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Indian J Physiol Pharmacol ; 1995 Jul; 39(3): 275-8
Article in English | IMSEAR | ID: sea-108242

ABSTRACT

Liver necrosis was produced in rats by administering 3 doses o a mixture o carbon tetrachloide+olive oil, 2 ml/kg, ip. The liver damage was evidenced by the elevated levels serun aspartate aminotrans ferase (AST), alanine aminotransferase (AIT) and gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Nitrendipine, nimodipine and nisoldipine (1 mg/100 g of rat, ip) significantly reduced these elevated levels of AST, AIT and gamma-GT. Carbon tetrachloride induced liver necrosis was also found to be significantly reduced in nitrendipine, nimodipine and nisoldipine pre-treated animals as observed macroscopically and histologically.


Subject(s)
Alanine Transaminase/blood , Animals , Aspartate Aminotransferases/blood , Calcium Channel Blockers/therapeutic use , Carbon Tetrachloride Poisoning/pathology , Chemical and Drug Induced Liver Injury/metabolism , Liver/metabolism , Male , Necrosis/pathology , Nimodipine/therapeutic use , Nisoldipine/therapeutic use , Nitrendipine/therapeutic use , Rats , Rats, Wistar , gamma-Glutamyltransferase/blood
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