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1.
Medicina (B.Aires) ; 81(5): 808-816, oct. 2021. graf
Article in Spanish | LILACS | ID: biblio-1351055

ABSTRACT

Resumen Las enfermedades tropicales desatendidas (ETD) constituyen un conjunto de afecciones altamente prevalentes en regiones tropicales y subtropicales, asociadas a pobreza y subdesarrollo. Constituyen una verdadera crisis sanitaria, incapacitando y llevando a la muerte a millones de personas anualmente. Esto se ve potenciado por las dificultades socioeconómicas que cursan estos países, mayormente en vías de desa rrollo, lo cual repercute en la calidad de la asistencia sanitaria que pueden proveer a la población. La morbilidad de estas enfermedades se explica por la amplia afectación orgánica que generan. El aparato cardiovascular resulta particularmente afectado, lo que explica en gran medida la morbimortalidad de las ETD. En el presente artículo se revisan los aspectos fundamentales de un proyecto llevado a cabo por los Líderes Emergentes de la Sociedad Interamericana de Cardiología (SIAC), cubriendo diferentes aspectos del impacto sobre el aparato cardiovascular de las ETD: el Proyecto NET-Heart (del inglés, Neglected Tropical Diseases and other Infectious Diseases Affecting the Heart).


Abstract Neglected tropical diseases (NTD) are a group of diseases with high prevalence in tropical and subtropi cal countries. They are associated to poverty and underdevelopment. Due to its high morbimortality, these conditions are considered a health crisis. The impact of these diseases can be worsened by the poor socioeconomic status of the affected countries, most of them under-developed, which affects the health care provided to patients. The morbidity of these diseases is explained by the wide organic impairment that they produce. The cardiovascular system is par ticularly affected, which explains the high morbimortality of NTD. In this article, we review the key issues of a project elaborated by Emerging Leaders of the Interamerican Society of Cardiology (SIAC), about the cardiovascular impact of NTD: the NET-Heart Project (Neglected Tropical Diseases and other Infectious Diseases affecting the Heart).


Subject(s)
Humans , Tropical Medicine , Cardiovascular System , Neglected Diseases/epidemiology
2.
Rev. bras. med. esporte ; 27(2): 147-150, Apr.-June 2021. tab, graf
Article in English | LILACS | ID: biblio-1280062

ABSTRACT

ABSTRACT Introduction: The indiscriminate use of androgenic steroids may have deleterious effects on human tissue. Objectives: Evaluate the effects of chronic administration of the steroid nandrolone decanoate (DECA) on autonomic cardiovascular modulation, kidney morphometry and the association between these variables in Wistar rats subjected to physical training with swimming. Methods: Thirty-two male Wistar rats aged 20 weeks were distributed among four experimental groups according to the training received: sedentary control (SC), sedentary treated with DECA (SD), trained control (TC) and trained treated with DECA (TD). The hemodynamic parameters, including blood pressure and variations in systolic blood pressure (SBPV) and diastolic blood pressure (DBPV), and kidney morphometry were evaluated. The level of significance adopted was 5%. Results: The SD group had higher baseline SBP and DBP values when compared to the SC, TC and TD groups, which were similar to each other. The rats in the SD group had higher systolic blood pressure (SBPV) and diastolic blood pressure (DBPV) variation values and higher absolute and normalized values in the LF band of the DBPV when compared to the animals in the SC, TC and TD groups. The animals in the SD group had a significantly higher rate of kidney fibrosis compared to the SC, TC and TD groups. There were no significant differences between the sympathetic modulation of SBPV through the LF component and kidney fibrosis. Conclusions: Physical training with swimming was effective in preventing the increase in blood pressure levels and lowering the occurrence of kidney fibrosis in animals treated with anabolic steroids. Level of Evidence IV; Series of cases .


RESUMEN Introducción: El uso indiscriminado de esteroides androgénicos puede tener consecuencias nocivas para el organismo. Objetivo: Evaluar los efectos de la administración crónica del esteroide decanoato de nandrolona (DECA) en ratones Wistar sometidos a entrenamiento físico con natación, sobre la modulación autonómica cardiovascular, morfometría renal y asociación entre esas variables. Métodos: Fueron utilizados 32 ratones Wistar machos con edad de 20 semanas, distribuidos en 4 grupos experimentales de acuerdo con el tratamiento recibido: sedentarios controles (SC), sedentarios que recibieron el DECA (SD), entrenados controles (EC) y entrenados que recibieron el DECA (ED). Se evaluaron parámetros hemodinámicos, como presión arterial y variación de la presión arterial sistólica (VPAS) y diastólica (VPAD) y morfometría renal. El nivel de significancia adoptado fue de 5%. Resultados: El grupo SD presentó valores basales mayores de PAS y PAD cuando comparados a los grupos SC, EC y ED, los cuales fueron semejantes entre sí. Los animales del grupo SD tuvieron valores mayores de la variancia de VPAS y VPAD y valores absolutos mayores y normalizados de la banda LF de la VPAD, en comparación con los animales de los grupos SC, EC y ED. El grupo SD tuvo tasa significativamente mayor de fibrosis renal en comparación con los animales de los grupos SC, EC y ED. No se evidenciaron diferencias considerables entre la modulación simpática de la VPAS a través del componente LF y fibrosis renal. Conclusiones: El entrenamiento físico con natación fue efectivo en prevenir el aumento de niveles presóricos y disminuir la ocurrencia de fibrosis renal en animales tratados con esteroide anabolizante. Nivel de Evidencia IV; Serie de casos .


RESUMO Introdução: O uso indiscriminado de esteroides androgênicos pode ter consequências deletérias no organismo. Objetivo: Avaliar os efeitos da administração crônica do esteroide decanoato de nandrolona (DECA) em ratos Wistar submetidos a treinamento físico com natação sobre a modulação autônoma cardiovascular, morfometria renal e associação entre essas variáveis. Métodos: Foram utilizados 32 ratos Wistar machos com idade de 20 semanas, distribuídos em 4 grupos experimentais de acordo com o tratamento recebido: sedentários controles (SC), sedentários que receberam o DECA (SD), treinados controles (TC) e treinados que receberam o DECA (TD). Avaliaram-se parâmetros hemodinâmicos, como pressão arterial e variação da pressão arterial sistólica (VPAS) e diastólica (VPAD) e morfometria renal. O nível de significância adotado foi de 5%. Resultados: O grupo SD apresentou valores basais maiores de PAS e PAD quando comparado aos grupos SC, TC e TD, os quais foram semelhantes entre si. Os animais do grupo SD tiveram valores maiores da variância da VPAS e VPAD e valores absolutos maiores e normalizados da banda LF da VPAD, em comparação com os animais dos grupos SC, TC e TD. O grupo SD teve taxa significativamente maior de fibrose renal em comparação com os animais dos grupos SC, TC e TD. Não se evidenciaram diferenças consideráveis entre a modulação simpática da VPAS através do componente LF e fibrose renal. Conclusões: O treinamento físico com natação foi efetivo em prevenir o aumento de níveis pressóricos e diminuir a ocorrência de fibrose renal em animais tratados com esteroide anabolizante. Nível de Evidência IV; Série de casos .


Subject(s)
Animals , Male , Rats , Autonomic Nervous System/drug effects , Swimming , Cardiovascular System/drug effects , Nandrolone Decanoate/adverse effects , Anabolic Agents/adverse effects , Kidney Diseases/chemically induced , Physical Conditioning, Animal , Rats, Wistar , Disease Models, Animal , Arterial Pressure/drug effects , Kidney Diseases/prevention & control
3.
Rev. enferm. UFSM ; 11: e5, 2021. tab
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1177498

ABSTRACT

Objetivo: identificar os fatores de risco cardiovascular e a percepção da qualidade de vida entre estudantes de enfermagem de uma universidade federal do Rio Grande do Sul, Brasil. Método: estudo transversal descritivo, realizado com 131 estudantes de enfermagem, em 2018. Os dados foram coletados por meio de instrumento de caracterização demográfica e socioeconômica, formulário de identificação de fatores de risco cardiovascular e do questionário The World Health Organization Quality of Life, bref (WHOQOL-BREF). Para análise dos dados empregou-se estatística descritiva. Resultados: evidenciou-se que 115 (87,8%) estudantes apresentavam fatores de risco cardiovascular. Quanto à qualidade de vida, a média dos escores foi de 70,1 (+17,0) para as relações sociais e 57,8 (+13,8) para o meio ambiente. Conclusão: constatou-se alta prevalência de fatores de risco cardiovascular, prevalecendo o sedentarismo e obesidade. Quanto à qualidade de vida, a pior percepção relacionou-se ao meio ambiente, já as relações sociais evidenciaram resultados positivos.


Objective: to identify cardiovascular risk factors and the perception of quality of life among nursing students from a federal university in Rio Grande do Sul, Brazil. Method: descriptive cross-sectional study, conducted with 131 nursing students, in 2018. Data were collected through an instrument for demographic and socioeconomic characterization, a form for identifying cardiovascular risk factors and the World Health Organization Quality of Life questionnaire, Bref (WHOQOL-BREF). In order to analyze data, we used descriptive statistics. Results: we found that 115 (87.8%) students had cardiovascular risk factors. As for quality of life, the average score was 70.1 (+17.0) for social relationships and 57.8 (+13.8) for the environment. Conclusion: there was a high prevalence of cardiovascular risk factors, with a prevalence of sedentariness and obesity. Still regarding the quality of life, the worst perception was related to the environment, while social relationships highlighted positive results.


Objetivo: identificar los factores de riesgo cardiovascular y la percepción de la calidad de vida en estudiantes de enfermería de una universidad federal de Rio Grande do Sul, Brasil. Método: estudio descriptivo transversal, efectuado con 131 estudiantes de enfermería, en 2018. Los datos se recolectaron mediante un instrumento de caracterización demográfica y socioeconómica, un formulario para identificar factores de riesgo cardiovascular y el cuestionario World Health Organization Quality of Life, Bref. (WHOQOL-BREF). Para analizar los datos, se utilizó estadística descriptiva. Resultados: se evidenció que 115 (87,8%) estudiantes tenían factores de riesgo cardiovascular. En cuanto a la calidad de vida, el promedio de puntuación fue de 70,1 (+17,0) para las relaciones sociales y 57,8 (+13,8) para el medio ambiente. Conclusión: se observó una alta prevalencia de factores de riesgo cardiovascular, predominando el sedentarismo y la obesidad. En cuanto a la calidad de vida, la peor percepción estuvo relacionada con el medio ambiente, mientras que las relaciones sociales señalaron resultados positivos.


Subject(s)
Humans , Quality of Life , Students, Nursing , Cardiovascular System , Student Health , Nursing
4.
Alger. J. health sci. (Online. Oran) ; 3(3): 88-94, 2021. Tables, figures
Article in English | AIM | ID: biblio-1292605

ABSTRACT

L'expansion planétaire du covid19 représente une crise sans précèdent ; cette pandémie a fait plus d'un million de mort en une année. En plus de l'atteinte pulmonaire, le virus a des implications majeures sur le système cardiovasculaire : les maladies cardiovasculaires pré existantes représentent un facteur de risque d'infection sévère avec augmentation de la mortalité, d'autre part l'infection entraine des complications cardiovasculaires qui aggravent le pronostic. Le lien entre le Covid19 et le système cardiovasculaire découle principalement de la voie d'entrée cellulaire du virus qui est assurée par sa liaison à une protéine membranaire l'enzyme de conversion de l'angiotensine (ECA), qui joue un rôle clé dans la régulation neurohumorale ; cette protéine est très présente au niveau du cœur et du poumon, d'où le tropisme du virus qui entraine la dysrégulation de cette voie cellulaire avec des répercussion sur la fonction cardiaque et respiratoire. Une polémique a déferlé concernant les traitements anti hypertenseurs et notamment les inhibiteurs du système rénine angiotensine aldostérone mais après évaluation des données actuelles, il est de consensus de ne pas arrêter ou changer les traitements anti hypertenseurs. L'augmentation des troponines cardiaques est un facteur de mauvais pronostic qui aggrave le tableau. La myocardite est définie par une inflammation myocardique, Les tableaux cliniques sont variables de la forme légère à la forme grave ; les biomarqueurs myocardiques restent un test incontournable en cas de suspicion clinique, le pronostic est incertain avec des formes fulminantes qui peuvent régresser et enfin pour le traitement les corticoïdes semblent être efficaces. Une autre complication du virus sont les accidents thrombo-emboliques et le dilemme occasionné par le risque accru aux thromboses et la thrombopénie induite par l'utilisation de l'héparine (TIH). On note une augmentation de l'incidence des syndromes coronaires aigus chez les sujets atteints du covid19.


The global expansion of covid19 represents a global crisis; this pandemic killed more than a million people in one year. In addition to pulmonary involvement, the virus has major implications on the cardiovascular system: pre-existing cardiovascular diseases represent a risk factor for severe infection with increased mortality, on the other hand the infection causes cardiovascular complications which worsen the prognosis. The link between the Covid19 and the cardiovascular system stems primarily from the virus's cellular entry pathway, which is provided by its binding to a membrane protein, the angiotensin converting enzyme (ACE) wich plays a key role in neurohumoral regulation; this protein is very present in the heart and lungs, hence the tropism of the virus which causes the dysregulation of this cellular pathway with repercussions on cardiac and respiratory function. A controversy broke out concerning the antihypertensive treatments and in particular the inhibitors of the renin angiotensin aldosterone system but after evaluation of the current data, there is a consensus not to withhold or change the treatments. The increase in cardiac troponins is a factor of poor prognosis which worsens the picture. Myocarditis is defined by myocardial inflammation, its clinical form ranges from the mild form to the severe one; the myocardial biomarkers remain an essential when the clinical suspicion rise, the prognosis is uncertain with fulminant forms which can regress; for treatment corticosteroids seem to be effective. Another complication of the virus are thromboembolic events and the dilemma caused by the increased risk of thrombosis and thrombocytopenia induced by the use of heparin (TIH), and there is an increase in the incidence of acute coronary syndromes in patients affected by covid19.


Subject(s)
COVID-19 , Thrombosis , Cardiovascular System , Algeria , COVID-19 Nucleic Acid Testing , Myocarditis
5.
Int. j. morphol ; 38(6): 1751-1759, Dec. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1134508

ABSTRACT

RESUMEN: Los textos escolares en Chile siguen siendo un recurso educativo ampliamente utilizado por los profesores/as, por lo tanto, son herramientas pedagógicas que deben contar con una correcta terminología, garantizando una comunicación eficiente y precisa. En este sentido, la Terminología Anatómica Internacional aborda la organización de nombres de estructuras humanas, sin embargo, se ha observado que aún existen problemas en la correcta denominación de estructuras, generando problemas de comunicación entre profesionales y estudiantes de ciencias. En esta investigación se analizaron los términos histológicos, embriológicos y anatómicos del sistema cardiovascular humano presentes en los libros de texto escolares de 7º a 12vo grado de Ciencias Naturales y Biología, impartidos por el Ministerio de Educación de Chile. El análisis fue realizado comparando los términos utilizados en los textos con los términos oficiales del Programa Federativo Internacional de Terminologías Anatómicas y del Comité Federativo Internacional en Terminología Anatómica. Los resultados indican que el 25 % de términos analizados presentan errores y de ellos un 100 % corresponden a sinonimias. Se concluye que persisten errores en la adecuada denominación de las estructuras del cuerpo humano en los textos escolares. Al respecto, se sugiere una serie de líneas de trabajo que deberán reunir a los profesores/as y especialistas como anatomistas y biólogos para corregir los errores existentes.


SUMMARY: School textbooks in Chile remain an educational resource widely used by teachers, therefore, they are pedagogical tools that must have a correct terminology, ensuring efficient and accurate communication. In this sense, The International Anatomical Terminology addresses the organization of names of human structures. However, it has been observed that there are still problems in the correct naming of structures, creating communication problems between professionals and science students. In this research, the histological, embryological, and anatomical terms of the human cardiovascular system present in school textbooks from 7th to 12th grade of Sciences and Biology, taught by the Chilean Ministry of Education, were analyzed. The analysis was carried out by comparing the terms used in the texts with the official terms of the Federative International Programme for Anatomical Terminology and International Federative Committee for Anatomical Terminology. The results indicate that 25 % of the terms analyzed have errors and of these 100 % correspond to synonyms. It is concluded that errors persist in the proper naming of the structures of the human body in school textbooks. In this regard, a series of lines of work are suggested, that should bring together teachers and specialists such as anatomists and biologists to correct existing errors.


Subject(s)
Humans , Textbooks as Topic , Cardiovascular System/anatomy & histology , Terminology as Topic , Natural Science Disciplines , Biology , Chile , Human Body
8.
Arq. bras. cardiol ; 115(4): 660-666, out. 2020. tab, graf
Article in Portuguese | LILACS, SES-SP | ID: biblio-1131337

ABSTRACT

Resumo Fundamento: A COVID-19 causa grave acometimento pulmonar, porém o sistema cardiovascular também pode ser afetado por miocardite, insuficiência cardíaca e choque. A elevação de biomarcadores cardíacos tem sido associada a um pior prognóstico. Objetivos: Avaliar o valor prognóstico da Troponina T (TnT) e do peptídeo natriurético tipo B (BNP) em pacientes internados por Covid-19. Métodos: Amostra de conveniência de pacientes hospitalizados por COVID-19. Foram coletados dados dos prontuários com o objetivo de avaliar a relação da TnT e o BNP medidos nas primeiras 24h de admissão com o desfecho combinado (DC) óbito ou necessidade de ventilação mecânica. Análise univariada comparou os grupos com e sem DC. Modelo multivariado de Cox foi utilizada para determinar preditores independentes do DC. Resultados: Avaliamos 183 pacientes (idade=66,8±17 anos, sendo 65,6% do sexo masculino). Tempo de acompanhamento foi de 7 dias (1 a 39 dias). O DC ocorreu em 24% dos pacientes. As medianas de TnT e BNP foram 0,011 e 0,041 ng/dl (p<0,001); 64 e 198 pg/dl (p<0,001) respectivamente para os grupos sem e com DC. Na análise univariada, além de TnT e BNP, idade, presença de doença coronariana, saturação de oxigênio, linfócitos, dímero-D, proteína C reativa titulada (PCR-t) e creatinina, foram diferentes entre os grupos com e sem desfechos. Na análise multivariada boostraped apenas TnT (1,12[IC95%1,03-1,47]) e PCR-t (1,04[IC95%1,00-1,10]) foram preditores independentes do DC. Conclusão: Nas primeiras 24h de admissão, TnT, mas não o BNP, foi marcador independente de mortalidade ou necessidade de ventilação mecânica invasiva. Este dado reforça ainda mais a importância clínica do acometimento cardíaco da COVID-19. (AArq Bras Cardiol. 2020; 115(4):660-666)


Abstract Background: COVID-19 causes severe pulmonary involvement, but the cardiovascular system can also be affected by myocarditis, heart failure and shock. The increase in cardiac biomarkers has been associated with a worse prognosis. Objectives: To evaluate the prognostic value of Troponin-T (TNT) and natriuretic peptide (BNP) in patients hospitalized for Covid-19. Methods: This was a convenience sample of patients hospitalized for COVID-19. Data were collected from medical records to assess the association of TnT and BNP measured in the first 24 hours of hospital admission with the combined outcome (CO) of death or need for mechanical ventilation. Univariate analysis was used to compare the groups with and without the CO. Cox's multivariate model was used to determine independent predictors of the CO. Results: We evaluated 183 patients (age = 66.8±17 years, 65.6% of which were males). The time of follow-up was 7 days (range 1 to 39 days). The CO occurred in 24% of the patients. The median troponin-T and BNP levels were 0.011 and 0.041ng/dL (p <0.001); 64 and 198 pg/dL (p <0.001), respectively, for the groups without and with the CO. In the univariate analysis, in addition to TnT and BNP, age, presence of coronary disease, oxygen saturation, lymphocytes, D-dimer, t-CRP and creatinine, were different between groups with and without outcomes. In the bootstrap multivariate analysis, only TnT (1.12 [95% CI 1.03-1.47]) and t-CRP (1.04 [95% CI 1.00-1.10]) were independent predictors of the CO. Conclusion: In the first 24h of admission, TnT, but not BNP, was an independent marker of mortality or need for invasive mechanical ventilation. This finding further reinforces the clinical importance of cardiac involvement in COVID-19. (Arq Bras Cardiol. 2020; 115(4):660-666)


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Pneumonia, Viral/diagnosis , Troponin/blood , Coronavirus Infections/diagnosis , Natriuretic Peptide, Brain/blood , Pneumonia, Viral/mortality , Prognosis , Biomarkers/blood , Cardiovascular System/physiopathology , Cardiovascular System/virology , Coronavirus Infections , Coronavirus Infections/mortality , Pandemics , Betacoronavirus
9.
Rev. Assoc. Med. Bras. (1992) ; 66(8): 1087-1092, Aug. 2020. tab, graf
Article in English | LILACS, SES-SP | ID: biblio-1136328

ABSTRACT

SUMMARY OBJECTIVE To identify the use of Potentially Inappropriate Medications with imminent risk of Cardiovascular and Cerebrovascular Adverse Events (PIM-CCVAE), in addition to the factors associated with a group of elderly individuals undergoing therapeutic care in a Brazilian public service. METHODS A cross-sectional retrospective study conducted at a secondary level service located in Carapicuíba, SP, Brasil. Only elderly individuals (≥60 years) who were treated in one of the outpatient departments were included. The use of PIM-CCVAE was defined based on the PIM-CCVAEs list. In this research, we used descriptive statistics and logistic regression to identify and track possible predictors of MPI use. All statistical analyses were performed using Stata software version 15.1 (Stata Corporation). RESULTS The sample included 233 elderly individuals, with a mean age of 74.9 (± 9.4) years. Of these, 74.2% used at least one PIM-CCVAE, with an average daily intake of 1.3 (± 1) PIM/elderly. The presence of comorbidities, diseases of the circulatory system, polypharmacy, and low to moderate scores in morbidity and mortality were important factors associated with an increased odds ratio for the consumption of PIM-CCVAE. It is also emphasized that the presence of neurological symptoms proved to be a protective factor for this outcome. CONCLUSION Given the clinical severity and imminent risk of CCVAE in the researched group, preventive measures should be instituted to minimize health problems related to medication in the public network.


RESUMO OBJETIVO Identificar o uso de Medicamentos Potencialmente Inapropriados (MPI) com risco iminente de EAM cardiovascular e cerebrovascular (EAM-CC), além dos fatores associados a um grupo de idosos em vigência terapêutica de um serviço público brasileiro. MÉTODOS Estudo seccional e retrospectivo realizado em um serviço de nível secundário localizado em Carapicuíba, SP, Brasil. Incluíram-se, apenas, idosos (idade ≥60 anos) que foram tratados em um departamento de atendimento ambulatorial. O uso de MPI com risco iminente de EAM-CC foi definido empregando a lista PIM-CCVAEs. Nesta pesquisa, apropriou-se da estatística descritiva e de regressão logística para identificação e rastreio de possíveis preditores de uso de MPI. Todas as análises estatísticas foram realizadas usando o software Stata version 15.1 (Stata Corporation). RESULTADOS Incluíram-se, na casuística, 233 idosos, com média de idade igual a 74,9 (±9,4) anos. Destes, 74,2% faziam uso de pelo menos um MPI com risco de EAM-CC, atingindo uma média de consumo diário igual a 1,3 (± 1) MPI/idoso. Verificou-se que a presença de comorbidades, doenças do aparelho circulatório, polifarmácia e score baixo a moderado em índices de morbimortalidade foram importantes fatores associados ao aumento da razão de chances para o consumo de MPI com risco de EAM-CC. Ressalta-se ainda que a presença de sintomas neurológicos mostrou-se como fator protetor para este desfecho. CONCLUSÃO Dada a gravidade clínica e o risco iminente de EAM-CC do grupo pesquisado, medidas de prevenção devem ser instituídas com o intuito de minimizar os problemas de saúde relacionados à medicação na rede pública.


Subject(s)
Humans , Aged , Aged, 80 and over , Cardiovascular System , Inappropriate Prescribing , Brazil , Cerebrovascular Disorders , Cross-Sectional Studies , Retrospective Studies , Risk Factors , Polypharmacy
10.
Rev. bras. cir. cardiovasc ; 35(4): 530-538, July-Aug. 2020. tab, graf
Article in English | LILACS, SES-SP | ID: biblio-1137302

ABSTRACT

Abstract In December 2019, a striking appearance of new cases of viral pneumonia in Wuhan led to the detection of a novel coronavirus (SARS-CoV2). By analyzing patients with severe manifestations, it became apparent that 20 to 35% of patients who died had preexisting cardiovascular disease. This finding warrants the important need to discuss the influence of SARS-CoV2 infection on the cardiovascular system and hemodynamics in the context of clinical management, particularly during mechanical ventilation. The SARS-CoV2 enters human cells through the spike protein binding to angiotensin-converting enzyme 2 (ACE2), which is important to cardiovascular modulation and endothelial signaling. As ACE2 is highly expressed in lung tissue, patients have been progressing to acute respiratory injury at an alarming frequency during the Coronavirus Disease (COVID-19) pandemic. Moreover, COVID-19 leads to high D-dimer levels and prothrombin time, which indicates a substantial coagulation disorder. It seems that an overwhelming inflammatory and thrombogenic condition is responsible for a mismatching of ventilation and perfusion, with a somewhat near-normal static lung compliance, which describes two types of pulmonary conditions. As such, positive pressure during invasive mechanical ventilation (IMV) must be applied with caution. The authors of this review appeal to the necessity of paying closer attention to assess microhemodynamic repercussion, by monitoring central venous oxygen saturation during strategies of IMV. It is well known that a severe respiratory infection and a scattered inflammatory process can cause non-ischemic myocardial injury, including progression to myocarditis. Early strategies that guide clinical decisions can be lifesaving and prevent extended myocardial damage. Moreover, cardiopulmonary failure refractory to standard treatment may necessitate the use of extreme therapeutic strategies, such as extracorporeal membrane oxygenation.


Subject(s)
Humans , Pneumonia, Viral/complications , Cardiovascular System/virology , Coronavirus Infections/complications , Hemodynamics , Respiration, Artificial , Cardiovascular System/physiopathology , Coronavirus Infections , Pandemics , Betacoronavirus , Myocardium/pathology
12.
Rev. chil. obstet. ginecol. (En línea) ; 85(4): 408-419, ago. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1138639

ABSTRACT

Las enfermedades cardiovasculares representan la mayor causa de morbimortalidad a nivel mundial. Si bien presenta un descenso en la población general, en las mujeres tiende a mantenerse estable la prevalencia de enfermedad coronaria. Varios factores propios de la mujer predisponen a que esto ocurra, incluyendo el embarazo, mediado tanto por los cambios hematológicos y cardiovasculares característicos de la gestación; como por patologías asociadas, principalmente trastornos hipertensivos del embarazo y diabetes gestacional. Su presencia se ha asociado fuertemente a la aparición a futuro de otras patologías de alto riesgo cardiovascular como hipertensión crónica, dislipidemia y diabetes mellitus. Dado el impacto que esto representa, se hace imperante la identificación de grupos de alto riesgo y la implementación de medidas preventivas, así como de diagnóstico precoz y tratamientos adecuados con el fin de disminuir complicaciones materno-fetales en las etapas perinatal y posparto.


Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Although there is a decrease in general population, the prevalence of coronary heart disease remains stable in women. Several factors typical of womenkind predispose to cardiovascular disease, including pregnancy, mediated by hematological and cardiovascular changes characteristic of it; and by associated pathologies, mainly hypertensive disorders and diabetes. The presence of these diseases has been strongly associated with future presence of other conditions of high cardiovascular risk such as chronic hypertension, dyslipidemia and diabetes mellitus. Given this impact, the identification of high-risk groups and the implementation of preventive measures, as well as early diagnosis and adequate treatment in order to reduce both maternal and fetal complications in perinatal and postpartum stages becomes imperative.


Subject(s)
Humans , Female , Pregnancy , Pre-Eclampsia , Pregnancy Complications, Cardiovascular/etiology , Cardiovascular Diseases/complications , Diabetes, Gestational , Hypertension/complications , Pre-Eclampsia/diagnosis , Pre-Eclampsia/therapy , Pregnancy Complications, Cardiovascular/diagnosis , Pregnancy Complications, Cardiovascular/therapy , Cardiovascular System/physiopathology , Risk Factors , Diabetes, Gestational/diagnosis , Diabetes, Gestational/therapy , Metabolic Diseases
13.
Educ. fis. deporte ; 39(2): https://revistas.udea.edu.co/index.php/educacionfisicaydeporte/article/view/338726, Julio 2020.
Article in English | LILACS | ID: biblio-1104467

ABSTRACT

Objective: To determine the time-domain (SDNN, RMSSD) of heart rate variability (HRV) and heart rate (HR) of young football players in different training sessions. Method: 15 football players voluntarily participated (mean age = 15.5 ± 0.5 years, height= 171.1 ± 7.9 cm, weight= 62.4 ± 8.9 kg, BMI= 21.2 ± 1.9 kg/m2). They performed three different training: speed, coordination, and match formation. The HRV and HR of the participants were measured during warm-up, main training, and cool-down in each of the three different training sessions. Results: There was a significant interaction between time and intervention on RMSSD (Frmat= 2.983) and HR (Frmat t= 4.894). The results show that HR and HRV are affected differently by diverse training practices in football.


Objetivo: determinar el dominio del tiempo (SDNN, RMSSD) de la variabilidad de la frecuencia cardíaca (HRV) y la frecuencia cardíaca (HR) de los futbolistas jóvenes en diferentes entrenamientos. Método: participaron voluntariamente 15 jugadores de fútbol (media de edad = 15.5 ± 0.5 años, altura = 171.1 ± 7.9 cm, peso = 62.4 ± 8.9 kg, IMC = 21.2 ± 1.9 kg / m2), quienes se sometieron a 3 entrenamientos diferentes: velocidad, coordinación y partido de entrenamiento. La HRV y la HR de los deportistas se midieron durante el calentamiento, el entrenamiento principal y el enfriamiento en cada uno de los 3 entrenamientos. Resultados: hubo una interacción significativa entre el tiempo y la intervención en RMSSD (Frmat = 2.983) y HR (Frmat = 4.894). Los resultados indican que la HR y la HRV se ven afectadas de manera diferente por diversas prácticas de entrenamiento en fútbol.


Objetivo: determinar o controle do tempo (SDNN, RMSSD) da variabilidade da frequência cardíaca (HRV) e da frequência cardíaca (HR) dos futebolistas jovens em diferentes treinamentos. Método: participaram voluntariamente 15 jogadores de futebol (media de idade = 15.5 ± 0.5 anos, altura = 171.1 ± 7.9 cm, peso = 62.4 ± 8.9 kg, IMC = 21.2 ± 1.9 kg / m2), eles realizaram 3 treinamentos diferentes: velocidade, coordenação e partido de treinamento. A HRV e a HR dos esportistas se mediram durante o aquecimento, o treinamento principal e o esfriamento em cada um dos 3 treinamentos. Resultados: houve uma interação significativa entre o tempo e a intervenção em RMSSD (Frmat = 2.983) e HR (Frmat = 4.894). Os resultados indicam que a HR e a HRV são afetadas de maneiras diferentes por diversas práticas de treinamento em futebol.


Subject(s)
Soccer , Cardiovascular System , Exercise/physiology , Heart Rate
14.
Diagn. tratamento ; 25(2): 01-06, abr.-jun. 2020. fig, tab
Article in Portuguese | LILACS | ID: biblio-1116058

ABSTRACT

Introdução: A frequência cardíaca de repouso (FCR) pode ser considerada como indicador de saúde, uma vez que a baixa FCR está associada a uma maior expectativa de vida. Objetivo: Descrever a tendência secular da FCR em escolares do Município de Ilhabela. Métodos: Foram selecionados para esta amostra um total de 196 meninos que envolviam três décadas, com dados de 1978 (n = 41), 1988 (n = 42), 1998 (n = 61) e 2008 (n = 52), com idades entre 12 a 14 anos. A FCR foi mensurada sempre antes de realizar o teste no cicloergômetro. Foi utilizada a análise de variância simples (ANOVA oneway) para comparar as médias da FCR de cada ano e um teste post-hoc Scheffé, com nível de significância de P < 0,01. Resultados: A média da FCR foi de 81,3 bpm no ano de 1978; 85,2 bpm no ano de 1988; 89,4 bpm no ano de 1998 e 91,7 bpm no ano de 2008. Esse aumento se mostrou significativo na comparação de 1998 e 2008 em relação a 1978 e 1988. Conclusão: Os resultados mostram que houve tendência secular positiva para o aumento da FCR, sugerindo declínio das condições cardiorrespiratórias dos escolares daquela região.


Subject(s)
Cardiovascular System , Child , Adolescent , Growth and Development , Heart Rate
15.
Arq. bras. cardiol ; 114(5): 823-826, maio 2020.
Article in Portuguese | LILACS, SES-SP | ID: biblio-1131221

ABSTRACT

Resumo Em dezembro de 2019, um novo coronavírus humano, chamado síndrome respiratória aguda grave do coronavírus 2 (SARS-CoV-2) ou nomeado doença de coronavírus (COVID-19) pela Organização Mundial da Saúde, surgiu na cidade de Wuhan, China. Difundido globalmente, é atualmente considerado pandêmico, com aproximadamente 3 milhões de casos no mundo no final de abril. Seus sintomas incluem febre, tosse, dor de cabeça e falta de ar, esse último considerado o sintoma principal. Por sua vez, acredita-se que haja uma relação entre o COVID-19 e danos ao músculo cardíaco, e pacientes com hipertensão e diabetes, por exemplo, parecem apresentar prognóstico pior. Portanto, o COVID-19 pode piorar em indivíduos com condições adversas subjacentes. Um número não negligenciável de pacientes internados com este vírus tinham doenças cardiovasculares ou cerebrovasculares. A resposta inflamatória sistêmica e distúrbios do sistema imunológico durante a progressão da doença podem estar por trás dessa associação. Além disso, o vírus usa os receptores da enzima conversora da angiotensina (ECA), mais especificamente da ECA2, para penetrar nas células; portanto, o uso de fármacos inibidores de ECA e bloqueadores de receptores de angiotensina pode causar um aumento nestes receptores, assim facilitando a entrada do vírus na célula. No entanto, não há evidências científicas que apóiem a interrupção desses medicamentos. Considerando que são fundamentais para o manejo de certas doenças crônicas, os riscos e benefícios da sua retirada devem ser cuidadosamente ponderados neste cenário. Finalmente, cardiologistas e profissionais de saúde devem estar cientes dos riscos de infecção e se proteger o máximo possível, dormindo adequadamente e evitando longos turnos de trabalho.


Abstract In December 2019, a new human coronavirus, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19) by the World Health Organization, emerged in the city of Wuhan, China. Spreading globally, it is now considered pandemic, with approximately 3 million cases worldwide at the end of April. Its symptoms include fever, cough, and headache, but the main one is shortness of breath. In turn, it is believed that there is a relationship between COVID-19 and damage to the heart muscle, and hypertensive and diabetic patients, for example, seem to have worse prognosis. Therefore, COVID-19 may worsen in individuals with underlying adverse conditions, and a not negligible number of patients hospitalized with this virus had cardiovascular or cerebrovascular diseases. Systemic inflammatory response and immune system disorders during disease progression may be behind this association. In addition, the virus uses angiotensin-converting enzyme (ACE) receptors, more precisely ACE2, to penetrate the cell; therefore, the use of ACE inhibitor drugs and angiotensin receptor blockers could cause an increase in these receptors, thus facilitating the entry of the virus into the cell. There is, however, no scientific evidence to support the interruption of these drugs. Since they are fundamental for certain chronic diseases, the risk and benefit of their withdrawal in this scenario should be carefully weighed. Finally, cardiologists and health professionals should be aware of the risks of infection and protect themselves as much as possible, sleeping properly and avoiding long working hours.


Subject(s)
Humans , Pneumonia, Viral/complications , Cardiovascular Diseases/virology , Coronavirus Infections/complications , Cardiovascular System/virology , Risk Factors , Coronavirus Infections , Peptidyl-Dipeptidase A/physiology , Pandemics , Betacoronavirus
18.
J. Health Biol. Sci. (Online) ; 8(1): 1-9, 01/01/2020. ilus
Article in Portuguese | LILACS | ID: biblio-1103270

ABSTRACT

Objetivo: descrever as implicações da COVID-19 no sistema cardiovascular: prognósticos e intercorrências. Método: trata-se de uma revisão integrativa da literatura, realizada nas bases de dados, Science Direct, National Library of Medicine National Institutes of Health dos EUA (PUBMED), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Cochrane Collaboration e Medical Literature Analysis and Retrieval System Online (MEDLINE) com os descritores, Cardiovascular System; Cardiovascular Diseases; Coronary Disease, e a palavra-chave Covid-19. Incluíram-se estudos originais, relatos de casos, revisões sistemáticas na série temporal 2019-2020. Resultados: a busca resultou em 13 artigos, todos na língua inglesa, emergindo os pontos-chave: potencialização das complicações cardiovasculares pela infecção por COVID-19; aumento da mortalidade de origens cardiovasculares influenciadas pela infecção por COVID-19. Conclusão: o envolvimento do sistema cardiovascular no COVID-19 pode determinar a gravidade da doença, potencializado na presença de fatores de riscos cardiovasculares, repercutindo em complicações que necessitam de tratamento intensivo e morte. De maneira geral, todos os pacientes com COVID-19 são passíveis de ter comprometimento cardiológico, fato que pode depender de antecedentes mórbidos pessoais, resposta inflamatória e liberadores bioquímicos.


Objective: to describe the implications of COVID-19 in the cardiovascular system: prognosis and intercurrences. Method: This is an Integrative Literature Review, performed in the databases, Science direct, National Library of Medicine National Institutes of Health (PUBMED), Latin American and Caribbean Literature in Health Sciences (LILACS), Cochrane Collaboration and Medical Literature Analysis and Retrieval System Online (MEDLINE) with the descriptors, Cardiovascular system; Cardiovascular Diseases; Coronary Disease, and the keyword Covid-19. It included original studies, case reports, systematic reviews in the time series 2019-2020. Results: The search resulted in 13 articles, all in English language, emerging the key points, Potentiation of cardiovascular complications by COVID-19 infection; Increased mortality of cardiovascular origin influenced by COVID-19 infection. Conclusion: The involvement of the cardiovascular system in COVID-19 may determine the severity of the disease, potentiated in the presence of cardiovascular risk factors, resulting in complications that require intensive treatment and death. In general, all patients with COVID-19 are likely to have cardiological impairment, which may depend on personal morbid antecedents, inflammatory response and biochemical liberators.


Subject(s)
Coronavirus Infections , Coronary Artery Disease , Cardiovascular Diseases , Cardiovascular System
19.
Article in English | WPRIM | ID: wpr-816635

ABSTRACT

Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver, adipose tissue, pancreas, bone, and the cardiovascular system. As individuals age, reduced levels of physical activity and sarcopenia (loss of skeletal muscle mass and strength) are associated with physical frailty and disability. Recently, several studies have suggested that the loss of skeletal muscle mass may contribute to metabolic disease. Therefore, herein, we focus on the relationships between skeletal muscle mass and metabolic diseases, including metabolic syndrome and non-alcoholic fatty liver disease.


Subject(s)
Adipose Tissue , Cardiovascular System , Liver , Metabolic Diseases , Motor Activity , Muscle, Skeletal , Non-alcoholic Fatty Liver Disease , Pancreas , Sarcopenia
20.
Article in Korean | WPRIM | ID: wpr-786181

ABSTRACT

To maintain homeostasis of the cardiovascular system, the heart and kidney act bidirectionally. Therefore, acute or chronic dysfunction of one organ can cause dysfunction in the other. This phenomenon is characterized as cardiorenal syndrome (CRS). Concurrent dysfunction of the heart and kidney adversely affects one another and eventually worsens patient outcomes through a vicious cycle. Although a CRS classification system has been proposed, the underlying pathophysiology is multifactorial and clinical access continues to be difficult. Although several therapies, including agents that target the renin-angiotensin-aldosterone system, have been utilized, there is not enough evidence to demonstrate their effectiveness for CRS. Thus, more effort should be made to optimize the diagnosis and treatment strategies for CRS patients. This review will introduce CRS as it is currently understood, discuss the pathophysiology, and examine management strategies.


Subject(s)
Acute Kidney Injury , Cardio-Renal Syndrome , Cardiovascular System , Classification , Diagnosis , Heart , Heart Failure , Homeostasis , Humans , Kidney , Renal Insufficiency, Chronic , Renin-Angiotensin System
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