ABSTRACT
Cutaneous manifestations in disseminated strongyloidiasis are infrequent but should raise the suspicion for its diagnosis. We retrospectively evaluated the charts of six patients with cancer and a proven diagnosis of disseminated strongyloidiasis. All patients had received prophylaxis with albendazole before starting antineoplastic therapy, which included high-dose steroids. They presented with septic shock, acute respiratory failure and characteristic purpuric periumbilical skin lesions. Strongyloides larvae were identified in tracheal aspirates (n=5), gastric aspirates (n=4), lung (n=2) and skin biopsies (n=2). All patients died despite antihelminthic therapy and intensive care support.
Subject(s)
Adult , Aged , Animals , Female , Humans , Male , Middle Aged , Neoplasms/parasitology , Neoplasms/pathology , Purpura/pathology , Skin Diseases, Parasitic/pathology , Strongyloides stercoralis/isolation & purification , Strongyloidiasis/pathology , Anthelmintics/therapeutic use , Biopsy , Fatal Outcome , Immunocompromised Host , Neoplasms/immunology , Purpura/immunology , Purpura/parasitology , Skin Diseases, Parasitic/complications , Skin/parasitology , Skin/pathology , Strongyloidiasis/complications , Strongyloidiasis/drug therapyABSTRACT
Las causas más importantes de morbimortalidad en los pacientes receptores de trasplantes de órganos son las infecciones y el rechazo del injerto. Las infecciones cutáneas en estos pacientes se presentan en forma proteiforme y es muy extensa la lista de diagnósticos diferenciales. Presentamos nuestra experiencia y una revisión sobre infecciones cutáneas en pacientes con trasplante de órganos sólidos destacando la importancia del diagnóstico precoz y la necesidad de instaurar un esquema terapéutico adecuado