ABSTRACT
Background: Thyroid hormone metabolism disrupts after cardiopulmonary bypass both in adults and pediatric patients. This is known as Euthyroid sick syndrome, and it is more evident in pediatric patients who were undergoing complex cardiac surgeries compared to adults. This decrease in serum T3 levels increases the incidence of low cardiac output, requirement of inotropes, prolonged mechanical ventilation, and prolonged intensive care unit (ICU) stay. Aims and Objectives: The primary objective was to compare the mean Vasoactive?inotropic score (VIS) at 72 hours postoperatively between T3 and Placebo groups. Materials and Methods: One hundred patients were screened, and 88 patients were included in the study. Triidothyronine 1 mic/kg 10 doses 8th hourly was given orally postoperatively to cases and sugar sachets to controls. The blood samples for analysis of FT3, FT4, and TSH were taken every 24 hours postoperatively, and baseline values were taken after induction. Mean VIS scores, ejection Fraction (EF), Left ventricular outflow tract velocity time integral (LVOT VTi), hemodynamics and partial pressure of oxygen/ fraction of inspired oxygen(PaO2/ FiO2) were recorded daily. Results: The Mean VIS scores at 72 Hours postoperatively were significantly less in the T3 group (5.49 ± 6.2) compared to the Placebo group (13.6 ± 11.7).The PaO2/FiO2 ratios were comparatively more in the T3 group than the Placebo group.The serum levels of FT3 FT4 were significantly higher in the T3?supplemented group than the Placebo group.TheVIS scores were significantly lower from48 hours postoperatively in children < 6 months of age. Conclusion: In this study, we observed that supplementing T3 postoperatively decreases the ionotropic requirement from 72 hours postoperatively. This is more useful in children <6 months of age undergoing complex cardiac surgeries.
ABSTRACT
Background: The present study was undertaken to assess the interdependent relationship between DM and thyroid disease among Type 2 diabetic patients attending to teaching hospital. Materials and methods: In the present study, 400 type 2 diabetic subjects and 100 healthy non diabetic subjects were investigated for total triidothyronine (T3), total thyroxin (T4), thyroid stimulating hormone (TSH), plasma glucose fasting(FPG), and glycosylated hemoglobin (HbA1c), Results: The level of T3 and T4 were significantly lower while the level of TSH was significantly higher in type 2 diabetics as compared to non-diabetics.
ABSTRACT
Background: In India, thyroid disorders are the most common among all the endocrine disorders and hypothyroidism being more common than hyperthyroid state and carcinoma. Bandi A, Pyadala N, Srivani N, Borugadda R, Maity SN, Ravi Kumar BN, Polavarapu R. A comparative assessment of thyroid hormones and lipid profile among hypothyroid patients: A hospital based case control study. IAIM, 2016; 3(9): 108- 114. Page 109 Objectives: The present study was undertaken to assess the association of dyslipidemia in hypothyroid patients. Materials and methods: A total of 50 study subjects of both gender groups were selected from the medicine ward of Maheshwara Hospital during the period from January 2016 to April 2016. Fasting venous blood sample were analysed for Thyroid hormones like, T3, T4, TSH and lipid profile. Statistical analysis was done using student unpaired t test. Result: The thyroid stimulating hormone (TSH) and total cholesterol, LDL, VLDL values were significantly higher, whereas T3, T4 and HDL values were in a decreasing order with that of control group. Conclusion: The present study concludes that hypothyroidism is associated with dyslipidemia having raise in all lipid parameters, which may increase the risk of cardiovascular diseases. Finally regular assessment of thyroid hormones and lipid profile among hypothyroid patients can prevent progression of the disease to severity
ABSTRACT
Background: It is well known that Thyroid Hormones play a key role in regulating energy homeostasis. The association between thyroid hormones and energy expenditure is well established. There is inverse relationship between obesity and energy expenditure. There is a limited data on thyroid function in euthyroid obese young individuals. Objectives: The present study was designed to evaluate the relationship between thyroid function and obesity in euthyroid young individuals. Materials & Methods: Obesity was defined as per Body Mass Index. (BMI)Undergraduate medical students were grouped as normal, overweight and obese as per their Body Mass Index Thyroid function was assessed by measuring fT3, fT4 and TSH levels by using automated chemiluminescence immunoassay system. Results: We found that the levels of TSH showed significant increase in overweight and obese subjects (p< 0.001) however there was no statistical difference in the levels of fT3and fT4 in overweight and obese students as compared to normal(p> 0.05). Interpretation & Conclusion: Our results suggest that thyroid function though within the normal range could be one of several factors acting in concert to determine body weight in a population. Even slightly elevated serum TSH levels are associated with an increase in BMI.