ABSTRACT
This incident case-control study of bleeding neonates in a Baby Friendly Hospital was done to obtain the prevalence and risk factors associated with bleeding disorders in the neonatal unit. During a 4-month period from August to November 1998; 175 out of 1628 admitted infants were found to have some sort of bleeding. These were compared with 414 control infants. Prematurity; Low Birth Weight; Caesarian Section and anesthesia; and presence of asphyxia were significantly associated with bleeding. The Prothrombin and Activated Partial thromboplastin Test were not significantly altered in bleeding infants and had a poor correlation with clinical presence of a bleeding disorder.The low prevalence of bleeding disorder and coagulation defects is discussed and suggested that Breast Feeding may not be a risk factor for bleeding disorder in this unit. Further studies are needed in this regard
Subject(s)
Hemorrhagic Disorders , Infant , Infant, Newborn , Risk Factors , Vitamin K Deficiency/therapyABSTRACT
To determine whether low-dose of vitamin k[1] konakion MM] in newborns is as effective as intramuscular injection, resulting in normal adult plasma of vitamin k1, normal International Normalized Ratio [INR]. Term, breast-fed newborns recruited by a doctor before delivery by interview using a clearly written information sheet and signed consent. On day O infants received 250ug konakion MM orally in two equally divided doses. The midwife was then supplied with a 250 ug dose to be given at the 5-6th day. Mothers and infants re-attended the hospital between days 27-29 for blood to be obtained for further analysis [Plasma vitamin k, PIVKA II, International Normalized Ratio]. At the same visit, infants received a further 250ug dose which was repeated every 4-5 weeks for another 4-5 doses. Vitamin k1 as konakion MM given orally in two small doses of 125ug on the first day of life and 250ug on the fifth day was associated with mean plasma level of vitamin k1 at four weeks that were similar or higher than normal adult values
Subject(s)
Humans , Male , Female , Vitamin K Deficiency/therapy , Vitamin K/therapy , Infant, NewbornABSTRACT
Con la intención de describir los cambios en la actividad funcional y la concentración antigénica del factor II de la coagulación (protrombina) en neonatos, posterior a la administración profiláctica de vitamina K bucal. Se estudió a 16 neonatos de término, que recibieron bisulfito sódico de menadiona a dosis de 1 mg por vía bucal, dentro de la primera hora de vida. Se recolectaron las muestras de sangre venosa al nacimiento a las 24 y 72 horas de vida. Se estudió la actividad funcional del factor II, mediante el tiempo de protrombina (TP) y la actividad antigénica (Ag) del mismo factor, cuantificada mediante nefelometría de rayo láser. Los valores promedios del TP en los tiempos indicados fueron: 15.9, 15.1 y 13.8 segundo, contra 11.2, 11.7 y 11.7 s de los plasmas controles. Con respecto al Ag, se obtuvieron valores promedios de 3.2, 5.0 y 5.8 mg/dL, en los tiempos señalados. La mediana de la concentración porcentual del antígeno de la protrombina, mostró incremento progresivo de 39.2, 51,5 y 70.5 por ciento en los tres tiempos estudiados. Los resultados sugieren una deficiencia real de vitamina K, más que una disminución en la concentración de la protrombina. La dosis de un mg de vitamina K bucal, promueve in vitro, cambios en las proteínas precoagulantes del recién nacido. Se documentó el acortamiento del TP y aumento en la concentración del Ag, dentro de los valores normales del adulto, posterior a la administración de la vitamina K. El efecto hemostático favorable secundario a la administración de la vitamina K bucal, es semejante al obtenido por otros autores por vía intramuscular, pero sin los costos o riesgos inherentes a ésta última vía de administración