ABSTRACT
Bone disease in beta-thalassemic patients has multifactorial etiology; increased iron stores and per-oxidative stress are involved factors. This study aimed to investigate the relationship between some bone turnover markers and some oxidants, antioxidants parameters of beta-thalassemic patients. The study included 50 patients were diagnosed as beta-thalassemia major aged between 3 and 40 years, 30 males and 20 females compared to 34 normal controls of same age and sex ratio. The patients and the controls were divided into 2 groups: group Al 18 years compared to their controls group B2. All were subjected to full clinical examination and laboratory analysis of their blood and urine for bone turnover markers; osteocalcin [OC], bone specific alkaline phosphatase [BAP] and urinary deoxypyridinoline [DPD].Also parathormone [PTH], serum calcium [Ca] and phosphorus [Ph]. Oxidants and antioxidants determined were; plasma malondialdehyde [MDA], nitric oxide [NO], blood reduced glutathione [GSH], erythrocyte Cu- Zn Superoxide dismutase [SOD]. Serum levels of copper [Cu], zinc [Zn], selenium [Se], vitamin E and total antioxidant capacity [TAOC] were also determined. The results showed significant increase in urinary DPD and decrease in serum OC, BAP and PTH in thalassemic groups compared to controls. Also, the results revealed significant elevation in plasma MDA, NO, SOD and serum Cu and TAOC especially in group Al. While there was significant decrease in GSH, serum Zn, Se, and vitamin E. Plasma OC was positively correlated with serum iron and NO and negatively correlated with plasma TAOC in thalassemic patients within age group 3