ABSTRACT
A polimiosite (PM) é uma doença sistêmica do grupo das miopatias inflamatórias idiopáticas, clinicamente caracterizada por fraqueza muscular proximal e simétrica. Há relatos na literatura de PM associada a neoplasias, doenças autoimunes e infecções virais. Entretanto, a associação entre PM e nefropatia não é frequente. Descrevemos o caso de um paciente com polimiosite que evoluiu com síndrome nefrótica devido à presença de glomerulonefrite mesangial.
Polymyositis (PM) is a systemic disease of the idiopathic inflammatory myopathy group, clinically characterized by symmetric and proximal muscle weakness. There are reports in literature of PM associated with malignancies, autoimmune diseases, and viral infections. However, the association between PM and nephropathy is not common. We describe a case report of a patient with polymyositis who developed nephrotic syndrome due to mesangial glomerulonephritis.
Subject(s)
Adult , Humans , Male , Nephrotic Syndrome/complications , Polymyositis/etiologySubject(s)
Humans , Deltaretrovirus Infections/complications , Tropical Medicine , Paraparesis, Tropical Spastic/diagnosis , Polymyositis/diagnosis , Human T-lymphotropic virus 1 , Diagnosis, Differential , Jamaica , Paraparesis, Tropical Spastic/etiology , Paraparesis, Tropical Spastic/pathology , Polymyositis/etiology , Polymyositis/pathologyABSTRACT
Transient weakness of the legs developed in a 17 year-old male high school student three weeks after the initial injection of a hepatitis B vaccine. Seventeen days after the second injection of the vaccine, low-grade fever, a pruritic maculopapular rash appeared and weakness of the legs recurred. This was associated with elevation of the creatinine kinase to 2,406 U/L. The day after admission he became afebrile and in the subsequent four days the rash improved but leg weakness persisted. One-month later, muscle strength had returned; and the creatinine kinase had returned to normal levels. The only case of dermatomyositis associated with hepatitis B vaccination and the findings in the six reported cases of surface antigen-positive hepatitis associated with polyomyositis or dermatomyositis are briefly reviewed. Hepatitis B vaccination should be encouraged, but it is important to be aware that, rarely, dermatomyositis, polymyositis or neurovascular complications may occur. Polymyositis associated with the administration of the hepatitis B vaccine or with hepatitis B virus infection is a rare occurrence. A Medline Search performed from 1960 to January 2002 associating hepatitis B vaccine or hepatitis B virus with myopathy, myositis, polymyositis and dermatomyositis, showed only one case of dermatomyositis related to the hepatitis B vaccine, and six case reports relating polymyositis to hepatitis B virus infection. We present a case where a causal relationship between polymyositis and hepatitis B vaccination appears quite likely
Subject(s)
Male , Adolescent , Humans , Shock, Septic/etiology , Polymyositis/etiology , Hepatitis B Vaccines/adverse effects , Shock, Septic/diagnosis , Shock, Septic/drug therapy , Diphenhydramine/therapeutic use , Fluid Therapy , Polymyositis/diagnosis , Polymyositis/drug therapy , Treatment OutcomeABSTRACT
Primary biliary cirrhosis (PBC) is a cholestatic liver disease, which is characterized by a chronic inflammatory destruction of intrahepatic bile ducts. It is a rare disorder whose precise etiology is still to be elucidated. Even though the liver is the principal target of PBC, other organ systems also might be affected. Muscular involvement has rarely been described in this disease, and in the majority of cases, muscular weakness has been interpreted as polymyositis. We report the case of a 48-year-old woman suffering from classic PBC, in association with a myopathy whose histological features are distinct from the cases reported before. We also performed a MEDLINE research for PBC and concomitant muscular diseases
Subject(s)
Humans , Female , Middle Aged , Liver Cirrhosis, Biliary/complications , Polymyositis/etiology , Liver Cirrhosis, Biliary/diagnosis , Liver Cirrhosis, Biliary/pathology , Polymyositis/pathologyABSTRACT
Os autores revisam o tema infecçäo pelo vírus HTLV-I (Human T Cell Lymphotropic Virus), sua transmissäo e conseqüências clínicas. FOcalizam preferencialmente a triagem de gestantes infectadas, o risco e forma de contaminaçäo de seus fetos e fazem orientaçäo com relaçäo à prevençäo
Subject(s)
Humans , Female , Pregnancy , Deltaretrovirus , HTLV-I Infections/prevention & control , HTLV-I Infections/transmission , Pregnancy Complications, Hematologic , Pregnancy, High-Risk , Facial Paralysis/etiology , Polymyositis/etiology , Polyradiculoneuropathy/etiologyABSTRACT
A unique case of carcinoma of ovary with an unusual presentation is reported here. Her presenting complaint was in no way related to ovarian malignancy. She presented to the neurologist with the features suggestive of polymyositis. She did not respond satisfactorily to the conventional treatment by steroids and on investigation, was found to have an underlying advanced ovarian malignancy.
Subject(s)
Cystadenocarcinoma, Mucinous/complications , Diagnosis, Differential , Female , Humans , Middle Aged , Ovarian Neoplasms/complications , Polymyositis/etiologySubject(s)
Humans , Male , Female , Rheumatic Diseases/etiology , HIV Infections/complications , Acquired Immunodeficiency Syndrome/complications , AIDS-Related Complex/etiology , Arthritis, Reactive/etiology , Diagnosis, Differential , Musculoskeletal Diseases/etiology , Lymphocytosis/etiology , Neuromuscular Diseases/etiology , Polymyositis/etiology , Vasculitis/etiologyABSTRACT
Musculo-skeletal symptoms in hypothyroidism are frequent [30 80%] ranging from myasthenia, hypertrophic myopathy to just motor delay or cramps. These muscular abnormalities may be the major feature of hypothyroidism. But polymyositis is unusual in primary hypothyroidism. Are these manifestations favorised by muscular toxicity of fibrates = By the way, we report the case of 55 year old woman who was entered the hospital for clinical and laboratory features of poly myositis. She was treated for hypercholesterolemia by fenofibrate. The investigation of polymyositis 's aetiology revealed a moderate hypothyroidism associated to the muscular toxicity of fibrates. The authors will discuss the physiopathology of muscular symptoms in hypothyroidism and the associated muscular toxicity of fibrates
Subject(s)
Humans , Female , Musculoskeletal System/physiopathology , Musculoskeletal Diseases , Polymyositis/etiology , Fenofibrate/toxicity , Muscles , Cholesterol/bloodABSTRACT
We report a 68 years old male with a polymyositis associated to HTLV-I. Diagnosis was based on clinical picture, an increased creatin-phosphokinase levels, electromyography and muscle biopsy. The patient had positive HTVL-I antibodies, measured by particle agglutination test, indirect immunofluorescence and polymerase chain reaction in lymphocytes. Skin biopsy showed a mycosis fungoides. Schirmer test and minor salivary gland biopsy showed a dacryosialoadenitis. There was no central nervous system involvement. This patient is the only with positive HTLV-I antibodies, among 18 patients with polymiositis in whom these antibodies were measured
Subject(s)
Humans , Male , Aged , HTLV-I Antibodies/isolation & purification , HTLV-I Infections/complications , Polymyositis/etiology , Biopsy , Human T-lymphotropic virus 1/isolation & purification , Polymyositis/pathology , Creatine KinaseSubject(s)
Humans , Rheumatic Diseases/etiology , Human T-lymphotropic virus 1/pathogenicity , Arthritis/diagnosis , Arthritis/etiology , Rheumatic Diseases/classification , HTLV-I Infections/diagnosis , HTLV-I Infections/transmission , Leukemia, T-Cell/etiology , Polymyositis/diagnosis , Polymyositis/etiology , Sjogren's Syndrome/etiologyABSTRACT
A 52-year-old male received continuous oral amiodarone therapy for 3 years for the management of ventricular tachycardia nonresponsive to other antiarrhythmics, after he sustained a Q wave anterior myocardial infarction. He developed pain and weakness in both thigh and shoulder muscles in addition to weight loss and profuse sweating. His investigations confirmed the diagnosis of acute polymyositis and hyperthyroidism. His symptoms disappeared and the abnormal biochemical tests returned to normal after the withdrawal of amiodarone. We have not been able to find any other such report and believe that these were adverse side-effects of this drug