ABSTRACT
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by the general population to alleviate inflammation and pain after oral surgeries. Piroxicam is among the most commonly used NSAIDs and excels in controlling pain, swelling, trismus and other common symptoms of inflammation. This study aimed to evaluate different concentrations of piroxicam and its major metabolite, 5'-hydroxypiroxicam, in human plasma samples over time using high performance liquid chromatography (HPLC) after liquid-liquid extraction. Briefly, 10 volunteers participated in this study after approval by the Ethics Committee of Bauru School of Dentistry, Universidade de São Paulo - USP, Brazil. Volunteers received a single dose oral of piroxicam (20 mg) and had blood collected at various times following an established protocol. The methodology of liquid-liquid extraction was effective for determining concentrations of piroxicam in plasma using HPLC in 10 out of 10 volunteers while 5'-hydroxypiroxicam was only detected in 2 out of 10 volunteers.
Subject(s)
Humans , Piroxicam/analogs & derivatives , Piroxicam/blood , Anti-Inflammatory Agents, Non-Steroidal/blood , Chromatography, High Pressure Liquid/methods , Liquid-Liquid Extraction/methods , Reference Values , Time Factors , Piroxicam/pharmacokinetics , Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics , Naproxen/blood , Naproxen/pharmacokinetics , Reproducibility of ResultsABSTRACT
In this work, the percutaneous absorption of naproxen in rabbits was investigated and compared with its in vitro release. The effect of incorporation of [+]-limonene [1-3%] as penetration enhancer on in vitro release of drug from gels and percutaneous absorption was studied using pluronic F127 as a gel base model. Percutaneous absorption was evaluated by determining the serum concentration of naproxen in rabbit's blood. The area under the curve and Cmax in plasma were also calculated. It was proved that the in vitro drug release and its percutaneous absorption were functions of the concentration of [+]-limonene. A significant increase in percutaneous absorption was obtained in the presence of enhancer
Subject(s)
Animals , Administration, Cutaneous , Skin Absorption , Gels , Naproxen/blood , RabbitsABSTRACT
A three-fold decrease of the in vitro ability of serum proteins to bind naproxen was shown in patients with cirrhosis of the liver compared to healthy individuals. This decrease was caused by quantitative changes in serum proteins in the sera of patients with liver damage. Lower doses of naproxen are therefore suggested in the treatment of patients with liver dysfunction
Subject(s)
Humans , Male , Female , Naproxen/blood , Naproxen/toxicityABSTRACT
Neste trabalho procurou-se avaliar os efeitos dos antiinflamatórios näo esteróides: Indometacina (indocid), Butazona (Fenilbutazona), Clinoril (Sulindac), Naprosin (Naproxen), Benflogin (Cloridrato de Benzidamina) e Inflaril (Acido neflúmico) nos leucogramas de ratos portadores de um processo inflamatório crônico provocado pela introduçäo intradérmica de lamínulas de vidro nos períodos de 3, 12 e 18 dias. O sangue para a contagem total dos leucócitos, eletrônica e diferencial, esfregaço, foi obtido por punçäo intracardíaca (Burhoe). A Indometacina, o Clinoril e a Butazona indicaram diminuiçäo de linfócitos e eosinófilos e aumento de monócitos e neutrófilos em todos os períodos e observaçäo em todos os períodos; o Inflaril reduziu o número de linfócitos, neutrofilia e eosinopenia em todos os períodos; o Inflaril reduziu o número de linfócitos e eosinófilos de aumentou os monócitos, com exceçäo de 3§ período, e os neutrófilos nos três períodos; e o Benflogin elevou os linfócitos na 1ª e 3ª fases, e os monócitos nos três períodos, e reduziu os neutrófilos nos dois primeiros, e os eosinfófilos nos dois últimos períodos. Todas as drogas usadas provocaram reduçäo de leucócitos em todos os períodos de tratamento, exceçäo feita ao Naprosin no 3§, ao Benflogin no 2§ e ao Inflaril no 1§ e 2§ períodos