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1.
Gac. méd. Méx ; 156(6): 542-548, nov.-dic. 2020. graf
Article in Spanish | LILACS | ID: biblio-1249965

ABSTRACT

Resumen Introducción: En 2017, el INEGI reportó 84 142 defunciones por tumores malignos en México y la Organización Mundial de la Salud indicó que la tasa de mortalidad por cáncer de mama en 2018 fue de 11.2 por 100 mil mujeres. Objetivo: Mostrar la tendencia de la mortalidad por cáncer de mama en mujeres según municipio y región sanitaria de Jalisco en el periodo 2010-2017. Método: Estudio analítico en el que se estimaron tasas estandarizadas de mortalidad y riesgos relativos por municipio de residencia de 3873 mujeres. Se utilizó estadística espacial de dispersión y tendencia central. Resultados: La tasa de mortalidad aumentó de 10.7 a 13.0 por 100 mil mujeres en el periodo 2010-2017. Los valores más altos se encontraron en los municipios de Chapala (21.2) y Guadalajara (19.5), la tasa de mortalidad aumentó en cuatro de cada 10 municipios y el riesgo relativo fue hasta 50 veces mayor en algunos del occidente y centro de Jalisco. Conclusiones: Se observó un incremento de 1.0 % anual, aunque territorialmente diferenciado. Los resultados representan una oportunidad para mejorar los procesos de detección y diagnóstico oportunos, así como para garantizar la cobertura de los servicios.


Abstract Introduction: In 2017, INEGI reported 84,142 deaths from malignant tumors in Mexico, while the World Health Organization indicated that the breast cancer mortality rate in 2018 was 11.2 per 100,000 women. Objective: To show the trend of breast cancer mortality in women by municipality and health region of Jalisco in the 2010-2017 period. Method: Analytical study in which standardized mortality rates and relative risks of 3873 women were estimated by municipality of residence. Dispersion and central tendency spatial statistics were used. Results: The mortality rate increased from 10.7 to 13.0 per 100,000 women in the 2010-2017 period. The highest values were found in the municipalities of Chapala (21.2) and Guadalajara (19.5); the mortality rate increased in four out of every 10 municipalities, and relative risk was up to 50-fold higher in some of the western and central Jalisco municipalities. Conclusions: An annual increase of 1.0 % was observed, although it was territorially differentiated. The results represent an opportunity to improve timely detection and diagnostic processes, as well as to guarantee the coverage of services.


Subject(s)
Humans , Female , Breast Neoplasms/mortality , Risk , Mortality/trends , Spatial Analysis , Mexico/epidemiology
2.
J. health med. sci. (Print) ; 6(1): 29-36, ene.-mar. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1096530

ABSTRACT

En la actualidad, los análisis de distribución espacial mediante el uso de técnicas de clusters para enfermedades crónicas como el cáncer de mama, son relevantes para la identificación de patrones espaciales de la mortalidad por cáncer según áreas geográficas. Identificar clústeres espaciales de la mortalidad por cáncer de mama en mujeres a nivel de las provincias del Ecuador, entre 2004 al 2018. Estudio observacional, de tipo descriptivo, ecológico multigrupal que compara a nivel espacio ­ temporal las tasas de mortalidad por cáncer de mama en mujeres según las provincias del Ecuador, utilizando el índice de Móran para el análisis de autocorrelación y el algoritmo de k-medias para el análisis de agrupamiento en períodos quinquenales mediante el programa informático ArcGIS versión 10.5. Resultados. En el Ecuador, el 86,5% de las muertes por cáncer de mama en mujeres se registraron en el área urbana, dichas muertes tienen un patrón no aleatorio según el índice de Morán, distinto al área rural que tiene un patrón aleatorio; se identificó diferencia en el agrupamiento de la mortalidad por cáncer de mama en las provincias urbanas y rurales, donde se obtuvo para el área urbana, clústeres con altas, media-altas, media-baja y bajas tasas de mortalidad, mientras que en lo rural se obtuvieron solo clústeres con altas, medias y bajas tasas de mortalidad. La distribución espacial y el análisis de agrupamiento identificó clústeres de la mortalidad por cáncer de mama en el Ecuador, evidenciando entre lo urbano y rural diferencias en los clústeres obtenidos, siendo esta información de utilidad para la implementación de estrategias de control del cáncer en el país.


Currently spatial distribution analyzes through the use of cluster techniques for chronic diseases such as breast cancer are revealing for the identification of spatial patterns of cancer mortality according to geographic areas. Objective. Identify spatial clusters of breast cancer mortality in women at the level of the provinces of Ecuador, between 2004 to 2018. We used an observational, descriptive, ecological multigroup study that compares at a Spatio-temporal level the rates of breast cancer mortality in women according to the provinces of Ecuador, using the Moran index for the autocorrelation analysis and the k-, means algorithm for cluster analysis in five-year periods using the ArcGIS version 10.5 software. Results. In Ecuador, 86.5% of breast cancer deaths in women were recorded in the urban area, these deaths have a non-random pattern according to the Morán Index different from the rural area that has a random pattern; difference was identified in the grouping of breast cancer mortality in urban and rural provinces, where it was obtained for urban areas, clusters with high, medium. high, medium-low and low mortality rates. While in rural areas only clusters with high, medium and low mortality rates were obtained. Conclusions. The spatial distribution and cluster analysis identified clusters of breast cancer mortality in Ecuador; evidencing between urban and rural differences in the clusters obtained, this information is useful for the development of cancer control strategies in the country.


Subject(s)
Humans , Female , Breast Neoplasms/mortality , Cluster Analysis , Rural Areas , Demography , Urban Area , Ecuador/epidemiology , Spatial Analysis
3.
Rev. saúde pública (Online) ; 54: 142, 2020. tab, graf
Article in English | LILACS, BBO, SES-SP | ID: biblio-1145051

ABSTRACT

ABSTRACT OBJECTIVE To verify the spatial pattern of mortality from breast and cervical cancer in areas of primary health care, considering socioeconomic conditions. METHODS This is an ecological study, from January 2000 to December 2016. The study area is the municipality of São Paulo, Brazil, and its 456 coverage areas of primary health units. Information on deaths of women aged 20 years or over were geocoded according to residence address. We calculated mortality rates, standardized by age, and smoothed by the local empirical Bayesian method, and grouped into three or two years to reduce the random fluctuation of the data. In addition, bivariate global and local Moran indexes were calculated to verify the existence of spatial agglomeration of standardized mortality rates with a domain of socioeconomic condition, elaborated based on the Índice Paulista de Vulnerabilidade Social (IPVS - São Paulo Index of Social Vulnerability). RESULTS The success rate of geocoding was 98.9%. Mortality from breast cancer, without stratification by time, showed a pattern with higher rates located in central regions with better socioeconomic conditions. It showed a decrease at the end of the period and a change in spatial pattern, with increased mortality in peripheral regions. On the other hand, mortality from cervical cancer remained with the highest rates in peripheral regions with worse socioeconomic conditions, despite being reduced over time. CONCLUSION The spatial pattern of mortality from the studied cancers, over time, suggests association with the best socioeconomic conditions of the municipality, either as protection (cervical) or risk (breast). This knowledge may direct resources to prevent and promote health in the territories.


RESUMO OBJETIVOS Verificar o padrão espacial da mortalidade pelos cânceres de mama e do colo do útero, em áreas da atenção primária à saúde, levando em consideração as condições socioeconômicas. MÉTODOS O estudo é ecológico, de janeiro de 2000 a dezembro de 2016. A área de estudo é o município de São Paulo, Brasil, e suas 456 áreas de abrangência das unidades básicas de saúde. As informações sobre óbitos de mulheres com 20 anos ou mais de idade foram geocodificadas segundo endereço de residência. Foram calculadas as taxas de mortalidade, padronizadas por idade, e suavizadas pelo método bayesiano empírico local, além de agrupadas em três ou dois anos para reduzir a flutuação aleatória dos dados. Além disso, foram calculados os índices de Moran global e local bivariados, para verificar a existência de aglomeração espacial das taxas de mortalidade padronizadas com um domínio de condição socioeconômica, elaborado a partir do Índice Paulista de Vulnerabilidade Social. RESULTADOS A taxa de sucesso da geocodificação foi de 98,9%. A mortalidade por câncer de mama, sem estratificação por tempo, apresentou um padrão com maiores taxas localizadas nas regiões centrais e com melhores condições socioeconômicas. Apresentou queda ao final do período e mudança de padrão espacial, com aumento da mortalidade nas regiões periféricas. Já a mortalidade por câncer do colo do útero manteve-se com as maiores taxas nas regiões periféricas e com piores condições socioeconômicas, apesar de apresentar redução ao longo do tempo. CONCLUSÃO O padrão espacial da mortalidade pelos cânceres do estudo, ao longo do tempo, sugere associação com as melhores condições socioeconômicas do município, seja como proteção (colo) ou risco (mama). Esse conhecimento pode direcionar recursos para a prevenção e a promoção da saúde nos territórios.


Subject(s)
Humans , Male , Adult , Young Adult , Breast Neoplasms/mortality , Uterine Cervical Neoplasms/mortality , Brazil/epidemiology , Bayes Theorem , Cities/epidemiology , Spatial Analysis
4.
Medwave ; 20(1): e7766, 2020.
Article in English, Spanish | LILACS | ID: biblio-1053124

ABSTRACT

INTRODUCCIÓN El cáncer de mama es la neoplasia maligna más común en las mujeres en todo el mundo y en Chile, siendo la primera causa de muerte oncológica femenina. Se ha reportado amplia variación en la mortalidad, con focos geográficos de mayor riesgo. OBJETIVO Analizar espacialmente la mortalidad por cáncer de mama en mujeres de la Región Metropolitana en 2015. MÉTODOS Estudio ecológico. Se utilizaron los datos de los registros de defunciones del año 2015 (C50 según CIE10), y las proyecciones poblacionales del Instituto Nacional de Estadísticas. Se calcularon tasas de mortalidad por cáncer de mama brutas y razones de mortalidad estandarizadas. Se realizó un análisis epidemiológico espacial estimando el índice I de Moran Global y Local para evaluar autocorrelación espacial. Los resultados se presentan en mapas (cartografía precenso 2016). RESULTADOS Se registraron 622 defunciones por cáncer de mama en la Región Metropolitana en 2015. La edad promedio de las mujeres fallecidas fue de 66 años (desviación estándar: 15,5). El 92,4% de las muertes se registró en zonas centrales o urbanas. Sin embargo, las mayores tasas de mortalidad se observaron en comunas periféricas. No se observó autocorrelación espacial global en la región (I de Moran de 0,007; p = 0,134). A nivel local, cuatro comunas se diferencian de forma significativa de sus vecinas. CONCLUSIONES El riesgo de morir por cáncer de mama en la Región Metropolitana de Chile se concentra en comunas periféricas. Cuatro comunas de la región presentan riesgos diferentes de sus comunas vecinas, por lo que es necesario explorar factores que explican la desigual distribución de las muertes.


INTRODUCTION Breast cancer is the most common malignancy in women worldwide and Chile, being the leading cause of female cancer death. A wide variation in mortality has been reported, with geographic clusters of higher risk. OBJECTIVE To spatially analyze mortality from breast cancer in women in the Metropolitan Region in 2015. METHODS Ecological study of location. We used death records in 2015 (C50 according to ICD10) and population projections of the Statistics Institute to estimate mortality rates. We calculated crude breast cancer mortality rates and standardized mortality ratios and performed a spatial epidemiological analysis of breast cancer mortality in women, estimating the global and local Moran I index to assess spatial autocorrelation. We present the results in maps according to the 2016 pre-census cartography. RESULTS There were 622 deaths from breast cancer in the Metropolitan Region in 2015. The mean age was 66 years (SD: 15.5). 92.4% of deaths were registered in urban or central areas. However, the highest mortality rates were observed in peripherical districts. No global spatial autocorrelation was observed in the region (Moran's I 0.007 p = 0.134). However, at the local level, four districts differ significantly from their neighbors. CONCLUSIONS The risk of dying from breast cancer in the Metropolitan Region of Chile is concentrated in women from peripherical communes. Four districts in the region present different risks from their neighboring districts. It is necessary to investigate local realities to prevent deaths from this pathology.


Subject(s)
Humans , Female , Aged , Breast Neoplasms/mortality , Rural Population/statistics & numerical data , Suburban Population/statistics & numerical data , Urban Population/statistics & numerical data , Chile/epidemiology , Death Certificates , Risk Factors
5.
Rev. bras. cancerol ; 66(1): 1-8, 20200129.
Article in Portuguese | LILACS | ID: biblio-1095192

ABSTRACT

Introdução: Informações sobre mortalidade por câncer de mama podem ser úteis para o planejamento de políticas públicas. Objetivo: Analisar a tendência da mortalidade por câncer de mama em mulheres no Estado do Ceará. Método: Estudo descritivo exploratório cujas variáveis utilizadas foram: ano e local da ocorrência do óbito, sexo, causa básica de morte e a idade em faixa etária. A análise estatística dos dados foi realizada no programa Gretl, por meio de regressão linear, no qual as taxas de mortalidade por câncer de mama foram consideradas variáveis dependentes e os anos do período estudado, variáveis independentes. Foram apresentados os coeficientes de regressão, seus intervalos de confiança de 95% e os respectivos valores-p dos testes de significância estatística. Resultados: Foram notificados 141.168 óbitos por câncer de mama em todo o Brasil. O Estado Ceará representa 3,73% desse total e apresentou um aumento de 92,7% no número de óbitos por câncer de mama. Observou-se um aumento das taxas específicas de mortalidade a partir dos 40 anos de idade se mantendo crescente até a última faixa etária pesquisada. Conclusão: A análise realizada neste estudo evidenciou uma tendência progressiva no número de óbitos no Ceará, no Nordeste e no Brasil. É imprescindível a elaboração de estratégias que priorizem ações, a fim reduzir o atraso na condução dos casos de câncer de mama nos serviços de saúde para que a detecção precoce reduza o número de óbitos.


Introduction: Information on breast cancer mortality can be useful for planning public policies. Objective: Analyze the trend of mortality from breast cancer in women in the state of Ceará. Method: Exploratory descriptive study whose variables were: year and place of death, sex, basic cause of death, and age in an age range. The statistical analysis of the data was performed in the Gretl program by means of linear regression where the breast cancer mortality rates were considered dependent variables and he years of the study period, the independent variables. The regression coefficients, their 95% confidence intervals and the respective p-values of the tests of statistical significance were presented. Results: 141,168 deaths from breast cancer were reported across Brazil. The state of Ceará represents 3.73% of this total and had a growth of 92.7% in the number of deaths from breast cancer. There was an increase in specific mortality rates from the age of 40 onwards, increasing until the last age group surveyed. Conclusion: The analysis carried out in this study showed a progressive trend in the number of deaths in Ceará, in the Northeast and in Brazil. It is essential to develop strategies that prioritize actions to shorten the delay in the management of breast cancer cases in health services so that early detection reduces the number of deaths.


Introducción: la información sobre mortalidad por cáncer de mama puede ser útil para planificar políticas públicas. Objetivo: Analizar la tendencia de mortalidad por cáncer de seno en mujeres en el Estado de Ceará. Método: Estudio exploratorio descriptivo cuyas variables utilizadas fueron: año y lugar de muerte, sexo, causa básica de muerte y edad en unrango de edad. El análisis estadístico de los datos se realizó en el programa Gretl mediante regresión lineal donde las tasas de mortalidad por cáncer de mama se consideraron variables dependientes y los años del período estudiado fueron variables independientes. Se presentaron los coeficientes de regresión, sus intervalos de confianza del 95% y los respectivos valores p de las pruebas de significación estadística. Resultados: Se notificaron 141.168 muertes por cáncer de mama en todo Brasil. El Estado de Ceará representa el 3,73% de este total e mostró un aumento del 92,7% en el número de muertes por cáncer de seno. Hubo un aumento en las tasas de mortalidad específicas a partir de los 40 años, aumentando hasta el último grupo de edad encuestado. Conclusión: El análisis realizado en este estudio mostró una tendencia progresiva en el número de muertes en Ceará, en el noreste y en Brasil. Es esencial desarrollar estrategias que prioricen las acciones para reducir la demora en el manejo de casos de cáncer de seno en los servicios de salud para que la detección temprana, reduciendo así el número de muertes.


Subject(s)
Humans , Female , Breast Neoplasms/mortality , Breast Neoplasms/epidemiology , Brazil , Time Series Studies , Mortality/trends , Age Distribution
6.
Rev. bras. cancerol ; 66(1)20200129.
Article in Portuguese | LILACS | ID: biblio-1094926

ABSTRACT

Introdução: O câncer de mama é a neoplasia que mais causa mortes na população feminina mundial e brasileira. Objetivo: Analisar o perfil epidemiológico, a tendência e a distribuição espacial da mortalidade por câncer de mama feminino em Alagoas no período de 2001 a 2016. Método: Trata-se de um estudo ecológico misto, incluindo os óbitos femininos por câncer de mama registrados em Alagoas durante esse período. Foram utilizadas as variáveis sociodemográficas (faixa etária, cor/raça, estado civil, escolaridade e local de ocorrência) e a taxa de mortalidade por faixa etária e por município do Estado. Os dados foram obtidos do Sistema de Informações sobre Mortalidade e os dados populacionais, do Instituto Brasileiro de Geografia e Estatística (IBGE). A análise de tendência utilizou o modelo de regressão por pontos de inflexão (joinpoint regression model) e a espacial, a estatística de Moran. Resultados: Houve 1.816 óbitos no período, 25,3% entre 50-59 anos, 46,3% de cor parda, 36,1% casadas, 35,5% com menos de oito anos de estudos e 67,2% de óbitos no ambiente hospitalar. As faixas etárias de 40 anos ou mais apresentaram tendências de crescimento, destacando-se 80 anos ou mais (percentual médio de variação anual: 9,2; p<0,001) com o maior crescimento. A distribuição espacial foi aleatória. Conclusão: A taxa de mortalidade por câncer de mama feminino cresceu no período de 2001 a 2016 nas faixas etárias de 40 anos ou mais no Estado e sem padrão espacial definido.


Introduction: Breast cancer is the neoplasm that causes more deaths in the female population worldwide and in Brazil. Objective: To analyze the epidemiological profile, trend and spatial distribution of female breast cancer mortality in Alagoas from 2001 to 2016. Method: Mixed ecological study, including female deaths from breast cancer recorded in Alagoas in the period. Sociodemographic variables (age, color/race, marital status, education and place of occurrence) and the specific mortality rate by age group and municipality were used. Data were obtained from the Mortality Information System and population data from the Brazilian Institute of Geography and Statistics (IBGE). The trend analysis used the Joinpoint regression model and Moran statistics for the spatial distribution. Results: 1,816 deaths in the period, 25.3% between 50-59 years, 46.3%, brown race, 36.1%, married, 35.5%, with less than 8 years of education and 67.2% of deaths within the hospital environment. The age groups of 40 years or older showed a growing trend and the highest growth, for 80 years old or more (average annual percent variation: 9.2; p<0.001). The spatial distribution was random. Conclusion: The mortality rate for female breast cancer increased in the period from 2001 to 2016 in the age group of 40 years and older in the state and without defined spatial pattern.


Introducción: El cáncer de mama es el cáncer que causa más muertes en la población femenina en todo el mundo y en Brasil. Objetivo: Analizar el perfil epidemiológico, la tendencia y la distribución espacial de la mortalidad por cáncer de mama femenino en Alagoas durante el período 2001 a 2016. Método: Este es un estudio ecológico mixto, que incluye muertes femeninas por cáncer de seno registradas en Alagoas durante el período. Se utilizaron variables sociodemográficas (grupo de edad, color/raza, estado civil, educación y lugar de ocurrencia) y tasa de mortalidad por grupo de edad y municipio del estado. Los datos se obtuvieron del Sistema de Información de Mortalidad y los datos de población del Instituto Brasileño de Geografía y Estadística (IBGE). El análisis de tendencias utilizó el modelo de regresión de punto de unión y el espacial con las estadísticas de Moran. Resultados: Hubo 1.816 muertes en el período, 25,3% entre 50-59 años, 46,3% marrón, 36,1% casados, 35,5% con menos de 8 años de educación y 67,2% de muertes en el período. Ambiente hospitalario. Los grupos de edad de 40 años y mayores mostraron una tendencia creciente, con un punto culminante de 80 años y mayores (cambio porcentual anual promedio: 9,2; p<0,001) con el mayor crecimiento. La distribución espacial fue aleatoria. Conclusión: La tasa de mortalidad por cáncer de mama femenino aumentó en el período 2001 a 2016 en el grupo de edad de 40 años y más en el estado y sin un patrón espacial definido.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Breast Neoplasms/mortality , Breast Neoplasms/epidemiology , Brazil , Time Series Studies , Mortality/trends , Ecological Studies
7.
Rev. cuba. cir ; 58(4): e828, oct.-dic. 2019. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1126389

ABSTRACT

RESUMEN Introducción: En los últimos diez años, la tasa de mortalidad por cáncer de mama se ha mantenido aparentemente estable, una de cada 8 mujeres está afectada por esta enfermedad, y de aquí a 20 años esta cifra podría elevarse. Objetivos: Estimar la tendencia de la mortalidad por cáncer de mama, y predecir la magnitud de la mortalidad por esta enfermedad para el quinquenio 2015 a 2020. Métodos: Se realizó un estudio multicéntrico, observacional, descriptivo, longitudinal y prospectivo en el Servicio de Cirugía General del Hospital Provincial "Saturnino Lora" de Santiago de Cuba, en el periodo comprendido entre septiembre del año 2012 y diciembre del año 2015. La población de referencia estuvo constituida por todos los pacientes fallecidos en la provincia de Santiago de Cuba 1579 portadores de cáncer de mama. Resultados: El 37,4 % del total falleció entre el año 2010 y el año 2014, tasa de letalidad más elevada fue en el periodo comprendido entre los años 2000 y 2004. Conclusiones: El riesgo de morir y la gravedad de la enfermedad han disminuido de forma significativa en el periodo de análisis. Se evidencia una tendencia ligeramente elevada de los casos de cáncer de mama en la provincia de Santiago de Cuba, donde se espera que esta situación de salud continúe al alza para el próximo lustro(AU)


ABSTRACT Introduction: In the last ten years, the mortality rate from breast cancer has remained apparently stable, one in 8 women is affected by this disease, and in 20 years this figure could rise. Objectives: Estimate the trend of mortality from breast cancer, and predict the magnitude of mortality from this disease for the five-year period 2015-2020. Methods: A multicenter, observational, descriptive, longitudinal and prospective study was carried out in the General Surgery Service of the Provincial Hospital "Saturnino Lora" in Santiago de Cuba, in the period between September 2012 and December 2015. The population The reference was made up of all 1579 patients who died in the province of Santiago de Cuba, carriers of breast cancer. Results: 37.4% of the total died between 2010 and 2014, the highest case fatality rate was in the period between 2000 and 2004. Conclusions: The risk of dying and the severity of the disease have decreased significantly in the analysis period. A slightly elevated trend is evident in breast cancer cases in the province of Santiago de Cuba, where it is expected that this health situation will continue to rise for the next five years(AU)


Subject(s)
Humans , Female , Severity of Illness Index , Breast Neoplasms/mortality , Breast Neoplasms/epidemiology , Epidemiology, Descriptive , Prospective Studies , Longitudinal Studies , Observational Studies as Topic
8.
Evid. actual. práct. ambul ; 22(3): e002023, nov. 2019.
Article in Spanish | LILACS | ID: biblio-1046944

ABSTRACT

Al igual en otras partes del mundo, en Argentina la mortalidad específica por cáncer mamario disminuyó de forma sostenida entre 1996 y 2017. Es probable que en la actualidad la mamografía sea la herramienta más importante para detectar precozmente, evaluar y llevar un seguimiento de las personas con esta patología. Sin embargo existe mucha controversia acerca de los beneficios del tamizaje poblacional y de la realización de diagnósticos precoces de cáncer de mama. El propósito de esta revisión narrativa es brindar una mirada contraintuitiva, cuestionadora de los beneficios de esta práctica,ponderando también sus riesgos, escasamente visibilizados por las estrategias comunicacionales concordantes con el modelo deprevenir es mejor que curar y la lucha contra la historia natural del cáncer. (AU)


As in other parts of the world, in Argentina, breast cancer specific mortality declined steadily between 1996 and 2017. Mammography is currently the most important tool for early detection, evaluation and follow-up of people suffering fromthis disease. However, there is a controversy about the benefits of population screening and early diagnosis of breastcancer. The aim of this narrative review is to provide a counterintuitive, questioning view of the benefits of this practice, also weighing its risks, poorly visible through communication strategies consistent with the model of prevention is betterthan cureand the fight against the natural history of cancer. (AU)


Subject(s)
Humans , Female , Adult , Middle Aged , Breast Neoplasms/diagnostic imaging , Mammography/adverse effects , Mass Screening/adverse effects , Argentina/epidemiology , Breast Neoplasms/diagnosis , Breast Neoplasms/mortality , Breast Neoplasms/prevention & control , Breast Neoplasms/therapy , Mammography/mortality , Mammography/trends , Public Health , Decision Making
9.
Ciênc. Saúde Colet ; 24(9): 3517-3528, set. 2019. tab
Article in Portuguese | LILACS | ID: biblio-1019670

ABSTRACT

Resumo A relevância do câncer de mama para as mulheres tem impulsionado pesquisas sobre a mortalidade desta doença. Todavia, estes estudos estão sujeitos aos problemas gerados pelos óbitos oriundos de causas mal definidas (CMD). A fim de evidenciar as possíveis distorções causadas pelas CMD em estudos que avaliam a mortalidade, foram calculadas taxas de mortalidade, padronizadas por faixa etária, com e sem correção para CMD, para os anos de 1990, 2000 e 2010. Feito isso, foram estimados modelos de regressão com dados em painel, que permitiram identificar que a correção para CMD: a taxa de mortalidade por câncer de mama dos municípios brasileiros elevou-se em cerca de 9% no período considerado; as taxas de mortalidade das regiões Sul, Sudeste, Nordeste e Norte se aproximaram; foi reduzida a tendência de crescimento da mortalidade em quase 60%, principalmente nas regiões Sudeste e Sul; aumentou, de forma mais acentuada, a mortalidade das cidades com menos de 5 mil habitantes; diminuiu a significância de grande parte dos fatores associados ao câncer de mama; revelou que o efeito da longevidade e dos gastos públicos em saúde estariam superestimados. Tais resultados ressaltam a importância da correção para CMD na geração de indicadores fidedignos de mortalidade.


Abstract The relevance of breast cancer for women has driven research about mortality of this disease. However, these studies are affected by problems generated by deaths due to ill-defined causes (IDC). To highlight distortions caused by IDC in studies that evaluate mortality, we calculated the age-standardized mortality rates of breast cancer, with and without adjustment for IDC for the years 1990, 2000, and 2010. Then, panel data regression models were estimated and enabled us to identify that the adjustment for IDC: has elevated breast cancer mortality rate of Brazilian municipalities by 9% in the period considered; has drawn mortality rates of the South, Southeast, Northeast and North regions closer; has reduced the increasing trend of mortality by almost 60%, mainly in the Southeast and South regions; has increased, more sharply, the mortality in cities with less than 5 thousand inhabitants; has curbed the significance of most factors associated with breast cancer; has revealed that the effect of longevity and the public health expenditure may be overestimated. These results highlight the importance of adjustment for IDC in producing reliable mortality indicators.


Subject(s)
Humans , Female , Breast Neoplasms/mortality , Mortality/trends , Cause of Death/trends , Brazil/epidemiology , Cities/statistics & numerical data
10.
Rev. méd. Chile ; 147(5): 557-567, mayo 2019. tab, graf
Article in English | LILACS | ID: biblio-1014264

ABSTRACT

ABSTRACT Background: Breast cancer (BC) is the most common malignancy in women. Aim: To assess the impact of HER2 status on axillary lymph node (ALN) involvement in patients with invasive ductal carcinoma of no special type (IDC-NST) both at diagnosis and during the 4-year postoperative period. Patients and Methods: We retrospectively included 375 women with an early clinical stage of non-luminal IDC-NST who between 2007 and 2013 underwent breast surgery at a clinical hospital. They were divided into phenotype-based groups: HR+HER2-, HR+HER2+, HR-HER2+ and HR-HER2-. Only patients with sentinel lymph node (SLN) macrometastases underwent ALN dissection. If > 3 ALNs were positive, radiotherapy was delivered. All patients were treated with chemotherapy, HER2+ BC patients received trastuzumab, and hormone receptor (HR)-positive BC patients received hormonal therapy. Results: Larger tumor size, higher grade, HR+, HER2+ status, and lymphovascular invasion (LVI) were predictive for ALN metastases at diagnosis. The poorest overall, disease-free, and distant recurrence-free survival (OS, DFS, DRFS) were found in the HR-HER2- group, while the poorest locoregional recurrence-free survival (LRFS) was observed in HR-HER2+ and HR-HER2- groups. HER2 status was not predictor of survival. Conclusions: HER2+ status was predictive for ALN involvement at diagnosis but had no effect on 4-year LRFS in these patients.


Antecedentes: El cáncer de mama es el tumor maligno más común en mujeres. Objetivo: Conocer el impacto del estado HER2 sobre el compromiso ganglionar axilar al momento del diagnóstico y durante los primeros cuatro años después de la cirugía en mujeres con carcinoma ductal invasivo de tipo no especial (IDC-NST). Pacientes y Métodos: Incluimos retrospectivamente a 375 mujeres en etapas clínicas iniciales de IDC-NST que fueron operadas en un hospital clínico. Ellas se dividieron en grupos de acuerdo al fenotipo: HR+HER2-, HR+HER2+, HR-HER2+y HR-HER2-. La disección de ganglios axilares se efectuó solo en las pacientes con macrometástasis en el ganglio centinela. Si había más de tres ganglios comprometidos, se efectuó radioterapia. Todas las pacientes se trataron con quimioterapia. Las pacientes HER2+ recibieron trastuzumab y las pacientes HR+ recibieron hormonoterapia. Resultados: Tumores más grandes, de mayor grado de malignidad, HR+, HER2+ y la invasión linfovascular fueron predictivos de la presencia de metástasis axilares al momento del diagnóstico. La sobrevida más baja se observó en pacientes HR-HER2+. La sobrevida libre de recurrencia locorregional más baja, se observó en pacientes HR-HER2+ y HR-HER2-. HER2 no fue predictor de sobrevida. Conclusiones: En estas mujeres, HER2+fue predictor de la presencia de compromiso ganglionar axilar al momento del diagnóstico pero no de la sobrevida a cuatro años.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/pathology , Receptor, ErbB-2/analysis , Sentinel Lymph Node/pathology , Axilla , Time Factors , Breast Neoplasms/mortality , Multivariate Analysis , Retrospective Studies , Carcinoma, Ductal, Breast/mortality , Statistics, Nonparametric , Disease-Free Survival , Ki-67 Antigen/analysis , Tumor Burden , Kaplan-Meier Estimate , Neoplasm Grading , Neoplasm Invasiveness , Neoplasm Recurrence, Local , Neoplasm Staging
11.
Rev. medica electron ; 41(1): 117-129, ene.-feb. 2019. graf
Article in Spanish | LILACS, CUMED | ID: biblio-991330

ABSTRACT

RESUMEN Introducción: en el último trienio la mortalidad por cáncer mamario en el sexo femenino en Cuba disminuyó ligeramente sus tasas, sin embargo no se han realizado estudios de supervivencia por esta enfermedad en la provincia Matanzas. Objetivo: evaluar el comportamiento del tiempo de supervivencia global a los 5 años en esta serie y valorar la sobrevida en función de variables seleccionadas. Materiales y métodos: se realizó un estudio observacional descriptivo, longitudinal y retrospectivo, en el que participaron 288 mujeres diagnosticadas con cáncer de mama en la consulta de mastología del Hospital "José Ramón López Tabranes" de la provincia Matanzas, desde el 1 de Enero del 2010 hasta el 31 de Diciembre del 2015. Se utilizó el método de Kaplan Meier para determinar el tiempo de supervivencia global a los 5 años y en función de variables seleccionadas. La comparación de las diferentes curvas para las variables de exposición se realizó con la prueba de Rangos Logarítmicos (Log Rank). Se consideró estadísticamente significativo el valor del estadígrafo mayor de 1 y p < 0.05. Resultados: la supervivencia global a los 5 años fue de un 66 %. Se registran supervivencias muy por debajo de los estándares internacionales para las pacientes en estadios III (37 %) y IV (0). La supervivencia global disminuye de manera significativa en la medida en que se incrementan el número de ganglios afectados y el tamaño del tumor al momento del diagnóstico. Conclusiones: la supervivencia global a los 5 años resultó inferior a la registrada en la mayoría de los estudios internacionales consultados. Se muestra una disminución marcada de la sobrevida en pacientes con estadios clínicos avanzados de la enfermedad: (III y IV).


ABSTRACT Introduction: in the last three years, mortality rates due to breast cancer in the female sex in Cuba slightly decreased, but studies of this disease survival have not been carried out in the province of Matanzas. Objective: to evaluate the behavior of the global survival time of this series at the 5th year and to assess survival according to chosen variables. Material and method: a retrospective, longitudinal, observational descriptive study was carried out; 288 women diagnosed with breast cancer took part on it; they were diagnosed in the mastology consultation of the hospital "Jose Ramon Lopez Tabrane", province of Matanzas during the period January 1st 2010- December 31st 2015. The Kaplan-Meier method was used to determine the global survival time at the 5th year according to chosen variables. The comparison of the different curves for the exposition variables was made using the Log Rank test. The test value higher than 1 and p < 0.05 was considered statistically significant. Results: global survival at the 5th year was 66 %. There are survival rates well below the international standards for the stage III (37 %) and stage IV (0) patients. Global survival significantly decreases insofar as the number of affected ganglia and the size of the tumor at the moment of the diagnosis increase. Conclusions: global survival at the 5th year was lower than the one recorded in most of the consulted international studies. There is a remarkable decrease of survival in patients with disease advanced clinical stages: III and IV.


Subject(s)
Humans , Female , Breast Neoplasms/diagnosis , Breast Neoplasms/mortality , Breast Neoplasms/pathology , Survival Analysis , Survival Rate , Epidemiology, Descriptive , Retrospective Studies , Longitudinal Studies , Kaplan-Meier Estimate , Observational Study
12.
Gac. méd. Méx ; 155(supl.1): 50-55, dic. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1286565

ABSTRACT

Resumen Antecedentes: La clasificación del cáncer de mama en subtipos mediante la expresión de receptores hormonales (RH) y del receptor 2 del factor de crecimiento epidérmico humano (HER2) por inmunohistoquímica (IHQ) es una práctica estándar para la toma de decisiones terapéuticas. Objetivo: Conocer las características y supervivencia de cada subtipo de pacientes, que es indispensable para poder diseñar futuros estudios. Método: Realizamos un estudio retrospectivo evaluando las características clinicopatológicas y la supervivencia por subtipo mediante IHQ en mujeres con cáncer de mama. Resultados: 211 mujeres con cáncer de mama RH(+)/HER2(-), 53 con RH(+)/HER2(+), 16 con HER2(+) y 23 con RH(-)/HER2(-), con una mediana de supervivencia global en meses de 39 (20.5-62.7), 42 (25.5-65), 42 (13.7-67.7) y 26 (11-78), respectivamente, para un cociente de riesgo (HR por sus siglas en inglés, Hazard Ratio): 3.7 (IC 95%: 1.3-10.3) en el grupo triple negativo comparado con RH(+)/HER2(-) (p = 0.01). Conclusión: Los subtipos con RH positivos por IHQ son los más frecuentes y este grupo de pacientes tienen una mejor supervivencia global comparada con las pacientes triple negativo.


Abstract Background: Breast cancer subtype classification according to hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) using immunohistochemistry is the standard practice for therapeutic decision making. Objective: To design future studies information on characteristics and survival of each subtype is essential. Method: We conducted a retrospective study to analyze clinical and pathologic features as well as survival data according to breast cancer immunohistochemistry subtype. Results: There were 211 women with a RH(+)/HER2(-) breast cancer subtype, 53 HR(+)/HER2(+), 16 HER2(+) and 23 HR(-)/HER2(-), with a median overall survival in months of 39 (20.5-62.7), 42 (25.5-65), 42 (13.7-67.7) and 26 (11-78), respectively, for a 3.7 hazard ratio of death (95% Confidence Interval [CI]: 1.3-10.3) for the triple negative group as compared to the HR(+)/HER2(-) group (p = 0.01). Conclusions: HR positive subtypes by immunohistochemistry where most frequent and showed a greater overall survival compared to the triple negative subtype.


Subject(s)
Humans , Female , Adult , Middle Aged , Breast Neoplasms/classification , Breast Neoplasms/mortality , Breast Neoplasms/pathology , Breast Neoplasms/chemistry , Immunohistochemistry , Survival Rate , Retrospective Studies , Cohort Studies , Receptor, ErbB-2/analysis
13.
Article in Portuguese | LILACS | ID: biblio-1026308

ABSTRACT

Introdução: O câncer de mama é considerado de relativo bom prognóstico se diagnosticado e tratado precocemente, com sobrevida média de 80% após cinco anos do diagnóstico, porém o que se observa é que se trata da segunda neoplasia mais incidente em todo o mundo. Objetivo: Analisar o crescimento da taxa de mortalidade por câncer de mama e as condições de desenvolvimento humano no Brasil. Método: Trata-se de um estudo descritivo de séries temporais nos dois períodos compreendidos entre 1998 a 2002 e 2008 a 2012. Resultados: Ao se analisarem as taxas de mortalidade e os índices de Desenvolvimento Humano (IDH), comparando o primeiro quinquênio (período de 1998-2002) com o segundo (período de 2008-2012), foi observado um aumento na taxa de mortalidade da maioria das capitais, com exceção de Maceió, Porto Alegre, Florianópolis e Palmas. Ocorreu um aumento do IDH em todas as capitais do país. Conclusão: Houve crescimento nos índices de câncer de mama no Brasil de forma geral mesmo havendo também uma melhoria das condições de desenvolvimento humano em todo o país.


Introduction: Breast cancer is disease of relatively good prognostics if diagnosed and treated precociously, an average of 80% of the patients survive after five years of the diagnoses, however what we observe is that it is the second neoplasm in the world. Objective: To analyze the growth of breast cancer mortality rate and the conditions of human development in Brazil. Method: It is a descriptive study of temporary series along the two terms from 1998 to 2002 and 2008 to 2012. Results: When we analyze the mortality rates and the Human Development Index, comparing the first five years (from 1998 to 2002) with the second term of five years (2008 to 2012), we observed a growth in the mortality rate in the majority of the capitals, except from Maceió, Porto Alegre, Florianópolis and Palmas. There was a growth in the HDI in all capitals of the country. There was a growth in the Human Development Index in all capitals of the country. Conclusion: There was a general growth in the breast cancer rates in Brasil, although the conditions of Human Development nation wide.


Introducción: El cáncer de mama es considerado de relativo buen pronóstico si se diagnostica y tratado precozmente con sobrevida media del 80% después de cinco años del diagnóstico, pero lo que se observa es que se trata de la segunda neoplasia más incidente en todo el mundo. Objetivo: Analizar el crecimiento de la tasa de mortalidad por cáncer de mama y las condiciones de desarrollo humano en Brasil. Método: Se trata de un estudio descriptivo de series temporales en los dos períodos comprendidos entre 1998 a 2002 y 2008 a 2012. Resultados: Ao se analizaren las tasas de mortalidad y los IDH comparando el primer quinquenio (período 1998-2002) con el segundo, (Período 2008-2012), se observó un aumento en la tasa de mortalidad de la mayoría de las capitales con excepción de Maceió, Porto Alegre, Florianópolis y Palmas. Y hubo un aumento del IDH en todas las capitales del país. Conclusión: Se ha producido un crecimiento del cáncer de mama en Brasil de forma general, incluso habiendo también una mejora de las condiciones de desarrollo humano en todo el país.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Breast Neoplasms/mortality , Development Indicators , Social Conditions/statistics & numerical data , Brazil , Breast Neoplasms/epidemiology , Time Series Studies
14.
Einstein (Säo Paulo) ; 17(1): eAO3434, 2019. tab, graf
Article in English | LILACS | ID: biblio-975108

ABSTRACT

ABSTRACT Objective To define a predictive factor for pathologic complete response, compare the oncologic outcomes associated with the degree of pathologic response after neoadjuvant chemotherapy, and to analyze pathologic complete response as a prognostic factor for overall survival and progression-free survival. Methods A retrospective study of patients admitted to Hospital Estadual Mário Covas and Hospital Anchieta from 2008 to 2012, with locally advanced breast cancer. Hormone receptor status, HER2 status, histologic and nuclear grade, age upon diagnosis and histological type of the tumor were analyzed. Pathologic evaluation of the tumor was subdivided into pathologic complete response, defined by the absence of tumor; intermediate response, considered as a favorable stage; and poor response, considering low-responder patients. Data obtained were submitted to statistical analysis. Results The study included 243 patients. There was an association of pathologic complete response with HER-2 negative, histological grade 3, stage III, hormone receptor negative, positive lymph node, older age and more advanced tumors. However, after multivariate analysis the only predictor of pathologic complete response was the presence of negative hormone receptor. By analyzing the prognostic factors, hormone receptor negative was considered as an independent risk factor, and pathologic complete response was considered as an independent protective factor. Conclusion Hormone receptor negative is predictive of pathologic complete response and is an isolated risk factor for lower progression-free survival and overall survival. Pathologic complete response is a protective factor for these same survival analyses.


RESUMO Objetivo Definir um fator preditivo para resposta patológica completa, comparar os resultados oncológicos associados com o grau de resposta patológica, após quimioterapia neoadjuvante, e analisar a resposta patológica completa como fator prognóstico para sobrevivência global e livre de progressão de doença. Métodos Estudo retrospectivo de pacientes admitidas no Hospital Estadual Mário Covas e Hospital Anchieta, no período de 2008 a 2012, com câncer de mama localmente avançado. Foram utilizados status dos receptores hormonais, proteína HER2, grau histológico e nuclear, idade do paciente ao diagnóstico e tipo histológico do tumor. A avaliação patológica do tumor foi subdividida em resposta patológica completa, definida com ausência de tumor; resposta intermediária, considerada como um estádio favorável; e resposta ruim, considerando os pacientes pouco respondedores. As informações obtidas foram submetidas à análise estatística. Resultados Foram incluídas 243 pacientes. Verificou-se associação de resposta patológica completa entre HER-2 negativo, grau histológico 3, estadiamento III, receptor hormonal negativo, linfonodo positivo, maior idade e tumores mais avançados. Porém, após análise multivariada, o único fator preditivo de resposta patológica completa foi presença de receptor hormonal negativo. Ao analisar fatores prognósticos, receptor hormonal negativo permaneceu como variável independente de risco, e resposta patológica completa, como variável independente de proteção. Conclusão O receptor hormonal negativo é fator preditivo isolado de resposta patológica completa e fator de risco para menor sobrevida livre de doença e sobrevida global. Já a resposta patológica completa é fator protetor para estas mesmas análises de sobrevivência.


Subject(s)
Humans , Female , Adult , Aged , Aged, 80 and over , Breast Neoplasms/pathology , Breast Neoplasms/drug therapy , Carcinoma/pathology , Carcinoma/drug therapy , Receptors, Progesterone/analysis , Receptors, Estrogen/analysis , Neoadjuvant Therapy/methods , Reference Values , Time Factors , Breast Neoplasms/mortality , Breast Neoplasms/chemistry , Carcinoma/mortality , Carcinoma/chemistry , Multivariate Analysis , Predictive Value of Tests , Retrospective Studies , Risk Factors , Analysis of Variance , Treatment Outcome , Disease-Free Survival , Kaplan-Meier Estimate , Middle Aged
15.
Rev. méd. Panamá ; 39(2): 35-39, 2019. ilus, tab
Article in Spanish | LILACS | ID: biblio-1100653

ABSTRACT

El cáncer de mama es el tumor de la mujer más diagnosticado en la gran mayoría de los países. Los factores no hereditarios son los principales impulsores de las diferencias internacionales e in­ter­étnicas observadas en la incidencia de este cáncer. Las tasas de incidencia del cáncer de ma­ma han aumentado en la mayoría de los países en transición en las últimas décadas, en tanto que en la mayoría de los países más avanzados, las tasas de mortalidad por cáncer de mama han ido en descenso como resultado de la detección temprana de la enfermedad, los avances en el trata­ miento y mayor accesibilidad a los servicios de salud. Los principales factores de riesgo para el cáncer de mama no son fácilmente modificables porque se derivan de exposiciones hormonales endógenas prolongadas. La prevención a través de la promoción de la lactancia materna, parti­cularmente su mayor duración, pudiera ser beneficioso. La incidencia de cáncer de mama en Pa­namá se comporta de manera similar a los países con índice de desarrollo Humano en transición; ha ido en aumento en las últimas décadas como resultado del aumento en la prevalencia de los factores de riesgo conocidos y la mejoría en la recolección de datos.


Breast cancer is the most diagnosed woman's tumor in the vast majority of countries. The non­here­ ditary factors are the main drivers of the international and inter­ethnic differences observed in the incidence of this cancer. Breast cancer incidence rates have increased in most countries in transi­tion in recent decades, while in most of the more advanced countries, breast cancer death rates ha­ve been declining asa result of breast cancer. early detection of the disease, advances in treatment and greater accessibility to health services . The main risk factors for breast cancer are not easily modifiable because they are derived from prolonged endogenous hormonal exposures. Prevention through the promotion of breastfeeding, particularly its longer duration, could be beneficial. The inci­ dence of breast cancer in Panama behaves similarly to countries with a Human Development Index in transition; It has been increasing in recent decades as a result of the inc rease in the prevalence of k nown risk factors and the improvement in data collection.


Subject(s)
Humans , Female , Middle Aged , History, 21st Century , Breast Neoplasms/ethnology , Breast Neoplasms/mortality , Literature , Breast Neoplasms/diagnosis , Breast Neoplasms/drug therapy , Data Collection/statistics & numerical data , Development Indicators , Delivery of Health Care
16.
Rev. méd. Chile ; 146(10): 1167-1169, dic. 2018. graf
Article in Spanish | LILACS | ID: biblio-1043146

ABSTRACT

Background: There is a misconception that the main cause of death among women is breast cancer, even among physicians, who may neglect cardiovascular preventive measures in this gender Aim: To assess the knowledge among physicians about the main cause of death among women. Material and methods: A survey was answered by 231 physicians attending a Cardiology and a Gynecology Meeting. Results: Sixty eight percent of respondents indicated that cardiovascular diseases are the main cause of death among women. A higher proportion of specialists than trainees, answered correctly the question (72 and 56% respectively). No gender differences in the answers were recorded. Conclusions: The knowledge about cardiovascular risk in women should be reinforced among physicians.


Subject(s)
Humans , Female , Physicians/statistics & numerical data , Cardiovascular Diseases/mortality , Health Knowledge, Attitudes, Practice , Pneumonia/mortality , Breast Neoplasms/mortality , Chile , Surveys and Questionnaires , Cause of Death , Myocardial Infarction/mortality
17.
Rev. méd. Chile ; 146(10): 1095-1101, dic. 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-978744

ABSTRACT

Background: HER2+ breast cancer (BC) subtype overexpresses the Human Epidermal growth factor Receptor type-2 (HER2) and is characterized by its aggressiveness and its high sensitivity to monoclonal antibody-based HER2-targeted therapies. Aim: To assess the prognosis and evaluate the impact of novel anti-HER2 therapies on advanced HER2+ BC patients treated at our institution over the last decades. Material and Methods: Analysis of the patient database at a cancer center of a university hospital. Information about the subtype of cancer was obtained in 2,149 of 2,724 patients in the database. Eighteen percent of the latter were HER2+. We analyzed data of 83 of these patients with advanced disease. Results: Median overall survival (OS) was 24 months. For patients treated between 1997-2006 median OS was 17 months and for those treated in the period 2007-2017 median OS was 32 months (p = 0.09). Conclusions: A non-significant trend towards better survival in the last decade was observed. HER2+ BC overall survival has improved in our center. This can be probably attributed to the use of novel more effective anti-HER2 therapies.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Breast Neoplasms/mortality , Breast Neoplasms/chemistry , Receptor, ErbB-2/analysis , Time Factors , Breast Neoplasms/pathology , Breast Neoplasms/drug therapy , Immunohistochemistry , Chile/epidemiology , Retrospective Studies , Receptor, ErbB-2/antagonists & inhibitors , Kaplan-Meier Estimate , Trastuzumab/therapeutic use , Lapatinib/therapeutic use , Neoplasm Recurrence, Local , Antineoplastic Agents/therapeutic use
18.
Rev. medica electron ; 40(4): 1186-1196, jul.-ago. 2018. ilus
Article in Spanish | LILACS, CUMED | ID: biblio-961291

ABSTRACT

RESUMEN El cáncer de mama es una enfermedad frecuente que constituye un problema de salud de gran repercusión en la población femenina, por su alta incidencia y mortalidad. El diagnóstico y tratamiento de esta enfermedad produce en las mujeres afectadas una gran incertidumbre y sentimientos de falta de control sobre su vida, puesto que consideran a la enfermedad potencialmente mortal y de una elevada frecuencia de recidiva tumoral. Todo ello afecta considerablemente la calidad de vida y resulta significativamente mayor cuando se presenta en mujeres jóvenes. En el presente trabajo se presentan dos pacientes una de 28 y otra de 30 años de edad, en las que su opinión fue tenida en cuenta para la opción quirúrgica de la enfermedad (AU).


ABSTRACT Breast cancer is a frequent disease and constitutes a health problem of great repercussion in the female population due to its high incidence and mortality. The diagnosis and treatment of this disease produces a great uncertainty and feelings of lack over their life in the affected women, because they consider the disease potentially deadly and having a high frequency of tumor recurrence. All of that considerably affects their quality of life, and is significantly greater when it occurs in young women. In the current study, two female patients are presented, one of them aged 28 years and the other aged 30 years; their opinion was taken into account for the option of the disease surgical treatment (AU).


Subject(s)
Humans , Female , Young Adult , Women/psychology , Breast Neoplasms/epidemiology , Quality of Life/psychology , Breast Neoplasms/diagnosis , Breast Neoplasms/mortality , Disease/psychology , Incidence , Surgical Oncology
19.
Rev. cuba. cir ; 57(2): 1-11, abr.-jun. 2018. tab
Article in Spanish | LILACS | ID: biblio-978373

ABSTRACT

Introducción: El cáncer de mama es el más frecuente y la principal causa de muerte por cáncer en la mujer. Es de peor pronóstico en las mujeres jóvenes por presentar una histología más agresiva y mayor índice de recidivas. Objetivo: Evaluar los resultados del tratamiento quirúrgico del cáncer de mama en mujeres hasta 40 años de edad en el Hospital Clínico Quirúrgico Hermanos Ameijeiras. Método: Se realizó un estudio descriptivo, longitudinal, retrospectivo y prospectivo en el período de mayo de 2005 a mayo de 2015. Se estudiaron 79 mujeres hasta 40 años que fueron operadas por diagnóstico de cáncer de mama. Resultados: Se encontró que 83,5 por ciento tenían entre 35 y 40 años, con solo 4 casos por debajo de los 30 años (5,1 por ciento). El 38,4 por ciento negaron historia familiar de cáncer. Las manifestaciones clínicas más frecuentes fueron la presencia de nódulos no dolorosos en 93,7 por ciento y nódulo de consistencia dura en 44,3 por ciento. Predominaron los tumores en estadio I con 48,1 por ciento, seguido del estadio II con 32,9 por ciento. La técnica quirúrgica más empleada fue la Mastectomía Radical Modificada en 58 casos (73,4 por ciento). En 37 pacientes (46,8 por ciento) hubo recaída de la enfermedad. Durante el seguimiento hubo 11 fallecidas (13,9 por ciento). El tiempo medio de supervivencia global fue de aproximadamente 9 años con una variación entre 7 y 10 años. El tiempo medio de supervivencia libre de enfermedad fue de 5,5 años con una variación entre 5 y 6 años para un intervalo de confianza del 95 por ciento. Conclusiones: En las mujeres menores de 40 años el cáncer de mama es de peor pronóstico por presentar una histología más agresiva y mayor índice de recidivas(AU)


Introduction: Breast cancer is the most frequent cancer and the main cause of death for cancer in women. It has a worse prognosis in young women due to more aggressive histology and higher recurrence rate. Objective: To assess the results of the surgical treatment of breast cancer in women up to 40 years of age in Hermanos Ameijeiras Clinical-Surgical Hospital. Method: A descriptive, longitudinal, retrospective and prospective study was carried out in the period from May 2005 to May 2015. Results: 79 women aged up to 40 years with a diagnosis of breast cancer who underwent surgery were studied. It was found that 83.5 percent were between 35 and 40 years old, with only 4 cases below 30 years (5.1 percent). 38.4 percent referred no family history of cancer. The most frequent clinical manifestations were the presence of non-painful nodules in 93.7 percent and nodule of hard consistency in 44.3 percent. The tumors in stage I predominated, with 48.1 percent, followed by other in stage II, with 32.9 percent. The most widely used surgical technique was modified radical mastectomy, in 58 cases (73.4 percent). In 37 patients (46.8 percent), there was relapse of the disease. During the follow-up, 11 patients (13.9 percent) deceased. The average time of overall survival was approximately 9 years, with a variation between 7 and 10 years. The mean time of disease-free survival was 5.5 years, with a variation between 5 and 6 years, which represents a 95 percent confidence interval. Conclusions: In women under 40 years of age, breast cancer has a worse prognosis due to a more aggressive histology and higher recurrence rate(AU)


Subject(s)
Humans , Female , Adult , Breast Neoplasms/diagnosis , Breast Neoplasms/mortality , Mastectomy, Modified Radical/methods , Epidemiology, Descriptive , Prospective Studies , Retrospective Studies , Longitudinal Studies
20.
Medisan ; 22(5)mayo 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-955030

ABSTRACT

Se realizó un estudio descriptivo, longitudinal y retrospectivo de las pacientes con cáncer de mama atendidas en el Hospital Oncológico Conrado Benítez de Santiago de Cuba, desde enero de 2012 hasta diciembre de 2016, para evaluar la supervivencia de esta población femenina e identificar algunos factores pronósticos. Se estimó la supervivencia global según el método de Kaplan-Meier y se determinaron los intervalos de confianza al 95 por ciento de la supervivencia media y mediana, así como los factores pronósticos mediante la regresión de Cox. La supervivencia media global fue de 52-55 meses aproximadamente y la tasa de supervivencia a los 5 años del diagnóstico, de 83,9 por ciento; asimismo, los factores de mal pronóstico resultaron ser la recurrencia, la afectación ganglionar, la metástasis, la extensión extracapsular, la invasión muscular y la radioterapia


A descriptive, longitudinal and retrospective study of patients with breast cancer assisted in Conrado Benítez Oncological Hospital in Santiago de Cuba, was carried out from January to December, 2016, to evaluate this female population survival and identify some prediction factors. The global survival according to the Kaplan-Meier method was considered and the confidence intervals were determined at 95 percent of median and mean survival, as well as the prediction factors by means of the Cox regression. Mean global survival was approximately of 52-55 months and the rate of survival was 83.9 percent at 5 years after the diagnosis; also, poor prediction factors were recurrence, ganglionar disorder, metastasis, extracapsular extension, muscular invasion and radiotherapy


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Prognosis , Breast Neoplasms/mortality , Breast Neoplasms/epidemiology , Survival Rate , Secondary Care , Longitudinal Studies
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