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1.
Rev. gastroenterol. Perú ; 37(4): 374-378, oct.-dic. 2017. ilus, tab
Article in Spanish | LILACS | ID: biblio-991283

ABSTRACT

El feocromocitoma quístico gigante es tumor adrenal raro en el que predomina el curso asintomático; por lo que muchos de los casos no son diagnosticados hasta el momento de la cirugía. La simple movilización del tumor se asocia con el paso a la sangre de grandes cantidades de catecolaminas y a una elevada morbimortalidad.; por esta razón la cirugía per se y su manejo perioperatorio constituyen un enorme desafío. En este artículo se presenta el caso de un feocromocitoma gigante maligno (35 cm) que ocupaba todo el hemiabdomen derecho. Aun con el diagnóstico preoperatorio de feocromocitoma, el bloqueo farmacológico preoperatorio y las medidas intraoperatorias, el paciente falleció poco antes de que finalizara la cirugía.


The giant cystic pheochromocytoma is a rare adrenal tumor in the predominantly asymptomatic course; so many cases are not diagnosed until the time of surgery. The simple mobilization of the tumor is associated with the passage to the blood of large amounts of catecholamines and high morbidity and mortality. So the surgery itself and perioperative management are a huge challenge. This article describes the case of a malignant giant pheochromocytoma (35 cm) which occupied the entire right abdomen. Even with the preoperative diagnosis of pheochromocytoma, pharmacological blockade preoperative and intraoperative measures, the patient died shortly before the end of surgery.


Subject(s)
Aged , Humans , Male , Pheochromocytoma/diagnostic imaging , Adrenal Gland Neoplasms/diagnostic imaging , Pheochromocytoma/surgery , Pheochromocytoma/metabolism , Pheochromocytoma/pathology , Preanesthetic Medication , Catecholamines/metabolism , Tomography, X-Ray Computed , Adrenal Gland Neoplasms/surgery , Adrenal Gland Neoplasms/metabolism , Adrenal Gland Neoplasms/pathology , Fatal Outcome , Adrenal Medulla/metabolism , Adrenal Medulla/pathology , Adrenergic alpha-Antagonists/administration & dosage , Adrenergic alpha-Antagonists/therapeutic use , Adrenergic beta-Antagonists/administration & dosage , Adrenergic beta-Antagonists/therapeutic use , Cysts/surgery , Cysts/metabolism , Cysts/pathology , Cysts/diagnostic imaging , Tumor Burden , Intraoperative Complications/etiology , Intraoperative Complications/physiopathology
2.
EMHJ-Eastern Mediterranean Health Journal. 2008; 14 (6): 1301-1307
in English | IMEMR | ID: emr-157273

ABSTRACT

Adrenal androgens, particularly dehydroepiandrosterone [DHEA], may have important regulatory effects on the immune system in humans. This study measured the changes in adrenal steroidogenesis in 13 non-infected cirrhosis patients with sterile ascites and 13 patients with spontaneous bacterial peritonitis and the relation with circulating interleukin-6 [IL-6] levels. Comparisons were made with 10 healthy age-matched control subjects. The severity of bacterial peritonitis in liver cirrhosis was significantly associated with enhanced serum IL-6 and cortisol levels, and a decrease in serum DHEA sulfate in relation to serum IL-6 concentrations. Careful, long-term studies on DHEA administered to cirrhosis patients are needed to assess its safety in improving a number of pathological conditions that complicate liver cirrhosis


Subject(s)
Humans , Humans , Dehydroepiandrosterone/chemical synthesis , Adrenal Medulla/metabolism , Androgens/chemical synthesis , Peritonitis/microbiology , Peritonitis/immunology , Ascites/immunology , Interleukin-6 , Liver Cirrhosis/prevention & control
3.
Bol. méd. Hosp. Infant. Méx ; 52(4): 249-55, abr. 1995. tab, ilus
Article in Spanish | LILACS | ID: lil-151328

ABSTRACT

Introducción. Los feocromocitomas son tumores que se originan en las células cromofines del sistema nervioso simpático y que se localizan en la médula suprarrenal. Liberan a la circulación epinefrina, norepinefrina o ambas, causando sintomatología adrenérgica. Caso clínico. Se presenta el caso de un escolar masculino con manifestaciones de hipersecreción adrenérgica caracterizada por cefalea, diaforesis, palpitaciones e hipertensión arterial severa. El laboratorio mostró niveles elevados de catecolaminas séricas y sus metabolitos urinarios. El ultrasonograma, la tomografía axial computada y la gamagrafía con I -MIBG demostraron tumores localizados en ambas suprarrenales, los cuales fueron extirpados exitosamente. Conclusiones. El diagnóstico de feocromocitoma debe sospecharse en base a los hallazgos clínicos y debe confirmarse con las determinaciones de catecolaminas y sus metabolismos urinarios. La extirpación quirúrgica del tumor no debe intentarse hasta no corroborar la localización exacta del mismo. Actualmente el método de localización específico y sensible es la gamagrafía con I -MIBG


Subject(s)
Child , Humans , Male , Adrenal Medulla/metabolism , Catecholamines/analysis , Pheochromocytoma/diagnosis , Pheochromocytoma/physiopathology , Epinephrine/metabolism , Norepinephrine/metabolism
5.
Medicina (Ribeiräo Preto) ; 11(1/2): 1-10, jan.-jun. 1980. ilus, tab
Article in Portuguese | LILACS | ID: lil-60973

ABSTRACT

A administraçäo de 200 U. I. de vitamina A/grama de peso corporal, no rato, permitiu aos autores observarem: 1) O peso da glândula adrenal apresentou-se maior no animal com hipervitaminose A (19,58 mg) quando comparado ao animal controle (10,86 mg); 2) A zona glomerulosa do côrtex adrenal do rato tratadfo apresentou-se histologicamente, com células ligeiramente mais volumosas e com citoplasma mais abundante, mais acidófilo e com núcleos pouco mais volumosas. As zonas fasciculada a reticular também apresentaram células mais volumosas, com citoplasma mais abundante, com maior número de vacúolos e núcleos de volume maior, além de vasos bem dilatados; 3) A medula adrenal no animal tratado, revelou células com citoplasma menos granuloso, vasos dilatadores, congestos e edema. Os dados acima foram confirmados com o emprego de técnicas morfométricas


Subject(s)
Rats , Animals , Male , Adrenal Cortex/metabolism , Adrenal Glands/metabolism , Adrenal Medulla/metabolism , Hypervitaminosis A/metabolism , Adrenal Cortex/pathology , Adrenal Medulla/pathology
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