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1.
Mem. Inst. Oswaldo Cruz ; 109(2): 229-235, abr. 2014. tab, graf
Article in English | LILACS | ID: lil-705817

ABSTRACT

During the influenza pandemic of 2009, the A(H1N1)pdm09, A/H3N2 seasonal and influenza B viruses were observed to be co-circulating with other respiratory viruses. To observe the epidemiological pattern of the influenza virus between May 2009-August 2011, 467 nasopharyngeal aspirates were collected from children less than five years of age in the city of Salvador. In addition, data on weather conditions were obtained. Indirect immunofluorescence, real-time transcription reverse polymerase chain reaction (RT-PCR), and sequencing assays were performed for influenza virus detection. Of all 467 samples, 34 (7%) specimens were positive for influenza A and of these, viral characterisation identified Flu A/H3N2 in 25/34 (74%) and A(H1N1)pdm09 in 9/34 (26%). Influenza B accounted for a small proportion (0.8%) and the other respiratory viruses for 27.2% (127/467). No deaths were registered and no pattern of seasonality or expected climatic conditions could be established. These observations are important for predicting the evolution of epidemics and in implementing future anti-pandemic measures.


Subject(s)
Child, Preschool , Humans , Infant , Infant, Newborn , Influenza A Virus, H1N1 Subtype/isolation & purification , /isolation & purification , Influenza B virus/isolation & purification , Influenza, Human/epidemiology , Seasons , Weather , Adenoviridae/isolation & purification , Brazil/epidemiology , Climatic Processes , Coinfection , Fluorescent Antibody Technique, Indirect , Influenza A Virus, H1N1 Subtype/physiology , /physiology , Influenza B virus/physiology , Influenza, Human/virology , Nasal Lavage Fluid/virology , Pandemics , Reverse Transcriptase Polymerase Chain Reaction , Rain/virology , Respiratory Syncytial Viruses/isolation & purification , Respirovirus/isolation & purification , Sequence Analysis , Sunlight , Viral Load
2.
Pan Afr. med. j ; 11(36): 1-9, 2012.
Article in French | AIM | ID: biblio-1268383

ABSTRACT

Introduction: Le but de cette etude est de decrire les caracteristiques epidemiologiques; cliniques; paracliniques ainsi que l'evolution des femmes enceintes ou en post partum atteintes de formes graves de Grippe A(H1N1) 2009. Methodes: C'est une etude prospective observationnelle monocentrique; menee au sein de notre service de reanimation mere et enfant au centre hospitalier universitaire Hassan II a Fes; sur une periode de 3 mois; allant de novembre 2009 a janvier 2010. Resultats: L'age moyen etait de 28 ans; dans 85 des cas la grossesse se situaient au troisieme trimestre; le syndrome grippal etait constant; la SpO2 initiale etait en moyenne de 86. A la radiographie thoracique; un syndrome alveolaire bilateral etait toujours present. L'infection virale etait confirmee dans tous les cas par la polymerase chain reaction. Chez 3 patientes la PaO2/FiO2 etait inferieure a 300. L'Oseltamivir etait l'antiviral utilise chez toutes les parturientes. Un syndrome de detresse respiratoire aigu a ete developpe chez 28 des parturientes; elles ont ete ventilees artificiellement avec des niveaux de pressions expiratoires positives a 14 +/- 1 cmH2O. L'evolution etait favorable dans 71 des cas; cependant; 2 deces ont ete deplores. Conclusion: Les resultats rejoignent les donnees de la litterature; a savoir; un risque accru pour la femme enceinte de developper une forme grave; une presentation clinique similaire au reste de la population; l'interet de la vaccination et d'un traitement antiviral precoce et le role de l'ECMO dans le traitement des hypoxemies refractaires


Subject(s)
Academic Medical Centers , Influenza A Virus, H1N1 Subtype/epidemiology , Influenza A Virus, H1N1 Subtype/etiology , Influenza A Virus, H1N1 Subtype/physiology , Review
3.
Rev. cuba. obstet. ginecol ; 37(2): 182-192, Mayo-ago. 2011.
Article in Spanish | LILACS | ID: lil-615197

ABSTRACT

Se realizó un estudio observacional analítico, de corte transversal, en el Hospital General Docente Enrique Cabrera, con el objetivo de caracterizar la morbilidad materna por enfermedad tipo influenza A H1N1 en las pacientes obstétricas ingresadas en la unidad de cuidados intensivos respiratorios, en el marco de la pandemia 2009 de influenza. Se compararon los ingresos en gestantes y puérperas que se produjeron entre el 1 de septiembre y el 31 de diciembre de 2009, en cuanto a variables sociodemográficas, obstétricas, epidemiológicas y clínicas, utilizando el sistema SPSS 11.5 para Windows como procesador estadístico. Durante el periodo de estudio ingresaron 103 pacientes en cuidados intensivos, 86 (83,5 por ciento) gestantes y 17 (16,5 por ciento) puérperas; el 87, por ciento de las gestantes estaban en el 2do y 3er trimestre del embarazo. El 55,8 por ciento de las gestantes y 47,1 por ciento de las puérperas tenían un antecedente patológico, el asma bronquial fue el más frecuente. El 69,9 por ciento de las pacientes iniciaron el tratamiento antiviral con más de 48 h de síntomas. La tos fue el síntoma más frecuente presente, significativamente, en mayor número de gestantes, 79 (91,9 por ciento) que de puérperas, 11 (61,7 por ciento), le siguieron en orden la disnea (69,9 por ciento) y la fiebre (50,5 por ciento). Los principales diagnósticos de ingreso fueron neumonía (36 por ciento gestantes y 58,8 por ciento puérperas) y bronconeumonía (33,7 por ciento gestantes y 23,5 por ciento puérperas). Las complicaciones fueron más frecuentes en las puérperas, 9 (52,9 por ciento). Concluimos que el trabajo multidisciplinario y en equipo contribuyó a los resultados obtenidos


A cross-sectional, analytical and observational study was conducted in the Enrique Cabrera Teaching Hospital to characterize the maternal morbidity due to A H1Ni influenza in the pregnant patients admitted in the respiratory intensive care unit during the influenza pandemic in 2009. The admissions of pregnants and puerperants from September 1, 2009 to December 31, 2009 as regards the sociodemographic, obstetric, epidemiological and clinical variables, using the SPSS 11.5 system for Windows as the statistic processor. During the study period 103 patients were admitted in intensive care unit, 86 (83.5 percent) pregnants and 17 (16.5 percent) puerperants; the 87 percent of pregnants were in the second and the third trimester of pregnancy. The 55.8 percent of pregnants and the 47.1 percent of puerperants had a pathologic background, the bronchial asthma was the more frequent one. The 69.9 percent of patients started the antiviral treatment with more than 48 hours from the symptoms. Cough was the more prevalent symptom, in a significant way in the greater number of pregnants, 79 (91.9 percent) than puerperants, 11 (61.7 percent), followed in order the dyspnea (69.9 percent) and fever (50.5 percent). The major diagnoses for admission were pneumonia (36 percent of pregnants and the 58.8 percent or puerperants) and bronchopneumonia (33.7 percent of pregnants and the 23.5 percent of puerperants). The complications were more frequent in the puerperants, 9 (52.9 percent). We conclude the multidisciplinary work and by teams contributed to the results obtained


Subject(s)
Humans , Female , Pregnancy , Pregnancy Complications, Infectious/prevention & control , Influenza A Virus, H1N1 Subtype/physiology , Cross-Sectional Studies , Observational Studies as Topic
4.
Article in Portuguese | LILACS | ID: lil-552740

ABSTRACT

Devido à relevância do tópico na atualidade, dois artigos nesse número da Revista abordam a epidemia de influenza - “Bioética e Pandemia de Influenza” (3) e “Pandemia de Influenza A (H1N1): o que aprender com ela?” (4). Goldim, revisando aspectos bioéticos, afirma que em uma situação de pandemia, todos são co-responsáveis, não havendo possibilidade de se manter neutro. Dentro desse espírito, este editorial foi delegado a um cardiologista e a um geriatra que procuraram se “engajar no mesmo esforço solidário”, sem representar qualquer entidade, mas como cidadãos brasileiros


Subject(s)
Humans , Bioethics/trends , Influenza A Virus, H1N1 Subtype/growth & development , Influenza A Virus, H1N1 Subtype/physiology , Influenza A Virus, H1N1 Subtype/immunology , Disease Outbreaks/statistics & numerical data , Disease Outbreaks/ethics , Disease Outbreaks/prevention & control
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