ABSTRACT
Control of hepatic coccidiosis in rabbits using two plant extracts [Calendula micrantha officinalis and Peganum harmala] was investigated. The LD[50] values of the two plant extracts against Eimeria stiedae oocyst viability in vitro were 31ppm for C.m.officinalis extract and I73pprn for P.harmala extract. The lethal effect of C.m.officinalis extract, which proved its potency in controlling E.stiedae oocysts as judged by LD[50], was probed by experimental infection of rabbits with C.m.officinalis treated oocyts. Occyst count and score lesions were considered as strong indications of plant extract efficacy in controlling hepatic coccidiosis. The curative effect of C.m.officinalis extract on hepatic coccidiosis was investigated by treating rabbits with a dose of 30ppm/ kg body weight. The present study indicated that, this plant extract could be effective as a new biological control agent of hepatic coccidial oocysts
Subject(s)
Animals, Laboratory , Liver/parasitology , Oocytes , Rabbits , Protective Agents/therapy , Plant Extracts , CalendulaABSTRACT
Paracetamol, in toxic doses is associated with extensive liver damage. This study was undertaken to investigate the hepatoprotective effect of cinnamon bark oil [CBO] and nigella sativa oil [NSO] in comparison to N- acetyl cysteine [NAC] in rats treated with toxic doses of Paracetamol [PCM]. The study included 6 groups, each group consists of 6 rats: control group received distilled water orally. Rats treated with toxic dose of PCM [400 mg/kg] three groups received NAC [800 mg/kg], CEO [300 mg/kg] and NSO [288 ml/kg] as antidotes 2 hours after PCM intoxication. The last group received CEO 8 hours post PCM intoxication Twenty-four hours after treatment the rats were sacrificed and blood was collected. The 3 antidotes decreased the activity of hepatic enzymes [AST and ALT] and billirubin compared to the PCM treated rats [P < 0.001]. Liver architecture showed improvement in the antidote treated groups compared to the PCM treated rats. The antidotes enhanced the elevation of the antioxidants [Glutathione [GSH], GSH-Peroxidase GSH-Reductase and Superoxide dismutase [SOD]] compared to their levels in PCM treated rats [P <0.001]. It is concluded that CBO either given early or late and NSO have hepatoprotective effect as well as that of NAC