Research progress on direct pulp capping of primary teeth / 口腔疾病防治

@#The timely treatment of dental caries and pulp disease in primary teeth holds significant importance for maintaining children's oral health. Direct pulp capping (DPC) is a vital pulp treatment that involves covering the exposed pulp with bioactive materials to promote dentin bridge formation. DPC is commonly used in primary teeth with vital pulp and mechanical pulp exposure not exceeding 1 mm. DPC offers advantages such as minimal invasiveness, comfort, simplicity of operation and short chair-side time, making it suitable for pediatric dental clinical practice. Early studies suggested negative treatment outcomes for DPC in primary teeth with carious pulp exposure. Over the years, there have been advancements in materials and technology demonstrating positive outcomes in the clinical research of primary teeth with deep caries. However, due to the limited quality of related studies, DPC has not been widely recommended for the treatment of primary teeth with carious pulp exposure, and its widespread use needs further support by more high-quality evidence-based medical research. The success rate of DPC in primary teeth is influenced by factors including pulp status, clinical operations (such as isolation and caries removal), pulp capping material, cavity type, tooth position, coronal sealing, and dental fear. In clinical operation, dentists should accurately assess pulp status and minimize bacterial contamination. Mineral trioxide aggregate (MTA) is a DPC agent with relatively sufficient evidence and good therapeutic effects, and the crown should be tightly sealed after pulp capping. Additionally, the effects of novel biocompatible materials such as iRoot BP Plus used in DPC of primary teeth, and the influence of other factors like hemostatic methods on the prognosis of affected teeth, need further exploration.

Comparison of the effect of iRoot BP Plus and MTA on direct pulp capping of carious pulp exposed mature permanent teeth / 口腔疾病防治

Objective@#To study the clinical efficacy of biological ceramics (iRoot BP Plus ) and mineral trioxide aggregate (MTA) in direct pulp capping of mature permanent teeth, to provide referrence for clinical application.@* Methods @# Seventy-four patients with pulp exposure due to deep caries or reversible pulpitis in 75 mature permanent teeth were selected and were randomly divided into two groups. iRoot BP Plus were used as pulp capping agents in the treatment group and MTA were used as pulp capping agents in the control group respectively. The clinical efficacy and imaging analysis were performed at 1, 3, 6 and 12 months after operation. Treatment success rate of the two groups were calculated, and the influence of various factors including gender, age, tooth position, cavity, number and size of pulp exposure on the efficacy of direct pulp capping were analyzed. @* Results @#Sixty patients with 61 mature permanent teeth were selected. Twelve mouths after treatment, 61 teeth of 60 patents were completely investigated (iRoot group: 31 teeth 30 patients; MTA group: 30 teeth 30 patients). The success rates of the 2 groups were 90.3% (iRoot BP Plus) and 90.0% (MTA), respectively. There was no statistical difference between 2 groups (P>0.05). Statistical analysis also showed that gender, age, tooth position, cavity, number and size of pulp exposure had no significant difference between the two groups (P>0.05). @*Conclusion@# Both iRoot BP Plus and MTA are effective in direct pulp capping of mature permanent teeth with carious pulp exposure, while the operation of iRoot is simple and convenient.

Experimental resin-based dual-cured calcium aluminate and calcium titanate materials for vital pulp therapy

Abstract: This paper evaluates the physicochemical and biological properties of experimental resin-based dual-cured calcium aluminate (CA) and calcium titanate (CTi) materials for vital pulp therapy (VPT). The experimental dual-cured materials were obtained as two pastes: a) Bis-EMA 10, PEG 400, DHEPT, EDAB, camphorquinone, and butylated hydroxytoluene; and b) fluoride ytterbium, Bis-EMA 10, Bis-EMA 30, benzoyl peroxide, and butylated hydroxytoluene. The materials were divided into six groups based on the added calcium component: MTA (MTA®, Angelus); CLQ (Clinker-Fillapex®, Angelus); CA (calcined at ,1200°C in pastes a and b); CA800 (calcined at 800°C in paste a); CA1200 (calcined at 1,200°C in paste a); and CTi (paste a). The real-time degree of conversion and rate of polymerization (n = 3), diametral tensile strength (n = 10), hydrogen potential (n = 15), calcium ion release (n = 10), water sorption and solubility (n = 10), and cell viability (n = 6) were evaluated. One- and two-way ANOVA and Tukey's post hoc test were used in the analysis of the parametric data, and Kruskal-Wallis and Dunn's multiple tests were used to analyze the nonparametric data (α = 0.05). CLQ, CA800 and CA1200 had the highest diametral tensile strength. The water solubility of MTA was similar to that of CA800, CA1200 and CTi. CA800 and CA1200 resulted in cell viabilities similar to those of MTA and CLQ. The experimental dual-cured CA-based material that calcined at 800°C showed physicochemical and biological properties suitable for VPT, and similar to those of MTA.

Pulpotomía parcial con agregado de trióxido mineral (MTA) comparado con hidróxido de calcio en caries dentinaria profunda en pacientes con dientes permanentes inmaduros / Partial pulpotomy with mineral trioxide aggregate (MTA) versus calcium hydroxide in immature permanent teeth with deep caries

RESUMEN: Introducción: La pulpotomía parcial se utiliza para el tratamiento de caries con exposición pulpar en dientes permanentes inmaduros. El agregado de trióxido mineral (MTA) ha sido propuesto como uno de los biomateriales de elección para el tratamiento, pero existe incertidumbre en relación a su efectividad comparado con la del hidróxido de calcio. Métodos: Realizamos una búsqueda en Epistemonikos, la mayor base de datos de revisiones sistemáticas en salud, la cual es mantenida mediante el cribado de múltiples fuentes de información, incluyendo MEDLINE, EMBASE, Cochrane, entre otras. Extrajimos los datos desde las revisiones identificadas, analizamos los datos de los estudios primarios, realizamos un metanálisis y preparamos una tabla de resumen de los resultados utilizando el método GRADE. Resultados y conclusiones: Encontramos cinco revisiones sistemáticas, que incluyeron tres estudios primarios, de los cuales todos corresponden a ensayos aleatorizados. Concluimos que la pulpotomía parcial con agregado de trióxido mineral (MTA) podría resultar en poca o nula diferencia en la tasa de éxito comparado a la pulpotomía parcial con hidróxido de calcio, pero la certeza de la evidencia es baja.

ABSTRACT: Introduction: Partial pulpotomy is the treatment of choice following carious pulp exposure in immature permanent teeth. Mineral trioxide aggregate (MTA) has been suggested as the biomaterial first option for treatment, but there is still uncertainty regarding its effectiveness compared to calcium hydroxide. Methods: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. Results and conclusions: We identified five systematic reviews including three studies overall, of which all were randomized trials. We conclude that partial pulpotomy with mineral trioxide aggregate (MTA) may make little or no difference to success rate compared to partial pulpotomy with calcium hydroxide, however, the certainty of the evidence has been assessed as low.

Efficacy of Lasers Treatment of Exposed Pulps to Stimulate Healing: A Systematic Review and Meta-Analysis

Abstract Objective: The present systematic review and meta-analysis aimed at evaluating the efficacy of laser's treatment of exposed pulps to stimulate healing. Material and Methods: MEDLINE, PubMed, Cochrane Library, Embase, ISI, Google Scholar have been searched as the electronic databases for performing systematic literature between 2005 to 2019. Searches were performed with MESH terms. The quality of the studies included was assessed using the Critical Appraisal Skills Program checklist. For Data extraction, two reviewers blind and independently extracted data from the abstract and full text of the studies included. Moreover, the fixed-effect model's odds ratio for a 95% confidence interval (CI) was calculated. Random effects were used to deal with potential heterogeneity, and I2 showed heterogeneity. The meta-analysis and forest plots have been evaluated using the Comprehensive Meta-Analysis Stata. Results: Five studies (3 RCTs and 2 animal studies) were included in this study. The Odds Ratio was 1.90 (95% CI 1.39-2.42; p=0.00); there was a statistically significant difference between the laser and the control groups (p=0.00). Conclusion: The success rate of laser treatment for exposed pulps is higher than mineral trioxide aggregate, resin, calcium hydroxide and resin-modified glass-ionomer cement. The exact mechanism of this effect has not yet been determined; further research on lasers' impact on exposed pulps treatment is required.

Consecuencias clínicas de caries dental no tratada en preescolares y escolares de instituciones educativas públicas / Clinical consequences of untreated dental caries in preschool and school children of public educational institutions

Objetivos: Evaluar la prevalencia y severidad de las consecuencias de la caries dental no tratada empleando el índice PUFA/pufa en preescolares y escolares de instituciones educativas públicas en una población urbano marginal del Callao. Material y métodos: El estudio fue descriptivo y observacional. Se empleó una base de datos generada que fue procesada con el programa Epi Info® y se exportó al programa estadístico IBM SPSS Statistics v. 19,0 (SPSS Inc.). Se realizó el análisis univariado y bivariado. Resultados: Se evaluaron 1085 niños entre 3 y 16 años. La mayor proporción fue del sexo masculino 557 (51,34%). La frecuencia del índice PUFA/pufa fue 25,71% y el promedio fue de 0,63 ± 1,48. El componente P+p representa el 24,70%, siendo las piezas deciduas las de mayor prevalencia. El grupo de 6-7 años y 8-10 años tuvieron la mayor frecuencia. El maxilar inferior fue el más afectado. Conclusiones: Las consecuencias clínicas de caries no tratada en la población estudiada son altamente frecuentes y severas.

Objectives: To evaluate the prevalence and severity of the consequences of untreated dental caries using the PUFA/pufa index in preschool and school children of public educational institutions in a marginal urban population of Callao. Material and methods: the study was descriptive and observational. A database was used and processed with the Epi Info® program and exported to the statistical program IBM SPSS Statistics v. 19.0 (SPSS Inc.). The univariate and bivariate analysis were performed. Results: 1085 children between 3 and 16 years old were evaluated. The highest proportion was male 557 (51.34%). The frequency of the PUFA/pufa index was 25.71% and the average was 0.63 ± 1.48. The P + p component represents 24.70%, the deciduous teeth was the most prevalent. The group of 6-7 and 8-10 years had the highest frequency. The lower jaw was the most affected. Conclusions: The clinical consequences of untreated caries in the studied population are highly frequent and severe.

Preventive endodontics by direct pulp capping with restorative dentin substitute-biodentine: A series of fifteen cases

Treatment of mechanical exposure of the pulp during caries excavation presents a clinical challenge. In this case series of 15 patients, with a follow-up period of over a year, the outcome of direct pulp capping with Biodentine (septodont) after mechanical pulp exposure was assessed. Aim of Study: The aim of this study is to evaluate the outcome of direct pulp capping with Biodentine in deeply carious teeth when pulp was mechanically exposed during caries excavation and cavity preparation. Vital pulps exposed during caries excavation in molar teeth were treated with 3% sodium hypochlorite for 2 min. If adequate hemostasis was achieved, the pulp tissue was capped with Biodentine, which covered the entire pulpal floor. This was followed by the placement of a layer of resin-modified glass ionomer cement and a final layer of composite resin (Filtek Z350-3M) to complete the restoration. The patients were recalled periodically and evaluated for any evidence of pulpal/periapical pathology. Results: In the follow-up period that ranged from 12 to 24 months, all teeth were asymptomatic. Conclusion: Biodentine appears to be a suitable material for direct pulp capping under clinical conditions. However, long-term follow-up studies and controlled trials involving a large sample size are warranted.

Tratamiento expectante en molar permanente joven: reporte de caso / Stepwise excavation in young permanent molar: case report

La caries dental es la causa principal por la que se realizan tratamientos de conducto, sin embargo existen procedimientos de protección pulpar para el manejo de lesiones cariosas profundas, que ayudan en la recuperación del tejido pulpar. Uno de los procedimientos es el tratamiento expectante, éste va a ser efectivo en preservar la pulpa que podría ser expuesta durante la remoción de caries profunda donde no hay signos clínicos que indiquen pulpitis irreversible. El tratamiento expectante, al ser en dos etapas tiene como objetivo detener el avance de la lesión cariosa, minimizar la dentina cariada retenida y permitirle a la pulpa recuperarse generando dentina reparativa para evitar cualquier exposición pulpar en una segunda sesión. Se describe el manejo de lesiones cariosas profundas en molar permanente joven mediante el tratamiento expectante a través de un reporte de caso. Paciente femenino de 15 años presenta dolor provocado a los cambios térmicos en el segundo molar inferior izquierdo. Las radiografías revelaron lesión cariosa profunda, clasificación R4 de Pitts, ausencia de radiolucidez apical y espacio del ligamento periodontal normal. A la prueba objetiva de diagnóstico con frío, se observó respuesta positiva, diagnosticándose Pulpitis Reversible. Basado en estos hallazgos se decide mantener la vitalidad pulpar y realizar el tratamiento expectante. El tratamiento expectante constó de dos fases, en la primera se retiró el tejido cariado de paredes y piso, dejándose dentina afectada y se colocó hidróxido de calcio seguido de una restauración temporal. En la segunda fase, 6 meses después, tras confirmar el mantenimiento de la vitalidad pulpar y formación de puente dentinario, se reabrió la cavidad y se colocó la restauración definitiva con resina compuesta. Se realizaron dos controles posteriores, el primero 12 meses después de iniciado el tratamiento y el segundo 60 meses después...

Dental caries is one of the main reasons to perform root canal treatments; however there are procedures to protect the pulp in case of deep caries lesions. During caries removal pulp tissue could be exposed, so stepwise excavation is one procedure which will be effective in pulp preservation. Stepwise excavation consists of two stages, its purpose is stop caries progression, change cariogenic environment and allow the pulp recover generating reparative dentine to avoid pulp exposure in a second visit. Below we describe the management of deep carious lesions in a young permanent molar treated with stepwise excavation. A 15-year-old female patient with cause pain due to thermal changes in second inferior left molar, X-Rays revealed deep caries lesion, R4 Pitts ́s classification, no signs of apical radiolucency or widening of the periodontal ligament space. Presents positive response to sensibility test with cold so Reversible Pulpitis is diagnosed, because of these findings it was decided to keep pulp vitality and perform stepwise excavation. This procedure consists in two phases: the first one is taking out the caries lesion from walls and floor, leaving affected dentin and placed calcium hidroxyde paste over, followed by a temporal restoration with glass ionomer. The second phase is six months later, once pulp vitality is confirmed and dentinal bridge is formed, so the cavity is reopened and definitive restoration is placed with composite resin.Two subsequent check-ups were carried out, the first one 12 months after stepwise excavation had been performed and the second control was 60 months later, clinical and radiographic controls were performed in both controls and no pathology was found considering the treatment as effective.

Tissue response to direct pulp capping with calcium hydroxide preceded by corticosteroid or corticosteroid/antibiotic dressing: a histological study in rats / Resposta do tecido pulpar à aplicação da pasta à base de hidróxido de cálcio precedida do emprego do curativo de corticosteróide ou corticosteróide/antibiótico: estudo histológico em ratos

Purpose: This study histologically evaluated the reaction of tooth pulp to treatment with calcium hydroxide in distilled water preceded by a corticosteroid (Decadron) or corticosteroid/antibiotic (Otosporin) dressing. Methods: Calcium hydroxide solution was applied to exposed tooth pulp for 5 min or for 72 h, using a sample of 120 molars of rats; histological examination was performed 7, 14, 30 and 60 days after treatment. Results: A mild inflammatory reaction was observed at 7 and 14 days whether the dressings were used for 5 min or for 72 h. When the corticosteroid/antibiotic dressing was used for 5 min, the tissue reaction and the mineralized barrier formed at 30 and 60 days were similar to those of animals in the control group. Use of the corticosteroid dressing for 5 min or 72 h or the corticosteroid/antibiotic dressing for 72 h delayed healing of the pulp tissue. Conclusion: Temporary dressings resulted in a milder inflammatory reaction during the early postoperative period. The tissue reaction and the quality of the barrier formed when the Otosporin temporary dressing was applied for 5 min were similar in the experimental and the control groups at longer postoperative periods. Temporary dressings of Decadron applied for 5 min or 72 h or Otosporin applied for 72 h caused a slight retardation of the healing process of the tissue that was apparent 30 days after the intervention.

Objetivo: Avaliar a reação pulpar à pasta de hidróxido de cálcio em água destilada, precedida de curativo de corticosteróide (Decadron) ou corticosteróide/antibiótico (Otosporin) por 5 min ou 72 h. Metodologia: Em 120 polpas de dentes de ratos expostas, a análise histológica foi realizada após 7, 14, 30 e 60 dias de cada tratamento. Resultados: Nos períodos iniciais observou-se leve reação inflamatória quando os curativos foram aplicados por 5 min ou 72 h. A reação tecidual e a barreira formada sob ação do hidróxido de cálcio após o curativo de Otosporin por 5 min foram semelhantes àquelas do grupo controle aos 30 e 60 dias. Os curativos de demora com Decadron por 5 min e 72 h e Otosporin por 72 h promoveram retardo no processo de reparação. Conclusão: Os curativos de demora promoveram reação inflamatória mais suave nos períodos iniciais de análise. A reação tecidual e a qualidade da barreira formada sob a ação do Otosporin por 5 min foram semelhantes àquelas do grupo controle nos períodos pós-operatórios mais longos. Os curativos de demora com Decadron por 5 min e 72 h e Otosporin por 72 h promoveram ligeiro retardo no processo de reparação tecidual a partir de 30 dias.

Clinical analysis of treated on perforation of pulp chamer with indoform and calcium hydroxide paste / 中国基层医药

Objective To study the clinical effect of indoform and calcium hydroxide paste.Methods The pulp chamer should be examinated timely when perforating.X-ray examination was helpful to diagosis,then a little indoform and calcium hydroxide paste was put into blockade the perforation of pulp chamer,again with indoform and calcium hydroxide paste progress root canal filling,after relining progress permanent filling,synthesis evaluation immediate restorative clinical effect.Results Among 52 cases,43 cases were cured(82.69%) after being treated timely.Conclusion The therapy method with indofrom and calcium hydroxide paste on perforation of pulp chamer is effective.