ABSTRACT
@#Body mass index (BMI) was one of the reasons people used weight loss products to lose weight. The purpose of this study is to look into the use of weight loss products and their relationship to BMI and associated factors. A cross-sectional study with convenient sampling was conducted on 133 students from Universiti Sains Malaysia, Kubang Kerian (USMKK) Health Campus. Participants were asked to complete an online questionnaire that included sociodemographic information, self-reported weight and height for BMI, weight loss product use, weight loss product usage characteristics, body weight perception and satisfaction, and weight loss product perception. The majority of participants were female (78.2%), 80.5% were Malay, and the mean age was 22 ± 3.1 years old. Majority had a normal BMI (56.4%), whereas 16.5% were underweight, 18.8% were overweight, and 8.3% were obese. Nevertheless, only 10.5% of participants utilised weight loss products. It was discovered that the use of weight loss products is statistically associated with BMI, with a high proportion of users having an overweight or obese BMI (p=0.042). Those who reported using a weight loss product had a higher BMI [25.56 (IQR 6.6) kg/m2 ] than those who did not [21.35 (IQR 5.3) kg/m2 ] (p = 0.015). The use of weight loss products was also statistically associated with perceived product safety (p=0.041) and body weight dissatisfaction (p=0.011). Universities should therefore provide students with appropriate weight loss advice, up-todate information on the safety and efficacy of various weight loss products, and opportunities to enhance their knowledge, self-efficacy, and social support. For future research, it is suggested to wider the research population to overweight and obese adults in Kelantan.
ABSTRACT
ABSTRACT The association of p-synephrine, ephedrine, salicin, and caffeine in dietary supplements and weight loss products is very common worldwide, even though ephedrine has been prohibited in many countries. The aim of this study was to evaluate a 28-day oral exposure toxicity profile of p-synephrine, ephedrine, salicin, and caffeine mixture (10:4:6:80 w/w respectively) in male and female Wistar rats. Body weight and signs of toxicity, morbidity, and mortality were observed daily. After 28 days, animals were euthanized and blood collected for hematological, biochemical, and oxidative stress evaluation. No clinical signs of toxicity, significant weight loss or deaths occurred, nor were there any significant alterations in hematological parameters. Biochemical and oxidative stress biomarkers showed lipid peroxidation, and hepatic and renal damage (p < 0.05; ANOVA/Bonferroni) in male rats (100 and 150 mg/kg) and a reduction (p < 0.05; ANOVA/Bonferroni) in glutathione (GSH) levels in all male groups. Female groups displayed no indications of oxidative stress or biochemical alterations. The different toxicity profile displayed by male and female rats suggests a hormonal influence on mixture effects. Results demonstrated that the tested mixture can alter oxidative status and promote renal and hepatic damages.
RESUMO A associação de p-sinefrina, efedrina, salicina, e cafeína em suplementos alimentares e produtos para perda de peso é muito utilizada em todo o mundo, embora a efedrina tenha sido proibida em muitos países. O objetivo deste estudo foi avaliar o perfil de toxicidade à exposição oral de 28 dias à associação de p-sinefrina, efedrina, salicina e cafeína (na proporção de 10:4:6:80 m/m respectivamente) em ratos Wistar machos e fêmeas. Diariamente, os animais foram observados quanto ao peso corporal, sinais de toxicidade, morbidade e mortalidade. Após 28 dias, os animais foram sacrificados e o sangue coletado para avaliações hematológicas, bioquímicas e de estresse oxidativo. Não se observaram sinais clínicos de toxicidade, tampouco perda significativa de peso, mortes, ou quaisquer alterações significativas nos parâmetros hematológicos. Biomarcadores do estresse oxidativo e bioquímicos mostraram peroxidação lipídica, danos renais e hepáticos (p < 0,05; ANOVA/Bonferroni) em ratos machos (100 e 150 mg/kg) e a redução (p < 0,05; ANOVA/Bonferroni) nos níveis de glutationa reduzida (GSH) em todos os grupos de machos tratados. Nas fêmeas, não houve indícios de estresse oxidativo, nem alterações bioquímicas. O diferente perfil de toxicidade entre os gêneros sugere influência hormonal nos efeitos de mistura administrada. A associação testada pode alterar o estado oxidativo e promover danos renais e hepáticos.