ABSTRACT
Background: There is scarcity of data on asbestos fiber burden in lung and pleural malignancies. Aim: To evaluate asbestos fiber burden in biopsy samples of suspected lung and pleural malignancies. Study Design: This was a single-centre, observational study. Study Period: From August 2010 to July 2010. Setting: Department of Pulmonary Medicine, CSMMU, UP, Lucknow, a tertiary care hospital in India. Study Population: Suspected cases of lung and pleural malignancy. Materials and Methods: Biopsy tissues taken by computed tomography (CT)-guided biopsy, bronchoscopic biopsy, and pleural biopsy by Cope's needle were analyzed for histopathology and asbestos burden by Haq et al.'s method. Results: 20 patients were studied. Mean fiber burden was 9.25 × 10 4 fibers/g. Average burden in lung malignancies (11 patients) was 9.178 × 10 4 fibers/g and in pleural tissue (9 patients) was 9.332 × 10 4fibers/g. Among the different cell types, mean fiber burden in squamous cell carcinoma was 8.99 × 10 4 fibers/g, in adenocarcinoma was 9.71 × 10 4 fibers/g, and in small cell carcinoma was 7.54 × 10 4 fibers/g. Mean fiber burden in bronchoscopic endobronchial biopsy tissue was 10.69 × 10 4 fibers/g, while in CT-guided biopsy was 8.60× 10 4fibers/g. Conclusion: Maximum number of fibers was found in adenocarcinoma.
Subject(s)
Adenocarcinoma/chemically induced , Adenocarcinoma/epidemiology , Asbestos/analysis , Asbestos/isolation & purification , Biopsy/methods , Humans , India/epidemiology , Image-Guided Biopsy/methods , Lung Neoplasms/chemically induced , Lung Neoplasms/diagnosis , Patients , Pleural Neoplasms/chemically induced , Pleural Neoplasms/epidemiology , Tertiary Care Centers , Tomography, X-Ray ComputedABSTRACT
Partindo-se da aparência radiológica altamente sugestiva de exposiçäo ao asbesto (caso 1) ou de uma história ocupacional positiva (casos 2 e 3), envestigamos a presença de fibras em tecido pulmonar em blocos de autópsia ou biópsia cirúrgica de três casos de carcinoma broncogênico, pelo método de digestäo de tecido pulmonar em hipoclorito de sódio, seguido da observaçäo do resíduo através da microscopia óptica por contraste de fase. Nos três casos, a pesquisa de fibras foi positiva. A relaçäo das neoplasias a exposiçäo ao asbesto é altamente provável, pelo fato de dois dos casos apresentaram fibrose pulmonar (casos 1 e 2) e, o terceiro caso, placas pleurais perietais típicas a toracotomia