ABSTRACT
Non syndromic hearing impairment is a common sensory disorder, which affects one in 600 newborns. Though more than 50 nuclear genes are involved in causing non syndromic hearing impairment, mutations in the connexin 26 (GJB2) gene explain a high proportion of congenital deafness in several populations worldwide. The diversity of genes and genetic loci implicated in hearing loss defines the complexity of the genetic basis of hearing. This review focuses on the role of connexin 26 and mitochondrial 12S rRNA genes in hearing which will be helpful for better understanding of genes in sporadic and aminoglycosideinduced non syndromic hearing impairment.
Subject(s)
Aminoglycosides/adverse effects , Connexins/genetics , Connexins/metabolism , Deafness/chemically induced , Deafness/genetics , Hearing/physiology , Hearing Loss/chemically induced , Hearing Loss/genetics , Humans , Mitochondria/genetics , Mutation , RNA, Ribosomal/genetics , RNA, Ribosomal/metabolismABSTRACT
Os autores revisam os principais aspectos da ototoxicidade, enfatizando aqueles relacionados ao uso de aminoglicosídeos. Säo abordados os fatores etiológicos, aspectos clínicos e as medidas de sua avaliaçäo e prevençäo
Subject(s)
Humans , Deafness/chemically induced , Anti-Bacterial Agents/toxicityABSTRACT
Se realizaron estudios audiológicos a 37 pacientes que recibieron tratamiento con cisplatino. Se encontraron alteraciones audiométricas bilaterales en la percepción de las frecuencias agudas del sonido a 4000 y a 8000 Hz por vía aérea y a 4000 Hz por vía ósea, en ambos oídos cuando se acumularon dosis de cisplatino mayores de 150 mg/m²
Subject(s)
Humans , Audiometry/instrumentation , Audiometry/statistics & numerical data , Cisplatin/adverse effects , Deafness/chemically induced , Deafness/diagnosis , Diagnostic Techniques, OtologicalABSTRACT
Este trabalho relata alteraçöes ototóxicas encontradas em dois pacientes portadores de neoplasias malignas e que foram submetidos a esquema quimioterápico com Cis-diamminedichloroplatinum (NSC 119875), tendo apresentado perda auditiva após o uso desta droga. Discutimos as causas, o tipo de lesäo e os danos cocleares ocasionados por esta droga. Outrossim, salientamos a importância do estudo da ototoxicidade dos agentes terapêuticos