Study of gamma-interferon in schhistosomiasis mansoni, autoimmune diseases and schistosomal arthhropathy

IFN-gamma, aTh1 cytokine, was quantitatively estimated using EASIA in the sera of patients with different stages of Schistosomiasis mansoni autoimmune diseases and schistosomal arthropathy. Level of IFN-gamma was significantly elevated in all the test groups compared to the control group. The highest level of IFN-gamma observed was in RA and SLE with insignificant statistical difference between them. Cases with early S. mansoni infection showed significant higher level of IFN-gamma compared to hepatosplenic schistosomiasis with and without ascites. A significant statistical difference concerning IFN-gamma level was observed when comparing RA and SLE to different stages of S. mansoni infection and schistosomal arthropathy. This study concluded that IFN-gamma estimation in sera of patients having joint complaint could be a good marker for differentiation between autoimmune collagen induced arthritis and schistosomiasis induced arthropathy

Estrongyloidiasis sistemica grave observacion de 3 casos / Sistemic strongy lodiasis. Report of 3 cases

El siguiente trabajo es un resumen de tres casos de Strongiloidiasis sistemica, en pacientes con factores predisponentes y uso de corticoides (los tres casos), droga inmunosupresoras (1 caso). La evolucion fue torpida en un inicio, pero con diagnostico oportuno y tratamiento adecuado, concluyeron bien . Tambien reportamos el uso de Ivermectina (derivado semisintetico de lactona macrociclica) nombre comercial Ivomec (actualmente se uso contra la filariasis y la cisticercosis en humano), droga utilizada en el paciente No.3, que no respondio al tratamiento convencional y cuya mejoria fue evidente luego del uso de esta.