ABSTRACT
Un grupo de 37 mujeres postmenopáusia recibieron mestranol (MEE) 20 ug/d/90 d. En cada una se tomaron muestras de moco cervical citología vaginal, biopsia de endometrio y sangre para medir 17 beta estradiol (E-2), fracciones de baja (LDL-C) y alta HDL-C densidad lipoproteica del colesterol antes (fase I) y después de ese tratamiento (fase II). Además de suprimir la sintomatología vasomotora, el moco endocervical y las células vaginales cariopicnóticas aumentaron y 3/4 de las biopsias presentaron proliferación en la fase II. No se produjo cambio en la concentración de estrógenos natural. La fracción LDL-C disminuyó (p=0.01) y la HLD-C aumentó (p=0.001) al comparar las fases I y II. Acetato de clormadinona fue administrado 2 mg/d/3 d para descamar el endometrio hacia el final del tratamiento con MEE. Para fundamentar esta dosis estrogénica y el nuevo régimen es necesario aumentar la casuística
Subject(s)
Middle Aged , Humans , Female , Estrogens/metabolism , Estrogens/therapeutic use , Mestranol/administration & dosage , Mestranol/therapeutic use , Estrogen Replacement Therapy/methods , Estrogen Replacement TherapyABSTRACT
The possibility that risk of a atherosclerosis complication increases with oral contraceptive use was examined by studying the effect of oral pill containing 0.067 mg menstranol and 0.667 mg ehtynodiol diacetate/kg body weight on the metabolism of lipids in female rats fed a hypercholesterolemic diet for three months. Experimental group clearly exhibited higher levels of triglycerides and cholesterol in plasma and tissues, increase in aorta observed to be two folds. Increased hepatic cholesterogenesis was noted with treatment of oral contraceptive as indicated by higher activity of HMG-CoA reductase. Activity of lipoprotein lipase of extrahepatic tissue was depressed in experimental group. Activity of plasma LCAT, an enzyme involved in the transport of cholesterol from tissues, was also lower with treatment of oral contraceptive. However, activity of malic enzyme and glucose-6-phosphate dehydrogenase enhanced considerably with administration of oral pill. The increase in plasma and aortic cholesterol levels, increase in LDL+VLDL cholesterol and considerable decrease in HDL cholesterol in animals treated with oral contraceptives and fed with atherogenic diet, indicates that prolonged administration of oral pill may predispose towards atherosclerosis.
Subject(s)
Animals , Arteriosclerosis/etiology , Contraceptives, Oral, Combined/toxicity , Contraceptives, Oral, Synthetic/toxicity , Diet, Atherogenic , Ethynodiol Diacetate/toxicity , Female , Lipid Metabolism , Mestranol/toxicity , RatsABSTRACT
Se estudió una formulación oral monofásica a base de 75 mcg de gestodeno y 30 mcg de etinilestradiol, con el objeto de probar su seguridad, eficacia y control del ciclo menstrual. En el estudio se incluyeron 67 mujeres sanas que acumularon 574 ciclos. Esta formulación mostró ser muy eficaz, ya que con el uso adecuado del método no se presentó ningún embarazo. los efectos secundarios observados fueron iguales o menores a los reportados con otros anticonceptivos hormonales orales. La administración de este nuevo preparado no modificó los parámetros hematológicos, bioquímicos o urinarios de las usuarias. Con respecto al control sobre el sangrado endometrial, las usuarias de mantuvieron dentro de un patrón menstrual considerado como acptable. En conclusión, se trata de un anticonceptivo oral que resultó ser eficaz, bien aceptado y cuyos efectos secundarios son semejantes o menores a los de otros anticonceptivos orales.
Subject(s)
Humans , Female , Adult , Middle Aged , Ethinyl Estradiol/pharmacology , Menstrual Cycle/drug effects , Mestranol/pharmacology , Contraceptives, Oral, Combined/pharmacologyABSTRACT
É relatado um caso de endometriose que se manifestou inicialmente na coxa. O tumor comprometia a face ântero-superior da coxa direita, era doloroso e aumentava de volume na época menstrual. No entanto, cerca de seis anos após as terapêuticas cirúrgica e hormonal houve recidiva do tumor e evidenciou-se a presença de foco primário, intraperitoneal. Por fim, säo feitas consideraçöes sobre a endometriose, intra e extraperitoneal, e descritas as principais teorias histogenéticas
Subject(s)
Adult , Humans , Female , Endometriosis/pathology , Thigh , Uterine Neoplasms/pathology , Drug Combinations , Endometriosis/drug therapy , Lynestrenol/therapeutic use , Mestranol/therapeutic use , RecurrenceABSTRACT
The effect of the two synthetic steroid hormones, mestranol and lynestrenol, on sodium, potassium, calcium and magnesium on serum, urine and aorta were investigated. Mestranol alone lead to a significant rise in serum sodium and a decrease in serum potassisum but lynesdtrenol is naturitic. The sodium content of the aorta decreases with mestranol and increases with lynestrenol. Serum magnesium increases with lynestrenol. The changes with mestranol was insignificant. Ser um calcium level decreases with Lyndiol therapy; this may suggest that combined oral contraceptives do not lead to bone re-sorption. So the combined use of lynestrenol and mestranol may minimize the electrolyte disturbance which occurs with either of them
Subject(s)
Animals, Laboratory , Female , Mestranol/pharmacology , Electrolytes/blood , Electrolytes/analysisABSTRACT
1- The effect of the two synthetic steroid hormones lynestrenol and mestranol on serum copper, zinc and iron was investigated in female rats and in women. 2. There was a rise of serum copper with mestranol and a decrease in its level with lynestrenol. 3. Serum copper rises with the combination of the two hormones in Lyndiol I. This rise was progressive with the duration of therapy. 4. Serum zinc decreases with Lyndiol both in the pre-and post-menstrual period under Lyndiol I medication. In rats, serum iron rises with mestranol. The relation between serum copper and zinc can be used as a test for the selection of cases or discondinuation of treatment with oral pill, especially in rural areas with endemic bilharziasis
Subject(s)
Animals, Laboratory , Male , Lynestrenol/pharmacology , Mestranol/pharmacology , SchistosomiasisABSTRACT
In view of continuous clinical reports of liver damage following oral contraceptive use, morphologic changes of the liver following the administration of a combined type of oral contraceptive (Norinyle) were studied in guinea pigs by light and electron microscopic examinations. Two interesting changes, one in Kupffer cells and another in the hepatocytes were observed. The Kupffer cells were hyperplastic and enlarged due to the phagocytosis of a large amount of fibrin which were apparently formed intravascularly and were being cleared by Kupffer cells. It is thought that enlarged Kupffer cells and excessive fibrin formation beyond the clearing capacity of Kupffer cells may lead to blockage of sinusoids resulting in a Budd-Chiari like syndrome. The nucleus of the hepatocytes showed mild enlargement and a clear nucleolar segregation which is regarded as one of the ultrastructural evidences of chemical carcinogenesis. Therefore, it is speculated that this change may be related to tumorigenesis in the liver following oral contraceptive administration. Other changes consisted of ischemic necrosis and fatty changes in occasional animals, alteration of mitochondrial configuration and hyperplasia of smooth endoplasmic reticulum in hepatocytes.