ABSTRACT
BACKGROUND: Drug hypersensitivity is responsible for substantial mortality and morbidity, and increased health costs. However, epidemiological data on drug hypersensitivity in general or specific populations are scarce. METHODS: We performed a cross-sectional survey of 1015 university students, using a self-reported questionnaire. RESULTS: The prevalence of self-reported drug hypersensitivity was 12,11 percent (123/1015). The most frequently implicated drugs were non-steroidal anti-inflammatory drugs (45,9 percent) and beta-lactam and sulfonamide antibiotics (25,40 percent). The majority of the patients reported dermatological manifestations (99), followed by respiratory (40), digestive (23) and other (19). Forty-five patients had an immediate type reaction, and 76,72 percent (89) had the drug by oral route. CONCLUSION: The results showed that drug hypersensitivity is highly prevalent in university students, and that nonsteroidal anti-inflammatory drug and antibiotics (beta-lactams and sulfonamide) are the most frequently concerned drugs.
Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , Drug Hypersensitivity/epidemiology , Students/statistics & numerical data , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Brazil/epidemiology , Cross-Sectional Studies , Drug Hypersensitivity/classification , Prevalence , Sulfonamides/adverse effects , beta-Lactams/adverse effectsSubject(s)
Humans , Drug Hypersensitivity/classification , Risk Factors , Acquired Immunodeficiency Syndrome/immunology , Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects , Trimethoprim, Sulfamethoxazole Drug Combination/immunology , Drug Hypersensitivity , Drug Hypersensitivity/complications , Acquired Immunodeficiency Syndrome/complicationsSubject(s)
Penicillin G , Penicillins/classification , Haemophilus influenzae/drug effects , Enterococcus/drug effects , Drug Hypersensitivity/classification , Gram-Negative Bacteria/classification , Gram-Positive Bacteria/classification , Ampicillin/pharmacology , Lactams/therapeutic use , Listeria/drug effectsABSTRACT
En este trabajo el autor expone los últimos conceptos sobre sustancias de contraste, reacciones adversas y tratamiento
Subject(s)
Humans , Contrast Media/adverse effects , Drug Hypersensitivity/prevention & control , Iodine/adverse effects , Cimetidine/therapeutic use , Contrast Media/classification , Drug Hypersensitivity/classification , Drug Hypersensitivity/drug therapy , EpinephrineSubject(s)
Humans , Male , Female , Anti-Bacterial Agents/adverse effects , Drug Hypersensitivity/diagnosis , In Vitro Techniques , Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects , Cross Reactions , Desensitization, Immunologic/standards , Drug Hypersensitivity/classification , Drug Hypersensitivity/prevention & control , Immunoglobulin E/drug effects , Lactams/adverse effects , Penicillins/adverse effects , Risk Factors , Surveys and QuestionnairesABSTRACT
Se comunican los resultados de un estudio prospectivo realizado en 31 pacientes con historia de reacción adversa a medicamentos con el propósito de descartar fondo alérgico. Se4 comparo la sensibilidad y especificidad de las pruebas del factor inhibidor de la migración de leucocitos y degranulación de basófilos contra las pruebas de exposición . Los resultados se analizaron estadisticamente y se concluyó que las pruebas de laboratorio antes mencionadas tienen poca sensibilidad y especificidad. La prueba de exposición es el método más rápido, útil y sencillo para determinar alergia a medicamentos, teniendo presente que implica mayor riesgo.