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1.
An. bras. dermatol ; 94(6): 754-756, Nov.-Dec. 2019. graf
Article in English | LILACS | ID: biblio-1054889

ABSTRACT

Abstract A 28-year-old white female patient presented with multiple erythematous-to-violaceous, painful, suppurative nodules on the buttocks and thighs that appeared after two weeks of mesotherapy with deoxycholate, caffeine, sunflower liposomes, and sinetrol for localized fat. She was treated for atypical mycobacteriosis, but with no satisfactory response after antibiotic therapy. Bacterial, mycobacterial, and fungal culture were all negative. Histopathologic examination of the biopsy showed noninfectious suppurative panniculitis. It resolved after treatment with methotrexate, prednisone, and hydroxychloroquine. This report highlights the rarity of this complication, the importance of its early recognition, and differentiation with atypical fast growing mycobacterioses.


Subject(s)
Humans , Female , Adult , Panniculitis, Nodular Nonsuppurative/chemically induced , Panniculitis, Nodular Nonsuppurative/pathology , Deoxycholic Acid/adverse effects , Mesotherapy/adverse effects , Biopsy , Panniculitis, Nodular Nonsuppurative/drug therapy , Treatment Outcome , Dermis/pathology
2.
Article in English | IMSEAR | ID: sea-89271

ABSTRACT

Weber Christian disease or idiopathic lobular panniculitis is a skin condition that features recurring inflammation in the fat layer of the skin. We report a case of a 17 year old boy with Weber Christian disease as its occurence is extremely rare with only sparse case reports available, who presented with eighteen-month history off fever with chills off and on, arthralgia predominantly of the knees, ankles, wrists and elbows without swelling or gross limitation of movement. There was also swelling around the eyes and puffiness of the face with lumpy swellings on the jaw, cheeks and chin and painful lumps on the anterior abdominal wall. On examination a febrile patient with pallor, pitting edema of the legs, periorbital edema and multiple non-matted firm to hard tender swellings of the face, jaw and chin and multiple firm tender lumps in the anterior abdominal wall was noted. Investigations revealed anemia, leucopenia, raised sedimentation rate and mild rise of liver enzymes. Biopsy of the abdominal nodule demonstrated a lobular panniculitis without vasculitis as seen in Weber Christian disease.


Subject(s)
Adolescent , Azathioprine/therapeutic use , Humans , Immunosuppressive Agents/therapeutic use , Male , Panniculitis, Nodular Nonsuppurative/drug therapy
3.
Journal of Korean Medical Science ; : 247-250, 2000.
Article in English | WPRIM | ID: wpr-140417

ABSTRACT

Weber-Christian disease (WCD) is a rare inflammatory disease of adipose tissue, which is characterized by painful cutaneous nodules and constitutional symptoms. Although any area of the body containing fat can be affected by WCD, the involvement of retrobulbar fat is uncommon and proptosis is a rare presenting manifestation. We report a case who presented with proptosis of the right eye which is accompanied by painful subcutaneous nodules, high fever and myalgia. Biopsies of retrobulbar tissue and suprapubic nodule showed lobular panniculitis with mixed cellular infiltration, mainly composed of histiocytes and lymphocytes. He responded well to high-dose glucocorticoid.


Subject(s)
Adult , Humans , Male , Biopsy , Exophthalmos/pathology , Exophthalmos/etiology , Exophthalmos/drug therapy , Glucocorticoids/administration & dosage , Magnetic Resonance Imaging , Panniculitis, Nodular Nonsuppurative/pathology , Panniculitis, Nodular Nonsuppurative/drug therapy , Panniculitis, Nodular Nonsuppurative/complications
4.
Journal of Korean Medical Science ; : 247-250, 2000.
Article in English | WPRIM | ID: wpr-140416

ABSTRACT

Weber-Christian disease (WCD) is a rare inflammatory disease of adipose tissue, which is characterized by painful cutaneous nodules and constitutional symptoms. Although any area of the body containing fat can be affected by WCD, the involvement of retrobulbar fat is uncommon and proptosis is a rare presenting manifestation. We report a case who presented with proptosis of the right eye which is accompanied by painful subcutaneous nodules, high fever and myalgia. Biopsies of retrobulbar tissue and suprapubic nodule showed lobular panniculitis with mixed cellular infiltration, mainly composed of histiocytes and lymphocytes. He responded well to high-dose glucocorticoid.


Subject(s)
Adult , Humans , Male , Biopsy , Exophthalmos/pathology , Exophthalmos/etiology , Exophthalmos/drug therapy , Glucocorticoids/administration & dosage , Magnetic Resonance Imaging , Panniculitis, Nodular Nonsuppurative/pathology , Panniculitis, Nodular Nonsuppurative/drug therapy , Panniculitis, Nodular Nonsuppurative/complications
5.
Asian Pac J Allergy Immunol ; 1997 Sep; 15(3): 161-6
Article in English | IMSEAR | ID: sea-36571

ABSTRACT

This is a report of a case, 7 1/2 year-old-boy having chronic febrile and recurrent crops of painful subcutaneous nodules on lower extremities, which had previously been diagnosed as Weber-Christian disease, which progressed to have cytophagic histiocytic activity in the skin, bone marrow with abnormal liver function and hemorrhagic diathesis. He was subsequently treated with corticosteroid without good response. After he was diagnosed as having cytophagic histiocytic panniculitis, cyclosporin A was administered intravenously in an initial dosage of 1 mg/kg/day and in oral maintenance dose of 10 mg/kg/day with a successful response and the patient completely recovered within 6 months with mild hypertension as an adverse effect.


Subject(s)
Child , Cyclosporine/therapeutic use , Erythrocytes/immunology , Fat Necrosis/drug therapy , Histiocytosis/drug therapy , Humans , Male , Panniculitis, Nodular Nonsuppurative/drug therapy , Phagocytosis
6.
Rev. chil. pediatr ; 62(3): 182-5, mayo-jun. 1991. ilus
Article in Spanish | LILACS | ID: lil-104674

ABSTRACT

Un niño de 14 meses de edad ingresó por presentar placa indurada en la piel del muslo izquierdo y fiebre alta de un mes de evolución. Durante su hospitalización aparecieron nódulos subcutáneos sensibles con características inflamatorias en cara y tronco, adenopatías cervicales y hepatomegalia. En la biopsia de la piel había extensa destrucción del tejido celular subcutáneo, células espumosas, vasculitis e infiltración por leucocitos polimorfonucleares; en la de ganglio linfático se comprobó proliferación histiocitaria y en una muestra de hígado obtenida por punción se encontró evidencia de esteatosis. Se descartaron osteoartritis, celulitis, septicemia, tuberculosis, enfermedad del colágeno y neoplasia linforreticular. Recibió tratamiento con prednisona con excelente respuesta. Se ha mantenido asintomático a lo largo de 12 meses de seguimiento


Subject(s)
Panniculitis, Nodular Nonsuppurative/pathology , Biopsy , Diagnosis, Differential , Panniculitis, Nodular Nonsuppurative/drug therapy , Prednisone/therapeutic use
7.
J. bras. med ; 57(4): 32, 34, out. 1989. ilus
Article in Portuguese | LILACS | ID: lil-90516

ABSTRACT

Os autores relatam um caso de doença de Weber-Christian (paniculite nodular recidivante näo-esclerosante), associada a gota, näo descrita anteriormente na literatura sem resposta ao uso de indometacina e razoável resposta ao uso de prednisona


Subject(s)
Aged , Humans , Male , Gout/complications , Panniculitis, Nodular Nonsuppurative/complications , Allopurinol/therapeutic use , Gout/drug therapy , Indomethacin/therapeutic use , Panniculitis, Nodular Nonsuppurative/drug therapy , Prednisone/therapeutic use
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