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1.
Rev. Odontol. Araçatuba (Impr.) ; 42(1): 24-32, jan.-abr. 2021. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1148164

ABSTRACT

O uso de próteses mal adaptadas pode ocasionar o surgimento de processos proliferativos não neoplásicos. A hiperplasia fibrosa inflamatória (HFI) é uma lesão benigna, proveniente de reação hiperplásica do tecido conjuntivo fibroso em resposta às injúrias crônicas de baixa intensidade. O objetivo do presente trabalho é relatar um caso clínico sobre remoção cirúrgica de HFI, seguida de reabilitação oral com próteses removíveis. Paciente de 75 anos do sexo masculino relatou que gostaria de fazer a troca da sua prótese, pois a mesma estava fraturada. Ao exame clínico intra-oral constatou-se que suas próteses possuíam higienização precária, e, a superior, possuía uma borda cortante que causou uma lesão hiperplásica na região de fundo de vestíbulo anterior. Quanto ao aspecto clínico, apresentava-se com consistência fibrosa e firme à palpação, de coloração semelhante a mucosa e assintomática. O plano de tratamento proposto foi reembasamento da prótese antiga com resina Soft Confort (Dencril, Brasil) eliminando as áreas que traumatizavam a mucosa, cirurgia pré-protética para a remoção da HFI, exame histopatológico e a confecção de novas próteses, sendo a superior prótese total convencional e a inferior prótese parcial removível. Observa-se a importância no cuidado do planejamento reabilitador protético dos pacientes, pois, como foi descrito neste caso, em algumas situações pode haver necessidade de lançarmos mão de diversas modalidades de tratamento prévias à reabilitação(AU)


The use of poorly adapted prostheses can lead to the emergence of non-neoplastic proliferative processes. Inflammatory fibrous hyperplasia (HFI) is a benign lesion, resulting from a hyperplastic reaction of fibrous connective tissue in response to low-intensity chronic injuries. The aim of the present study is to report a clinical case about surgical removal of HFI, followed by oral rehabilitation with removable prostheses. A 75-year-old male patient reported that he would like to change his prosthesis, because it was fractured. On intra-oral clinical examination, it was found that his prostheses had poor hygiene, and the upper one had a cutting edge that caused a hyperplastic lesion in the deep region of the anterior vestibule. As for the clinical aspect, it was fibrous and firm on palpation, mucosa-like and asymptomatic. The proposed treatment plan was to repurpose the old prosthesis with Soft Confort resin (Dencril, Brazil), eliminating the areas that traumatized the mucosa, pre-prosthetic surgery for the removal of HFI, histopathological examination and the making of new prostheses, the upper prosthesis being conventional total and the lower partial removable prosthesis. It is observed the importance in the care of the prosthetic rehabilitation planning of the patients, because, as it was described in this case, in some situations it may be necessary to resort to different treatment modalities prior to the rehabilitation(AU)


Subject(s)
Dental Prosthesis Design , Hyperplasia , Connective Tissue , Denture, Complete , Denture, Partial, Removable , Denture Rebasing
2.
Braz. dent. sci ; 24(3): 1-7, 2021. tab, ilus
Article in English | LILACS, BBO | ID: biblio-1281389

ABSTRACT

Background: Oral submucous fibrosis (OSMF) is graded according to various histological factors which include the epithelial changes and the connective tissue changes. These features could be identified in routine Hematoxylin and Eosin (H and E) staining in shades of pink. However, the use of special stains provides a contrast to various connective tissue components thereby aiding in better visualization of these connective tissue changes in advanced OSMF cases. Objective:To compare and evaluate muscle involvement and degeneration in advanced oral submucous fibrosis using three different stains namely, H&E, Van Gieson, and Masson's Trichrome. Material and Methods: 10 Formalin-fixed paraffin-embedded tissue sections of advanced OSMFwere stained using 3 different stains namely Hematoxylin and Eosin (H&E), Van-Gieson, and Masson trichrome. The results obtained were tabulated and statistically analyzed using Kruskal Wallis ANOVA. Results: The hyalinization and fibrosis involving the skeletal muscle were better visualized in Masson's Trichrome but were not statistically significant. The muscle degeneration in deeper areas was better visualized in Masson's trichrome when compared to the H&E and Van Gieson. Conclusion: Hematoxylin and eosin stains all the connective tissue components in various shades of pink, use of special stains bestows contrast between different components of connective tissue, thus improvising grading of OSMF. Masson's trichrome stain can be used as a single adjunct to hematoxylin and eosin stain as changes in the superficial and deeper connective tissue could be ascertained (AU)


Contexto: A fibrose submucosa oral (FSO) é classificada de acordo com vários fatores histológicos que incluem alterações epiteliais e do tecido conjuntivo. Essas características podem ser identificadas na coloração de rotina com Hematoxilina e Eosina (H&E) em tons de rosa. No entanto, o uso de colorações especiais fornece um contraste para vários componentes do tecido conjuntivo, auxiliando assim na melhor visualização dessas alterações do tecido conjuntivo em casos avançados de FSO. Objetivo: Comparar e avaliar o envolvimento e degeneração muscular da fibrose submucosa oral avançada usando três colorações diferentes: H&E, Van Gieson e Tricrômio de Masson. Material e Métodos: 10 seções de tecido fixadas em formalina e embebidas em parafina de FSO avançada foram coradas usando essas três colorações. Os resultados obtidos foram tabulados e analisados estatisticamente por meio do teste de Kruskal Wallis. Resultados: A hialinização e fibrose envolvendo o músculo esquelético foram melhor visualizadas no tricromo de Masson, mas não foram estatisticamente significativas. A degeneração muscular em áreas mais profundas foi melhor visualizada no tricrômico de Masson, quando comparado ao H&E e Van Gieson. Conclusão: Hematoxilina e Eosina coloram todos os componentes do tecido conjuntivo em vários tons de rosa. O uso de colorações especiais confere contraste entre os diferentes componentes do tecido conjuntivo, melhorando assim a avaliação da FSO. A coloração com tricrômio de Masson pode ser usada como um único adjunto para a coloração de Hematoxilina e Eosina, pois assim é possível verificar alterações superficiais e profundas no tecido conjuntivo. (AU)


Subject(s)
Oral Submucous Fibrosis , Fibrosis , Connective Tissue
3.
Rev. bras. cir. cardiovasc ; 35(6): 977-985, Nov.-Dec. 2020. tab, graf
Article in English | SES-SP, LILACS, SES-SP | ID: biblio-1144002

ABSTRACT

Abstract Objective: To review the currently available literature to define the role of thoracic endovascular aortic repair (TEVAR) in patients with connective tissue disorders (CTD). Methods: A comprehensive electronic database search was performed in PubMed, SCOPUS, Embase, Google scholar, and OVID to identify all the articles that reported on outcomes of utilizing TEVAR in patients with CTD during elective and emergency settings. The search was not limited to time or language of the published study. Results: All the relevant studies have been summarized in its correspondence section. The outcomes were analyzed in narrative format. The role of TEVAR has been elaborated as per each study. Currently, there is limited large cohort size studies outlining the use of TEVAR in patients with CTD. The use of endovascular repair in patients with CTD is limited due to progressive aortic dilatations and high possibility of further reinterventions at later stage of life. Conclusion: Open repair remains the gold standard method of intervention in young patients with progressive CTD, especially in the setting of acute type A aortic dissection. However, TEVAR can be sought as a reliable alternative in emergency setting of diseases involving the descending thoracic aorta; yet the long-term data needs to be published to support such practice.


Subject(s)
Humans , Aortic Diseases/surgery , Blood Vessel Prosthesis Implantation , Endovascular Procedures , Aorta, Thoracic/surgery , Postoperative Complications/surgery , Retrospective Studies , Risk Factors , Treatment Outcome , Aortic Aneurysm, Thoracic/surgery , Connective Tissue
4.
Rev. bras. ortop ; 55(6): 804-807, Nov.-Dec. 2020. graf
Article in English | LILACS | ID: biblio-1156184

ABSTRACT

Abstract Neurothekeomas, also known as neural sheath myxomas, are rare benign tumors of the neural sheath affecting most commonly the head, arms and shoulder of women in their 2nd and 3rd decades of life. Due to the low prevalence and undefined clinical picture, they are hardly considered in the initial differential diagnosis of skin tumors. We report the case of a 24 year-old woman who was seen in 2016 reporting > 1 year of moderate pain and limited mobility of her left shoulder. Clinical evaluation revealed restricted mobility of the affected shoulder and nuclear magnetic resonance imaging showed a T2-weighted contrast-enhanced multilobular mass in the quadrilateral area apparently invading the adjacent humeral cortical region. Histopathology of a needle sample material revealed loose fibroconnective tissue with no signs of invasion, mitosis or atypical figures. Successful surgical excision was performed and the diagnosis of neurothekeoma was confirmed after detailed histopathology, including immunohistochemistry. The patient was asymptomatic at 18 months of follow-up, with full recovery of shoulder movement and no signs of relapse.


Resumo Neurotecomas, também conhecidos como mixomas da bainha neural, são tumores benignos raros da bainha neural afetando mais comumente a cabeça, braços e ombros de mulheres entre 20 e 40 anos de idade. Devido à baixa prevalência e quadro clínico mal definido, essas lesões são raramente consideradas no diagnóstico diferencial de tumores cutâneos. Relatamos o caso de uma mulher de 24 anos de idade que procurou atendimento em 2016 relatando dor moderada por mais de um ano e limitação dos movimentos do ombro esquerdo. Ao exame, foi constatada restrição da mobilidade dessa articulação e uma ressonância magnética revelou imagem multilobular com aumento de sinal em T2 na região quadrilateral, aparentando invasão da região cortical do úmero subjacente. A histopatologia de uma biópsia incisional mostrou lesão composta por tecido conjuntivo frouxo, sem sinais de invasão, figuras de mitose ou atipias. Foi realizada excisão completa da lesão e o diagnóstico de neurotecoma foi confirmado após análise histopatológica que incluiu painel imunohistoquímico. À revisão de 18 meses, a paciente estava assintomática com recuperação completa do movimento e sem evidência de recidiva da lesão.


Subject(s)
Humans , Female , Adult , Arm , Recurrence , Skin Neoplasms , Axilla , Biopsy , Magnetic Resonance Spectroscopy , Neurothekeoma , Connective Tissue , Shoulder Pain , Diagnosis, Differential , Head , Joints , Mitosis , Myxoma , Neoplasms
5.
Rev. colomb. reumatol ; 27(supl.1): 170-174, Oct.-Dec. 2020. tab, graf
Article in English | LILACS | ID: biblio-1341331

ABSTRACT

ABSTRACT Raynaud's phenomenon is a sentinel event in systemic sclerosis; it is generally long- lasting, and repeated attacks produce, ultimately, structural consequences and complications, such as digital ulcers. Nailfold videocapillaroscopy is a non-invasive tool that allows assessing accurately these changes. Digital ulcers are the most aggressive and frequent microvascular complication in this disease, causing severe pain and significant functional sequelae. This literature review focuses on Raynaud's phenomenon as a central event in systemic sclerosis, its peculiarities in this entity, the role of capillaroscopy as a biomarker in this vasculopathic phenomenon, as well as a on a clinical and pharmacological approach to digital ulcers in this illness.


RESUMEN El fenómeno de Raynaud es un evento centinela en la esclerosis sistémica, por lo general es de larga duración y los ataques repetidos producen, en última instancia, consecuencias estructurales y complicaciones tales como úlceras digitales. La videocapilaroscopia del lecho ungueal es una herramienta no invasiva que permite evaluar en forma precisa estos cambios. Las úlceras digitales son la complicación microvascular más agresiva y frecuente en esta enfermedad, causando dolor severo y secuelas funcionales importantes. Esta revisión de la literatura se centra en el fenómeno de Raynaud como evento central en la esclerosis sistémica, sus peculiaridades en esta entidad y el papel de la capilaroscopia como biomarcador para este fenómeno vasculopático, así como en un enfoque clínico y farmacológico de las úlceras digitales en esta enfermedad.


Subject(s)
Humans , Raynaud Disease , Scleroderma, Systemic , Microscopic Angioscopy , Ulcer , Connective Tissue
6.
Int. j. odontostomatol. (Print) ; 14(4): 602-609, dic. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1134546

ABSTRACT

RESUMEN: Comparar mediante una revisión sistemática los resultados clínicos de los procedimientos de cirugía plástica periodontal/periimplantar (CP) con injerto de tejido blando autógeno (ITB) obtenido del área lateral del paladar (ALP) versus del área de la tuberosidad (AT). Se realizó una búsqueda electrónica de ensayos clínicos en la base de datos Medline/Pubmed, Cochrane y las revistas de Periodoncia e Implantes de mayor impacto según la Web of Science, para hallar artículos publicados hasta abril del 2020. Se valoró el riesgo de sesgo de los artículos añadidos según el manual Cochrane Versión 5.1.0 para ensayos clínicos aleatorizados y la escala Newcastle-Ottawa para ensayos clínicos controlados. De una muestra inicial de 930 artículos, cuatro ensayos clínicos (tres aleatorizados) fueron incluidos en el presente estudio, donde se realizaron un total de 87 CP alrededor de piezas e implantes dentales, de las cuales 42 cirugías fueron realizadas con ITB del ALP y 45 cirugías con ITB del AT, se evaluó los resultados desde las 8 semanas hasta los 12 meses. No se hallaron diferencias estadísticamente significativas en los resultados clínicos entre ambos grupos, se mejoró el fenotipo gingival en la zona receptora para el grupo que obtuvo el ITB del AT y el nivel del dolor del sitio donador del AT fue menor en las dos primeras semanas que el sitio donante del ALP. Los estudios incluidos manifestaron un bajo riesgo de sesgo en promedio. Ambas áreas donantes de injerto de tejido blando proporcionan resultados clínicos similares, el injerto del área de la tuberosidad mejora el fenotipo gingival de la zona receptora y reduce el dolor post operatorio en las primeras semanas del sitio donador.


ABSTRACT: The objective of the study was to compare, through a systematic review, the clinical results of periodontal / peri-implant plastic surgery (CP) procedures with autogenous soft tissue graft (ITB) obtained from the lateral palate area (ALP) versus the tuberosity area (AT). We conducted an electronic search of clinical trials in the Medline/Pubmed, Cochrane database and the journals of Periodontics and Implants with the greatest impact according to the Web of Science, to find articles published until April 2020. The risk of bias of the articles added was assessed according to the Cochrane Manual Version 5.1.0 for randomized clinical trials and the Newcastle-Ottawa scale for controlled clinical trials. From the initial sample of 930 articles, four clinical trials were included (three randomized) in the present study, where a total of 87 PC were performed around dental pieces and implants, of which 42 surgeries were performed with ITB of the ALP and 45 surgeries with ITB of the AT, the results were evaluated from the 8 weeks to 12 months. No statistically significant differences were found in the clinical results between the two groups, the gingival phenotype in the receiving area was improved for the group that obtained the ITB of the AT and the level of pain at the donor site was lower in the first two weeks than the ALP donor site. The studies showed a lowrisk of bias on average. Both soft tissue graft donor areas provide similar clinical results, grafting the tuberosity area improves the gingival phenotype of the recipient area and reduces post-operative pain of the donor site in the first few weeks.


Subject(s)
Humans , Dental Implants/statistics & numerical data , Oral Surgical Procedures , Dental Implantation, Endosseous , Palate , Transplantation, Autologous , Selection Bias , Tissue Transplantation , Connective Tissue/transplantation , Gingival Recession
7.
Int. j. morphol ; 38(5): 1165-1172, oct. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1134419

ABSTRACT

RESUMEN: Las conexiones intertendinosas (CIT) son bandas estrechas de tejido conectivo que unen tendones adyacentes del músculo extensor de los dedos. Dichas bandas se ubican de manera superficial en el dorso del segundo, tercer y cuarto espacios intermetacarpianos (EIMC) presentando funciones importantes como colaborar en la estabilización de la articulación metacarpofalángica y permitir la redistribución de fuerzas extensoras sobre esta articulación. El objetivo del presente estudio fue establecer la biometría de las CIT. Para ello se utilizaron 24 miembros superiores formolizados, pertenecientes al laboratorio de Anatomía, de la Universidad Andrés Bello, sede Viña del Mar, Chile. Se registraron las longitudes de inserción lateral y medial, el ancho y la longitud total de cada CIT. Siguiendo dos criterios, las CIT se clasificaron según morfología y además se localizaron según tercios del dorso de la mano. De las 69 CIT encontradas, el 39 % presentó una disposición transversa y 61 % una oblicua. En relación a la clasificación morfológica de la CIT se identificó un 29 % del tipo 1; 39 % del tipo 2. Para el caso del tipo 3, un 20 % presentó la forma "r" y en un 12 % la forma "y". Respecto a su localización se estableció que en el segundo EIMC el 18 % de las CIT se ubicaron el tercio distal del dorso y el 82 % en el tercio medio. En el tercer EIMC el 96 % de las CIT se localizó en el tercio distal y 4 % en el tercio medio. En el cuarto EIMC el 96 % se ubicó en el tercio distal y el 4 % en el tercio medio. Considerando como referencia la línea biestiloidea, las CIT en el segundo EIMC presentaron un promedio de ancho de 8,16 ± 1,94 mm y una longitud total promedio de 13,71 ± 4,70 mm. En el tercer EIMC, un promedio de 10,94 ± 4,39 mm para el ancho y 6,29 ± 3,26 mm de longitud total promedio. En el cuarto EIMC el promedio de ancho fue de 7,00 ± 3,06 mm y la longitud total promedio 7,08 ± 4,42 mm. Estos hallazgos aportan datos respecto de la biometría y localización de las CIT, lo que resulta de utilidad en procedimientos de reparación quirúrgica del dorso de la mano humana.


SUMMARY: Intertendinous connections (IC) are narrow connective tissue bands extending between the extensor digitorum (ED) tendons. These bands are located superficially on the dorsum of the second, third and fourth intermetacarpal (IMC) space, presenting important functions such as collaborating in the stabilization of the metacarpophalangeal joint (MCP) and allowing the redistribution of extensor forces on this joint. The objective of the present study was to establish the biometric characteristics of IC. To do this, 24 formalized upper limbs are used, belonging to the Anatomy laboratory of the Universidad Andrés Bello, Viña del Mar, Chile. Lateral and medial insertion lengths, width and total length of each IC were recorded. Following two criteria, IC were classified according to morphology and were also located according to thirds of the back of the hand. 69 IC were found, 39% presented a transverse arrangement and 61 % an oblique arrangement. In relation to the morphological classification of IC, 29 % of type 1 were identified, 39 % of type 2. In the case of type 3, 20 % presented the form "r" and 12 % the form "y". Regarding its location, it was established that in the second IMC space, 18 % of the IC were located in the distal third of the back and 82 % in the middle third. In the third IMC space, 96 % of the IC was located in the distal third and 4 % in the middle third. In the fourth IMC space, 96 % were located in the distal third and 4 % in the middle third. Considering the biestiloid line as a reference, the IC in the second IMC space considers an average width of 8.16 + 1.94 mm and an average total length of 13.71 + 4.70 mm. In the third IMC space, an average of 10.94 + 4.39 mm for the width and 6.29 + 3.26 mm of average total length. In the fourth IMC space the average total width of 7.00 + 3.06 mm and the average total length of 7.08 + 4.42 mm. These findings provide data regarding the biometrics and location of IC, which is useful in surgical repair procedures on the back of the human hand.


Subject(s)
Humans , Tendons/anatomy & histology , Muscle, Skeletal/anatomy & histology , Hand/anatomy & histology , Cadaver , Connective Tissue
8.
Rev. ADM ; 77(3): 168-171, mayo-jun. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1128903

ABSTRACT

El póntico E es una alternativa de tratamiento para la pérdida prematura dental, este tipo de póntico fue publicado por primera vez en 2014 por Robert P. Korman. El diseño del póntico permite ofrecer predictibilidad en cuanto a soporte y mantenimiento de la arquitectura gingival, también promueve que el tejido vestibular migre coronalmente sobre el póntico, creando un surco gingival. Se recibió a una paciente que presentaba fragmento radicular del diente 21 y ausencia del diente 12, reborde residual atrófico (clase I según Seibert). Como plan de tratamiento, se realizó la extracción atraumática del fragmento radicular del diente 21 para retardar el colapso del reborde alveolar y se colocó injerto de tejido conectivo en la zona del diente 12 para corregir el defecto clase I de Seibert, se realizó la conformación de los nichos gingivales con electrobisturí en conjunto con la prótesis provisional y la preparación de los dientes pilares para la recepción y rehabilitación con pónticos E. Se colocó una prótesis fija de cinco unidades (dientes 13 al 23) en material núcleo de Zr y estratificada con cerámica (AU)


Pontic E is an alternative treatment for premature dental loss, this type of pontic was published for the first time in 2014 by Robert P. Korman. The design of the pontic allows to offer predictability in terms of support and maintenance of the gingival architecture, it also promotes that the vestibular tissue migrates coronally over the pontic, creating a gingival groove. A patient was received who presented a radicular fragment of tooth 21 and absence of tooth 12, atrophic residual ridge (class I according to Seibert). As a treatment plan, atraumatic extraction of the root fragment of tooth 21 was performed to delay the collapse of the alveolar ridge and connective tissue graft was placed in the area of tooth 12 to correct Seibert's class I defect, conformation was performed of the gingival niches with electrocautery in conjunction with the provisional prosthesis and the preparation of the abutment teeth for the reception and rehabilitation with pontics E. A fixed prosthesis of five units was placed (teeth from 13 to 23) of Zr core material and stratified with ceramic (AU)


Subject(s)
Humans , Female , Adult , Denture, Partial, Fixed , Esthetics, Dental , Alveolar Ridge Augmentation , Patient Care Planning , Tooth Extraction , Ceramics , Connective Tissue/transplantation , Electrosurgery , Mexico
9.
Rev. argent. reumatolg. (En línea) ; 31(2): 25-30, jun. 2020. tab
Article in Spanish | LILACS, BINACIS | ID: biblio-1143928

ABSTRACT

Objetivos: Determinar la relación de los anticuerpos con los antígenos del núcleo extraíble y las enfermedades del tejido conectivo identificadas por Immunoblot en un hospital de Lima, Perú. Material y métodos: Estudio de tipo observacional, ciencias básicas, analíticas y transversales, realizado en el Servicio de Inmunología del Hospital Nacional Arzobispo Loayza entre enero de 2018 y junio de 2018. Analizamos 291 historias clínicas de pacientes con enfermedad del tejido conectivo y para la detección de anticuerpos contra los antígenos extraíbles del núcleo se empleó el método de Immunoblots. Resultados: La frecuencia de los anticuerpos contra antígenos nucleares extraíbles en pacientes con enfermedad del tejido conectivo identificados por Immunoblot fue 789 (100%). Se demostró que existe una relación significativa p <0.05 de Anti-histonas (X2 = 64.19; p = 0,000), anti-nucleosomas (X2 = 71,16; p = 0,000), anti-dsDNA (X2 = 71,44; p = 0,000), anti-SM (X2 = 10,08; p = 0,003) y lupus eritematoso sistémico con prueba de Chi-cuadrado de Pearson. Se demostró que existe una relación significativa p <0.05 del Anti-SSA (X2 = 61,33; p = 0.001), anti-SSB (x2 = 51,00; p = 0.001), anti-Ro 52 (X2 = 62,60; p = 0,000) y síndrome de Sjogren con prueba de Chi-cuadrado de Pearson. Se demostró que existe una relación significativa p <0.05 de Anti-CENP B (p = 0.001) y calcinosis, fenómeno de Raynaud, dismotilidad esofágica, esclerodactilia y Telangiectasia (CREST) con Fisher. Conclusiones: Existe relación de anticuerpos con antígenos de núcleo extraíbles y lupus eritematoso sistémico, síndrome de Sjogren, enfermedad mixta del tejido conectivo, enfermedad del CREST, esclerodermia y polimiositis.


Objectives: To determine the relationship of antibodies to extractable nucleus antigens and connective tissue diseases identified by Immunoblot in a hospital in Lima, Peru. Material and methods: Study of the observational type, basic sciences, analytical and transversal, carried out in the Immunology service of the national Hospital Archbishop Loayza between January 2018 and June 2018. We analyzed 291 clinical histories of patients with connective tissue disease and for the detection of antibodies to the extractable antigens of the nucleus the method of Immunoblot was employed. Results: The frequency of the antibodies against extractable nuclear antigens in patients with connective tissue disease identified by Immunoblot was 789 (100%). It was demonstrated that there is significant relationship p < 0.05 of Anti-histones (X2 = 64.19; p = 0,000), anti-nucleosomas (X2 = 71,16; p = 0,000), anti-dsDNA (X2 = 71,44; p = 0,000), anti-SM (X2 = 10,08; p = 0,003) and Lupus Systemic erythematosus with Pearson Chi-square test. It was demonstrated that there is significant relationship p < 0.05 of the Anti-SSA (X2 = 61,33; p = 0.001), anti-SSB (X2 = 51,00; p = 0.001), anti-Ro 52 (X2 = 62,60; p = 0,000) and Sjogren's syndrome with Pearson Chi-square test. It was demonstrated that there is significant relationship p < 0.05 of Anti-CENP B (p = 0.001) and calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and Telangiectasia (CREST) with exact Fisher statistician. Conclusions: There is a relationship of antibodies to extractable nucleus antigens and systemic lupus erythematosus, Sjogren's syndrome, mixed connective tissue disease, calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and Telangiectasias (CREST), Scleroderma and Polymyositis.


Subject(s)
Humans , Antibodies , Connective Tissue , Connective Tissue Diseases , Mixed Connective Tissue Disease , Antigens
10.
Int. j. morphol ; 38(2): 367-373, abr. 2020. tab, graf
Article in English | LILACS | ID: biblio-1056449

ABSTRACT

Sexual dimorphism in Homo-sapiens is a phenomenon of a direct product of evolution by natural selection where evolutionary forces acted separately on the sexes which brought about the differences in appearance between male and female such as in shape and size. Advances in morphometrics have skyrocketed the rate of research on sex differences in human and other species. However, the current challenges facing 3D in the acquisition of facial data such as lack of homology, insufficient landmarks to characterize the facial shape and complex computational process for facial point digitization require further study in the domain of sex dimorphism. This study investigates sexual dimorphism in the human face with the application of Automatic Homologous Multi-points Warping (AHMW) for 3D facial landmark by building a template mesh as a reference object which is thereby applied to each of the target mesh on Stirling/ESRC dataset containing 101 subjects (male = 47, female = 54). The semi-landmarks are subjected to sliding along tangents to the curves and surfaces until the bending energy between a template and a target form is minimal. Principal Component Analysis (PCA) is used for feature selection and the features are classified using Linear Discriminant Analysis (LDA) with an accuracy of 99.01 % which demonstrates that the method is robust.


El dimorfismo sexual en el Homo-sapiens es un fenómeno directo de la evolución por selección natural, donde las fuerzas evolutivas actuaron por separado en los sexos, lo que provocó las diferencias en la apariencia entre hombres y mujeres, tal como la forma y tamaño. Los avances en el área de la morfometría, han generado un aumento significativo de las investigaciones en las diferencias de sexo en humanos y otras especies. Sin embargo, los desafíos actuales que enfrenta el 3D en el análisis de datos faciales, como la falta de homología, puntos de referencia insuficientes para caracterizar la forma facial y la complejidad del proceso computacional para la digitalización de puntos faciales, requiere un estudio adicional en el área del dimorfismo sexual. Este estudio investiga el dimorfismo sexual en el rostro humano con la aplicación de la deformación automática de múltiples puntos homólogos para el hito facial 3D, mediante la elaboración de una malla de plantilla como objeto de referencia, y se aplica en cada una de las mallas objetivas en el conjunto de datos Stirling / ESRC que contiene 101 sujetos (hombre = 47, mujer = 54). Los semi-puntos de referencia se deslizan a lo largo de las tangentes a las curvas y superficies hasta que la energía de flexión entre una plantilla y una forma objetivo es mínima. El análisis de componentes principales (PCA) se utiliza para la selección de características y las características se clasifican mediante el análisis discriminante lineal (ADL) con una precisión del 99,01 %, lo que demuestra la validez del método.


Subject(s)
Humans , Male , Female , Sex Characteristics , Connective Tissue/anatomy & histology , Face/anatomy & histology , Discriminant Analysis , Multivariate Analysis , Connective Tissue/diagnostic imaging , Imaging, Three-Dimensional , Face/diagnostic imaging , Anatomic Landmarks
11.
Arq. odontol ; 56: 1-7, jan.-dez. 2020. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1097355

ABSTRACT

Objetivo:O objetivo desta revisão foi realizar uma análise crítica da literatura quanto à utilização do procedimento enxerto de tecido conjuntivo e da membrana de fibrina rica em plaquetas para recobrimento da raiz exposta, frisando os benefícios e previsibilidade de sucesso de cada uma. Métodos:Foi realizada uma busca nas bases PubMed, SciELO e BIREME em março de 2019, sendo incluídos estudos relevantes relacionados ao tema para síntese deste trabalho. Resultados: Foram selecionados 5 artigos para serem incluídos nessa revisão crítica, sendo 3 ensaios clínicos controlados randomizados, 1 ensaio clínico e 1 um relato de caso. Conclusão:O recobrimento radicular com uso de enxerto de tecido conjuntivo e fibrina rica em plaquetas apresentou resultados satisfatórios, devolvendo estética, saúde e regeneração dos tecidos gengivais e periodontais. Em relação à fibrina rica em plaquetas, há poucos casos na literatura quanto aos resultados clínicos a longo prazo.


Aim: This review sought to perform a critical analysis of the literature regarding the use of the graft procedure of connective tissue and Platelet-rich fibrin to cover the exposed root, emphasizing the benefits and predictability of success of each. Methods: This study performed a search on the PubMed, SciELO, and BIREME databases, and included relevant studies related to the topic for the synthesis of this work. Results:Five articles were selected to be included in this critical review, three randomized controlled clinical trials, one clinical trial, and one case report. Conclusion:The root covering using a subepithelial connective tissue graft and platelet-rich fibrin presents satisfactory results, restoring esthetics and health, and regenerating the gingival and periodontal tissues. Regarding platelet-rich fibrin, there are few cases in the literature regarding long-term clinical outcomes.


Subject(s)
Connective Tissue , Linings , Platelet-Rich Fibrin , Gingival Recession , Transplantation, Autologous , Tissue Transplantation
12.
Article in English | WPRIM | ID: wpr-811262

ABSTRACT

PURPOSE: Subepithelial connective tissue grafts (SCTGs) are commonly performed for the treatment of gingival recession due to their high predictability. This study evaluated and histologically compared connective tissue grafts in terms of the presence of epithelial remnants and composition of the tissue types that were present (epithelium, lamina propria, and submucosa).METHODS: Ten patients underwent epithelium removal using 2 different techniques: the use of a blade (group B) and through abrasion (group A). Twenty samples were collected and each tissue type was analyzed histologically in terms of its area, thickness, and proportion of the total area of the graft.RESULTS: In 4 samples (40%) from group B (n=10) and 2 samples (20%) from group A (n=10), the presence of an epithelial remnant was observed, but the difference between the groups was not statistically significant (P>0.05). Likewise, no statistically significant differences were observed between the groups regarding the area, mean thickness, or proportion of the total area for any of the tissue types (P>0.05).CONCLUSIONS: Histologically, SCTGs did not show statistically significant differences in terms of their tissue composition depending on whether they were separated from the epithelial tissue by abrasion or by using a blade.


Subject(s)
Connective Tissue , Epithelium , Gingival Recession , Humans , Mucous Membrane , Transplants
13.
Chinese Journal of Traumatology ; (6): 238-242, 2020.
Article in English | WPRIM | ID: wpr-827843

ABSTRACT

PURPOSE@#Tibial plateau fracture (TPF) is a devastating injury as it shatters lower articular surface of the largest joint. Apart from bony injury, TPF can lead to great soft tissue envelope compromise which affects the treatment plan and outcome. In the present study, clinical results were assessed in cases of high energy TPFs treated in staged manner.@*METHODS@#Twenty-three (20 males and 3 females) patients of high energy communited TPFs (Schatzker type V and VI) were consecutively treated. All the patient had compromise of overlying skin conditions. They were all successively scheduled for staged treatment plan which comprised of application of bridging knee external fixator on the first day of admission and definitive internal fixation after skin and soft tissue overlying the fracture were healed. Schatzker type I, II, III and IV were excluded from the study. Primary survey was done and patient who had head injury, chest and abdominal injury, pelvic injury and contralateral limb injury and open fractures were excluded from the study. The patients were also evaluated in terms of wound complications, axial and rotary alignment of limb, fixation failure, articular congruity and range of motion of the knees and post injury employment. Statistical analysis was done using SPSS software.@*RESULTS@#Maximum follow-up period was 13 months. All the fractures were united at final follow-up. Clinical evaluation was done with the Tegner Lysholm knee scoring scale. Excellent results were found in 78% cases and good and fair results in 22% cases. There was significant correlation between range of motion and the Tegner Lysholm knee score (p < 0.001, Pearson correlation coefficient = 0.741). The correlation between the score and the radiographical union duration was significant (p = 0.006, Pearson correlation coefficient = -0.554).@*CONCLUSION@#A staged treatment plan allows healing of soft tissue envelope, with avoidance of dreadful complications such as compartment syndrome and chronic infection. In addition, a staged treatment strategy does not hamper the fracture reduction, bony union and the functional results.


Subject(s)
Adult , Compartment Syndromes , Connective Tissue , Female , Fracture Fixation, Internal , Methods , Fracture Healing , Fractures, Comminuted , General Surgery , Humans , Knee , Male , Middle Aged , Range of Motion, Articular , Tibial Fractures , General Surgery , Treatment Outcome
14.
Article in Chinese | WPRIM | ID: wpr-826658

ABSTRACT

OBJECTIVE@#To observe the effect of electroacupuncture (EA) preconditioning on the expressions of tyrosine kinase Lyn and spleen tyrosine kinase (Syk) in mast cells of subcutaneous loose connective tissue in the rats with urticaria and explore the potential biological mechanism of EA in the intervention of urticaria.@*METHODS@#A total of 32 SD rats were randomized into a blank group, a model group, an EA group and a positive medication group, 8 rats in each one. Except of the blank group, the passive cutaneous anaphylaxis (PCA) was adopted to prepare the model of urticaria in the rats of the rest three groups. In the EA group, EA was applied to bilateral "Quchi" (LI 11), "Xuehai" (SP 10) and "Zusanli" (ST 36), with disperse-dense wave, 2 Hz/15 Hz in frequency and 1 mA in current intensity, once daily, for 20 min each time, consecutively for 7 days. In the positive medication group, loratadine (1 mg•kg•d) was for intragastric administration, once daily, consecutively for 7 days. The samples were collected for index detection 30 min after PCA antigen challenge in the rats of each group. Spectrophotometer was adopted to determine the effusion quantity of Evans blue in the allergized site of skin. HE staining was used to observe the morphological changes in the allergized site of skin. Toluidine blue staining was provided to observe mast cell degranulation in subcutaneous loose connective tissue in the allergized site of skin. Immunohistochemistry was applied to determine the protein expressions of Lyn and Syk during degranulation of mast cells.@*RESULTS@#In the rats of the odel group, the eipdermis of allergized site was thickening, cells were disorganized in hierarchy and inflammatory cells were infiltrated largely in the dermis. In the positive medication group and the EA group, the epidermis was getting thin, cell arrangement was clear and the inflammatory cell infiltration was obviously alleviated as compared with the model group. Compared with the blank group, the OD value of skin dye effusion quantity, the degranulation rate of mast cells and the positive expressions of Lyn and Syk were all increased in the model group (<0.01). Compared with the model group, the OD value of skin dye effusion quantity, the degranulation rate of mast cells and the positive expressions of Lyn and Syk were all reduced in the EA group and the positive medication group (<0.01). Compared with the positive medication group, the degranulation rate of mast cells was increased significantly in the EA group (<0.01).@*CONCLUSION@#Electroacupuncture at "Quchi" (LI 11), "Xuehai" (SP 10) and "Zusanli" (ST 36) reduces vascular permeability and gives play to the role of anti-allergy by the way of regulating and controlling the degranulation of mast cells in the rats with urticaria and the effect mechanism of electroacupuncture may be related to the inhibition of protein expressions of Lyn and Syk in mast cells.


Subject(s)
Acupuncture Points , Animals , Connective Tissue , Metabolism , Electroacupuncture , Mast Cells , Metabolism , Random Allocation , Rats , Rats, Sprague-Dawley , Syk Kinase , Metabolism , Urticaria , Therapeutics , src-Family Kinases , Metabolism
15.
Int. j. odontostomatol. (Print) ; 14(3): 457-463, 2020. tab, graf
Article in English | LILACS | ID: biblio-1114921

ABSTRACT

To evaluate clinically the results of two surgical techniques used for root coverage, the coronally advanced flap in '' L '' isolated (CAF) or associated with subepithelial connective tissue graft (SCTG). The surgical procedures were performed in seventeen individuals, ten individuals in the control group (coronally advanced flap in "L") and seven individuals in the test group (coronally advanced flap in "L" associated with SCTG), who presented Miller class I and II gingival recession. The depth gingival recession (GR) index was evaluated in the following periods: immediate preoperative and 180 postoperative days. The control group had a success rate of 85 +/- 18 % and the test group had a success rate of 95 +/- 4 %. The variable success rates (p=0.36) did not present a statistically significant difference. The isolated CAF or its association with SCTG showed favorable outcomes in the treatments of Miller's class I and II gingival recessions.


El objetivo fue evaluar clínicamente los resultados de dos técnicas quirúrgicas utilizadas para la cobertura radicular, el colgajo coronalmente avanzado en "L" aislado (CAF) o asociado con injerto de tejido conectivo subepitelial (SCTG). Los procedimientos quirúrgicos se realizaron en diecisiete individuos, diez individuos en el grupo de control (colgajo coronario avanzado en "L") y siete individuos en el grupo de prueba (colgajo coronalmente avanzado en "L" asociado con SCTG), que presentaron la clase I de Miller y II recesión gingival. El índice de recesión gingival profunda (RG) se evaluó en los siguientes períodos: preoperatorio inmediato y 180 días postoperatorios. El grupo de control tuvo una tasa de éxito de 85 +/- 18 % y el grupo de prueba tuvo una tasa de éxito de 95 +/- 4 %. Las tasas de éxito variables (p = 0,36) no presentaron una diferencia estadísticamente significativa. La CAF aislada o su asociación con SCTG mostraron resultados favorables en los tratamientos de las recesiones gingivales de clase I y II de Miller.


Subject(s)
Humans , Surgical Flaps , Connective Tissue/transplantation , Gingival Recession/surgery , Tooth Root , Case-Control Studies , Treatment Outcome
16.
J. appl. oral sci ; 28: e20190236, 2020. tab, graf
Article in English | LILACS, BBO | ID: biblio-1090786

ABSTRACT

Abstract Objective This clinical trial sought to evaluate the clinical effectiveness of concentrated growth factor (CGF) and compare it with connective tissue graft (CTG) with coronally advanced flap (CAF) in the treatment of Miller Class I gingival recessions (GR). Methodology This split-mouth study included 74 Miller Class I isolated (24 teeth) or multiple (50 teeth) GRs in 23 jaws of 19 patients. GRs were randomly treated using CGF (test group: 37 teeth; 12 teeth in isolated GRs, 25 teeth in multiple GRs) or CTG with CAF (control group: 37 teeth;12 teeth isolated GRs, 25 teeth in multiple GRs). Clinical variables, plaque index (PI), gingival index (GI), probing depth (PD), recession depth (RD), recession width (RW), clinical attachment level (CAL), keratinized tissue thickness (KTT), keratinized tissue width (KTW), and root coverage (RC) were assessed at the baseline as well as at three and six months post-surgery. Healing index (HI) were obtained in the second and third weeks post-surgery. Postoperative pain was assessed for the first seven days using a horizontal visual analog scale (VAS). Results No significant change was observed in PI, GI, or PD values in either the intergroup or the intragroup comparisons. A statistically significant decrease was observed in CAL, RD, and RW, and KTT increased in all groups at three and six months compared with the baseline. The control group had greater increases in KTW, KTT, and RC at three and six months. No significant difference was found in CAL or RD at the third and sixth months between the two groups. Healing was found to be similar for both groups in the second and third weeks post-surgery. The VAS values in the control group were higher than in the test group, especially at the second, fourth, fifth, and seventh days postoperatively. Conclusions CTG is superior to CGF with CAF for increasing KTT, KTW, and RC. CGF may be preferable due to decreased postoperative pain.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Surgical Flaps/transplantation , Connective Tissue/transplantation , Intercellular Signaling Peptides and Proteins/therapeutic use , Gingival Recession/surgery , Pain, Postoperative , Reference Values , Time Factors , Wound Healing , Blood Platelets , Periodontal Index , Dental Plaque Index , Reproducibility of Results , Treatment Outcome , Statistics, Nonparametric
18.
Rev. cientif. cienc. med ; 23(2): 252-257, 2020. ilus.
Article in Spanish | LILACS | ID: biblio-1358642

ABSTRACT

El Síndrome de Marfan es una enfermedad del tejido conectivo causada por mutaciones en el gen FBN1, mismo que codifica la fibrilina-1, glucoproteína fundamental del componente de las microfibrillas. Entre las manifestaciones clínicas, la afectación cardiovascular merece una consideración especial, debido a su pronóstico. Se presenta un varón de 40 años quien acude al Instituto Nacional del Tórax por un cuadro clínico de 2 años de evolución caracterizado por clínica de insuficiencia cardiaca descompensada, insuficiencia aortica y criterios colagenopatía subyacente, ante lo cual tras los estudios de gabinete y el uso de los criterios pertinentes (Ghent modificados) se llega al diagnóstico de Síndrome de Marfan. La supervivencia de estos pacientes depende del diagnóstico temprano evitando las complicaciones que en su mayoría son mortales, el uso de los scores es de ayuda y la intervención oportuna lleva a un mejor pronóstico de vida y evita los procedimientos invasivos y por ende demás complicaciones


Marfan syndrome is a connective tissue disease caused by mutations in the FBN1 gene, which encodes fibrillin-1, a fundamental glycoprotein of the microfibril component. Among the clinical manifestations, cardiovascular involvement deserves special consideration, due to its prognosis. We present a 40-year-old man who came to the National Thorax Institute for a clinical picture of 2 years of evolution characterized by symptoms of decompensated heart failure, aortic insufficiency and underlying collagenous criteria, before which, after cabinet studies and the use of the relevant criteria (modified Ghent) leads to the diagnosis of Marfan Syndrome. The survival of these patients depends on early diagnosis, avoiding complications that are mostly fatal, the use of scores is helpful and timely intervention leads to a better prognosis for life and avoids invasive procedures and therefore other complications.


Subject(s)
Male , Adult , Marfan Syndrome , Thorax , Connective Tissue , Microfibrils
19.
Rev. colomb. nefrol. (En línea) ; 6(2): 159-165, jul.-dic. 2019. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1093040

ABSTRACT

Resumen La fibrosis retroperitoneal es una patología rara, en la mayoría de los casos idiopática, aunque se ha asociado a medicamentos, neoplasias y otras enfermedades de tejido conectivo. Histopatológicamente se evidencia inflamación y depósito de tejido fibrótico en el retroperitoneo y se caracteriza por cubrir los uréteres provocando lesión renal aguda obstructiva siendo ésta, la manifestación más frecuente; el diagnóstico definitivo se obtiene únicamente con biopsia y la base del tratamiento es la corticoterapia, aunque en casos severos y en resistencia a los corticoides se han usado otras terapias como los inmunomuladores. En ocasiones son necesarias las intervenciones quirúrgicas para el manejo de las complicaciones. Se presenta el caso de un hombre de 50 años que ingresó al servicio de urgencias del Hospital San José por dolor abdominal, los paraclínicos demostraron elevación de los azoados y en las imágenes diagnósticas hidronefrosis izquierda con componente de tejido blando interaortocava y periaórtico, se realizó biopsia retroperitoneal y se hizo diagnóstico de fibrosis retroperitoneal idiopática, se instauraron nefrostomías bilaterales y se inició manejo con corticoide.


Abstract Retroperitoneal fibrosis is a rare, in most cases idiopathic, pathology, although it has been associated with medications, neoplasms and other connective tissue diseases. In terms of histopathology, inflammation and deposits of fibrotic tissue in the retroperitoneum are observed and, characteristically, this covers the urethra, provoking acute obstructive kidney damage, the most frequent manifestation of the disease. The definitive diagnosis is obtained solely via biopsy, and the basis of treatment is corticotherapy, although in severe cases, and where resistance to corticosteroids exists, other treatments have been used, such as immunomodulators. Occasionally, surgical interventions are necessary to manage complications. The case of a 50-year-old man who came to the Hospital emergency service due to abdominal pain is presented. Paraclinical studies showed azotemia, and diagnostic images showed left hydronephrosis with a component of interaortocaval and periaortic soft tissue. A retroperitoneal biopsy was conducted, and a diagnosis of idiopathic retroperitoneal fibrosis was made. Bilateral nephrostomies were put in place and treatment with corticosteroids was initiated.


Subject(s)
Humans , Male , Female , Retroperitoneal Fibrosis , Acute Kidney Injury , Urethra , Colombia , Connective Tissue , Nephrotomy , Hydronephrosis
20.
Int. j. morphol ; 37(4): 1245-1251, Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1040119

ABSTRACT

The aim of this study was to evaluate the effect of soft tissue thickness of upper lip on lip retraction in orthodonticaltreated females and identify the ratio of maxillary incisor retraction to upper lip retraction. Pre- and post-treatment lateral cephalograms of 100 adults were examined to measure the lip thickness in upper lip and establish the classification standard. All subjects were treated with 4 first premolar extractions followed by upper central incisors retraction. Pre- and post-treatment lateral cephalograms of 19 patients were reviewed to determine the changes of the upper lip and incisor positions through landmarks displacement. An independent-samples t test and one-way analysis of variance were performed. The correlations between maxillary incisor retraction and upper lip retraction were explored by the Pearson correlation method. P-values<0.05 were considered statistically significant. The lip thickness of adult male patients was greater than that of adult female patients. The average ratio of maxillary incisor retraction to upper lip repositioning was 1.6:1,1.9:1 and 2.2:1 in the thin lips group, normal lips group and thick lips group, respectively. Gender differences exist in the thickness of upper lip. Horizontal changes of the maxillary incisor showed a significant correlation to horizontal changes of the upper lip (P<0.001).There were negative correlations between the thickness of upper lip and the ratio between change in maxillary incisor protrusion and change in upper lip protrusion.


El objetivo de este estudio fue evaluar el efecto del grosor de los tejidos blandos del labio superior, sobre la retracción del labio en mujeres tratadas con ortodoncia e identificar la proporción de retracción del diente incisivo maxilar con respecto a la retracción del labio superior. Se examinaron cefalogramas laterales, previos y posteriores al tratamiento de 100 adultos, para medir el grosor del labio superior y establecer un estándar de clasificación. Todos los sujetos fueron tratados con 4 extracciones de los primeros premolares seguidas de retracción de los incisivos centrales superiores. Se revisaron los cefalogramas laterales, previos y posteriores al tratamiento de 19 pacientes, para determinar los cambios del labio superior y las posiciones de los incisivos a través del desplazamiento de los puntos de referencia. Se realizó una prueba t de muestras independientes y un análisis de varianza de una vía. Las correlaciones entre la retracción del incisivo maxilar y la retracción del labio superior se exploraron mediante el método de correlación de Pearson. Los valores de p<0,05 fueron considerados estadísticamente significativos. El grosor de los labios de los pacientes adultos masculinos fue mayor que el de las pacientes adultas. La relación promedio de la retracción del incisivo maxilar al reposicionamiento del labio superior fue de 1,6:1,1; 9:1 y 2,2:1 en el grupo de labios delgados, grupo de labios normales y grupo de labios gruesos, respectivamente. Existen diferencias de sexo en el grosor del labio superior. Los cambios horizontales del incisivo maxilar mostraron una correlación significativa con los cambios horizontales del labio superior (P<0,001). Hubo correlaciones negativas entre el grosor del labio superior y la relación entre el cambio en la protuberancia del incisivo maxilar y el cambio en la protrusión del labio superior.


Subject(s)
Humans , Male , Female , Adult , Tooth Movement Techniques , Connective Tissue/anatomy & histology , Lip/anatomy & histology , Orthodontics , Cephalometry , Malocclusion/therapy
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