ABSTRACT
Abstract: Methotrexate is one of the most used drugs in the treatment of psoriasis with indication of systemic therapy. Cutaneous and mucous side effects are described by pharmacological characteristics of the drug itself or due to overdose. We report the case of a patient with ulcerations in oral mucosa and psoriatic plaques after incorrect use of Methotrexate. Prescribed in a weekly dose, it was used continuously for 10 days and without simultaneous intake of folic acid. It is important to ensure correct comprehension of the prescription.
Subject(s)
Humans , Female , Middle Aged , Skin Ulcer/chemically induced , Methotrexate/adverse effects , Drug Eruptions/etiology , Oral Ulcer/chemically induced , Folic Acid Antagonists/adverse effects , Psoriasis/drug therapy , Skin Ulcer/pathology , Methotrexate/administration & dosage , Administration, Oral , Drug Eruptions/pathology , Oral Ulcer/pathology , Prescription Drug Overuse/adverse effects , Folic Acid Antagonists/administration & dosage , Leukopenia/chemically induced , Medication Errors/adverse effectsABSTRACT
Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone.
.Subject(s)
Female , Humans , Middle Aged , Dapsone/adverse effects , Folic Acid Antagonists/adverse effects , Glucocorticoids/administration & dosage , Pemphigus/drug therapy , Prednisone/administration & dosage , Chemotherapy, Adjuvant , Dose-Response Relationship, Drug , Dapsone/administration & dosage , Chemical and Drug Induced Liver Injury/etiology , Folic Acid Antagonists/administration & dosage , Liver/drug effects , Pemphigus/pathology , Time Factors , Treatment OutcomeABSTRACT
In 1915 the Rockefeller Foundation took its hookworm eradication campaign to Suriname, but was soon disappointed because of opposition from its main target group: the Javanese. Moreover, authorities and planters objected to the construction of latrines because of the costs and their belief that the Javanese were “unhygienic”. In describing the labor migration from Java to Suriname, I show that this “lack of hygiene” was closely related to the system’s organization. I argue that uncleanliness was the consequence of harmful socio-economic and ecological conditions. Secondly I suggest that even though the Foundation did not manage to cleanse Suriname of hookworm, its educational efforts, its emphasis on prevention, and its training of local health workers probably had more impact than Rockefeller officials thought.
Em 1915, a Fundação Rockefeller levou sua campanha de erradicação da ancilostomíase ao Suriname, logo sofrendo a oposição de seu principal alvo, os javaneses. Autoridades e proprietários rurais também reagiram à instalação de latrinas devido aos custos implicados e à crença de que os javaneses eram “anti-higiênicos”. Ao descrever a migração de trabalhadores de Java para o Suriname, mostro que a “falta de higiene” ligava-se à organização do sistema. Argumento que a sujeira era consequência de condições ecológicas e socioeconômicas danosas. Sugiro ainda que, embora a Fundação não tenha livrado o Suriname da anciolostomíase, seus esforços educacionais, sua ênfase na prevenção e o treinamento de profissionais de saúde locais tiveram maior impacto do que o imaginado pelos funcionários da agência norte-americana.
Subject(s)
Animals , Male , Mice , Rats , Analgesics/pharmacology , Dimaprit/analogs & derivatives , Enzyme Inhibitors/pharmacology , Folic Acid Antagonists/pharmacology , Histamine Agonists/pharmacology , Histamine N-Methyltransferase/antagonists & inhibitors , Pyrimidines/pharmacology , Analgesics/administration & dosage , Dose-Response Relationship, Drug , Dimaprit/administration & dosage , Dimaprit/pharmacology , Enzyme Inhibitors/administration & dosage , Folic Acid Antagonists/administration & dosage , Histamine Agonists/administration & dosage , Injections, Intraventricular , Methylhistamines/pharmacology , Muscle Contraction/drug effects , Pain Measurement/drug effects , Postural Balance/drug effects , Psychomotor Performance/drug effects , Pyrimidines/administration & dosage , Pyrimidines/antagonists & inhibitors , Rats, WistarABSTRACT
Estudo que teve como objetivo apreender a percepção de enfermeiros sobre o uso do computador no ambiente de trabalho hospitalar. Participaram 14 enfermeiros de um hospital público. A coleta de dados realizou-se por meio de entrevista gravada e Diário de Campo. Os dados foram analisados de acordo com a técnica Análise de Conteúdo. Das entrevistas emergiram seis categorias temáticas abordando aspectos positivos tais como: rapidez, legibilidade e exatidão das informações; maior segurança do paciente e melhorias na qualidade do cuidado. Dentre os aspectos negativos se destacaram a conduta de copiar e colar as Prescrições Médicas e de Enfermagem; falta de computadores e distanciamento do enfermeiro do paciente. Apesar das fragilidades relatadas, os enfermeiros manifestaram-se favoráveis ao uso da tecnologia computacional no trabalho e indicaramna como recurso indispensável à qualidade do cuidado.
The objective of this study was to apprehend the perception nurses have on the use of computer in the hospital environment. Took part in the study 14 nurses of a public hospital. Collection of data took place through recorded interview and Field Diary. Data was analyzed according to Content Analysis technique. Six thematic categories emerged from the interviews such as the one that approached the positive aspects: speed, legibility and accuracy of the information; patients' safety and; improvements in the quality of care. Among the negative aspects copy and paste the Medical Prescriptions and Nursing; lack of computers and the nurse distancing to the patient were highlighted. In spite of the fragilities, they were all in favor of the use of computer technology at the work and they pointed it as indispensable resource to the quality of care.
Estudio que tuvo como objetivo aprehender la percepción de enfermeros sobre el uso de la computadora en el ambiente de trabajo hospitalario. Participaron 14 enfermeros de un hospital público. La recolección de datos fue realizado por medio de entrevista grabada y Diario de Campo. Los datos fueron analizados de acuerdo con la técnica Análisis de Contenido. De las entrevistas emergieron seis categorías temáticas como aquella que abarcó los aspectos positivos tales como: rapidez, legibilidad y exactitud de las informaciones; mayor seguridad del paciente y; mejorías en la calidad del cuidado. Entre los aspectos negativos se destacaron la conducta de copiar y pegar las Prescripciones Médicas y de Enfermería; falta de computadoras y alejamiento del enfermero con el paciente. A pesar de las fragilidades, todos se manifestaron favorables al uso de la tecnología computacional en el trabajo y la señalaron como recurso indispensable a la calidad del cuidado.