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Background: The relationship between elevated serum lipids and atherosclerosis is well established. Recent studies have demonstrated not only that the serum lipid concentration but also the distribution of TG and cholesterol within major lipoprotein classes are of importance for the development of atherosclerosis. Elevated plasma concentrations of LDL and decreased HDL are associated with increased risk of atherosclerosis. To study the influence of lipid profile in diabetic patients on the incidence of cerebrovascular events.Methods: The study was based on 60 patients meeting the inclusion criteria from those who were admitted at Shadan Institute of Medical Sciences, Hyderabad, India from Feb 2013-May 2014. Detailed history was taken and thorough physical examination done pertaining to the involved condition. Patients who were conscious, slow progression of neurological deficit, rapid onset of lateralizing signs with variable blood pressure were considered to be suffering from infarction.Results: The mean values of lipid profile were significantly different among the gender. There were more females with medium and high TC values as compared to females and this difference was found to be significant. Though the number of females with high HDL values was more than males, the difference was not found to be significant. The number of females with high LDL values was far more than males and this difference was found to be significant. Though the number of females was more with high TG values, the difference was not found to be significant.Conclusions: In conclusion, our study gives evidence that poor glycemic control is a strong risk factor for stroke in patients with NIDDM.
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Introduction: Patients of DM are known to have low levelsof serum magnesium levels as compared to non-diabetics.There is a link between the low magnesium levels and poorglycemic controls and subsequently leading to complicationsin diabetic patients. The aim of this study was to assess theserum magnesium levels in relation to glycemic status indiabetic patients as compared to non-diabetics.Material and Methods: 172 cases of previously diagnosedDM were taken along with the age and sex matched controlswho were healthy and non-diabetic and their blood sampleswere analyzed for magnesium and blood sugar fasting andpost prandial.Results: In our study we have found that there is a significanthypomagnesemia in diabetic cases as compared to nondiabetic controls which is in accordance with other studies.There also exists a negative correlation between mean serummagnesium levels (2.08 ± 0.4 mg/dL) and mean fastingplasma sugar (FBS) (159.72 ± 71.60 mg/dL) and mean postprandial sugar (PPS) (222.76 ± 100.86 mg/dL) levels. Nosignificant variation as per age and sex in serum magnesiumlevels amongst diabetic subjects have been found in our study.Conclusion: Hypomagnesemia is common in diabetics ashas been found in our study also, and it helps in regulationof glycemic levels and in turn also affects magnesium levels.Considering estimation of magnesium as a routine laboratorywork up protocol in the management of diabetes may preventvarious complications due to hypomagnesemia with earlytherapeutic intervention.
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Background: The incidence of Tuberculosis and severity increased in immunocompromised state like Diabetes mellitus. When combined with ATT and antidiabetic drugs, the adverse reaction are increased. Aim of the study: To study the incidence of adverse drug reaction associated co-morbid symptoms on newly diagnosed TB patients with Diabetes Mellitus. Materials and methods: 100 cases of newly diagnosed sputum positive pulmonary tuberculosis (50 diabetic and 50 non -diabetic) fitting the inclusion criteria admitted over the period of 2 years from 2016-2017. Subjects were selected from medicine ward, pulmonology ward and Tuberculosis ward under DTC. The diagnosis of Pulmonary tuberculosis was made with clinical presentation and verification by detection of acid fast bacilli under microscope. Results: Among the diabetic population, 28 (28.00%) were received biguanides, 10 (10.00%) were received insulin, and 12 (12.00%) were received sulphonylureas. Among the study population, 28 (28.00%) had peripheral neuropathy, 25 (25.00%) had liver injury, 4 (4.00%) had hypoglycemia, 11 (11.00%) had back pain, and 52 (52.00%) had nausea vomiting. Conculsion: When treating patients with diabetes and TB, there is increased incidence of polyneuropathy and liver toxicity
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Introduction: Peripheral vascular disease (PVD) is one of the significant Macro vascular complications of type 2 diabetes mellitus. Peripheral vascular disease assumes importance, for prevention of morbidity and mortality related to diabetic foot. PVD is the single most important factor which raises the incidence of leg amputation risk in type 2 DM patients. While peripheral neuropathy alone leads to, trophic ulcer which has a chronic indolent course provided super added infection is prevented and controlled, the presence of PVD leads to the ischemic foot which leads to rapid spread of infection. The aim of the study: To investigate the prevalence of PVD among type 2 diabetes patients, to assess the risk factors associated with the development of pvd.to correlate the prevalence of cardiovascular risk factors and vascular complications of type 2 diabetes patients. Materials and Methods: Cross sectional observational analytical study was conducted. Patients were interviewed with a special note on elicitation of history regarding symptoms of PVD, in the form of intermittent claudication, Ischemic rest pain, history of foot ulcers in the past and present. Smoking was recorded in pack-years of cigarettes smoked. Duration of diabetes since diagnosis was recorded and they were grouped accordingly. The anthropometric measurements were recorded and the body- M. Arivumani. A study of the prevalence and risk factors associated with peripheral vascular disease in type 2 diabetes mellitus patients in Government Dharmapuri Medical College Hospital, Dharmapuri. IAIM, 2017; 4(9): 12-18. Page 13 mass index was calculated. Waist-hip ratio was also recorded. The blood pressure was recorded in both the upper limbs and both the lower legs using the standard B.P cuff. An comprehensive physical examination was done and findings recorded. Special importance was given to foot examination. Peripheral neuropathy assessment was done using Simmel-Weiss monofilament testing and timed vibration sense perception recordings. Symptoms of peripheral neuropathy were also noted. Results: The duration of diabetes ranged from newly detected to 28 years, with a mean duration of 8.2 years + 6.24 S.D. For patients affected with PVD, the duration of diabetes was found to be longer than others. The mean FPG for the PVD sub group is 173.6mg % + 34.9 SD, while for the other subjects the mean FPG is 151.8 mg % + 36.3 SD and the difference was statistically significant. (P = 0.006). Among the hypertensive diabetic subjects (n=57), 26.3% had peripheral vascular disease and the prevalence of PVD among normotensive diabetes subjects (n = 55) was 9.1% (P = 0.0329). Smokers among Hypertensive Diabetic males had 58.3% prevalence of PVD (ABI < 1) compared to 14.3% among non – smoking Hypertensive Diabetic males. Difference in the lipid parameters above was all statistically significant. This shows that individuals with a triad of increased LDL – cholesterol, lower HDL – cholesterol (Higher LDL / HDL ratio) and increased triglycerides were more at higher risk for peripheral vascular disease. Conclusion: As the duration of diabetes increased, the risk of PVD increased. There was relatively poor glycemic control in the PVD sub-set. Hypertension, when associated with Type2 Diabetes raised the risk of PVD nearly threefold. The duration of Hypertension also significantly correlated with the risk of PVD.
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Objective To explore the clinical efficacy of combination therapy with promethrin and gliclazide sustained-release tablets in the treatment of obese patients with type 2 diabetes mellitus with poor blood glucose control. Methods Selected from December 2015 to March 2017 in our hospital treated 96 cases of insulin treatment of poor blood glucose control in obese patients with type 2 diabetes, were randomly divided into study group and control group, 48 cases in each group.The study group were treated with Novolin 70/30(Novolin 30R)combined with Gliclazide Sustained-release Tablets,while the patients in control group were treated with Novolin 30R combined with repaglinide. Results The decrease of FBG, 2h PG, HbAlc, HOMA-IR and the increase of HOMA-IS in the study group were better than those in the control group (P<0.05).There was no significant difference in BMI between the two groups after treatment and BMI in the control group was significantly higher than that before treatment (P<0.05),CRP was not statistically significant before treatment.Conclusion The application of Novolin 30R and Gliclazide Sustained-release Tablets after treatment can make the use of insulin alone poor glycemic control in obese patients with type 2 diabetes have more desirable clinical efficacy,is conducive to ensuring the safety and effectiveness of drugs.
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Objective To investigate the effect of psychological intervention combined with gliclazide and sitagliptin on the treatment of poorly obese obese patients with type 2 diabetes mellitus. Methods 96 obese patients with type 2 diabetes mellitus who had poor control of blood glucose after insulin treatment were randomly divided into control group and experimental group,48 cases in each groups. Gliclazide and sitagliptin (FBG), glycosylated hemoglobin (HbA1c), 2h postprandial blood glucose (2hPG), fasting insulin (FIns) were measured before and after 15 weeks of treatment in the control group. situation. Results FBG, HbA1c, 2hPG and FIns were significantly lower in the experimental group than in the control group (P<0.05). Conclusion The combination of gliclazide and sitagliptin on the treatment of poorly obese type 2 diabetes mellitus with insulin treatment can significantly reduce the blood glucose level of patients and promote it.
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Objective To explore the effect of gliclazide and Sig Leo Dean on insulin treatment for poor glycemic control in obese patients with type 2 diabetes mellitus. Methods 80 cases of insulin treatment for poor glycemic control in obese patients with type 2 diabetes mellitus treated in our hospital from March 2015 to January 2017 were randomly divided into two groups,with 40 cases in each group.The control group was treated with gliclazide The observation group was treated with Sig Leo Dean.The therapeutic effects of the two groups were observed and compared. Results 2 hours postprandial blood glucose levels improved in the observation group was better than that of the control group, the body weight, blood pressure, fasting blood glucose of two groups were improved, and there were no significant difference between the two groups; The incidence rate of adverse reactions was 2.5% in the observation group, 10% in the control group, the difference was not statistically significant (P<0.05). Conclusion Analysis of gliclazide and Sig Leo Dean on insulin treatment for poor glycemic control in obese patients with type 2 diabetes mellitus curative effect, Sig Leo Dean for the glycaemic improvement effect is higher, reduce the incidence of adverse reactions, so more medication safety, it is worthy of clinical promotion Application.
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BACKGROUND: Glycemic control is an effective way to reduce the cardiovascular complications of diabetes, but more than half of the adults with diabetes in Korea are improperly controlling their glycemic levels. The purpose of this study is to identify the factors associated with poor glycemic control in type 2 diabetes patients. METHODS: This study analyzed 1,261 subjects ≥30 years old diagnosed with type 2 diabetes who participated in the fifth Korean National Health and Nutrition Examination Survey (2010-2012). Poor glycemic control rates were defined as hemoglobin A1c (HbA1c) level ≥7%. To shed light on the causes of poor glycemic control, socio-demographics, diabetes severity, health status, and health behavior factors were adjusted and logistic regression was done. RESULTS: Of the total 1,261 patients, 53.0% of patients with type 2 diabetes had HbA1c ≥7%. After running a logistic regression model, the odds ratio of poor glycemic control was higher in high school graduates than elementary school graduates; in people living in Chungcheong and Jeolla/Jeju than those living in Seoul; in the group with diabetes for over 5 years had diabetes less than 5 years; in a group with insulin and oral hypoglycemic agent treatment than non-treatment; in a group with hypertriglyceridemia than without hypertriglyceridemia; and in the group with slept less than 6 hours slept 7-8 hours. CONCLUSION: We need a comprehensive public health policy to reduce the poor glycemic control rates in type 2 diabetes patients. We should recognize the education levels, duration of diabetes, diabetes treatment, hypertriglyceridemia, and sleep duration were associated with poor glycemic control.
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Adult , Humans , Diabetes Mellitus, Type 2 , Education , Health Behavior , Hypertriglyceridemia , Insulin , Korea , Logistic Models , Nutrition Surveys , Odds Ratio , Public Health , Running , SeoulABSTRACT
Periodontal disease (PD) and diabetes mellitus (DM) hold a consistent relationship. DM not only increases the risk of having PD and with that its prevalence, but it also augments the progression of more aggressive and quickly defining signs. There is a bidirectional relationship between DM and PD. The treatment of periodontitis in diabetic patients favors a reduction in mediators responsible for the destruction of periodontal tissue and decreases with it, resistance to insulin. PD is characterized by low grade chronic inflammation that may remain silent in diabetics causing damage that is not locally limited but may extend systemically. Our aim of this article is to make aware, both general dental and medical practioner about interrelationship between periodontal disease and diabetes with special emphasis on importance of mutual consultation between the two fraternity, which in turn significantly contributes to general well being of an individual.