ABSTRACT
Intraperitoneal (i.p.) administration of (+/-) pentazocine (10, 30 & 50 mg/kg), a Sigma opioid agonist, resulted in a dose dependent anticonvulsant action against maximal electroshock seizures in mice. This anticonvulsant effect of pentazocine was not antagonized by both the doses of naloxone (1 and 10 mg/kg) suggesting thereby that its anticonvulsant action is probably mediated by Sigma opiate binding sites. Its anticonvulsant effect was potentiated by both the anticonvulsant drugs viz. diazepam and diphenylhydantoin. Morphine, mu opioid agonist, on the other hand, failed to protect the animals against maximal electroshock seizures when it was given in doses of 10-40 mg/kg body wt.
Subject(s)
Analgesics, Opioid/therapeutic use , Animals , Anticonvulsants/therapeutic use , Diazepam/therapeutic use , Disease Models, Animal , Dose-Response Relationship, Drug , Drug Interactions , Female , Male , Mice , Mice, Inbred Strains , Naloxone/therapeutic use , Narcotic Antagonists/therapeutic use , Pentazocine/therapeutic use , Seizures/drug therapy , Treatment OutcomeABSTRACT
In immediate postoperative period, many injectable analgesics are being used with diverse side effects. The present study was conducted on 75 patients of both sexes, who underwent various types of surgery, to evaluate pain relief in immediate postoperative period. The drugs used for producing postoperative analgesia are buprenorphine, pentazocine and nefopam, all by intramuscular route.
Subject(s)
Adolescent , Adult , Buprenorphine/therapeutic use , Female , Humans , Injections, Intramuscular , Intraoperative Period , Male , Middle Aged , Nefopam/therapeutic use , Pain Measurement , Pain, Postoperative/diagnosis , Pentazocine/therapeutic use , Time FactorsABSTRACT
Seventy four patients presented with eclampsia at N.W.M. Hospital. Bombay. Among the patients with eclampsia, 64.9% were primis, 29.7% were gravida II-IV and 5.4% were grand multis. As many as 40.5% patients were less than 20 years of age, while 2.7% were over 30 years of age. 48.7% had antepartum convulsions, 40.5% had intrapartum convulsions, while 8 patients convulsed in the postpartum period. Besides standard management of eclamptic patients, 3 protocols of anticonvulsant therapy were utilised. 27% were managed with diphenyl hydantoin sodium, 43% with magnesium sulphate, and 30% by combination of diazepam and pentazocine. The maternal and perinatal outcome was evaluated. Control of convulsions was superior with magnesium sulphate while perinatal outcome was best with diphenyl hydantoin.
Subject(s)
Adult , Anticonvulsants/therapeutic use , Diazepam/therapeutic use , Drug Therapy, Combination , Eclampsia/drug therapy , Female , Humans , Infant Mortality , Magnesium Sulfate/therapeutic use , Maternal Mortality , Pentazocine/therapeutic use , Phenytoin/therapeutic use , PregnancySubject(s)
Adolescent , Adult , Aged , Female , Humans , Injections, Spinal , Male , Middle Aged , Pain, Postoperative/drug therapy , Pentazocine/therapeutic use , Random AllocationABSTRACT
Se evoluó la eficacia y la tolerancia de la ceruletida en el dolor postoperatorio, en un estudo doble ciego, randomizado y comparado