ABSTRACT
A significant effort worldwide is being directed toward development of novel biocides against drug-resistant bacterial and viruses because of the significant potential human infection risks in the general population. We report here the discovery of a strong antiviral biocide, dialdheyde starch (DAS). Antiviral tests were carried out against three non-envelop viruses, including two bacterial viruses MS2 and PRD1, and one human virus Poliovirus. Dialdehyde starch aqueous suspensions were effective biocides against these three test viruses in a 1 hr exposure test. The antiviral activity was significantly enhanced in a four-hour exposure test, with maximum seven orders of magnitude reductions against MS2 and PRD1, and four-order reduction against Poliovirus. The antiviral activity of dialdehyde starch was found to be pH dependent, being more active in alkaline and acidic conditions than in neutral conditions.
Subject(s)
Aldehydes/analysis , Aldehydes/therapeutic use , Starch/analysis , Starch/therapeutic use , Pesticides/chemical synthesis , Antiviral Agents/chemical synthesis , Antiviral Agents/therapeutic use , Drug Resistance, Bacterial , Drug Resistance, ViralABSTRACT
Através dos testes in vitro por imersäo de fêmeas ingurgitadas de carrapatos (Teste de Drumond), utilizados para estimativa da eficiência de drogas carrapaticidas, objetivou-se avaliar o grau de sensibilidade de Linhagem de Boophilus microplus proveniente de Jacarei, estado de Säo Paulo, Brasil, quando submetida a açäo de substâncias carrapaticidas usualmente utilizadas na regiäo, tais como: 1) triclorfon + coumafós; 2) amitraz; 3) fenvalerato; 4) decametrina; 5) cipermetrina "high cis" + diclcorvos; 6) cipermetrina "high cis". Dos carrapaticidas empregados, cipermetrina "high cis" + diclorvos foi aquele que apresentou melhor percentual de controle, evidenciando sua alta eficiência ovariostática e anti-embriogênica, bem como sugerindo que pode ser um dos mais efetivos no controle de B. microplus na regiäo