ABSTRACT
We report a rare case of isolated pleural hemangioma presenting as recurrent, haemorrhagic pleural effusion. Chest radiograph and computed tomography of chest was suggestive of left apical tumour. Diagnosis of hemangioma was revealed only after thoracotomy and excision of the tumour mass.
Subject(s)
Blood Cells , Hemangioma/complications , Hemorrhage/etiology , Humans , Male , Middle Aged , Pleural Effusion, Malignant/cytology , Pleural Neoplasms/complications , RecurrenceABSTRACT
Con el propósito de evaluar la calidad del diagnóstico citopatológico en casos de efusión pleural maligna, se estudiaron 75 pacientes afectados por tal patología (50 mujeres y 25 hombres con edad promedio de 56 años). Las historias clínicas y material histológico disponible permitieron la localización del tumor primario en 88 por ciento de los casos. En mujeres los tumores primarios más frecuentes fueron carcinomas de mama (34 por ciento), pulmón (30 por ciento), neoplasias de origen desconocido (12 por ciento) y linfomas/leucemias (10 por ciento), mientras que en hombres comprendieron carcinomas de pulmón (72 por ciento), neoplasias de origen desconocido (12 por ciento) y linfomas/leucemias (8 por ciento). El adenocarcinoma representó el tipo histológico predominante. El porcentaje de positividad de las citologías pleurales fue superior al obtenido en el material de biopsia (87,63 por ciento vs 64,44 por ciento; P= 0,0004) y aportó el primer diagnóstico morfológico de cáncer en 57,33 por ciento de los casos. Un diagnóstico concluyente de malignidad fue obtenido con la primera muestra del líquido pleural en 90,67 por ciento de los pacientes y con dos muestras en el 100 por ciento, mientras que para las biopsias el porcentaje de positividad no alcanzó el 70 por ciento con una tercera muestra. Los valores de sensibilidad y especificidad del método citológico fueron 100 por ciento y 42,86 por ciento, respectivamente. Se concluye que la citología del líquido pleural es un método de gran valor para el estudio de los pacientes con efusión pleural maligna
Subject(s)
Humans , Male , Female , Biopsy , Carcinoma , Cell Biology , Pleural Effusion, Malignant/cytology , Sensitivity and Specificity , Medicine , VenezuelaABSTRACT
Nineteen patients with malignant pleural mesothelioma seen at the Alexandria University Hospitals between 1987 and 1991 were the material of this study. The tumours were classified as epithelial, sarcomatous or of mixed type, also four samples from pleural effusion were subjected to routine cytological examination as well as electron microscopic studies. Most of the patients presented with locally advanced disease, the overall response to irradiation and chemotherapy was 55.3% with complete response rate of 33.3%. The response to treatment was correlated to some prognostic factors. The duration of response ranged between three and fifteen months and the median survival for responders was twenty months
Subject(s)
Humans , Male , Female , Histology , Pleural Effusion, Malignant/cytology , Mesothelioma/radiotherapy , Chemotherapy, Adjuvant , Follow-Up Studies , PrognosisABSTRACT
This study was conducted on 563 cases of body cavity effusions to establish the following points: 1. Determination of the underlying malignant causes 2. A search for the morphological feature of malignant cells for determination of their nature and site of origin 3. Differentiation between mesothelioma, cells and metastatic adenocarcinoma. Also, differentiation between non - Hosgkin's lymphoma and non- neoplastic lymphoid reaction.Qualitative cytoplasmic feature of prepared smears were studied by May- Grueniwald Giemsa [MGG] and nuclear feature in slides stained by Papanicolaou's stain [PAP]PAS stain and AB stain were used when needed 100 cells were assessed. Malignant effusions constituted 17.23% of all studied cases metaststic carcinoma was found to be the most common cause of pleural and peritoneal effusions.Adenocarcinomas formed the majority and the different primarysite of origin were breast, lung GIT and ovaries. Lymphoma/leukemia constituted the second frequent cause of body cavity effusions. It has been shown that MGG stain is highly valuable in differentiation of small cell lymphoma from lymphoid reaction. In small cell lymphoma all cells show monotonous nuclear staining, while in lymphoid reaction it is variable Methothelioma was the last frequent cause of malignant effusions. The most discriminating feature from reactive and highly reactive effusions are morula formation, cytoplasmic vacuolation, nuclear shape [irregular and oval] chromatin pattern [irregular and hyperchromatic], and prominent nucleoli. Metholelioma cells are PAS positive and negative after diastase digestion