ABSTRACT
Abstract Objective To determine the effectiveness of chlorhexidine 0.12% mouthwash (CHX) after tooth extraction for the prevention of alveolar osteitis (AO). Material and methods We conducted a double-blind randomised clinical trial stratified by risk factors. We enrolled a cohort of 822 patients who underwent dental extractions, and were considered to be at risk of developing AO (previous surgical site infection, traumatic extraction, and tobacco smoking). After extraction, patients were randomly allocated for CHX group or placebo group, matched by risk factors. The primary outcome was clinical diagnosis of AO: increasing postoperative pain for 4 d within and around the socket, and total or partial breakdown of the blood clot in the socket with or without bone exposure. Results Follow-up was completed by 744 participants (372 chlorhexidine and 372 placebo). We detected no significant differences between the two groups at baseline. After completed follow-up, risk factors were equally distributed between the two groups. Overall incidence of OA was 4.97%, in which 27 participants treated with placebo (7.26%) and 10 participants treated with CHX (2.69%) developed AO. CHX reduced the incidence of AO by 63% [Absolute Risk Reduction: 4.57 (95% CI 1.5-7.7), Number Needed to Treat: 21.88 (95% CI 13.0-69.3), Fisher's exact test: p=0.006]. No adverse effects were reported. Conclusion The use of chlorhexidine 0.12% mouthwash after tooth extraction is safe and effective in reducing the incidence of AO in high-risk patients.
Subject(s)
Humans , Male , Female , Adult , Postoperative Complications/prevention & control , Tooth Extraction/adverse effects , Chlorhexidine/therapeutic use , Dry Socket/prevention & control , Mouthwashes/therapeutic use , Placebo Effect , Double-Blind Method , Reproducibility of Results , Risk Factors , Treatment Outcome , Dry Socket/etiology , Middle AgedABSTRACT
Alveolar osteitis is a common post extraction complication developing within 1-4 days following surgery.1-3. It is characterized by intense pain that is not relieved by analgesics. 1 The most frequent site of occurrence is the mandibular third molar region. Females are known to show a higher incidence of occurrence. 4 Studies indicate smoking, traumatic extractions, leaving tooth and bone debrisin extraction sockets, excessive irrigation of socket, compromised blood supply and use of contraceptives, as possible predisposing factors.5-25. Inflammation of the socket is believed to be a result of dislodgment or disintegration of the blood clot that forms within the socket immediately after extraction. 11, 26-27 Dry socket can be prevented by ensuring sterile surgery and by the use of numerous non-pharmacological measures; good history, identification and elimination of risk factors, and pharmacological agents; systemic antibiotics, antiseptics, antifibrinolytics, obtundant dressings and photodynamic therapy.8,28-34 Once the condition develops it is treated symptomatically and by use of obtundant dressings. Initial results of a study carried out in Khyber College of Dentistry, Peshawar are showing promising results with surgical management. This literature review summarizes the current understanding of etiology, pathogenesis, prevention and management of alveolar osteitis
Subject(s)
Humans , Male , Female , Dry Socket/etiology , Dry Socket/surgery , Dry Socket/prevention & control , Treatment OutcomeABSTRACT
The aim of the present study was to evaluate the effects of local tetracycline on the occurrence of alveolar osteitis in rats, and on the microbiota associated to this infection. Forty Wistar rats were randomly assigned to 4 groups (n=10): I - the rats had the maxillary right incisor extracted and the alveolar wound did not receive any treatment; II - adrenaline and Ringer-PRAS were introduced into the alveolar wound; III - the alveolar wound was irrigated with sterile saline; and IV - the alveolar wound was irrigated with an aqueous solution of tetracycline. Microbial samples from the alveolar wounds were collected 2 days after surgery and inoculated on blood agar (with and without 8 µg/mL of tetracycline) and other selective media, and were incubated in either aerobiosis or anaerobiosis at 37ºC, for 2 to 14 days. It was verified that tetracycline reduced the occurrence of alveolar osteitis in the rats and caused significant changes in the microbiota of the surgical sites, decreasing the number of anaerobes and increasing the participation of tetracycline-resistant and multi-resistant microorganisms.
O objetivo do presente estudo foi avaliar os efeitos do uso tópico de tetraciclina sobre a ocorrência de alveolite em ratos e sobre a microbiota a ela associada. Quarenta ratos foram divididos, ao acaso, em 4 grupos (n=10): grupo I, realizou-se somente a extração do incisivo superior direito e a ferida alveolar não recebeu nenhum tratamento; grupo II, além da extração dental, soluções de adrenalina e Ringer-PRAS foram introduzidas no interior do alvéolo; grupo III, a ferida alveolar foi irrigada com solução salina estéril; grupo IV, a ferida alveolar foi irrigada com solução aquosa de cloridrato de tetraciclina a 10 por cento. As amostras dos alvéolos para processamento microbiológico foram coletadas dois dias após a realização das cirurgias e foram inoculadas em ágar sangue com ou sem 8 µg/mL de tetraciclina e em outros meios de cultura seletivos, incubadas em aerobiose ou anaerobiose, a 37ºC, de 2 a 14 dias. Verificou-se que a tetraciclina reduziu a ocorrência de alveolite e provocou uma modificação significativa na microbiota do sítio cirúrgico, levando a uma redução nas proporções ocupadas pelos microrganismos anaeróbios e uma elevação da participação de microrganismos resistentes à tetraciclina e outros antimicrobianos.
Subject(s)
Animals , Male , Rats , Anti-Bacterial Agents/therapeutic use , Dry Socket/microbiology , Tetracycline/therapeutic use , Actinomyces/drug effects , Bacteroides/drug effects , Colony Count, Microbial , Drug Resistance, Multiple, Bacterial , Dry Socket/prevention & control , Enterobacteriaceae/drug effects , Enterococcus/drug effects , Epinephrine/therapeutic use , Eubacterium/drug effects , Fusobacterium/drug effects , Isotonic Solutions , Incisor/surgery , Peptostreptococcus/drug effects , Random Allocation , Rats, Wistar , Suppuration , Tetracycline Resistance , Therapeutic Irrigation , Tooth Extraction , Tooth Socket/drug effects , Tooth Socket/microbiology , Vasoconstrictor Agents/therapeutic use , Veillonella/drug effectsABSTRACT
La definición y modalidad de tratamiento profiláctico para la osteítis alveolar, son presentados. Aunque el número de pacientes y extracciones efectuadas no son representativas para determinar, con las variables presentadas, la aparición de osteítis alveolar, sería recomendable aumentar el número de pacientes y variables para poder predecir la aparición de la enfermedad
Subject(s)
Humans , Male , Female , Adolescent , Adult , Mouthwashes/therapeutic use , Dry Socket/epidemiology , Dry Socket/prevention & control , Tooth Extraction/adverse effects , Molar, Third/surgeryABSTRACT
La osteítis alveolar (OA) es una patología descrita desde 1896 por Crawford. Desde siempre ha acompañado a la profesión odontológica, sin saberse a ciencia cierta su etiopatogenia ni la forma de prevenirla. En este artículo revisamos las dos teorías etiológicas más postuladas, la fibrinolítica y la bacteriana. Además revisamos las formas de prevención de la OA usadas en los últimos tiempos y por último los factores que predisponen a que sea más fácil que se genere una OA. En su prevención lo más importante es la indicación del momento dela extracción dentaria y generar el menor trauma quirúrgico. En el tratamiento lo importante es el control de la sintomatología, irrigar el alveolo, rellenarlo con sustancias entumecedoras y nunca curetearlo efusivamente
Subject(s)
Antifibrinolytic Agents/pharmacology , Dry Socket/prevention & control , Tooth Extraction , OsteitisABSTRACT
Os autores compararam a efetividade dos produtos Alveoliten e Alveosan no tratamento preventivo das alveolites