Conclusion respiratory disease history, family history of cancer, poor interpersonal relationship and psychological problems are main risk factors of lung cancer among non -smoking women.

Genome-Wide Association Study of Lung Cancer in Korean Non-Smoking Women

Lung cancer in never-smokers ranks as the seventh most common cause of cancer death worldwide, and the incidence of lung cancer in non-smoking Korean women appears to be steadily increasing. To identify the effect of genetic polymorphisms on lung cancer risk in non-smoking Korean women, we conducted a genome-wide association study of Korean female non-smokers with lung cancer. We analyzed 440,794 genotype data of 285 cases and 1,455 controls, and nineteen SNPs were associated with lung cancer development (P < 0.001). For external validation, nineteen SNPs were replicated in another sample set composed of 293 cases and 495 controls, and only rs10187911 on 2p16.3 was significantly associated with lung cancer development (dominant model, OR of TG or GG, 1.58, P = 0.025). We confirmed this SNP again in another replication set composed of 546 cases and 744 controls (recessive model, OR of GG, 1.32, P = 0.027). OR and P value in combined set were 1.37 and < 0.001 in additive model, 1.51 and < 0.001 in dominant model, and 1.54 and < 0.001 in recessive model. The effect of this SNP was found to be consistent only in adenocarcinoma patients (1.36 and < 0.001 in additive model, 1.49 and < 0.001 in dominant model, and 1.54 and < 0.001 in recessive model). Furthermore, after imputation with HapMap data, we found regional significance near rs10187911, and five SNPs showed P value less than that of rs10187911 (rs12478012, rs4377361, rs13005521, rs12475464, and rs7564130). Therefore, we concluded that a region on chromosome 2 is significantly associated with lung cancer risk in Korean non-smoking women.

Relationships between survival and expressions of estrogen receptorαandβin non-smoking non- small cell lung cancer patients / 中国癌症杂志

Background and purpose:The involvement of estrogen signaling in lung cancer is controversial. But the findings showed that ERβ might play an important role in neoplastic lung biology. Several studies have evaluated expression of ERβin both normal and neoplastic human lung tissues with variable conclusions. We aimed to evaluate the expressive of estrogen receptors (ER)α,βin non-smoking non-small cell lung cancer (NSCLC) and investigate the relationships between the survival and expressions of ERα,β. Methods:Immunohistochemical assay was used to detect the expression ERαand ERβin 144 NSCLC patients, and analyzed the expressions status of ERα,βand survival. Results:The positive rate of ERαwas 7.6%, only in adenocarcinoma cancer. The positive rate of ERβwas 52.1%, and the expressions of stageⅠandⅡwas signiifcantly higher than that of stageⅢandⅣ(P=0.020). The median survival time (MST) of ERβpositive expression was better than that of negative expression (43 months vs 38 months, P=0.028). The MST of ERβpositive expression of female patients was better than that of negative expression (45 months vs 37 months, P=0.033). The MST of ERβpositive expression of adenocarcinoma were 46 months and better than negative 38 months (P=0.021). Conclusion:The expression of ERβwas signiifcantly higher in early-stage non-smoking NSCLC. It indicated that the positive expression of ERβwas related to the better MST, especially in female adenocarcinoma patients.

A resposta da indústria do tabaco à criação de espaços livres de fumo no Brasil / Response of the tobacco industry to the creation of smoke-free environments in Brazil

Objetivos: Documentar a reação da indústria do cigarro à regulamentação do fumo em locais públicos no Brasil, iniciada com legislação em 1996 Métodos: Foram pesquisados os bancos de dados Legacy Tobacco Documents Library (legacy.library.ucsf.edu/) e British American Tobacco (BAT) Company Documents (bat.library.ucsf.edu/). Utilizaram-se as palavras-chave Brasil/Brazil; Souza Cruz; fumo passivo, tabagismo passivo/passive smoking; fumo de segunda mão/secondhand smoking; convivência em harmonia/courtesy of choice; e nomes de instituições, políticos e pessoas atuantes na área de controle de tabaco. Foram pesquisados ainda os websites de fabricantes de cigarro e de estabelecimentos da indústria da hospitalidade no Brasil, e sites de notícias, jornais e revistas. A pesquisa foi limitada a documentos com datas entre 1995 e 2005. Resultados: A primeira lei a restringir o fumo no Brasil (lei 9 294 de 1996) beneficiou a indústria por sua redação, pela qual um mesmo espaço poderia ser compartilhado por fumantes e não-fumantes desde que houvesse uma separação entre as duas categorias (área de fumantes e área de não-fumantes). Como em outros países, a indústria do cigarro criou parcerias com associações de hotéis, bares e restaurantes para evitar a aprovação de leis que exijam espaços 100 por cento livres de fumo, conforme preconizado pela Organização Mundial da Saúde. Entretanto, leis locais em municípios e estados representativos (como Rio de Janeiro e São Paulo) têm tido sucesso em criar espaços 100 por cento livres de fumo. Conclusões: É fundamental que o Brasil reconheça os prejuízos causados pelo fumo e revise a sua lei federal de regulamentação do fumo em locais fechados. O conhecimento acerca das estratégias da indústria permite que políticos e profissionais de saúde preparem argumentos de oposição a medidas que podem comprometer a saúde pública.

Objectives: To document the response of the tobacco industry to the regulation of smoking in public places in Brazil starting in 1996. Methods: The Legacy Tobacco Documents Library (legacy.library.ucsf.edu/) and the British American Tobacco (BAT) Company Documents (bat.library.ucsf.edu/) were searched. The following key words were used: Brasil/Brazil; Souza Cruz; fumo passivo, tabagismo passivo/passive smoking; fumo de segunda mão/secondhand smoking; convivência em harmonia/courtesy of choice; along with the names of institutions, politicians, and individuals associated with tobacco control. We also searched the websites of cigarette manufacturers and hospitality industry organizations and businesses, news websites, and online newspapers and magazines. The search was limited to the period from 1995 to 2005. Results: The text of the first law restricting smoking in Brazil (no. 9 294, of 1996) benefited the industry by stating that smokers and nonsmokers could share the same space provided that specific areas were designated as smoking and nonsmoking. As in other countries, the tobacco industry established partnerships with hotel, bar, and restaurant associations to prevent the passing of laws creating 100 percent smoke-free environments, as recommended by the World Health Organization. However, local state and city laws in major cities and states (such as Rio de Janeiro and São Paulo) have been successful in ensuring the creation of 100 percent smoke-free places. Conclusions: It is essential that Brazil recognize the damage caused by smoking and revise its federal law regulating smoking in closed environments. The knowledge concerning the strategies employed by the industry may be useful for politicians and health care professionals to prepare arguments opposing measures that can be detrimental to public health.

The Effect of Non-Smoking Campaign for Subway Workers on Their Health Behavior / 산업간호학회지

PURPOSE: This study was done to investigate the effect of non-smoking campaign for subway workers on their health behavior such as smoking, drinking, and exercise. METHOD: The study was done on the subjects of 112 male employees for 3 years from 2003 to 2005 working at the Seoul Metropolitan Rapid Transit Corporation. However, the subjects decreased to 105 in 2004 and 111 in 2005 due to work transfer. The data were obtained through administering questionnaires. The non-smoking campaign was done with health education using various strategies and methods by an administrator-in-charge assisted by the community health center. RESULTS: Smoking rate and cigarette consumption decreased but there was no statistical significance. Smokers' frequency of drinking and exercise were higher than that of non-smokers, but there was no statistical significance. CONCLUSION: The result indicated the program was not effective to change the subjects' health behavior; therefore, tailored program considering the subjects is recommended.

The Effect of Non-Smoking Campaign for Subway Workers on Their Health Behavior / 산업간호학회지

PURPOSE: This study was done to investigate the effect of non-smoking campaign for subway workers on their health behavior such as smoking, drinking, and exercise. METHOD: The study was done on the subjects of 112 male employees for 3 years from 2003 to 2005 working at the Seoul Metropolitan Rapid Transit Corporation. However, the subjects decreased to 105 in 2004 and 111 in 2005 due to work transfer. The data were obtained through administering questionnaires. The non-smoking campaign was done with health education using various strategies and methods by an administrator-in-charge assisted by the community health center. RESULTS: Smoking rate and cigarette consumption decreased but there was no statistical significance. Smokers' frequency of drinking and exercise were higher than that of non-smokers, but there was no statistical significance. CONCLUSION: The result indicated the program was not effective to change the subjects' health behavior; therefore, tailored program considering the subjects is recommended.