Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Rosacea/diagnosis , Rosacea/etiology , Rosacea/parasitology , Rosacea/therapy , Aurum Fulminans , Erythema , TelangiectasisABSTRACT
Abstract Recent studies about the cutaneous barrier demonstrated consistent evidence that the stratum corneum is a metabolically active structure and also has adaptive functions, may play a regulatory role in the inflammatory response with activation of keratinocytes, angiogenesis and fibroplasia, whose intensity depends primarily on the intensity the stimulus. There are few studies investigating the abnormalities of the skin barrier in rosacea, but the existing data already show that there are changes resulting from inflammation, which can generate a vicious circle caused a prolongation of flare-ups and worsening of symptoms. This article aims to gather the most relevant literature data about the characteristics and effects of the state of the skin barrier in rosacea.
Subject(s)
Humans , Skin/physiopathology , Rosacea/physiopathology , Skin/blood supply , Skin Physiological Phenomena , Water Loss, Insensible/physiology , Sebum/physiology , Rosacea/etiology , Dermatitis/physiopathologyABSTRACT
Rosacea is a prevalent chronic cutaneous disorder with variable presentation and severity. Although considered a skin disease, rosacea may evolve the eyes in 58-72% of the patients, causing eyelid and ocular surface inflammation. About one third of the patients develop potentially sight-threatening corneal involvement. Untreated rosacea may cause varying degrees of ocular morbidity. The importance of early diagnosis and adequate treatment cannot be overemphasized. There is not yet a diagnostic test for rosacea. The diagnosis of ocular rosacea relies on observation of clinical features, which can be challenging in up to 90% of patients in whom accompanying roseatic skin changes may be subtle or inexistent. In this review, we describe the pathophysiologic mechanisms proposed in the literature, clinical features, diagnosis and management of ocular rosacea, as well as discuss the need for a diagnostic test for the disease.
A rosácea é uma condição cutânea crônica, que possui apresentações clínicas variáveis. Apesar de considerada uma doença dermatológica, os olhos podem ser acometidos em 58-72% dos casos, causando inflamação palpebral e da superfície ocular. Aproximadamente um terço dos pacientes desenvolve acometimento corneano, podendo causar baixa visual significativa. Diagnóstico precoce e tratamento adequado são de extrema importância, devido à significativa morbidade ocular que a doença pode causar. Não há, até o momento, um teste diagnóstico para rosácea. O diagnóstico da rosácea ocular depende da observação das manifestações clínicas, o que pode ser bastante desafiador em até 90% dos pacientes, em que os achados cutâneos são discretos ou inexistentes. Nesta revisão, descrevemos os mecanismos fisiopatológicos propostos na literatura, manifestações clínicas, diagnóstico e tratamento da rosácea ocular, assim como abordamos a necessidade de um teste diagnóstico.
Subject(s)
Humans , Rosacea , Diagnosis, Differential , Rosacea/diagnosis , Rosacea/etiology , Rosacea/physiopathology , Rosacea/therapySubject(s)
Humans , Rosacea/diagnosis , Rosacea/therapy , Diagnosis, Differential , Rosacea/classification , Rosacea/etiologyABSTRACT
Demodex spp of humans are encountered frequently all over the world. The role of these parasites is controversial in the causation of skin diseases. This study was carried out to determine the prevalence and the association of Demodex spp with acne rosacea. The study was conducted between the years of 2005-2008 in the output clinic of Dermatology and Parasitology Laboratory of Health Research and Training Hospital of Yuzuncu Yil University. One hundred two patients [patient group] composing of 59 females and 43 males with acne rosacea and randomly selected 50 healthy subjects [control group] were examined for Demodex spp. Twenty seven patients were under the age of 35, and 75 patients were aging 35 years old and over. Samples were plucked out from surface of nose and forehead of patients with acne rosacea and healthy subjects by standardized surface skin biopsy [SSSB] method in the Laboratory. The preparations prepared in Hoyer solution were examined under 4X and 10X objectives of light microscope. The detected parasites were higher in the patient group with acne rosacea [67.65%] than the control group [6%], in females [76.27%] than males [55.81%] and in patients aging 35 years old and over [74.67%] than the patients under 35 years of age [48.15%]. Significant relationships were detected between acne rosacea and demodicosis, sex and demodicosis, and age and demodicosis [p<0.001, p<0.05 and p<0.05, respectively]. It was concluded that there is a relationship between the demodicosis and acne rosacea, and dermatologists should take into consideration the Demodex spp. in the etiology of acne rosacea
Subject(s)
Humans , Male , Female , Adult , Rosacea/etiology , Prevalence , BiopsySubject(s)
Humans , Antimicrobial Cationic Peptides/metabolism , Rosacea/metabolism , Rosacea/pathology , Kallikreins/metabolism , Oxidative Stress/physiology , Ferritins/radiation effects , Ferritins/metabolism , Inflammation/metabolism , Antimicrobial Cationic Peptides/physiology , Rosacea/etiologyABSTRACT
La rosácea es una condición crónica muy común en la práctica clínica diaria, principalmente en poblaciones de origen celta. Se caracteriza más frecuentemente por eritema centrofacial transitorio o persistente, vasos sanguíneos visibles, y a menudo, pápulas y pústulas. Fimas y compromiso ocular pueden presentarse. Basados en los hallazgos clínicos, se divide en cuatro subtipos: eritemato-telangiectásica, papulopustular, fimatosa y ocular. La causa es a la fecha desconocida y varias hipótesis plantean que incluyen el papel potencial de anomalías vasculares, degeneración de la matriz dérmica, factores ambientales y microorganismos tales como Demodex folliculorum y Helicobacter pylori. El tratamiento dependerá del subtipo clínico. Se discuten las indicaciones y las alternativas terapéuticas, ya sean tópicas, orales, láser y luz.
Rosacea is a chronic condition very common in clinical practice mainly among celtic population. It is characterized by transient or persistent central facial erythema, visible blood vessels, and often papules and pustules. Phymas and ocular involvement can be found. Based on the physical findings, rosacea can be classified into 4 broad subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. The cause is unknown and several hypotheses have been postulated and include potential roles for vascular abnormalities, dermal matrix degeneration, environmental factors, and microorganisms such as Demodex folliculorum and Helicobacter pylori. Treatment depends on the clinical subtype. Indications and different therapeutics oral, topical, laser and lights are discussed.
Subject(s)
Humans , Rosacea/classification , Rosacea/diagnosis , Rosacea/therapy , Rosacea/etiologyABSTRACT
La rosácea es una enfermedad crónica que puede asociarse e incluso debutar con un compromiso ocular (rosácea ocular), siendo ésta principalmente de predominio palpebral (blefaritis), conjuntiva y/o corneal, es decir, fundamentalmente del polo anterior del ojo. Se presume multifactorial, siendo la alteración de la composición del componente lipídico de la lágrima, motivada por lipasas estafilocócicas aumentadas y meibomitis, los eventos precursores más ampliamente aceptados. Actualmente el tratamiento se basa en fotoprotección ocular, uso de lágrimas artificiales y antibioticoterapia oral y tópica. Otras alternativas de segunda línea son el metronidazol, isotretinoína tópica y sistémica, cirugía y oclusión del punto lacrimal.
Subject(s)
Humans , Eye Diseases/etiology , Eye/pathology , Rosacea/complications , Rosacea/etiology , Rosacea/therapy , Adjuvants, Immunologic/therapeutic use , Anti-Bacterial Agents/therapeutic use , Blepharitis/etiology , Conjunctivitis/etiology , Corneal Diseases/etiology , Lacrimal Apparatus Diseases/physiopathology , Scleritis/etiology , Iritis/etiology , Lubrication , Eyelids/pathology , Ophthalmic Solutions/therapeutic useABSTRACT
In rosacea patients [ages 11-50 years old] 44% were infested with D. folliculorum as compared to normal controls [23.0%]. The difference was significant. The mean +/- SD of mite density ranged between 13.2 +/- 0.9 to 18.2 +/- 1.2 as compared to normal controls with mite density ranged between 1.4 +/- 0.25 to 2.4 +/- 0.3. Demodex infestation in rosacea patients was 66.1% in squamous, 66.7% in erythemato-telangiectate and 83.3% in papulo pustular rosacea. The highly infested site was check [27.3%] with mean mite density of 25.3 +/- 1.3, followed by the area around the orbit [23.4%] with a density of 19.0 +/- 1.2, the area around the nose [19.5%] with mite density of 7.1 +/- 1.5, then chin [15.6%] with a density of 8.2 +/- 1.4 and lastly the area around the mouth [14.1%] with a mite density of 14.2 +/- 1.3. Undoubtedly, infestation with D. folliculorum particularly in large number causes rosacea
Subject(s)
Humans , Female , Rosacea/etiology , Mite Infestations , Tick ControlSubject(s)
Humans , Male , Female , Helicobacter pylori/pathogenicity , Helicobacter Infections/complications , Helicobacter Infections/physiopathology , Lymphoma, B-Cell/classification , Lymphoma, B-Cell/physiopathology , Lymphoma, T-Cell/classification , Lymphoma, T-Cell/physiopathology , Autoimmune Diseases/etiology , Coronary Disease/etiology , Diabetes Mellitus/etiology , Raynaud Disease/etiology , Failure to Thrive/etiology , Menarche , Puberty, Delayed/etiology , IgA Vasculitis/etiology , Gastroesophageal Reflux/etiology , Rosacea/etiology , Skin Diseases/etiology , Thyroiditis, Autoimmune/etiology , Urticaria/etiologyABSTRACT
Utilizando consideraçöes encontradas na literatura,säo apresentadas as principais características da rosácea quanto a três aspectos fundamentais para sua compreensäo: os fatores de risco (idade, sexo, fototipo cutâneo e suscetibilidade ao flushing), a etiologia (predisposiçäo genética e fatores provocativos) e a patogênese (alteraçöes no tecido de sustençäo da derme, reatividade vascular anormal, capilarogênese e processo inflamatório). O autor conclui que pesquisas na área da bioquímica seräo importantes na definiçäo de prováveis mediadores envolvidos no desenvolvimento da rosácea (alguns neuropeptídeos e certas citoquinas)
Subject(s)
Humans , Risk Factors , Rosacea/etiology , Rosacea/geneticsABSTRACT
Se estudió un grupo de 84 mujeres (promedio de edad 24 años, rango 16 a 37) que consultaron por alguna manifestación del síndrome androgénico cutáneo (75 por ciento acné, 15 por ciento alopecia y 10 por ciento hirsutismo). De este grupo de enfermas, el 54 por ciento presentaba asociado algún tipo de dismenorrea (principalmente oligomenorrea 45 por ciento). Se pudo comprobar que un 52 por ciento de ellas presentaba valores elevados de la 17 alfa-hidroxiprogesterona (x= 1,48 ng/ml), lo cual abrió la sospecha de una hiperplasia adrenal congénica de presentación tardía y leve como causa de androgenismo cutáneo. Este diagnóstico se pudo comprobar en un 7 por ciento por pruebas funcionales, además de haber observado un 8,3 por ciento de poliquistosis ovárica y un 9,5 por ciento de hipotiroidismo