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1.
Rev. cuba. cir ; 60(2): e1049, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1280215

ABSTRACT

Introducción: El cáncer de colon mantiene un importante impacto social y una alta morbilidad a pesar de programas de detección precoz existentes. Ocupa el cuarto lugar entre los tumores malignos y un número importante de pacientes son operados de urgencia por las complicaciones de esta enfermedad, muchas veces desconocida hasta el momento de la cirugía. Objetivo: Caracterizar la cirugía de urgencia realizada a los pacientes con diagnóstico de cáncer de colon complicado. Método: Se realizó un estudio observacional, descriptivo, de corte transversal entre enero de 2014 y diciembre de 2016, en el Servicio de Cirugía General. La muestra fue de 96 pacientes portadores de esta entidad en el Hospital Universitario "General Calixto García". Resultados: Se analizó la incidencia según sexo, relación sexo/localización, relación localización/complicación, estadificación y mortalidad. Prevalecieron los tumores de colon en el sexo femenino y por ende fueron más frecuente las pacientes con complicaciones quirúrgicas por esta entidad en nuestro centro. Predominó la localización derecha globalmente, con predominio femenino. La oclusión intestinal fue la complicación más frecuente. Sobresalió el estadio II según TNM con un 37,5 por ciento y una mortalidad postoperatoria del 31 por ciento. Conclusiones: Nuestros datos coinciden con la tendencia nacional sobre la mayor incidencia del cáncer de colon en pacientes femeninas, son estas las que mayor tasa de morbilidad y mortalidad reportan. Seguir perfeccionando el programa de prevención y detección temprana de la entidad y su tratamiento oportuno causará la reducción de los índices que hoy se exhiben(AU)


Introduction: Colon cancer still has an important social impact and high morbidity despite existing early detection programs. It ranks fourth among malignant tumors, while a significant number of patients undergo emergency surgery for complications of this disease, many times unknown until the time of surgery. Objective: To characterize the emergency surgery performed to patients with a diagnosis of complicated colon cancer. Method: An observational, descriptive, cross-sectional study was carried out, between January 2014 and December 2016, in the general surgery service. The sample consisted of 96 patients with this entity and from General Calixto García University Hospital. Results: The incidence was analyzed according to sex, sex/location relationship, location/complication relationship, staging and mortality. Colon tumors prevailed in the female sex and, therefore, patients with surgical complications from this entity were more frequent in our center. There right location predominated globally, with a predominance in the female sex. Intestinal obstruction was the most frequent complication. Stage two, according to the TNM classification, stood out, accounting for 37.5 percent, together with a postoperative mortality of 31 percent. Conclusions: Our data coincide with the national trend on the highest incidence of colon cancer in female patients, who account for the highest morbidity and mortality rates. Continuing to improve the entity's prevention and early detection program, as well as its timely treatment, will bring about a reduction in the rates nowadays reported(AU)


Subject(s)
Humans , Male , Female , Colonic Neoplasms/diagnosis , Emergencies , Intestinal Obstruction/complications , Neoplasm Staging/methods , Epidemiology, Descriptive , Cross-Sectional Studies , Colonic Neoplasms/epidemiology , Observational Studies as Topic
2.
Rev. cuba. cir ; 60(1): e1020, ene.-mar. 2021. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1289371

ABSTRACT

Introducción: El cáncer de colon se erige como la neoplasia del tubo digestivo más frecuente en la presente centuria. Objetivo: Identificar algunos factores clínicos, epidemiológicos y diagnósticos en pacientes operados de cáncer de colon con metástasis hepática sincrónica. Métodos: Se realizó un estudio observacional, descriptivo y transversal de una muestra de 31 pacientes operados con diagnóstico definitivo de cáncer de colon con metástasis hepática sincrónica, en el servicio de Cirugía General del Hospital Provincial Docente "Saturnino Lora" de Santiago de Cuba durante el periodo comprendido entre 2010 y 2019. Resultados: La edad promedio fue de 63,2 años. Existió predominio de la enfermedad inflamatoria intestinal como antecedente patológico personal, y del alcoholismo como factor de riesgo. La sintomatología predominante fue dolor abdominal y cambios del hábito intestinal, así como el tumor palpable al examen físico del abdomen. La ecografía abdominal y el colon por enema fueron los procederes de diagnóstico más utilizados. Prevalecieron los tumores en el colon izquierdo a nivel del descendente. Todos los tumores malignos fueron adenocarcinomas a predominio de los moderadamente diferenciados. Conclusiones: Las edades avanzadas de la vida, así como la presencia de tabaquismo y alcoholismo son factores epidemiológicos característicos de la población de enfermos aquejados de cáncer de colon con metástasis hepática. Los elementos clínicos identificados constituyeron los habitualmente descritos en la literatura médica, aunque los estudios imaginológicos utilizados preoperatoriamente resultaron limitados para el diagnóstico del cáncer de colon con metástasis hepática sincrónica, precisándose el hallazgo de las lesiones metastásicas durante la intervención quirúrgica(AU)


Introduction: Colon cancer is the most frequent digestive-tract neoplasm in the present century. Objective: To identify some clinical, epidemiological and diagnostic factors in patients operated on for colon cancer and synchronic hepatic metastasis. Methods: An observational, descriptive and cross-sectional study was carried out in a sample of 31 patients operated on with a definitive diagnosis of colon cancer and synchronic hepatic metastasis, in the general surgery service of Saturnino Provincial Teaching Hospital in Santiago de Cuba, during the period between 2010 and 2019. Results: The average age was 63.2 years. There was a predominance of inflammatory intestinal disease as a personal pathological antecedent, as well as alcoholism as a risk factor. The predominant symptoms were abdominal pain and changes in intestinal habits, as well as a tumor palpable on physical abdominal examination. Abdominal ultrasound and lower barium enema were the most used diagnostic procedures. Tumors prevailed at the level of the left descending colon. All malignant tumors were adenocarcinomas, predominantly moderately differentiated ones. Conclusions: Advanced ages of life, as well as smoking and alcoholism are characteristic epidemiological factors among the population of patients suffering from colon cancer with hepatic metastases. The clinical elements identified were those usually described in the medical literature, although the imaging studies used preoperatively were limited for the diagnosis of colon cancer with synchronic hepatic metastasis, a fact that required finding metastatic lesions during surgery(AU)


Subject(s)
Humans , Male , Female , Middle Aged , Surgical Procedures, Operative/methods , Abdominal Pain/etiology , Colonic Neoplasms/diagnosis , Neoplasm Metastasis/diagnostic imaging , Epidemiologic Factors , Epidemiology, Descriptive , Cross-Sectional Studies , Observational Studies as Topic
3.
Braz. j. med. biol. res ; 54(2): e10394, 2021. tab, graf
Article in English | LILACS | ID: biblio-1153512

ABSTRACT

MicroRNAs (miRNAs) have been indicated to be frequently dysregulated in various cancers and promising biomarkers for colon cancer. The present study aimed to assess the prognostic significance and biological function of miR-1273a in colon cancer. The expression levels of miR-1273a was estimated using quantitative real-time polymerase chain reaction. Kaplan-Meier survival curves and Cox regression analysis were used to evaluate the prognostic value of miR-1273a in patients of colon cancer. The effects of miR-1273a on cell proliferation, migration, and invasion were investigated by cell experiments. The expression of miR-1273a was downregulated in colon cancer tissues and tumor cell lines compared with the normal controls (all P<0.001). The aberrant expression of miR-1273a was associated with vascular invasion (P=0.005), differentiation (P=0.023), lymph node metastasis (P=0.021), and TNM stage (P=0.004). The patients with low miR-1273a expression had low overall survival compared with the patients with high miR-1273a expression (log-rank P=0.002). miR-1273a was detected to be an independent prognostic biomarker for patients. Furthermore, the results of cell experiments revealed that miR-1273a downregulation promoted, while miR-1273a upregulation suppressed the cell proliferation, migration, and invasion. In conclusion, all data indicated that a downregulated expression of miR-1273a predicted poor prognosis for colon cancer and enhanced tumor cell proliferation, migration, and invasion. Thus, we suggest that methods to promote miR-1273a expression may serve as novel therapeutic strategies in colon cancer.


Subject(s)
Humans , Male , Female , Middle Aged , Colonic Neoplasms/diagnosis , MicroRNAs/genetics , Biomarkers, Tumor/genetics , Cell Movement/genetics , Colonic Neoplasms/genetics , Cell Proliferation/genetics , Neoplasm Invasiveness
4.
J. coloproctol. (Rio J., Impr.) ; 40(4): 315-320, Oct.-Dec. 2020. tab, graf
Article in English | LILACS | ID: biblio-1143170

ABSTRACT

ABSTRACT Background Current threshold for minimum lymph node harvest may not be adequate for appropriate staging in colon cancer and newer surgical techniques may allow more lymph nodes to be harvested. The aim of this study was to examine the prognostic role of harvesting and examining lymph nodes higher in number than the recommended threshold (≥12), in patients with colon cancer. Methods This retrospective study included 179 patients that underwent open colon resection for adenocarcinoma of the colon. A D3 resection with high vascular ligation was made so that large number of lymph nodes was removed in most patients. Differences in overall survival between below and above three cutoff points (≥18, ≥24, ≥40) were estimated. Results During median 33 months of follow-up, 45 patients died and mean overall survival was 108.7 ± 5.6 months (95% CI, 97.7-119.7). The mean number of lymph nodes harvested and examined was 44.0 ± 25.7 (median 38; range, 7-150). No significant effect was found for three different cut-off values (≥18, ≥24, or ≥40 nodes) on mean overall survival (p > 0.05 for all comparisons). The same was true for the whole study population as well as for N0 (N negative) and N1-2 (N positive) patient subgroups, when they are analyzed separately. Conclusions Our findings do not support the survival benefit of substantially higher number of lymph nodes harvested in colon cancer.


RESUMO Fundamento: O limite atual para a coleta mínima de linfonodos pode não ser adequado para o estadiamento adequado no câncer de cólon e novas técnicas cirúrgicas podem permitir que um número maior de linfonodos seja coletado. O objetivo deste estudo foi examinar o papel prognóstico da coleta e exame de linfonodos em número maior do que o limite recomendado (≥ 12), em pacientes com câncer de cólon. Método: Este estudo retrospectivo incluiu 179 pacientes submetidos à ressecção aberta de cólon para adenocarcinoma de cólon. A ressecção D3 com ligadura vascular alta foi realizada para que um grande número de linfonodos fosse removido na maioria dos pacientes. As diferenças na sobrevida global entre abaixo e acima de três pontos de corte (≥ 18, ≥ 24, ≥ 40) foram estimadas. Resultados: Durante a mediana de 33 meses de seguimento, 45 pacientes morreram e a sobrevida global média foi de 108,7 ± 5,6 meses (IC 95%: 97,7-119,7). O número médio de linfonodos coletados e examinados foi de 44,0 ± 25,7 (mediana = 38; variação: 7-150). Nenhum efeito significativo foi encontrado para três valores de corte diferentes (≥ 18, ≥ 24 ou ≥ 40 linfonodos) na sobrevida global média (p >0,05 para todas as comparações). O mesmo foi verdadeiro para toda a população do estudo, bem como para os subgrupos de pacientes N0 (N negativos) e N1-2 (N positivos), quando analisados separadamente. Conclusões: Nossos achados não apoiam o benefício na sobrevida de um número substancialmente maior de linfonodos coletados no câncer de cólon.


Subject(s)
Humans , Male , Female , Adenocarcinoma/diagnosis , Colonic Neoplasms/diagnosis , Colonic Neoplasms/mortality , Lymph Node Excision/methods , Prognosis , Survival Analysis
5.
Rev. argent. cir ; 111(4): 245-267, dic. 2019. ilus, graf, tab
Article in Spanish | LILACS | ID: biblio-1057368

ABSTRACT

Antecedentes: la hemicolectomía derecha laparoscópica con abordaje suprapúbico (HDLS) y empleo de tecnología. En los pacientes con cáncer de colon con metástasis hepáticas sincrónicas (CCMHS), la resección completa del tumor primario con las metástasis es la única opción de tratamiento con intención curativa. Se conocen varios informes de series de casos en el mundo; sin embargo, no existe ningún estudio aleatorizado controlado. Objetivo: el objetivo es evaluar la factibilidad y seguridad del abordaje laparoscópico simultáneo de la resección del tumor primario de colon y de la metástasis hepática. Material y métodos: es un estudio retrospectivo; a tal fin se recolectaron todos los pacientes con sospecha de CCMHS abordados por laparoscopia con intención de resección simultánea del tumor primario de colon con las metástasis hepáticas. Se analizaron variables preoperatorias, operatorias, resultados a corto y largo plazo, y anatomopatológicas. Resultados: en el período de estudio se realizaron 89 resecciones hepáticas laparoscópicas (RHL). En 28 pacientes se realizó ‒en forma simultánea con la RHL‒ otro procedimiento, en 21 de los cuales fue una colectomía laparoscópica. El tiempo quirúrgico promedio total de los dos procedimientos llegó a 407 minutos. El promedio de días de estadía hospitalaria fue de 8 días. No hubo mortalidad en la serie, y la morbilidad global fue del 71%, pero un solo caso con morbilidad mayor. La sobrevida global y la sobrevida libre de recurrencia a los 3 años fue de 55,2% y 16,3%, respectivamente. Conclusión: Esta es la primera publicación acerca del tema en nuestro país. Podemos decir que, en casos bien seleccionados, el abordaje laparoscópico simultáneo es factible de realizar, con aceptable morbimortalidad y sin comprometer los resultados oncológicos.


Background: In patients with colorectal cancer with synchronous liver metastases (CLM), complete resection of the primary tumor with the metastases is the only option for curative treatment. Several case series have been reported but no randomized controlled trials have been published. Objective: The aim was to evaluate if the simultaneous laparoscopic resection of the primary colon tumor and liver metastases is feasible and safe. Material and methods: A retrospective study was conducted with patients with suspected CLM scheduled for simultaneous laparoscopic resection of the primary tumor of the colon and liver metastases. The preoperative and operative variables, short- and long-term outcomes and pathological variables were analyzed. Results: A total of 89 laparoscopic liver resections (LLR) were performed during the study period. In 28 patients, LLR was simultaneous with other procedures, 21 of which corresponded to laparoscopic colon resection. Mean surgical time for both procedures was 407 minutes. Mean hospital length of stay was 8 days. None of the patients died and overall morbidity rate was 71% with only one major complication. Overall survival and relapse-free survival at three years was 55.2% and 16.3%, respectively. Conclusion: This is the first publication analyzing this approach in our country. In well selected cases, the simultaneous laparoscopic approach is feasible, with low morbidity and mortality and acceptable oncological results.


Subject(s)
Humans , Morbidity , Colectomy , Colon , Colonic Neoplasms/diagnosis , Methods , Neoplasms , Patients , Recurrence , Safety , Survival , Time , Indicators of Morbidity and Mortality , Retrospective Studies , Colonic Neoplasms , Intention , Employment , Operative Time , Hospitals , Length of Stay , Liver
6.
J. coloproctol. (Rio J., Impr.) ; 39(3): 231-236, June-Sept. 2019. tab
Article in English | LILACS | ID: biblio-1040321

ABSTRACT

ABSTRACT Objectives: Different clinicopathological and molecular features have been demonstrated between right and left sided colon cancers. We aimed to characterize colon cancer and sidedness among a North-Pakistani rural population diagnosed with colon cancer in our institution. Methods: Seventy patients were included in the study that received adjuvant chemotherapy at Bannu Institute of Nuclear Medicine Oncology and Radiotherapy) Bannu, Pakistan from January 2014 to December 2017. Chi-square test was used for significance of categorical variables. p-Values less than 0.05 were considered significant. Results: Mean age at diagnosis for right side colon cancer patients was 43.94 years and for left side colon cancer, it was 49.83 with no significant difference. Male patients were presented more with right (77% vs. 54%, p = 0.044) and females with predominantly left sided tumours i.e. (46% vs. 23%, p = 0.044). Right sided cancer tended to be more poorly differentiated (20% vs. 0%, p = 0.020). Mucinous adenocarcinoma was seen mostly in right sided colon cancer (37% vs. 3%, p ≤ 0.001). There were more locally advanced presentation of right side colon cancer with more node positive (83% vs. 60%, p = 0.025) and lymphovascular invasion (51% vs. 37%, p = 0.016). Sigmoid colon was the most common tumour subsite involved. Conclusion: Our study is the first report of colon cancer in a rural population in North-Pakistan. An earlier onset of tumours (44-50 years) was observed in comparison with global data.


RESUMO Objetivo: Características clínico-patológicas e moleculares distintas foram observadas em tumores de cólon no lado direito ou esquerdo. O presente estudo teve como objetivo caracterizar o câncer de cólon e sua lateralidade em uma população rural norte-paquistanesa diagnosticada com câncer de cólon nesta instituição. Métodos: O estudo incluiu 70 pacientes que foram submetidos a quimioterapia adjuvante no Instituto Bannu de Medicina Nuclear Radioterapia Oncológica (BINOR), Bannu, Paquistão, entre janeiro de 2014 e dezembro de 2017. O teste qui-quadrado foi utilizado para mensurar a significância das variáveis categóricas. Valores de p menores que 0,05 foram considerados significativos. Resultados: A média de idade ao diagnóstico entre pacientes com câncer de cólon no lado direito foi de 43,94 anos e entre aqueles com câncer de cólon no lado esquerdo, 49,83, sem diferença significativa. Os pacientes do sexo masculino apresentaram mais tumores no lado direito (77% vs. 54%, p = 0,044) e as pacientes do sexo feminino apresentaram mais tumores no lado esquerdo (46% vs. 23%, p = 0,044). Tumores mal diferenciados foram mais comumente observados no lado direito (20% vs. 0%, p = 0,020). Adenocarcinoma mucinoso foi observado principalmente em casos de tumores no lado direito (37% vs. 3%, p ≤ 0,001). A apresentação local estava mais avançada em tumores de cólon no lado direito, com mais linfonodos positivos (83% vs. 60%, p = 0,025) e invasão linfovascular (51% vs. 37%, p = 0,016). O cólon sigmoide foi o sublocal mais comum. Conclusão: O presente estudo é o primeiro relato de câncer de cólon em uma população rural no norte do Paquistão. Em comparação com dados globais, observou-se um surgimento mais precoce dos tumores (44-50 anos).


Subject(s)
Humans , Male , Female , Colonic Neoplasms/diagnosis , Colonic Neoplasms/pathology
8.
In. Madrid Karlen, Fausto. Abordaje clínico del paciente con patología quirúrgica. Montevideo, s.n, 2019. p.137-147.
Monography in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1291009
9.
Rev. inf. cient ; 97(1): i:95-f:105, 2018. tab
Article in Spanish | LILACS, CUMED | ID: biblio-995853

ABSTRACT

Se realizó un estudio retrospectivo en el policlínico Omar Ranedo Pubillones en el período comprendido de enero-diciembre de 2016 con el objetivo de conocer la repercusión del cáncer de colon a través de la pesquisa de sangre oculta en heces fecales (Sumasohf) como método de pesquisaje en la atención primaria de salud. El universo estuvo conformado por 10 216 pacientes, que constituyeron el 50 por ciento de los adultos mayores de 50 años del área, se pesquisaron 1 795, previo consentimiento informado para participar en el estudio y así actuar de forma preventiva en los casos que la pesquisa de sangre oculta que resultara positiva. Se confeccionó una planilla de recolección de información (edad, sexo, antecedentes patológicos personales o familiares, positividad en la pesquisa, así como pacientes fallecidos por cáncer de colon). Los resultados se presentaron en números y por cientos, mediante tablas. Predominaron los pacientes entre 70 años y más, pertenecientes al sexo femenino, el pesquisaje fue positivo en 146 casos y hubo un total de 27 fallecidos, muchos de ellos con sangre oculta positiva(AU)


A retrospective study was carried out in the polyclinic Omar Ranedo Pubillones in the period between January and December 2016, with the objective of knowing the repercussion of colon cancer through the occult blood fecal occult (Sumasohf) as a screening method in Primary health care. The universe consisted of 10 216 patients, who constituted 50 percent of the adults over 50 years of age in the area, 1 795 were searched, with prior informed consent to participate in the study and thus to act in a preventive way in cases that the blind blood research which was positive. A data collection sheet (age, sex, personal and/or familial pathological history, research positivity, as well as patients deceased by colon cancer) was prepared. The results were represented in numbers and by hundreds, using tables. Patients aged 70 years and older predominated, belonging to the female sex, the survey was positive in 146 cases and there were a total of 27 deceased, many of them with positive occult blood(AU)


Subject(s)
Humans , Colonic Neoplasms/diagnosis , Occult Blood , Retrospective Studies
10.
Biol. Res ; 51: 10, 2018. tab, graf
Article in English | LILACS | ID: biblio-950896

ABSTRACT

PROPOSE: We aimed to explore the potential molecular mechanism and independent prognostic genes for colon cancer (CC). METHODS: Microarray datasets GSE17536 and GSE39582 were downloaded from Gene Expression Omnibus. Meanwhile, the whole CC-related dataset were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed mRNA (DEMs) were identified between cancer tissue samples and para-carcinoma tissue samples in TCGA dataset, followed by the KEGG pathway and GO function analyses. Furthermore, the clinical prognostic analysis including overall survival (OS) and disease-free survival (DFS) were performed in all three datasets. RESULTS: A total of 633 up- and 321 down-regulated mRNAs were revealed in TCGA dataset. The up-regulated mRNAs were mainly assembled in functions including extracellular matrix and pathways including Wnt signaling. The down-regulated mRNAs were mainly assembled in functions like Digestion and pathways like Drug metabolism. Furthermore, up-regulation of UL16-binding protein 2 (ULBP2) was associated with OS in CC patients. A total of 12 DEMs including Surfactant Associated 2 (SFTA2) were potential DFS prognostic genes in CC patients. Meanwhile, the GRP and Transmembrane Protein 37 (TMEM37) were two outstanding independent DFS prognostic genes in CC. CONCLUSIONS: ULBP2 might be a potential novel OS prognostic biomarker in CC, while GRP and TMEM37 could be served as the independent DFS prognostic genes in CC. Furthermore, functions including extracellular matrix and digestion, as well as pathways including Wnt signaling and drug metabolism might play important roles in the process of CC.


Subject(s)
Humans , Animals , Colonic Neoplasms/diagnosis , Colonic Neoplasms/genetics , Gene Expression Profiling/methods , RNA, Messenger/genetics , RNA, Messenger/metabolism , Biomarkers, Tumor/genetics , Biomarkers, Tumor/metabolism , Genetic Markers , Down-Regulation/genetics , Gene Expression Regulation, Neoplastic , Up-Regulation/genetics , Risk Factors , Colonic Neoplasms/metabolism , Disease-Free Survival , Gastrin-Releasing Peptide/genetics , Gastrin-Releasing Peptide/metabolism , Intercellular Signaling Peptides and Proteins/genetics , Intercellular Signaling Peptides and Proteins/metabolism , Pulmonary Surfactant-Associated Protein A/genetics , Pulmonary Surfactant-Associated Protein A/metabolism , Microarray Analysis , Murinae , Kaplan-Meier Estimate , GPI-Linked Proteins/genetics , GPI-Linked Proteins/metabolism
11.
Clinics ; 72(7): 395-399, July 2017. tab
Article in English | LILACS | ID: biblio-890716

ABSTRACT

OBJECTIVES: The removal of pre-malignant colorectal lesions prevents cancer. Hyoscine has been proposed as a means of improving diagnosis by reducing colonic movements. The aim of this study was to analyze whether this anti-spasmodic enhances the detection of pre-malignant colorectal lesions. METHODS: In a randomized, double-blinded fashion patients received hyoscine or a saline solution in all consecutive colonoscopies in which the cecum was reached. Lesions were analysed with respect to number, size, location, histology and capillary pattern. RESULTS: A total of 440 colonoscopies were randomized. The overall polyp detection rate (PDR) and the adenoma detection rate (ADR) were 65.2% and 49.3%, respectively. In the hyoscine group, non-polypoid lesions were detected significantly more often (p=0.01). In the placebo group 281 lesions were diagnosed (202 adenomas) and in the hyoscine group 282 lesions were detected (189 adenomas) (p=0.23). The PDR and ADR were similar between the placebo and hyoscine groups (64% vs 66% and 50% vs 47%, respectively). No differences were observed between the two groups in the advanced-ADR or advanced neoplasia detection rate, as well the mean numbers of polyps, adenomas, advanced adenomas and advanced neoplasias detected per patient. The administration of hyoscine also did not improve the diagnostic accuracy of digital chromoendoscopy. The presence of adenomatous polyps in the right colon was detected significantly more frequently in the hyoscine group (OR 5.41 95% CI 2.7 - 11; p<0.01 vs OR 2.3 95% CI 1.1 - 4.6; p=0.02). CONCLUSION: The use of hyoscine before beginning the withdrawal of the colonoscope does not seem to enhance the PDR and the ADR.


Subject(s)
Humans , Male , Female , Middle Aged , Butylscopolammonium Bromide , Colonic Neoplasms/diagnosis , Colonic Polyps/diagnosis , Colonoscopy/methods , Double-Blind Method , Precancerous Conditions/diagnosis , Predictive Value of Tests , Prospective Studies , Sensitivity and Specificity
12.
Cir. parag ; 41(1): 1-13, abr. 2017. ilus
Article in Spanish | LILACS, BDNPAR | ID: biblio-972598

ABSTRACT

Objetivo: Determinar las características clínico-quirúrgicas e histológicas de un grupo de pacientes con diagnóstico de cáncer de colon, y causas de morbi-mortalidad. Material: estudio observacional descriptivo, retrospectivo, transversal de 40 pacientes con diagnostico histológico de cáncer de colon, de ambos sexos, ingresados en el Servicio de Cirugía del Hospital Central de IPS, de enero a julio del año de 2016.Resultados:52,5% correspondió al género masculino, con un promedio de 60 años. Los motivos de consulta más frecuentes fueron 33% dolor abdominal, 15% rectorragía, 10% obstrucción intestinal. El asiento más común para estos fueron el colon sigmoides 50%, ciego 20%, ascendente 15%, transverso 7,5%, esplénico 5%, descendente 2,5%. Fueron operados de manera electiva 90% de los pacientes. El tipo histopatológico más común fue el adenocarcinoma 95%. La vía de absceso más utilizada fue la convencional en 90% y laparoscópica 10%. Las complicaciones observadas fueron la dehiscencia de la anastomosis 15% e infección del sitio quirúrgico 25%. No hubo diferencia entre la sutura mecánica y manual en cuanto a la dehiscencia. El hígado fue el sitio más frecuente de asiento de las metástasis. La estancia hospitalaria media fue de 16 días. Pacientes mayores a 60 años reportan mayor estancia hospitalaria. La mortalidad intrahospitalaria fue baja y en la mayoría de los casos tribuida al acto quirúrgico. Influyendo también el estado previo del paciente.


Objective: To determine the clinical-surgical and histological characteristics of a group of patients diagnosed with colon cancer, and causes of morbidity and mortality of them. Material: a study descriptive, retrospective, of transverse cut about 40 patients with histological diagnosis of colon cancer, over 16 years, of both sexes admitted to the Department of Surgery of the Central Hospital of IPS, since January to July of 2016. Results: 52.5% were male, the most number of cases in the age range between 60-70 years, with predominance an average of 60 years. The most frequent reasons for medical consultation were 33% abdominal pain, bleeding by anus 15%, 10% intestinal obstruction. The most common seat for the tumor was the sigmoid colon were 50%, 20% cecun, ascending colon 15%, transverse 7.5%, colon spleen 5% descending colon 2.5%. They were operated elective so 90% of patients. The most common histological type was adenocarcinoma 95%. The way most comon used was abscess more conventional laparoscopic 90%. The observed complications were anastomotic leakage in 15% and surgical site infection by 25%. There was no difference between mechanical and manual suture regarding dehiscence. 62% the liver was the most frequent site of metastases seat. The average hospital stay was 16 days. Observed shorter stay in males. Shorter stay in patients undergoing elective surgery. patients over 60 years reported longer hospital stay. The hospital mortality was low and in most cases was inherent in the surgery, also influencing the previous state of the patient.


Subject(s)
Male , Female , Humans , Middle Aged , Aged , Colonic Neoplasms/complications , Colonic Neoplasms/diagnosis , Colonic Neoplasms/surgery
13.
Rev. chil. cir ; 69(2): 167-170, abr. 2017. ilus
Article in Spanish | LILACS | ID: biblio-844350

ABSTRACT

Introducción: La gangrena espontánea por Clostridium septicum es una entidad poco frecuente con una alta mortalidad que se asocia a pacientes neoplásicos y/o inmunodeprimidos. Caso clínico: Presentamos un caso de gangrena clostridial en un paciente con neoplasia de colon ascendente perforada a retroperitoneo. Discusión-conclusiones: Aunque es poco común deberemos pensar en una infección clostridial en pacientes sépticos y sospecha de neoplasia colónica. En ausencia de diagnóstico y tratamiento precoz, el pronóstico es fatal.


Introduction: Spontaneous gangrene due to Clostridium septicum is a low frequency pathology with a high mortality rate. It is related to neoplasic and/or immunodeficient patients. Case report: We present the case of a patient who presented clostridial gangrene associated with a perforated colon neoplasm. Discussion-conclusions: Although it is not very common it must supposed a clostridial infection in septic patients with colon neoplasm suspect. If diagnosis and treatment are delayed the prognostic of the patient is fatal.


Subject(s)
Humans , Male , Aged , Colonic Neoplasms/complications , Colonic Neoplasms/diagnosis , Fasciitis, Necrotizing/diagnosis , Fasciitis, Necrotizing/etiology , Clostridium septicum , Colonic Neoplasms/surgery , Fasciitis, Necrotizing/surgery , Fatal Outcome , Intestinal Perforation/etiology
14.
Rev. cuba. cir ; 55(4): 287-295, oct.-dic. 2016. tab
Article in Spanish | LILACS | ID: biblio-844828

ABSTRACT

Introducción: la oclusión intestinal es un padecimiento complejo y de difícil manejo, la etiología neoplásica es la primera causa de mortalidad. Objetivo: identificar los factores predictivos de mortalidad en la oclusión intestinal por cáncer de colon. Métodos: estudio explicativo, analítico, de cohorte realizado en el Hospital Provincial Saturnino Lora Torres de Santiago de Cuba, desde enero de 2010 hasta diciembre de 2015. Se seleccionó una muestra de 78 pacientes. Se utilizó la prueba de comparación de proporciones con un nivel de significación de p≤ 0,05 y la prueba de regresión logística multivariable para la identificación de los factores predictivos de la mortalidad. Resultados: existió predominio de los pacientes masculinos (53,8 por ciento); además de la localización del tumor a nivel del colon izquierdo (71,8 por ciento), sin evidenciarse asociación significativa entre estas variables y la mortalidad. El modelo multivariado de regresión logística, arrojó que la edad mayor a los 61 años, el tiempo de inicio de los síntomas superior a las 48 horas, el estado físico ASA IV y V, los procedimientos resecativos y la presencia de choque séptico; se erigen como factores causales en la explicación de la mortalidad. Se estimó una sensibilidad de 86,2, especificidad de 91,2 y porcentaje global predictivo de 89,7. Conclusiones: fue posible la construcción de un modelo predictivo de mortalidad para la oclusión intestinal por cáncer de colon a través de la identificación de las variables altamente influyentes en la defunción(AU)


Introduction: Bowel obstruction is a complex and difficult to manage disease and its neoplastic etiology is the leading cause of mortality. Objective: To identify predictive mortality factors in the bowel obstruction due to colon cancer. Methods: Cohort, explanatory and analytical study conducted in "Saturnino Lora Torres" provincial hospital of Santiago de Cuba, during the period of January 2010 to December 2015. A sample of 78 patients was selected. The proportion comparison test with a significance level of p ≤ 0.05 and the multivariable logistic regression test to identify mortality predictors were used. Results: Male patients (53.8 percent, and the location of tumor at the left colon (71.8 percent) predominated, with no evidence of significant association between these variables and mortality. Multivariate logistic regression model showed that patients aged more than 61 years, the onset of symptoms after 48 hours, ASA IV and V physical state, resection procedures and the presence of septic shock represent causative factors for mortality. Estimated sensitivity was 86.2, specificity 91.2 and overall predictive percentage 89.7. Conclusions: It was possible to design a predictive mortality model for bowel obstruction caused by the colon cancer through the identification of highly influential variables on death(AU)


Subject(s)
Humans , Male , Middle Aged , Colonic Neoplasms/diagnosis , Intestinal Obstruction/mortality , Cohort Studies , Intestinal Obstruction/etiology , Predictive Value of Tests
15.
Yonsei Medical Journal ; : 1106-1114, 2016.
Article in English | WPRIM | ID: wpr-34055

ABSTRACT

PURPOSE: Although there is a consensus about the need for surveillance colonoscopy after endoscopic resection, the interval remains controversial for large sessile colorectal polyps. The aim of this study was to evaluate the long-term outcome and the adequate surveillance colonoscopy interval required for sessile and flat colorectal polyps larger than 20 mm. MATERIALS AND METHODS: A total of 204 patients with large sessile and flat polyps who received endoscopic treatment from May 2005 to November 2011 in a tertiary referral center were included. RESULTS: The mean age was 65.1 years and 62.7% of the patients were male. The mean follow-up duration was 44.2 months and the median tumor size was 25 mm. One hundred and ten patients (53.9%) received a short interval surveillance colonoscopy (median interval of 6.3 months with range of 1-11 months) and 94 patients (46.1%) received a long interval surveillance colonoscopy (median interval of 13.6 months with range of 12-66 months). There were 14 patients (6.9%) who had local recurrence at the surveillance colonoscopy. Using multivariate regression analysis, a polyp size greater than 40 mm was shown to be independent risk factor for local recurrence. However, piecemeal resection and surveillance colonoscopy interval did not significantly influence local recurrence. CONCLUSION: Endoscopic treatment of large sessile colorectal polyps shows a favorable long-term outcome. Further prospective study is mandatory to define an adequate interval of surveillance colonoscopy.


Subject(s)
Adult , Aged , Colonic Neoplasms/diagnosis , Colonic Polyps/diagnosis , Colonoscopy , Endoscopic Mucosal Resection , Female , Humans , Male , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Prospective Studies , Time Factors , Watchful Waiting/methods
16.
J. coloproctol. (Rio J., Impr.) ; 35(4): 203-211, Oct.-Dec. 2015. graf
Article in English | LILACS | ID: lil-770455

ABSTRACT

Pathologic staging is currently the most important prognostic factor in colon cancer, although individually this procedure does not provide a complete clinical outcome. This study aimed to determine the disease-specific survival of patients with colon cancer treated in the Braga Hospital from January 2005 to December 2013, according to the American Joint Committee on Cancer, 6th edition, and the disease-free survival and disease- specific survival of high- and low-risk stage II patients, whether in use, or not, of adjuvant chemotherapy. We obtained a total sample of 578 patients, with 145 and 65 high- and low-risk stage II patients, respectively. We observed a 5-year disease-specific survival rate of 93%, 27.4% and 75% for stage IIA, IIB and IIIA patients, respectively, where IIIA and IIB present statistically significant differences (p = 0.001). In high-risk stage II patients, disease-free survival (p = 0.107) and disease-specific survival (p = 0.037) were higher in the group submitted to chemotherapy. In low- risk patients, disease-free survival was higher in the group submitted to chemotherapy (p = 0.494), while disease-specific survival was lower (p = 0.426). The differences observed between stage IIB and IIIA survival can be explained by the consensual use of adjuvant chemotherapy in stage IIIA, and by its controversial use in stage IIB. Adjuvant chemotherapy showed to be effective only in high-risk stage II patients in terms of disease-specific survival. In the future, other markers, namely molecular ones, may be used to stratify the risk of stage II patients and determine who will benefit from adjuvant chemotherapy. (AU)


O estadiamento patológico é, atualmente, o fator de prognóstico mais importante do câncer de cólon, embora individualmente não preveja totalmente o resultado clínico. Neste estudo, pretendeu-se determinar a sobrevivência para uma doença específica (SDE) dos pacientes com câncer de cólon tratados no Hospital de Braga entre janeiro de 2005 e dezembro de 2013, de acordo com a 6a edição da American Joint Committee on Cancer e a Sobrevivência Livre de Doença (SLD) e SDE dos doentes em estadio II, classificados em alto e baixo risco, de acordo com a realização ou não de quimioterapia adjuvante. Obtivemos uma amostra total de 578 pacientes, dos quais uma parcela pertencia ao estadio II de alto ou de baixo risco (145 e 65 pacientes, respetivamente). Observamos SDE a 5 anos de: 93%, 27,4% e 75% para os estadios IIA, IIB e IIIA, respetivamente; IIIA e IIB apresentaram diferenças significativas (p = 0,001). SLD (p = 0,107) e SDE (p = 0,037) para o estadio II de alto risco foram superiores no grupo tratado com quimioterapia. Nos doentes de baixo risco, SLD foi superior no grupo tratado com quimioterapia (p = 0,494), enquanto que SDE foi inferior (p = 0,426). As diferenças de sobrevivência observadas para os estadios IIB e IIIA podem se dever ao uso controverso da quimioterapia em IIB e ao uso consensual em IIIA. O uso da quimioterapia adjuvante demonstrou ser efetivo nos doentes em estadio II de alto risco em termos de SDE. Futuramente, outros marcadores, nomeadamente moleculares, poderão vir a ser uti- lizados para estratificar o risco do estadio II e definir quem se beneficiará com o tratamento adjuvante. (AU)


Subject(s)
Humans , Male , Female , Aged , Colonic Neoplasms/diagnosis , Neoplasm Staging , Prognosis , Mortality , Colonic Neoplasms/therapy , Disease-Free Survival
17.
Medisan ; 19(6)jun.-jun. 2015.
Article in Spanish | LILACS, CUMED | ID: lil-752951

ABSTRACT

Aproximadamente hasta 30 % de todos los pacientes con cáncer de colon, intervenidos con intención curativa, presentarán enfermedad recurrente, la cual puede provocar la muerte o motivar nuevos tratamientos con alto grado de morbilidad, sin que se haya logrado definir un modelo efectivo sobre la conducta a seguir, habida cuenta que aún no existen criterios uniformes con respecto a su prevención, tratamiento y seguimiento posoperatorio luego de la cirugía inicial, por cuanto se desconocen las posibilidades reales de supervivencia y las causas asociadas a la mortalidad. Sobre la base de tales reflexiones, se revisó la bibliografía pertinente sobre algunas cuestiones elementales al respect.


Approximately up to a 30% of patients with colon cancer, surgically treated with healing aims, will have a recurrent disease, which can cause death or motivate new treatments with high morbidity degree, without achieving yet a definite and effective model on the behaviour to be followed, taking into account that there are no uniform approaches with regard to its prevention, treatment and postoperative follow-up after the initial surgery, so that the real possibilities of survival and the causes associated with mortality are ignored. On the basis of such conclusions, the pertinent literature was reviewed on some elementary questions in this respect.


Subject(s)
Colonic Neoplasms , Colonic Neoplasms/diagnosis , Radiotherapy , Colonic Neoplasms/mortality , Drug Therapy , Immunotherapy
18.
Article in English | WPRIM | ID: wpr-191018

ABSTRACT

Primary colorectal choriocarcinoma is a rare neoplasm. Only 19 cases have been reported worldwide, most of which involved adenocarcinomas. The prognosis is usually poor, and the standard therapy for this tumor has not been established. A 61-year-old woman presented with constipation and lower abdominal discomfort. She was diagnosed with primary adenocarcinoma with focal choriocarcinomatous differentiation in the sigmoid colon and liver metastasis. Because the serum beta-human chorionic gonadotropin level was not significantly elevated, and because only focal choriocarcinomatous differentiation was diagnosed, we selected the chemotherapy regimen that is used for the treatment of metastatic colorectal adenocarcinoma. The patient survived for 13 months after the initial diagnosis. This is the first case in Korea to assess the suppressive effects of the standard chemotherapy for colorectal adenocarcinoma against coexisting colorectal choriocarcinoma and adenocarcinoma.


Subject(s)
Adenocarcinoma/diagnosis , Antineoplastic Agents/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , CA-19-9 Antigen/analysis , Chorionic Gonadotropin, beta Subunit, Human/blood , Colon, Sigmoid/pathology , Colonic Neoplasms/diagnosis , Colonoscopy , Constipation/etiology , Female , Fluorouracil/therapeutic use , Humans , Leucovorin/therapeutic use , Liver Neoplasms/secondary , Middle Aged , Organoplatinum Compounds/therapeutic use , Prognosis , Tomography, X-Ray Computed
19.
Article in Korean | WPRIM | ID: wpr-153828

ABSTRACT

Gastric cancer frequently disseminates to the liver, lung, and bone via hematogeneous, lymphatic, or peritoneal routes. However, gastric adenocarcinoma that metastasize to the colon and that shows typical linea platisca pattern on colonofiberscopy has rarely been reported. Recently, the authors experience a case of advanced gastric cancer with colonic metastases in a 55-year-old female patient. Multiple colonic lymphoid hyperplasias were detected on colonofiberscopy and biopsy revealed metastatic gastric cancer to the colonic wall. She was treated with mFOLFOX (5-FU, oxaliplatin, leucovorin) and has achieved stable disease status without disease progression. Herein, we report a rare case of signet ring-cell gastric cancer which metastasized to the colon in the form of multiple colonic lymphoid hyperplasias.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Colonic Neoplasms/diagnosis , Colonoscopy , Female , Fluorouracil/administration & dosage , Gastroscopy , Humans , Hyperplasia/diagnosis , Leucovorin/administration & dosage , Middle Aged , Organoplatinum Compounds/administration & dosage , Positron-Emission Tomography , Stomach Neoplasms/diagnosis , Tomography, X-Ray Computed
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