ABSTRACT
A 76-year-old man presented with features of bilateral herpes simplex virus (HSV) keratitis. It was found to be recurrence of bilateral HSV keratitis following the use of Bimatoprost eye drops for uncontrolled intraocular pressure in a case of bilateral primary open-angle glaucoma.
Subject(s)
Aged , Amides , Cloprostenol/analogs & derivatives , Cornea/pathology , Follow-Up Studies , Glaucoma, Open-Angle/complications , Humans , Keratitis, Herpetic/chemically induced , Lipids/adverse effects , Male , RecurrenceABSTRACT
Two different procedures for inoculation of HSV on corneas of balb/c mice were evaluated. The first was by the use of HSV suspensions directly on the corneas and the other was after corneal scarification. Animals by this later method presented greater morbidity and mortalitythan those of first group, suggesting than inoculation of HSV without scarification of the cornea should be the method of choice for the study of HSV ophthalmic infection. This model showed also be an efficient experimental system to testing antiviral drugs.