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Objective:To investigate the clinical efficacy of Gancao Xiexintang combined with vitamin B12 on recurrent oral ulcer (ROU) in children. Method:Totally 116 children with ROU admitted in Jiangxi Provincial Children's Hospital from June 2016 to June 2018 were divided into observation group and control group on the basis of random number table,with 58 cases in each group. The control group was orally treated with vitamin B12, while the observation group was orally treated with Gancao Xiexintang in addition to the therapy of the control group. All of the children were treated for 14 days. Clinical efficacy, changes of T lymphocyte subset (CD3+, CD4+, CD8+, CD4+/CD8+), ulcer area, content of oral flora (veillonella, streptococcus) before and after treatment, and side effect were compared between the two groups. Result:The overall effective rate of the observation group was 96.6%(56/58), which was much higher than 84.5%(49/58) of the control group (P+, CD4+, CD4+/CD8+in peripheral blood, but lower CD8+compared with those before treatment (P+, CD4+, CD8+, CD4+/CD8+) indexes in observation group was improved more significantly (PPPPPConclusion:In treating ROU in children, the combination of Gancao Xiexintang and vitamin B12 can significantly correct imbalance of T lymphocyte subset, promote the recovery of oral ulcer, and positively regulate oral micro-ecological environment, with an exact curative effect and high patient tolerance.
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SUMMARY: Inflammatory bowel disease (IBD) is an autoinflammatory chronic disorder of the gastrointestinal tract with a dysregulated immune response, being Crohn's Disease (CD) and Ulcerative Colitis (UC) the two main conditions. In literature the extra intestinal manifestations associated with IBD have been well documented. However, in our country, there are no studies about the oral manifestations. Having this information, is fundamental in order to optimize resources involved in diagnosis and treatment in a multidisciplinary level. Descriptive observational cross-sectional study, with a non-probabilistic sample for convenience with patients diagnosed with IBD belonging to the "CD-UC Group". In a period of four months the intraoral exam, diagnosis, and description of the lesions according location, type of illness, age, and sex were carried out. Thirty (30) patients (23 UC and 7 CD) filled the criteria of inclusion, 30 % men and 70 % women. 11 patients presented at least one oral lesion, being recurrent oral ulcer the most frequent, and two more specific lesions (macrocheilia and corrugated lesion). Of these patients, 37 % presented at least one oral lesion, being the most frequent one recurrent oral ulcer (ROU).
RESUMEN: La Enfermedad Inflamatoria Intestinal (EII) es un desorden inmunitario autoinflamatorio crónico del tracto gastrointestinal, siendo la Enfermedad de Crohn (EC) y la Colitis Ulcerativa (CU) sus dos condiciones principales. Se ha documentado en la literatura acerca de las manifestaciones extraintestinales asociadas a EII. Sin embargo, en nuestro país, no existen estudios acerca de las manifestaciones orales. Contar con esta información es fundamental para optimizar los recursos involucrados en el diagnóstico y tratamiento a nivel multidisciplinario. Se realizó un estudio observacional descriptivo de corte transversal, con un muestreo no probabilístico por conveniencia con pacientes diagnosticados de EII pertenecientes a la "Agrupación EC-CU". En un periodo de 4 meses se realizó el examen intraoral, diagnóstico y descripción de lesiones según localización, tipo de enfermedad, edad y sexo. Resultados: 30 pacientes (23 CU y 7 EC) cumplieron con los criterios de inclusión, 30 % hombres y 70 % mujeres. De los sujetos, 11 pacientes presentaron al menos una lesión oral, la úlcera recurrente oral fue la lesión más frecuente y se encontraron dos lesiones específicas (macroqueilia y lesión de aspecto corrugado). Un 37 % de los pacientes presentaron al menos una lesión oral, en donde la lesión más frecuente fue la úlcera recurrente oral.
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Humans , Male , Female , Adult , Inflammatory Bowel Diseases/complications , Colitis, Ulcerative/diagnosis , Crohn Disease/diagnosis , Oral Ulcer/diagnosis , Recurrence , Prevalence , Sex Distribution , Age Distribution , GingivitisABSTRACT
Objective@# To observe the clinical effect of traditional Chinese medicine on recurrent oral ulcer.@*Methods @#68 patients with recurrent oral ulcer were treated in our hospital, 68 outpatients were randomly divided into two groups: treatment group and control group. The control group received outpatient symptomatic treatment and uninterrupted given cydiodin, vitamin C and compound vitamin B tablets for oral treatment; treatment group were given outpatient treatment and traditional Chinese medicine ointment conditioning based on syndrome differentiation. To observe and compare clinical efficacy of the treatment group.@*Results @#The total effective rate of the treatment group was 86.11%, which was significantly better than that of the control group 28.13%, the difference was statistically significant (P<0.01).@*Conclusion@#Traditional Chinese medicine ointment in the treatment of recurrent oral ulcer can significantly reduce recurrence rate, improve the immune function of the body, clinical efficacy, the quality of life of patients.
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Objective To discuss theoretical structure model for the scale of recurrent oral ulcer (ROU) with traditional Chinese medicine characteristics; To lay a theoretical foundation for further developing scale. Methods This study followed international patients reported outcome (PRO) scale development specification, combined TCM theories, including the theory of mouth dominate and five internal organs correlation, uniformed spirit and body, correspondence between human and the universe, seven emotions, constructed theoretical structure of PRO scale of ROU. Results The theoretical structure of PRO scale of ROU included four major areas as physiology, psychology, independence, and society and nature. Conclusion Theoretical model of PRO scale of ROU laies the foundation and provides the oretical guidance for the formulation of PRO scale of the ROU.
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Objective To observe the clinical efficacy of modified Huanglian Qingxin Decoction for the treatment of recurrent oral ulcer. Methods Eighty recurrent oral ulcer patients were randomly divided into treatment group and control group by random number table method,40 cases in each group. The treatment group was given oral use of modified Huanglian Qingxin Decoction, and the control group was treated with Zinc Sulfate Tablets and Compound Vitamin B Tablets. Four weeks constituted one course of treatment. The scores of oral symptoms and signs of the two groups were observed before and after treatment,and the short-term effect and long-term effect of the two groups were evaluated after treatment. Results (1)After treatment for 5 days,ulcer area,ulcer pain, congestion area,exudation area,and sleep of the treatment group were much relieved (P < 0.01), and ulcer area,congestion area,and exudation area of the control group were improved (P < 0.05). The treatment group had better effect on improving ulcer area, ulcer pain, congestion area, exudation area, and sleep than the control group (P < 0.01). (2)After treatment for 5 days, the total short-term effective rate of the treatment group was 95.0%,and that of the control group was 72.5%,the difference being significant (P < 0.05).(3) Within one year after the suspension of treatment, total intermission period for ulcer attack in the two groups was prolonged (P < 0.05), and the amount of ulcer foci were much reduced (P < 0.05), the effect of the treatment group being superior to that of the control group(P < 0.05).(4)Within one year after the suspension of treatment,the total long-term effective rate of the treatment group was 70.0%,and that of the control group was 45.0%,the difference being significant (P<0.05). (5)During the treatment,the results of blood and urine routine examination,hepatic and renal function,and electrocardiography showed no abnormal changes. Conclusion Modified Huanglian Qingxin Decoction has better clinical efficacy for the treatment of recurrent oral ulcer than western medicine by relieving clinical symptoms and signs, prolonging the intermission period for ulcer attack, and reducing the total amount of ulcer foci.
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Objective To study the the application and influence to quality of life of Kangfuxin liquid combined with psychological intervention in the patients with recurrent oral ulcer. Methods In Wenzhou people's hospital from February 2016 to February 2017, 62 patients suffering from recurrent oral ulcer were divided into two groups. The control group were given Kangfu liquid, at this basis, the observation group were received Kangfuxin liquid combined with psychological nursing intervention. The effect and quality of life in the two groups were compared. Results The cure rate was 93.5％(29/31) in the observation group, while 90.3％(28/31) in the control group. The difference of the cure rate in the two groups was no statistically significant. The scores of physical condition in the observation group were significantly higher than those in the control group (P < 0.05). Conclusion Kangfuxin Liquid combined with psychological nursing intervention can effectively improve the quality of life in the patients with recurrent oral ulcer, which is suitable for clinical application.
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Objective:To explore the clinical effect of four oral vitamins [vitamin E (Vit E) +folic acid (FA)+ vitamin B2 (Vit B2) + vitamin B12 (Vit B12)] combined with FE complex enzyme rash on the recurrent oral ulcer (ROU) and on the serum inflammatory factors levels.Methods:126 cases with ROU in our hospital from January 2014 to February 2016 were selected as research objectives and randomly divided into two groups.FE complex enzyme was provided to the control group,while FE complex enzyme and four Vietnam (Vit E+FA+Vit B2+Vit B12) were given to the observation group.The local efficacy,long-term efficacy,serum inflammatory factor levels before and after treatment as well as the incidence of adverse drug reactions were recorded and compared between two groups.Results:Compared with the control group,the pain index was significantly decreased on 30th treating day in the observation group(P＜0.01),and the average ulcer period was shorten (P＜0.01).After being treated for 6 months,the overall effective rate was 95.2％ in the observation group,which was significantly higher than that of the control group (81.0％,P＜0.05).The serum TNF-α and IL-17 levels on the 30th treating day was significantly lower in both groups after treatment than those before treatment (P＜0.01),but the serum 1L-2 level was significantly increased (P＜0.01),and the improvement of each above inflammatory factors in the observation group were more significant than those of the control group (P＜0.01).No significant difference was found in the incidence of adverse reactions between two groups (P＞0.05).Conclusions:Four oral Vietnam combined with FE complex enzyme could promote the ulcer wound healing,reduce the pain,regulate the body to promote/anti-inflammatory factor balance and improve the long-term efficacy in the treatment of patients with ROU with high safety.
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Objective:To investigate the effects of Jianpijiedutang combined with Kangfuxin Liquid in the treatment of recurrent oral ulcer(ROU).Methods:80 patients with ROU were divided into 2 groups(n=40).The patients in control group were treated with Kangfuxin Liquid local spray,those in the test group were treated with Jianpijiedutang combined with Kangfuxin Liquid spray.The patients were followed up for 24 weeks.The effects were evaluated according to the trial standard of Chinese Stomatological Association.Results:The interval of ROU increased and ulcer number decreased in the 2 groups during the observation period,the test group showed more effective outcome than the control group(P<0.05).In the treatment group ROU interval increased more than in the control group(P<0.01),and ROU ulcer number decreased more(P<0.01).Conclusion:The Jianpijiedutang combined with Kangfuxin Liquid spray is more effective than the latter used only.
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Objective:To explore the possible relationship between recurrent aphthous ulcer( RAU) and the single nucleotide polymor-phism(SNP)of IFN-γ+874A/T site and IL-2-330T/G site. Methods:138 RAU patients and the 124 health control subjects were in-cluded. IFN-γand IL-2 serum concentration were detected by ELISA. IFN-γ+874A/T site and IL-2-330T/G site of the whole blood were detected by RFLP-PCR and SSP-PCR. Results:IFN-γand IL-2 levels in serum of the patients were significantly lower than those of the controls(P0. 05). Conclusion: IFN-γ+874A/T site was associated with the risk of RAU. But,IL-2-330T/G site was not.
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Objective To explore the effects of dialectical nursing on recurrent oral ulcers in children. Methods One hundred and eighty-eight cases of children with recurrent oral ulcer hospitalized from March 2013 to June 2015 were randomized into study group and control group using random digit table with 94 cases in each group. The control group was intervened with the modern medical care pattern and the study group was with dialectical nursing care of Chinese medicine besides the modern medical care pattern. The two groups were compared in terms of the curative effect, time for ulcer healing, pains and level of the children′s and parents′satisfaction. Results The curative effect in the study group was significantly better than that of the control group (P<0.01). The time of the study group was shorter than that of the control one (P<0.001). The level of pains was lower but the degree of satisfaction was higher than that in the control group (all P<0.01). Conclusions The dialectical nursing care combined with modern medical care pattern is effective in treating recurrent oral ulcers in children. It can shorten the healing time and enhance the satisfaction. It can have high value of clinical application and promotion.
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Objective:To examine the plasma soluble interleukin 2 receptor (sIL-2R)and the expression of IFN-γR in helper T (Th)cells in peripheral blood of patients with recurrent oral ulcer(ROU).Methods:The peripheral blood was obtained from 21 pa-tients in active stage of ROU and 21 healthy controls.Flow cytometry was used to detect the quantity of IFN-γR in CD +4 T cells,ELISA was used to detect the level of sIL-2R.Results:The expression of IFN-γR in CD +4 T cells and sIL-2R content in plasma of the patients with ROU were significantly higher than those in the healthy controls(P <0.05).Conclusion:Over expression of IFN-γR in CD +4 T cells and sIL-2R in peripheral blood may be related to the genesis of ROU.
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OBJECTIVE:To observe clinical efficacy of recurrent oral ulceration with combination of Zhibai dihuang pills and Compound danshen tablets. METHODS:110 patients with recurrent oral ulceration were selected and divided into control group and tri-al group with 55 cases in each group. Control group individually received vitamin C 0.2 g/time+vitamin B2 10 mg/time+levamisole 45 mg/time,three times a day,Cetylpyridinium chloride collutory,15 ml/time,for 1 min,3 times a day. Trial group received Zhibai di-huang pills orally,8 pills/time,Compound danshen tablets,3 tablets/time,3 times a day. A treatment course lasted for 10 days. Both groups received 2 courses of treatment. Therapeutic efficacy,VAS and relapse were observed and compared between 2 groups. RE-SULTS:The cure rate(80.00%)and total effective rate(94.55%)of trial group were higher than those of control group(47.27%, 74.55%),with statistical significance(P<0.05). The VAS score of trial group were significantly lower than that of control group after 3 and 7 days of treatment,with statistical significance(P<0.05). After 2,6,10 and 12 months of treatment,the recurrence rates of tri-al group were 0,7.27%,9.09% and 16.36%,which were all significantly lower than those of control group(18.18%,34.55%, 47.27%,56.36%),with statistical significance(P<0.05). CONCLUSIONS:Combination of Zhibai dihuang pills and Compound danshen tablets has definite effect on recurrent oral ulcer,showing high cure rate and not easily recur.
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46 cases of recurrent oral ulcer were treated by acupuncture,after treatment CD +3 ,CD +4 ,and CD +4 /CD +8 ratio of T lymphocytes in peripheral blood of the patients were increased(P ＜0.05),CD +8 lymphocyte decreased(P ＜0.05).Acupuncture may improve cellular immune function of the patients with recurrent oral ulcer.
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Objective To explore flora of patients with recurrent oral ulcer,to analyze the relationship between oral microecology and recurrent oral ulcer.Methods The saliva of 20 patients with recurrent oral ulcer,21 patients with recurrent oral ulcer healing,20 healthy volunteers were collected.Gb marked as gram-negative bacilli,Gb+marked as gram-positive bacteria,Gc marked as gram-negative cocci,Gc+ as standard standard of Gram-positive cocci.The oral flora was quantitatively analyzed.Neisseria,Streptococcus,Wei Rongshi bacteria content in the saliva were analyzed in the three groups.The oral microecology changes was studied.Results Wei Rong bacteria and streptococci content value in the ulcer group were significantly lower than the healthy control group (P ＜ 0.05).Neisseria and Wei Rong bacteria content between healing group and ulcer group had significant differences (P ＜ 0.05).A streptococci value of the healing group was significantly lower than the healthy control group(P ＜ 0.05).Conclusion Recurrent oral ulcer has correlation with oral microecology,Wei Rongshi bacteria content is closely related with the incidence of recurrent oral ulcer and may maintain the stable of oral environment.
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Objective To study the effect of combined vitamin therapy of B2 and Zhibai-Dihuang Wan on recurrent oral ulcer.Methods A total of 178 patients with recurrent oral ulcer were randomly recruited into a control group and a treatment group.The control group was treated with vitamin B2,0.2g/time,3 times/day;while the treatment group WaS treated with Zhibai-Dihuang Wan,9g/time,twice/day,on the basis of the control group.The therapeutic effects were observed in both groups after 14 days.Results The obvious effective rate in the treatment group was significantly higher than the control group(P=0.0083).while total effective rate did not show significant difierence between the two groups(P=0.0712).The relapse rate in the treatment group was significant lower than the control group.Conclusion It is effective to treat recurrent oral ulcer with the combination of vitamin B2 and Zhibai-Dihuang Wan.
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Objective To observe clinical effect of treating recurrent oral ulcer with modified Zengye decoction combined with levamisole. Methods 65 patients with recurrent oral ulcer were randomly recurited into a control group and a treatment group. The control group was treated with levamisole, and the treatment group was treated with modified zengye decoction plus levamisole. The therapeutic effects of both groups were observed. Results The therapeutic effect of the treatment group was significantly better than that of the control group (P<0.05). Conclusion The clinical effect of treating recurrent oral ulcer with levamisole combined with modified Zengye decoction has better effect than using levamisole alone.
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Objective To systemically evaluate the quality of randomized controlled trials(RCTs) of recurrent oral ulcer(ROU) treated by traditional Chinese medicine.Methods The randomized controlled trials of TCM treatment on ROU were retrieved,and the related information from database was retrieved and assessed with Cochrane Handbook.Results Fifty-three articles in 41 journals were found.There were 12 diagnostic criteria and 8 effect criteria.Base-line comparision in 39 articles,blind methods in 3 articles,follow-up survey in 2 articles,adverse reaction in 10 articles,no case loss in all articles were reported.Conclusions The quality of RCTs of TCM for ROU should be improved.
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OBJECTIVE:To observe the efficacy of Compound Epidermal Growth Factor Pellicles for recurrent oral ulcer. METHODS: 106 patients with recurrent oral ulcer were randomly assigned to receive Compound Epidermal Growth Factor Pellicles with efficacy-confirmed hospital preparation as control. The clinical efficacy in two groups was compared. RESULTS: The effective rate was significantly higher in patients treated with Compound Epidermal Growth Factor Pellicles than with hospital preparation (control) (89.66% vs. 75.00%,P