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Purpose: To investigate the clinical effect of sodium hyaluronate eye drops combined with tobramycin, dexamethasone, and pranoprofen eye drops in the treatment of dry eye after phacoemulsification. Methods: Medical records of 188 patients with dry eye after phacoemulsification, treated in our hospital from August 2020 to August 2021, were included and divided into groups based on the type of dry eye treatment. Patients in the control group (n = 90) were treated with tobramycin, dexamethasone, and pranoprofen eye drops. Patients in the test group (n = 98) were treated with sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops. The tear secretion test (TST), film rupture time (BUT), corneal fluorescence staining (FS) score, levels of interleukin (IL)?6, and tumor necrosis factor (TNF)?? before the treatment and at 1 month follow?up, the overall total effective rate and the number of completely cured cases were compared between the two groups. Multiple linear regression was used to calculate coefficients for predicting clinical variables. Ordinal logistic regression was used to compute coefficients and odds ratios for predicting effective scores. Results: The total effective rate in the observation group (99%) was significantly higher than that in the control group (80.00%). After the treatment, the TST and BUT indexes of the observation group were higher compared to the control group, and the FS score of the observation group was lower than that of the control group. TNF?? and IL?6 levels of the observation group were lower compared to the control group. Logistic regression analysis demonstrated that the differences in the effective rate and clinical variables between the two groups remained significant after adjusting for the effect of age. Conclusion: A combination of sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops for the treatment of dry eye after phacoemulsification can improve the curative effect, reduce corneal fluorescein staining and inflammatory factor index levels compared to the treatment regimen lacking sodium hyaluronate eye drops.
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Objective To analyze the effect of moistening room mirror combined with pranoprofen eye drops on dry eye and its effect on serum MMP-2 and STRA6 levels. Methods 100 cases with dry eye disease treated in our hospital from January 2016 to August 2017 were randomly divided into the observation group and the control group. The control and observation group were treated with pranoprofen eye drops and moisturizing room mirror combined with pranoprofen eye drops. The clinical efficacy of the patients was evaluated, and the symptoms and the survival quality, MMP-2 and STRA6 of the patients were analyzed. Results Significant clinical efficiency was significantly higher in the observation group than in the control group (P < 0.05). BUT, SIt, visual related quality of life scores in the observation group were significantly higher than the control group (P < 0.05). Symptom score, MMP-2 and STRA6 levels in the observation group were significantly lower than the control group (P < 0.05).Conclusions The combination of moisturizing chamber mirror and pralofen eye drops in the treatment of dry eye can effectively improve the clinical efficacy and reduce the levels of MMP-2 and STRA6.
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@#AIM: To evaluate the short-term clinical efficacy of pranoprofen eye drops combined with sodium hyaluronate eye drops in the treatment of moderate to severe dry eye and its influence on the psychological status of patients.<p>METHODS: From January to December 2018, 318 patients with moderate to severe dry eye were selected and treated in ophthalmology department of our hospital. The patients were divided into experimental group(238 patients)and control group(80 patients)by random number table method, and the control group was treated with sodium hyaluronate eye drops, while the test group was treated with pranoprofen eye drops combined with sodium hyaluronate eye drops. The general data of the patients were statistically analyzed. Before treatment, 7d, 14d, 28d after treatment, the patients' scores of conscious symptoms and signs were investigated by questionnaire, the degree of conjunctival congestion, tear breakup time, corneal fluorescein staining and tear secretion were examined, and the degree of anxiety and depression were evaluated.<p>RESULTS: There was no significant difference in general data between the two groups(<i>P</i>>0.05). In terms of patients' scores of conscious symptoms and signs, degree of conjunctival congestion, tear breakup time, corneal fluorescein staining and tear secretion, the experimental group was significantly improved 7d after treatment, and the effect was more significant with the prolonged treatment, while the control group was gradually improved 14 or 28d after treatment. At the same treatment time point, the efficacy of the experimental group was significantly better than that of the control group, and the difference was statistically significant(<i>P</i><0.05). With the improvement of the condition after treatment, the anxiety or depression symptoms of the patients were improved. The experimental group was significantly improved 7d after treatment, while the control group was gradually improved 14d or 28d after treatment. At the same treatment time point, compared with the control group,the anxiety and depression degree of the patients in the experimental group were significantly reduced(<i>P</i><0.05).<p>CONCLUSION: Pranoprofen eye drops combined with sodium hyaluronate eye drops for treatment of dry eye syndrome had fast and significant effect, patients' self-consciousness symptoms and signs are significantly improved, conjunctival congestion and corneal fluorescein staining are reduced, tear breakup time is prolonged, tear secretion is increased, and anxiety or depression are significantly improved.
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@#AIM: To evaluate the effects of pranoprofen on the retinal structure and serum levels of vascular endothelial growth factor(VEGF)in patients with cataract surgery.<p>METHODS: One hundred and seventy two cataract patients(200 eyes)were enrolled in this study. All the patients were randomly divided into observation group and control group. The patients of observation group were treated with pranoprofen combined with normal post-operative therapy for 1mo. We set 4 points(1d, 7d, 15d and 30d after surgery)to dynamically analyze the fluctuation of inflammation score, central macular retinal thickness(CMT), macular foveola retinal thickness(MFRT), and the light receptor inner segment and outer segment layer(IS/OS). We set two points(before and 30d after surgery)to dynamically observe the alteration of superoxide dismutase(SOD), malondialdehyde(MDA)and VEGF.<p>RESULTS: The levels of inflammation index in control group were higher than those in observation group 7d, 15d and 30d after surgery, respectively(<i>P</i><0.001). The levels of CMT in control group were higher than those in observation group 15d and 30d after surgery, respectively(<i>P</i><0.001). The levels of IS/OS in control group were lower than those in observation group 7d, 15d and 30d after surgery, respectively(<i>P</i><0.001). Both of two groups expressed a markedly increasing of SOD levels(<i>P</i><0.001)and decreasing of MDA and VEGF levels(<i>P</i><0.001)30d after surgery compared with those before surgery. The levels of SOD in control group were lower than those in observation group(<i>P</i><0.001), whereas the contents of MDA and VEGF in control group were higher than those in observation group(<i>P</i><0.001)30d after surgery.<p>CONCLUSION: Pranoprofen considerably relieve levels of inflammation injury and down-regulate circulating levels of VEGF, which contributes its promotion in the recovery of retinal structure after surgery.
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@#AIM:To evaluate the efficacy of pranoprofen combined with sodium hyaluronate in treatment of dry eye in recent years by Meta-analysis.<p>METHODS: According to the Cochrane systematic review method, the computer searched Medline, EMbase, Cochrane Library, Wanfang database, Weipu database, China Knowledge Network database, and included in the randomized controlled study of pranoprofen combined with sodium hyaluronate in the treatment of dry eye in 2014-2018, RevMan5.3 statistical software for data extraction and Meta-analysis.<p>RESULTS: A total of 8 randomized controlled trials, all in Chinese, totally 1 008 patients. Meta-analysis showed that compared with the use of sodium hyaluronate alone, prano fraction combined with sodium hyaluronate significantly improved the BUT, SⅠt, FL, dry eye symptoms and overall efficacy of the patients, the difference was statistically significant.<p>CONCLUSION: The efficacy of pranoprofen combined with sodium hyaluronate in treatment of dry eye was better than that of sodium hyaluronate alone.
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· AIM:To investigate the efficacy and safety of short-term application of pranoprofen eye drops in the treatment of dry eyes in senile patients.· METHODS:Totally 100 elderly patients with dry eyes treated in our hospital from June 2016 to May 2017 were randomly divided into 2 groups.All cases were bilateral onset,and the right eyes were marked as the observation eyes.The 50 eyes in the observation group were treated with 1 g/L pranoprofen eye drops combined with 1 g/L sodium hyaluronate eye drops,while 50 in the control group were treated with 1 g/L sodium hyaluronate eye drops.The results of Schirmer Ⅰ,ocular surface disease index (OSDI),break-up time (BUT),ocular surface staining(OSS),human leukocyte antigen-DR (HLA-DR) and CD11b in conjunctival epithelial cells before and at 2wk after treatment,and adverse reactions in 2 groups were observed.· RESULTS:Before treatment,results of Schirmer I,OSDI,BUT,OSS,HLA-DR and CD11b in the two groups were similar,there were no statistically significant differences (P＞0.05).After treatment,OSDI,OSS,HLA-DR,CD11b significantly decreased,BUT significantly increased in both groups,the differences were statistically significant (P＜ 0.05).After treatment,OSDI,OSS and HLA-DR in the observation group were significantly lower than those in the control group,BUT in the observation group was significantly higher than those in the control group,the differences were statistically significant (P＜ 0.01).The expression of HLA-DR was positively correlated with OSDI and OSS,and negatively correlated with BUT,and the correlations were statistically significant (P＜0.06).· CONCLUSION:Short term application of pranoprofen eye drops can effectively enhance the efficacy in treating elderly patients with dry eyes,release clinical symptoms,and the therapeutic mechanism may be related to the inhibitory effect on HLA-DR.
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·AIM: To explore clinical effect of pranoprofen combined with deproteinized calf blood extract eye drops for moderate to severe dry eye. ·METHODS: A total of 84 patients (132 eyes) who received treatment at the Zhengzhou Second Hospital were selected from January 2016 to January 2017. According to random number table method they were divided into control group 42 cases (68 eyes) and observation group 42 cases (64 eyes), the control group using polyvinyl alcohol eye drops with pranoprofen, observation group with pranoprofen with deproteinized extract of calf blood eye drops. Subjective and objective scores before and after treatment were recorded. · RESULTS: There was no statistically significant difference on the four objective indicators of pretreatment FL,BUT,SⅠt,and vision between the two groups (P>0.05). Dry eye symptom scores of the two groups decreased after treatment,both with significantly different (P<0.05);after treatment,the symptom scores of the observation group were significantly lower than those in the control group, and the difference was statistically significant (P< 0. 05), indicating that the subjective symptoms of the observation group were better than that of the control group after treatment. After treatment of the control group and the observation group,the FL index was significantly lower than before treatment, BUT, S Ⅰ t and vision were significantly higher than before treatment, and the differences within either group were statistically significant(P<0.05);those indexes of observation group were different compared with control group (P < 0. 05), indicating that the objective symptoms of the observation group were better than that of the control group after treatment. None of the patients showed serious adverse reactions. ·CONCLUSION: The clinical effect of praprofen on the treatment of moderate to severe dry eye with the deproteinized calf blood extract is better.
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·AIM:To investigate the effect and safety of pranoprofen treatment of keratoconjunctivitis sicca. · METHODS: Totally 100 cases ( 200 eyes ) of keratoconjunctivitis sicca treated in our hospital in January 2014 to May 2016 were divided into control group and study group according to different treatment methods. The patients in the control group were treated with artificial tear and the patients in the study group were treated with artificial tear combined with pranoprofen eye drops. The clinical effects of the two groups were observed and analyzed. ·RESULTS:In the study group,20 cases (40 eyes) were cured, 26 cases (52 eyes) were effective. The total effective rate was 92.0% higher than that of the control group. The difference was statistically significant (P<0.05). The symptoms,BUT and FL scores of two groups after treatment were better than before treatment (P<0.05),but SIT score was not statistically significant (P>0.05). The symptoms and FL scores of study group after treatment were lower than those of the control group after treatment, the BUT score was higher than that of the control group (P<0.05). After treatment, the levels of TNF-α,IL-6 and IL-1β in the two groups were lower than those before treatment,and the levels of TNF-α,IL-6 and IL-1β in the study group were significantly lower than in the control group (P<0. 05). the difference of patients with adverse reactions between two groups was not statistically significant (P=1.00). ·CONCLUSION: Pranoprofen has a significant effect on the treatment of keratoconjunctivitis sicca, can improve symptoms and signs, control the infection, with high safety.
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AIM:To observe the effect of pranoprofen eye drops on corneal endothelium and tears inflammatory factors in perioperative period of cataract surgery.METHODS:Totally 60 cases (60 eyes) of senile cataract patients were enrolled in this study.Patients with diabetes or other systemic diseases,with other eye diseases or eye surgery,drug allergy were excluded.All the patients were given ophthalmic surgery for the first time.All the patients were randomly divided into 4 groups,15 patients per group.Each group of patients had been given levofloxacin eye drops preoperatively for 3d,4 times per day,and tobramycin dexamethasone eye drops postoperatively,3 times per day for the first week,2 times per day for the second week.Group A was the control group,without any other drugs.Group B was given pranoprofen eye drops 4 times per day for 3d before the operation.Group C was given pranoprofen eye drops 4 times per day for 1wk after the operation.Group D was given pranoprofen eye drops 4 times per day for 3d before the operation and 1wk after the operation.All the surgeries were done by the same ophthalmologist,using the same phacoemulsification machine and the same ultrasound energy parameters.The loss rate of endothelial cell was measured by corneal endothelium counterometry.Interleukin-6 (IL-6) and tumor necrosis factor (TNF) in the tear fluid were measured by ELISA before surgery (before using eye drops) and 1wk,1mo and 3mo postoperatively.RESULTS:There was no significant difference in patients' gender,age and phacoemulsification time among 4 groups.The levels of inflammatory cytokines IL-6 in the tear fluid of the Group B before surgery had no significant difference compared to that at 3mo postoperatively(P＞ 0.05),but the differences among the other groups at different time points were statistically significant (P＜0.05).There was no significant difference in preoperative among the four groups (P＞0.05).At 1wk after the operation,there was significant difference between the Group A and the other three groups (P＜ 0.05),and there was significant difference between the Group B and the Group D (P＜0.05),but there was no significant difference between the Group B and the Group C,the Group C and the Group D (P＞0.05).At 1mo after the operation,there was significant difference between the Group A and the other three groups (P＜0.05),and there was significant difference between the Group B and the Group C,the Group C and the Group D (P＜0.05),but there was no significant difference between the Group B and the Group D (P＞0.05).At 3mo after the operation,there was significant difference between the Group A and the other three groups (P＜ 0.05),but there was no significant difference between the Group B,the Group C and the Group D (P＞0.05).The levels of inflammatory cytokines TNF in the tear fluid at different time points among each group were significantly different (P＜0.05).There was no significant difference among the four groups in preoperative (P＞ 0.05).At 1w after the operation,there was significant difference between the Group A and the other three groups (P＜0.05),but there was no significant difference between the other three groups respectively (P ＞ 0.05).At 1 mo after the operation,there was significant difference between the Group A and the other three groups (P＜0.05),and there was significant difference between the Group B and the Group C,the Group C and the Group D (P＜0.05),but there was no significant difference between the Group B and the Group D (P＞0.05).At 3mo after the operation,there was significant difference between the Group A and the other three groups (P＜ 0.05),but there was no significant difference between the other three groups respectively (P＞0.05).CONCLUSION:Pranoprofen eye drops have no effect on the loss rate of corneal endothelium.Pranoprofen eye drops could significantly reduced the tears inflammatory factors in perioperative period of cataract surgery.The role to reduce inflammatory cytokines in the postoperative application of pranoprofen eye drops is not obvious compared to other two modes of administration,but the difference is not statistically significant at 3mo.The administration of preoperative and postoperative use of pranoprofen eye drops has no significant advantage in reducing inflammatory cytokines compared with only preoperative use.
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@#AIM: To explore the therapy efficacy of different drugs for dry eyes after cataract surgery.<p>METHODS: Collected from June 2014 to June 2016 in patients with dry eyes in our departments of cataract surgery, a total of 60 cases with 120 eyes, according to the doctor order divided into pure sodium hyaluronate eye drops group 20 cases(40 eyes, sodium hyaluronate eye drops combined pranoprofen eye drops group 20 cases(40 eyes), sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill group of 20 cases(40 eyes). All patients were treated for 1mo. Observation of break up time(BUT), Shimmer Ⅰ test(SIt)and fluorescein corneal staining(FI)were recorded before the treatment and 1, 2wk, 1, 3mo after treatment. <p>RESULTS: Difference of efficient rates of three groups 1mo after treatment were statistically significant(<i>P</i><0.05). BUT: there was no statistically significant difference among three groups before treatment(<i>P</i>>0.05); at 1, 3mo after treatment compared with before treatment, the differences of the three groups were statistically significant(<i>P</i><0.05); among the three groups 1, 2wk and 1mo after treatment, the differences were statistically significant(<i>P</i><0.05); at 3mo after treatment the difference among the three groups was not statistically significant(<i>P</i>>0.05); but sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill group(12.14±1.97s)was superior to pure sodium hyaluronate eye drops group(10.54±1.88s)and sodium hyaluronate eye drops combined pranoprofen eye drops group(12.05±1.63s).SIt: there was no statistically significant difference among three groups before treatment(<i>P</i>>0.05); at 1, 3mo after treatment compared with before treatment, the differences of the three groups were statistically significant(<i>P</i><0.05); among the three groups 1, 2wk and 1mo after treatment, the differences were statistically significant(<i>P</i><0.05); but sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill group(14.24±1.89mm/5min)was superior to pure sodium hyaluronate eye drops group(12.22±2.54mm/5min)and sodium hyaluronate eye drops combined pranoprofen eye drops group(12.27±2.31mm/5 min).FL: there was no statistically significant difference among three groups before treatment(<i>P</i>>0.05); at 1, 3mo after treatment compared with before treatment, the differences of the three groups were statistically significant(<i>P</i><0.05); among the three groups 1, 2wk and 1mo after treatment, the differences were statistically significant(<i>P</i><0.05); at 3mo after treatment the difference among the three groups was not statistically significant(<i>P</i>>0.05).<p>CONCLUSION:Sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill in the treatment of dry eye after cataract surgery is better than that of sodium hyaluronate eye drops combined pranoprofen eye drops group and simple application of sodium hyaluronate eye drops, which can better improve the visual function, improve tear film stability, get better treatment effect.
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Objective To investigate the effect and clinical efficacy of pranoprofen eye drops on lysozyme, EGF and LF levels in type 2 diabetic patients with dry eye syndrome.Methods70 Type 2 diabetes patients with dry eye from department of ophthalmology, Yuyao People's Hospital of Zhejiang Province from September 2013 to May 2015.They were selected and randomly divided into the treatment group and the control group with 35 cases in each group.The control group were treated by artificial tears eye drops 0.1mL/time, 6 times/day treatment.The treatment group were treated on the base of the control group with pranoprofen eye drops 0.15mL/eye drops, 4 times/day treatment.2 groups were 14 days for 1 courses of treatment, a total of 2 courses of treatment.The tear break-up time, basal lacrimal secretion, corneal fluorescein staining positive rate and clinical efficacy were compared between two groups before and after treatment.ResultsWith the total effective rate in the treatment group,was higher than the control group(P<0.05).Compared with before treatment, the tear break-up time prolonged, basal lacrimal secretion, tear lysozyme, EGF and LF levels were higher(P<0.05), the positive reaction rate of corneal fluorescence staining was lower(P<0.05).Compared with the control group after treatment, the tear break-up time prolonged, basal lacrimal secretion, tear lysozyme, EGF and LF levels were higher(P<0.05), the positive reaction rate of corneal fluorescence staining was lower(P<0.05).ConclusionThe clinical efficacy of pranoprofen eye drops in type 2 diabetic patients with dry eye syndromeis good.It is speculated that the mechanism and tear break-up time prolonged, basal lacrimal secretion increase and lysozyme, epidermal growth factor(EGF)and the level of LF increased.
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AIM: To analyzed the effect of keratoconjunctivitis sicca treated by different medicines after phacoemulsification in patients with diabetes.METHODS: Totally 78 diabetic patients 78 eyes with keratoconjunctivitis sicca (KCS) after phacoemulsification from March 2015 to March 2016 were selected and divided into two groups using random number table.In Group A, 39 eyes were treated with pranoprofen eye drops + artificial tears + Qiming granules.In Group B, 39 eyes were treated with pranoprofen eye drops + artificial tears.the two groups were observed for clinical symptoms, tear film break up time(BUT), corneal fluorescein staining and adverse reaction and so on before and after treatment.RESULTS: Total effective rate of Group A was 97%, significantly higher than that of Group B (64%)(P<0.05).After treatment, symptoms and signs scores of the two groups were significantly lower, BUT were significantly prolonged.At 1, 2wk and 1mo after treatment, symptoms and signs scores of Group A were significantly lower the BUT was longer than those of Group B (P<0.05).Corneal fluorescein staining of Group A at 2wk was lower than that of Group B (P<0.05).CONCLUSION: The combined therapy, pranoprofen eye drops + artificial tears + Qiming granules, is able to quickly and effectively improve the clinical symptoms and signs, with no serious adverse reactions for keratoconjunctivitis sicca after phacoemulsification in patients with diabetes.
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AIM:To explore the application effect of pranoprofen combined with tobramycin and dexamethasone ophthalmic suspension in cataract extraction after IOL implantation.METHODS:Retrospective analysis of the clinical data of cataract patients treated from May 2015 to June 2016 in our hospital.According to the treatment methods, patients were divided into tobramycin and dexamethasone ophthalmic suspension with pranoprofen group (combined treatment group) and pranoprofen treatment group.The difference of visual acuity, intraocular pressure, anterior chamber flash change, satisfaction rate and symptom score before and after treatment in two groups were observed.RESULTS:The vision of the two groups before treatment had no difference(P>0.05).At 1wk and 1mo after treatment, the visual acuity of the two groups all improved compared with before treatment, there was no significant difference between the two groups (P>0.05).Before treatment, the anterior chamber flare of the two groups had no difference(P>0.05).At 1wk and 1mo after treatment, the anterior chamber flare of combined treatment group was lower, the difference was statistically different (t=2.435, 1.864;P0.05).After treatment, the symptoms and signs of combined treatment group was significantly lower than that of pranoprofen group (t=2.586, 7.820;P<0.05).The satisfaction rate of the combined treatment group patients was 100%, significantly higher than pranoprofen group.CONCLUSION:Pranoprofen and tobradex in the treatment of cataract extraction and intraocular lens implantation has good application effect, can significantly improve the patient's symptoms and signs.
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Objective To evaluate the clinical effect of emedastine difumarate eye drops combined with pranoprofen eye drops on histamine (HA), eosinophil cationic protein (ECP), leukotrienes B4(LTB4) and, IgE levels of allergic conjunctival and provide reference for clinical diagnosis and treatment.Methods 76 cases of patients with allergic conjunctivitis were randomly divided into control group and experimental group , control group were treated with fumaric acid emedastine eye drops, experimental group were treated with fumarate emedastine combined with pranoprofen eye drops, and then compare the efficacy and serum ECP, HA, LTB4 and IgE levels between two groups before and after treatment of the symptoms and signs score . Results The total efficacy of experimental group was significantly higher than that in control group (94.70%vs.81.60%)(P<0.05).The serum ECP, HA, LTB4 and IgE levels of experimental group were significantly lower than those in control group(P<0.05).Conclusion The emedastine difumarate combined with pranoprofen eye drops in the treatment of allergic conjunctivitis is better than single medication, and ECP, HA, LTB4, IgE significantly decrease.
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AIM: To observe the efficacy and compliance of cetirizine hydrochloride and pranoprofen eye drops on children with vernal keratoconjunctivitis. ● METHODS: A total of 63 children with vernal keratoconjunctivitis, from the outpatient department in our hospital between Jan. 2014 and Dec. 2015, were randomly divided into two groups including experimental group and control group. The cases in experimental group were treated with cetirizine hydrochloride, 2 times/d, 5 drops (0. 25ml, 2. 5mg) each time (≤6 years) or 10 drops (0. 5ml, 5mg) each time (>6 years), oral or oral with beverage and food, 1g/L pranoprofen eye drops, 4 times/d, 1 drop each time. The cases in control group were only treated with cetirizine hydrochloride, 2 times /d, 5 drops (0. 25ml, 2. 5mg) each time (≤6 years) or 10 drops (0. 5ml, 5mg) each time (>6 years), oral or oral with beverage and food for 14d. All the children were detected the scores of symptom and pathology before and after treatment. Compliance and side effect of the drug were surveyed by questionnaire. ● RESULTS: The scores of symptom, pathology and overall total after treatment were significantly lower than those before treatment in each group ( texperimental, symptom =10. 41, P ● CONCLUSION: Cetirizine hydrochloride and pranoprofen eye drops in combination may offer a safety and effective treatment on children with vernal keratoconjunctivitis and have good compliance.
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OBJECTIVE:To explore the effectiveness and safety of pranoprofen combined with sodium hyaluronate in the treat-ment of moderate and severe dry eyes. METHODS:180 patients with moderate and severe dry eyes were divided into observation group and control group by random number table method,with 90 cases in each group. Control group was given Sodium hyaluro-nate eye drops,one drop each time,tid,and received physical therapy as cleaning eyelid,hot compress and glandulae tarsales mas-sage. Observation group was additionally given Pranoprofen eye drops,one drop each time,tid. A treatment course lasted for 2 weeks. The monocular corneal fluorescence staining score,break-up time of tear film(BUT),dry eye symptom scores,ShirmerⅠtest (SIT) before and after treatment,clinical efficacy and ADR were compared between 2 groups. RESULTS:2,4 weeks after treatment,monocular corneal fluorescence staining scores and dry eye symptom scores of 2 groups were significantly lower than be-fore treatment;BUT and SIT were significantly longer than before;those indexes after 4 weeks of treatment were significantly bet-ter than after 2 weeks of treatment;those indexes of observation group after 2,4 weeks of treatment were significantly better than those of control group at the same time,with statistical significance (P0.05). CONCLUSIONS:For moderate and severe dry eyes,prano-profen combined with sodium hyaluronate can effectively control ocular inflammation and improve tear film stability. It shows defi-nite therapeutic efficacy and good safety.
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? AlM: To investigate the therapeutic effects of Pranoprofen on tear dynamic abnormity induced by conjunctivochalasis ( CCh) . ?METHODS: Seventy cases ( 70 eyes ) whose the main symptoms was epiphora induced by CCh were divided into II, Ⅲ and Ⅳ in 3 groups according to Zhang’s grading standards, meanwhile, all the patients were treated with the eye drops of Pranoprofen for 2wk. After that, the curative effect of each group was analyzed before and after treatments according to the symptoms, dye disappearance test, bitter taste test and tear break-up time. ?RESULTS: After 2wk treatment of Pranoprofen, the symptom of patients at grade I and II improved obviously grade Ⅲ improved more, grade Ⅳ did little. The positive rate of dye disappearance was the highest in grade II, the second in grade Ⅲ, and the third in gradeⅣ. There was significant difference among the 3 groups (P0. 05). ?CONCLUSlON: Pranoprofen has good effects on tear dynamic abnormity induced by grade II of cch.
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AlM:To evaluate the efficacy of combined pranoprofen eye drops and artificial tears on the treatment of mild to moderate dry eye syndrome after trabbeculectomy.METHODS:This prospective case control study included 63 cases (63 eyes) of patients with mild to moderate dry eye syndrome after trabbeculectomy in our hospital from November 2013 to June 2013. All subjects were randomly divided into two groups. Observation group was treated with combined pranoprofen eye drops and artificial tears and control group received simple artificial tears marking the eyes at 1, 2, 4wk. The patient's symptoms, signs, BUT, S▏t, and FL were observed before treatment and 1, 2, 4wk after treatment.RESULTS: After 2wk, the symptoms of observation group were improved, there was statistically significant difference (P<0. 05). FL difference of each group was statistically significant ( P<0. 05 ); After 4wk, symptoms and signs were improved. There was statistically significant difference ( P < 0. 05 ). The BUT of the observation group and corneal FL scores of two groups showed significant differences (P<0. 05). CONCLUSlON: Artificial tears joint pranoprofen eye drops has good curative effect in the treatment of mild to moderate dry eye syndrome after trabbeculectomy.
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This study investigated the toxicity of commercial non-steroid anti-inflammatory drug (NSAID) eye solutions against corneal epithelial cells in vitro. The biologic effects of 1/100-, 1/50-, and 1/10-diluted bromfenac sodium, pranoprofen, diclofenac sodium, and the fluorometholone on corneal epithelial cells were evaluated after 1-, 4-, 12-, and 24-hr of exposure compared to corneal epithelial cell treated with balanced salt solution as control. Cellular metabolic activity, cellular damage, and morphology were assessed. Corneal epithelial cell migration was quantified by the scratch-wound assay. Compared to bromfenac and pranoprofen, the cellular metabolic activity of diclofenac and fluorometholone significantly decreased after 12-hr exposure, which was maintained for 24-hr compared to control. Especially, at 1/10-diluted eye solution for 24-hr exposure, the LDH titers of fluorometholone and diclofenac sodium markedly increased more than those of bromfenac and pranoprofen. In diclofenac sodium, the Na+ concentration was lower and amount of preservatives was higher than other NSAIDs eye solutions tested. However, the K+ and Cl- concentration, pH, and osmolarity were similar for all NSAIDs eye solutions. Bromfenac and pranoprofen significantly promoted cell migration, and restored wound gap after 48-hr exposure, compared with that of diclofenac or fluorometholone. At 1/50-diluted eye solution for 48-hr exposure, the corneal epithelial cellular morphology of diclofenac and fluorometholone induced more damage than that of bromfenac or pranoprofen. Overall, the corneal epithelial cells in bromfenac and pranoprofen NSAID eye solutions are less damaged compared to those in diclofenac, included fluorometholone as steroid eye solution.
Subject(s)
Humans , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Benzophenones/administration & dosage , Benzopyrans/administration & dosage , Bromobenzenes/administration & dosage , Cell Movement/drug effects , Cells, Cultured , Diclofenac/administration & dosage , Epithelial Cells/drug effects , Epithelium, Corneal/cytology , Fluorometholone/administration & dosage , L-Lactate Dehydrogenase/metabolism , Microscopy, Electron, Transmission , Ophthalmic Solutions , Propionates/administration & dosageABSTRACT
Objective To observe the efficacy of combination of pranoprofen and artificial tears in treatment of dry eye syndrome after recovery from acute conjunctivitis. Methods This study involved 206 eyes of 157 consecutive patients who had recovered from acute conjunctivitis after routine treatment between July 2008 and September 2010. All cases were randomly divided into artificial tears group (79cases,104eyes) : artificial tears eye drops alone and combination group(78cases,102eyes) : pranoprofen combined with application of artificial tears eye drops. All patients'symptoms, signs such as tear film break 2 up time (BUT ) ,Schirmer I test (SIT) , corneal fluoresce staining (FL) score at 3,7,14days after treatment Were observed. Results All patients finished the trial at the end of the follow-up duration. There were significant differences in symptoms, BUT and corneal fluoresce staining between the two groups after treatment,combination group was superior to artificial tears group in BUT and FL. Conclusion Pranoprofen combined with artificial tears eye drops is superior to artificial tears eye drops alone