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Objective:To discuss the efficacy of modified Qingzao Jiufei Tang combined with adjuvant chemotherapy on quality of life and survival period of patients with non-small cell lung cancer (NSCLC) and the moderation effect on immune function and cytokines. Method:One hundred and twenty patients were randomly divided into control group (60 cases) and observation group (60 cases) by random number table. Patients in two group got paclitaxel and cisplatin chemotherapy.The control group took Yifei Qinghua granules orally,2 bags/time,3 times/day. In addition to the therapy of control group, patients in observation group were added with modified Qingzao Jiufei Tang from the first day after chemotherapy to the 12th week after chemotherapy, 1 dose/day. Six-month and one-year survival rates and survival period were recorded. Before and after treatment, lung cancer quality of life scale (FACT-L 4.0) and M.D. Anderson Symptom Inventory (MDASI-C) were scored. And levels of CD3+, CD4+, CD8+ and CD4+/CD8+ , natural killer cells (NK), cytokeratin 19 fragment 21-1 (CYFRA21-1), squamous cell carcinoma antigen (SCC-Ag), neuron-specific enolase (NSE), vascular endothelial growth factor (VEGF), nuclear transcription factor-κB (NF-κB), intercellular adhesion molecule 1 (ICAM-1), transforming growth factor (TGF)-β1 were all detected. Result:The 6-month survival rate of in observation group was 78.33%(47/60), which was higher than 60.00%(36/60) in control group (χ2=4.728, P<0.05). The one-year survival rate in observation group was 48.33%(29/60), which was higher than 30.00%(18/60) in control group (χ2=4.232, P<0.05). And the survival period in observation group was 15 months, which was longer than 11 months in control group (P<0.01). And scores of FACT-L and various factors were all higher than those in control group (P<0.01). Scores of disease symptoms, gastrointestinal symptoms, fatigue symptoms and emotional symptoms were all lower than those in control group (P<0.01), and scores of effect of symptoms on daily life in six aspects, such as enjoyment of life, were all lower than those in control group (P<0.01). And levels of NK, CD3+, CD4+ and CD4+/CD8+ were higher than those in control group (P<0.05), while levels of CD8+, TGF-β1, NF-κB, ICAM-1, VEGF, CYFRA21-1, SCC-Ag and NSE were all lower than those in control group (P<0.01). Conclusion:Modified Qingzao Jiufei Tang combined with adjuvant chemotherapy can prolong the survival time, improve the survival rate, alleviate the effect of symptoms on daily life, improve the quality of life, inhibit the expression of tumor markers and cytokines, and stabilize the immune function of the body, with a positive clinical significance in improving the prognosis of NSCLC.
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Objective:To study the expression of coagulation factorⅢin patients with non-small cell lung cancer(NSCLC)with hyperco-agulability and its clinical significance,and to explore the relationship between its expression level and the clinicopathological features and the survival period.Methods:There were 74 patients with NSCLC with hypercoagulability and 42 without hypercoagulability,con-firmed using pathological and biochemical tests in Yunnan Cancer Hospital from January 2013 to October 2014.The enzyme-linked im-munosorbent assay(ELISA)was performed to detect the expression of serum coagulation factorⅢand its relationship with clinico-pathological features and prognosis was analyzed.Results:Serum coagulation factorⅢlevel in patients with hypercoagulable NSCLC before chemotherapy was 560.32-200.34 ng/L,which was significantly higher than that in patients without hypercoagulability(463.29-159.22 ng/L)(P=0.008),and significantly higher than that in patients after chemotherapy(471.39±160.31 ng/L)(P=0.000).Serum coag-ulation factorⅢlevel in patients with hypercoagulable state of NSCLC was related to lymph node metastasis(P=0.026),distant metas-tasis(P=0.025),and tumor-node-metastasis staging(P=0.007).They were negatively correlated with prothrombin time(r=?0.638,P=0.032)and activated partial thromboplastin time(r=?0.702,P=0.028),and positively correlated with fibrinogen(r=0.715,P=0.008)and platelets (r=0.597,P=0.007).The 1-to 3-year overall survival of patients with NSCLC with high coagulation factorⅢexpression was significantly lower than that of patients with low coagulation factorⅢexpression.Conclusions: The expression level of serum coagu-lation factorⅢin patients with high coagulation state of NSCLC is related to lymph node metastasis and TNM staging,which has cer-tain guiding significance for predicting the survival of patients.
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Objective@#To investigate the effect of thalidomide on the expressions of Th17 cells, interleukin 17 (IL-17), macrophage inflammatory protein 3α (MIP3α) in peripheral blood of patients with diffuse large B-cell (DLBCL) and 3-year survival rate.@*Methods@#Sixty patients with DLBCL from January 2009 to January 2013 in the Affiliated Hospital of Hebei University of Engineering were enrolled. According to envelope method, the patients were randomly divided into the combined group (n = 30, thalidomide combined with CHOP regimen) and chemotherapy group (n = 30, CHOP regimen alone). Clinical adverse reactions, efficacy, the expressions of Th17 cells, IL-17, MIP3α in peripheral blood before and after treatment, and 3-year survival rate between two groups were compared.@*Results@#The total effective rate and 3-year survival rate were 73.3% (22/30) vs. 46.7% (14/30), 87.4% vs. 40.7% respectively in the combined group and the chemotherapy group (both P < 0.05). The levels of Th17 cells percentage and the expression level of IL-17 before and after treatment in combined group were (0.52±0.14)% vs. (1.61±0.53)%, (5.61±0.75) pg/ml vs. (8.87±1.84) pg/ml, and the difference was statistically significant (both P < 0.05). However, the expression levels of Th17 cells and IL-17 before and after treatment in the chemotherapy group were (0.75±0.05)% vs. (0.74±0.07)%, (5.69±0.29) pg/ml vs. (5.26±0.24) pg/ml, and there was no statistical difference (both P > 0.05). The levels of IL-17 and MIP3α mRNA in peripheral serum before and after treatment in the combined group were 8.51±0.23 vs.13.96±0.89, 27.4±1.5 vs. 83.0±8.5 (both P < 0.05). While in the treatment group before and after treatment the above mentioned were 8.85±0.32 vs. 9.45±0.55, 23.7±1.8 vs. 38.7±5.5, and the difference was no statistically significant (both P > 0.05). There was no statistical difference in the adverse reactions between the combined group and the chemotherapy group (P > 0.05).@*Conclusion@#Thalidomide may prolong survival time of DLBCL patients by intervening Th17 cells and associated cytokines.
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<p><b>OBJECTIVE</b>To investigate the effect of Chinese medicine (CM) on survival of patients with stage II and III colorectal cancer (CRC).</p><p><b>METHODS</b>A total of 295 patients who received chemotherapy were assigned to Group 1. The other 171 patients received the same chemotherapy treatment combined with the usage of CM Jianpi Jiedu Formula (, JPJD) for more than 3 months (Group 2). Patients' survival time, relapse and metastasis, and cause of death were observed. Cox proportional hazard regression models were established for the analysis of the effect of independent factors on the survival prognosis of patients with CRC.</p><p><b>RESULTS</b>The survival rate of patients in Group 2 was higher than that of Group 1 (P<0.05). Compared with Group 1, the mean survival time was prolonged by 5.594 months and the median survival time was prolonged by 6 months in Group 2 (P=0.004). Cox regression analysis indicated that CM combined with chemotherapy provided signifificant protective effect, as observed with the improvements in the survival rates of CRC patients (P<0.01).</p><p><b>CONCLUSION</b>CM can improve the survival rate in patients with stage II and III CRC.</p>
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Incubation period of HIV to AIDS is a vital tool that plays an important role in estimating the longevity or survivability of the HIV infected patients. However, death of AIDS patients when considered as end point becomes meaningful while finding the actual survivability of an individual. The present study is focused in analyzing the data on 343 AIDS patients who were recommended to undergo treatment in the ART centre followed up for a period of 6 years. The study included a cohesive treatment of censored observations based on lost to follow-up, deaths, recovered and alive cases till the end of study as well as uncensored observations. On the basis of diagnosed AIDS cases, the estimates of survivability under various conditions have been obtained. This paper also incorporates the trend of survivability for the reported AIDS patients with respect to age, sex, stages and mode of transmission across these 6 years. Kaplan Meier estimation method and Cox proportional hazard model were applied to determine the effect of various covariates that may be responsible for the death of the AIDS patients, survival pattern.
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Objective To systematically analyze the effect of adjuvant chemotherapy after radical operation in advanced gastric cancer .Methods The related literatures published at home and abroad were retrieved from the electronic databases including CNKI ,PubMed ,Elsevier ,Springer ,Oxford from January 2003 to December 2013 ,then 11 articles of the randomized controlled trial (RCT) of the comparison between the postoperative adjuvant chemotherapy and simple operation were collected .The effect merging and the quantitative systematic evaluation in the aspects of the total survival ,disease free survival and relapse free survival were per-formed with RevMan5 .2 provided by the Cochrane collaboration network .Results 11 articles of RCT were included with 4 points and more by the Jadad scale ,involving 4 433 patients ,among them 2 203 patients with operation plus postoperative chemotherapy and 2 230 patients with surgery alone .The results analysis indicated that the postoperative adjuvant chemotherapy made the pa-tients to obtain the apparent benefit during survival period ,the significant difference had statistical significance .OS :HR= 0 .80 , 95% CI(0 .73 ,0 .88) ,P<0 .01 ;DFS :HR=0 .78 ,95% CI(0 .63 ,0 .97) ,P=0 .02 ;RFS :HR=0 .67 ,95% CI(0 .53 ,0 .85) ,P=0 .001 . Conclusion The postoperative adjuvant chemotherapy can make the patients with radical operation to obtain the apparent benefit during the survival period .The adjuvant chemotherapy of oral capecitabine plus oxaliplatin or oral Tegafur Gimeracil Oteracil Potas-sium after D2 radical operation may be the best scheme at present .
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Objective To investigate the relationship between genetic polymorphisms of ERCC1 and survival rate in advanced non-small cell lung cancer (NSCLC) patients treated with platinum based chemotherapy.Methods A total of 204 patients with advanced NSCLC were routinely treated by platinbased chemotherapy.The polymorphic genotypes were analyzed by MALDI-TOF-MS nethod using DNA samples isolated from peripheral blood before treatment.Besides,5 ％ samples werc extracted randomly for sequencing to test the accuracy of this method.To explored the association between SNP of ERCC1 (118) and prognosis to platinum-based chemotherapy in advanced NSCLC patients.Results Among 204 patients,61 achieved partial response,116 achieved stable response,and 27 achieved progressive disease.The overall response rate was 29.9 ％ (61/204).The effective rates of patients with the ERCC1 (118) C/C genotype,C/T + T/T genotype were 24.0 ％ (29/121) and 38.6 ％ (32/83),respectively,with significant difference (P ＜ 0.05).The response rate of ERCC1 (118) C/T allele carriers was 1.992-fold than that of C/C allele carriers (95 ％ confidence interval:1.083-3.650,P =0.025).MST,1-year survival and 2-year survival rates of patients with the ERCC1 (118) C/C genotype,C/T + T/T genotype were 9.0 months,34.7 ％ (42/121) and 4.1％ (5/121) vs 12.0 months,60.2 ％ (50/83) and 12.0 ％ (10/83),respectively,with significant difference (P ＜ 0.05).Conclusions Polymorphisms of ERCC1 might be associated with overall survival period in patients with advanced NSCLC after treatment with platin-based chemotherapy,which might be the predictive markers for overall survival.
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Objective To investigate the feasibility of using a new type carina type tracheal prosthesis made of complex material to replace trachea and carina defects. Methods According to biomechanics index, a new carina type tracheal prosthesis was designed and constituted with carbon fiber and silicon. 19 dogs were divided into two groups randomly: group A(n=11), the carina type tracheal prosthesis anastomosed directly to dog′s trachea and bronchus;group B(n=8), based on group A, meanwhile the diaphragm was incised and the pedicel caul was transplanted from abdominal cavity to thorax to enwrap the carina type tracheal prosthesis and anastomotic site. Results The average survival period post operation in group A and group B were (3.462?1.849)d and (6.475?1.062)d ,respectively. There was significant difference of the survival period between two groups(P
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Objective:To investigate the influence of different depression degree status on the clinic symptoms and survival status in the patients with metastasis tumor in spine (MTS). Methods: By using Zung's self rating depression scale (SDS), we studied 125 patients with MTS between 1999 and 2001. Results: It was found that 44% patients with MTS were affected by depression. The survival period in the negative depression group(NDP) was longer than that in the moderate and the severe groups after a mean of 21 months follow up( P
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BACKGROUND: Despite concern about prevention of dermatophytosis, little is known about the survival period of dermatophytes. OBJECTIVE: The purpose of the study was to investigate the survival period of dermatophytes according to various environmental conditions. METHODS: Scales for testing were collected from skin lesions of 25 patients with dermatophytosis. They were categorised into different treatment groups: kept scales themselves(S), scales in a humid condition(S+H), scales mixed with sterilized dusts(S+D), and scales mixed with sterilized dusts in a humid condition(S+D+H). They were then cultured on Sabouraud dextrose agar once a week until there was no colony growth. Data was evaluated with the Mann-Whitney U-test. RESULTS: 1) The mean survival period of Microsporum canis isolated from 5 patients with tinea(T.) capitis was 17.6(S+D+H), 16.6(S+D), 8.4(S+H) and 7 weeks(S). 2) The mean survival period of Trichophyton rubrum isolated from 20 patients of T. corporis, T. cruris, T. pedis & T. unguium was 11.8, 7.4, 9.4 and 12.2 weeks(S+D+H); 7.4, 6.8, 9.2 and 7.4 weeks(S+D); 6.6, 3.4, 8.0 and 10.4 weeks(S+H); 5.0, 2.8, 5.4, 8.2 weeks(S), respectively. CONCLUSION: We found that the survival period of dermatophytes was longest in scales mixed with sterilized dusts in a humid condition.