Fulminant auricular mucormycosis in a diabetic patient

Human mucormycosis is an atypical fungal infection that commonly affects the skin, but rarely the auricular region. A 32-year-old diabetic woman, agricultural worker, was admitted with swelling, redness and mild signs of epidermolysis of the left ear, associated with intense pain, facial paralysis and septic signs. The ear cellulitis evolved into necrosis of the same region on the following day. Surgical debridement was performed and antimycotic therapy was started with poor response. The patient died in 48h. Culture was confirmatory for Rhizopus sp. (AU)

Cutaneous mucormycosis of scalp and eyelids in a child with type I diabetes mellitus.

Scalp mucormycosis in children is extremely rare. We present a case of pediatric scalp mucormycosis caused by Rhizopus oryzae in a 9-year-old diabetic girl who was successfully diagnosed and treated with amphotericin B deoxycholate and wound debridement. At 3 months follow up, the patient was stable although she had lost her vision.

Actividad antifúngica del quitosano y aceites esenciales sobre Rhizopus stolonifer -Ehrenb: Fr Vuill, agente causal de la pudrición blanda del tomate / Antifungal activity of chitosan and essential oils on Rhizopus stolonifer Ehrenb: Fr Vuill causal agent of soft rot of tomato

Rhizopus stolonifer es el agente causal de la pudrición blanda, enfermedad poscosecha que ocasiona pérdidas económicas importantes. Se han empleado fungicidas sintéticos como el dicloran para controlar a este microorganismo, sin embargo, se ha demostrado que los fungicidas representan un riesgo para el ambiente y la salud humana. Actualmente se buscan alternativas naturales para el control de las pudriciones poscosecha. Se evaluó in vitro e in situ el efecto antifúngico del quitosano y de los aceites esenciales de canela (Cinnamomum zeylanicum), clavo (Syzygium aromaticum) y tomillo (Thymus vulgaris) y dicloran sobre Rhizopus stolonifer. Los tratamientos más efectivos para inhibir in vitro a Rhizopus stolonifer fueron obtenidos con quitosano a 10 mg mL-1, con los tres aceites esenciales probados a la concentración de 0,3 mg mL-1, las mezclas de quitosano a 10 mg mL-1 con los aceites a 0,3 mg mL-1 y el dicloran a 1 mg mL-1. Los experimentos in situ mostraron que el tratamiento individual con quitosano fue el mejor para reducir el porcentaje de infección de los frutos de tomate (Lycopersicon esculentum) inoculados con Rhizopus stolonifer y que la mezcla de quitosano con aceites esenciales no mejora la actividad antifúngica. El quitosano y el dicloran fueron los mejores tratamientos para reducir la pérdida de peso de los frutos. Los tratamientos individuales con quitosano representan una alternativa natural para controlar la pudrición blanda en frutos de tomate.

Rhizopus stolonifer is the causal agent of soft rot, postharvest disease that causes important economic losses. Synthetic fungicides such as dichloran have been used to control this microorganism; however, it has been shown that fungicides represent a risk for the environment and human health. Actually, natural alternatives are looked for the control of postharvest rotting. In vitro and in situ experiments the antifungal effect of chitosan, essential oils of cinnamon (Cinnamomum zeylanicum), clove (Syzygium aromaticum), and thyme (Thymus vulgaris) and dichloran on Rhizopus stolonifer were evaluated. The most effective treatments for in vitro inhibition of Rhizopus stolonifer were obtained by quitosano to 10 mg mL-1, with the three essential oils proved to the concentration of 0.3 mg mL-1, the mixtures chitosan to 10 mg mL-1 with the oils at 0.3 mg mL-1 and dichloran at 1 mg mL-1. In situ experiments showed that the individual treatment with chitosan was the best to reduce the infection percentage of the tomato (Lycopersicon esculentum) fruits inoculated with Rhizopus stolonifer and chitosan mixture with essential oils did not improve its antifungal activity. Chitosan and dichloran were the best treatments to reduce the weight loss of the fruits. Individual treatments with chitosan represent a natural alternative for the control of soft rot on tomato fruits.

unusual case of nasal mucormycosis caused by Rhizopus oryzae in a German shepherd dog

This study represents an unusual case of mucormycosis localized in nasal cavity of a German shepherd dog. The patient was a 1-year-old male guard dog with unilateral nasal epistaxis, mucopurulent nasal discharge, sneezing and nose pawing. The dog had a history of head trauma about 2 months before admission, which was associated with mild self-limited epistaxis. Initial nasal rhinoscopy showed severe turbinate destruction. The samples of nasal discharge were collected by nasal flush technique and submitted to the Central Laboratory of School of Veterinary Medicine in Tehran for routine cytological, mycological and bacteriological examinations. Direct microscopic examination with 10% KOH/DMSO wet mount revealed the fragments of non-septate hyphae. The fungus was recovered in culture and identified as Rhizopus oryzae. This case showed that the veterinary practitioners should be aware of the possibility of localized nasal mucormycosis when examining dogs with chronic nasal discharge

Mucormicosis: estudio de cinco casos hallados en los hospitales San Juan de Dios y Sor María Ludovica, La Plata, Argentina / Mucormicosis: study of five cases found in San Juan de Dios and Sor María Ludovica Hospitals of La Plata, Argentina

Se estudiaron cinco casos de micromicosis en los hospitales San Juan de Dios y Sor María Ludovica de La Plata entre los años 1980 y 1997. La mucormicosis se presenta como una enfermedad oportunista, grave, frecuentemente mortal, que afecta a individuos con una afección primaria que favorece la invasión del microorganismo (diabetes, inmunodepresión, linfomas, leucemia, quemados, etc.). En este trabajo presentamos tres casos de mucormicosis cutáneas en niños de 3, 10 y 11 años de edad, secundarias a politrautamismos y fracturas expuestas sufridas en accidentes automovilísticos; un caso de mucormicosis pulmonar en un adulto de 28 años de edad que había recibido corticoterapia prolongada y una mucormicosis rinocerebral en un paciente de 38 años de edad, cuya enfermedad primaria era una leucemia linfoide aguda

Zigomicosis rino-sinuso-orbital post-traumática / Post-traumatic rhino-sinus-orbital zygomycosis

Se describe un caso de zigomicosis rino-seno-orbital en un paciente sin antecedentes de inmunodeficiencia que presenta exolftalmia izquierda y lesiones infiltrativas edematosas en párpado inferior, nariz y región molar homolateral de rápida evolución. El hallazgo de abundantes hifas hialinas anchas, no tabicadas y tortuosas en biopsia cutánea de fistula intraorbitaria y en secreción nasal, junto a la obtención de cultivos puros de rhizopus oryzae, confirmaron el diagnóstico. La extracción del 2º molar superior izquierdo se interpretó como factor local de implantación traumática del agente etiológico y el reconocimiento de los síntomas clínicos iniciales fue crucial para el diagnóstico precoz. esta micosis no constituye un grave problema de salud, no obstante, en Tucumán debe tenerse presente su existencia

Mucormicosis rinocerebral por Rhizopus sp / Cerebral mucormycosis by Rhizopus sp

Masculino de 24 años de edad con diabetes mellitus insulino-dependiente descompensada, cetoacidosis y mucormicosis rinocerebral por Rhizopus sp. Se trató en forma multidisciplinaria con control metabólico, anfotericina B y extensa debridación del área necrótica. El resultado fue satisfactorio; se planeó reconstrucción quirúrgica

role of plant growth regulators on spore germination, dry weight and nucleic acids content of pathogenic fungus rhizopus stolonifer

The effect of two plant growth regulator substances [GA3 and IAA] on spore germination, dry weight and nucleic acid content has been investigated on the growth of pathogenic fungus Rhizopus stolonifer/At low concentrations of both susbtances [GA3 and IAA] no stimulatory effect was observed on vegetative growth and nucleic acids content, while a gradual inhibition was observed at high concentration. The only stimulatory effect with both substances [GA3 and IAA] was detected on sporangiospore germination of Rhizopus stolonifer at the range of concentration between 10 and 100 ppm. Higher concentration showed a delay of germination

Mucormicosis: infeccion necrosante de tejidos blandos por Rhizopus arrhizus / Mucormycosis: necrotizing infection of soft tissues by Rhizopus arrhizus

Se informa un nuevo caso de mucormicosis cutanea por Rhizopus arrhizus, observado en una paciente lesionada durante la catastrofe acaecida en Armero, Colombia, en noviembre de 1985. Se revisa la literatura y se plantea una nueva forma de clasificacion de las infecciones necrosantes de la piel y tejidos blandos, dividiendolas en clostridiales, no clostridiales y micoticas para facilitar su diagnostico y tratamiento.