ABSTRACT
OBJECT@#To investigate the changes in the expression_level of synaptophysin following diffuse brain injury (DBI) in rats and to correlate the changes of the synaptophysin expression_level with the post injury time interval.@*METHODS@#Wister rats were used as a DBI model induced by Marmarou method. The changes of synaptophysin immunoreactivity on coronal sections of the rats sampled at different post-injury time intervals were used as a marker. The densitometry of the synaptophysin immunoreactivity was documented by imaging technique and analyzed by SPSS software.@*RESULTS@#The expression level of synaptophysin in DBI rats showed dynamic changes following DBI as well as during the repairing period.@*CONCLUSION@#The changes of synaptophysin level may be used as a marker for estimation of the post injury time interval in DBI.