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1.
Rev. bras. neurol ; 57(4): 16-22, out.-dez. 2021. tab, graf
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1359204

ABSTRACT

INTRODUÇÃO: A neuropatia periférica diabética (ND) é comum na nefropatia diabética (NFD) e não há informações se o hiperparatireoidismo secundário (HPS) aumenta seus sintomas. O objetivo foi determinar ND por sinais em pacientes com HPS. MATERIAL E MÉTODOS: É um estudo caso-controle. O Grupo Controle (GC) é composto por doentes com NFD e valores de paratormônio (PTH)<60pg / ml. O Grupo de Hiperparatireoidismo (GH) engloba pacientes com NFD e PTH≥60pg/ml e critérios bioquímicos de HPS. As variáveis foram, entre outras, a presença de sinais de ND e foram comparados com o teste t de Student e o qui-quadrado. RESULTADOS: Foram 60 participantes em cada grupo, sendo 35 (58,3%) homens no GC vs 33 (55,0%) em GH (p = 0,713). A idade do GC foi de 67±11,0 anos, vs 72±11 anos GH (p=0,009). A taxa de filtração glomerular (TFG) no GC foi 53,82±25,13 vs GH 35,34±18,43ml/min/1,73m2 (p <0,001). O PTH no GC foi de 38,02±15,32 pg/ml, em GH 119,07±84,33 pg/ml (p <0,001). A ND, devido aos sintomas no GC, foi de 28,3% e 36,6% no GH (p=0,330). A neuropatia por sinais no GC foi de 38,3% e no GH 83,3% (p<0,001). O odds ratio de GH para neuropatia presente devido a sinais foi de 8,044 (IC 95% 3,42­8,92). CONCLUSÃO: Constatou-se uma maior presença de sinais de NPD em pacientes com HPS em nosso centro


BACKGROUND: Diabetic peripheral neuropathy (DN) is common in diabetic nephropathy (DNP), and there is no information if secondary hyperparathyroidism (SHP) increases its symptoms. The purpose was to determine DN by signs in patients with SHP. METHODS: It is a case-control study. Control patients (CG) with DN and parathyroid hormone (PTH) values<60pg/ml. The Hyperparathyroidism group (HG), patients with DNP and PTH≥60pg/ml and HPS biochemical criteria. The variables were, among others, the presence of DN signs, and were compared with Student's t and chi-square. RESULTS: There were 60 participants in each group, 35(58.3%) men in CG vs.33(55.0%) in GH (p=0.713). The age of the CG was 67±11.0 years, vs 72±11years HG (p=0.009). The glomerular filtration rate (GFR) in the CG was 53.82±25.13 vs in HG 35.34±18.43ml/min/1.73m2(p<0.001). The PTH in the CG were 38.02±15.32pg/ml and in GH 119.07±84.33pg/ml(p<0.001). The DN due to symptoms in CG was 28.3% and in GH 36.6%(p=0.330). Neuropathy due to signs in the CG was 38.3% and in GH 83.3% (p<0.001). The HG odds ratio to present neuropathy due to signs was 8.044 (95% CI 3.42­18.92). CONCLUSION: There was a statistical association between HPS and signs of DN in patients with DNP in our canter.


Subject(s)
Humans , Male , Adult , Middle Aged , Aged , Diabetes Mellitus, Type 2/diagnosis , Diabetic Neuropathies/complications , Diabetic Neuropathies/diagnosis , Diabetic Neuropathies/epidemiology , Hyperparathyroidism, Secondary/etiology , Case-Control Studies , Prevalence , Diabetes Mellitus, Type 2/complications , Diabetic Nephropathies
2.
Femina ; 49(9): 520-524, 20211030.
Article in Portuguese | LILACS | ID: biblio-1342318

ABSTRACT

A síndrome dos ovários policísticos (SOP) é frequentemente acompanhada de distúrbio metabólico, principalmente dos carboidratos e dos lipídeos, aumentando o risco de síndrome metabólica. Por essa razão, alguns investigadores ainda denominam a SOP de síndrome metabólica-reprodutiva. O objetivo deste capítulo é descrever as principais repercussões metabólicas, bem como como investigá-las e saber como suas consequências podem ser deletérias para a saúde da mulher. Esta é uma revisão narrativa mostrando a implicação do metabolismo dos carboidratos e dos lipídeos nas dislipidemias, bem como da síndrome metabólica sobre o sistema reprodutor, e o risco cardiovascular da mulher com SOP. Conclui-se que o manejo adequado dos distúrbios metabólicos na SOP é benéfico a curto e a longo prazo tanto para o sistema reprodutor quanto para o cardiovascular.(AU)


Subject(s)
Humans , Female , Polycystic Ovary Syndrome/metabolism , Metabolic Syndrome/diagnosis , Metabolic Syndrome/physiopathology , Insulin Resistance , Risk Factors , Glucose Intolerance/diagnosis , Glucose Metabolism Disorders/physiopathology , Diabetes Mellitus, Type 2/diagnosis , Dyslipidemias/physiopathology , Lipid Metabolism Disorders/physiopathology
3.
Prensa méd. argent ; 107(6): 299-306, 20210000. tab, fig
Article in English | LILACS, BINACIS | ID: biblio-1359089

ABSTRACT

Introducción. El consumo de alcohol daña la mayoría de los órganos y sistemas de nuestro organismo, con un efecto nocivo sobre la diabetes tipo 2. En nuestro país, el consumo de alcohol es tolerado y socialmente bien considerado, lo que provoca que una parte importante de la población tenga una ingesta excesiva de alcohol. Por tanto, quisimos evaluar el efecto de la ingesta excesiva de alcohol en la población trabajadora y su efecto sobre el riesgo de desarrollar diabetes tipo 2. Métodos. Estudio descriptivo y transversal en 55.147 trabajadores españoles en el que se evaluó el efecto del consumo excesivo de alcohol sobre el riesgo de desarrollar diabetes tipo 2. El riesgo de diabetes se evaluó con las escalas Findrisk y QDScore. El consumo de alcohol se evalúa con la unidad de bebida estándar, equivalente a 10 g de alcohol. Se considera consumo excesivo cuando se superan semanalmente 35 unidades de bebida estándar en hombres y 20 en mujeres. Resultados. El consumo excesivo de alcohol en comparación con no beber, beber poco o moderadamente aumenta el riesgo de diabetes tipo 2 en ambas escalas de riesgo. La razón de probabilidades es 12,22 (IC 95 11,51-12,99) para la escala Findrisk y 13,36 (IC 95% 12,04-14,69) para el riesgo relativo con QDScore. Conclusión. El consumo excesivo de alcohol aumenta el riesgo de diabetes tipo 2 con las escalas Findrisk y QDScore en la población laboral española


Introduction. Alcohol consumption damages most of the organs and systems of our organism, with a harmful effect on type 2 diabetes. In our country, alcohol consumption is tolerated and socially well regarded, which causes an important part of the population to have an excessive alcohol intake. Therefore, we want to evaluate the effect of excessive alcohol intake in the working population and its effect on the risk of developing type 2 diabetes. Methods. Descriptive and cross-sectional study in 55,147 Spanish workers in which the effect of excessive alcohol consumption on the risk of developing type 2 diabetes was assessed. Diabetes risk was assessed with the Findrisk and QDScore scales. Alcohol consumption is assessed with the standard drinking unit, equivalent to 10g of alcohol. Excessive consumption is considered when 35 standard drinking unit in men and 20 in women are exceeded weekly. Results. Heavy drinking compared to no, low or moderate drinking increases the risk of type 2 diabetes on both risk scales. The Odds ratio is 12.22 (CI 95 11.51-12.99) for the Findrisk scale and 13.36 (CI 95% 12.04-14.69) for the relative risk with QDScore. Conclusion. Excessive alcohol consumption increases the risk of type 2 diabetes with the Findrisk and QDScore scales in the Spanish working population


Subject(s)
Humans , Alcohol Drinking/adverse effects , Risk Assessment , Diabetes Mellitus/diagnosis , Diabetes Mellitus, Type 2/diagnosis , Binge Drinking/complications , Occupational Groups
4.
Rev. medica electron ; 43(3): 716-731, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1289814

ABSTRACT

RESUMEN Introducción: los carcinomas diferenciados de tiroides se originan en el epitelio folicular. De ellos el carcinoma papilar muestra una mayor incidencia. Una variante del mismo es la folicular, que en ocasiones muestra un patrón arquitectural que imita a un adenoma folicular. Objetivo: contribuir al diagnóstico diferencial entre el carcinoma papilar variante folicular y el adenoma folicular de tiroides, utilizando variables cariométricas de las células foliculares. Materiales y métodos: se aplicaron técnicas morfométricas a muestras de biopsias de tiroides con carcinoma papilar variante folicular y adenoma folicular, así como a muestras sin patología, en el período comprendido de enero de 2013 a diciembre de 2016, obtenidas en el Hospital Universitario Clínico Quirúrgico Comandante Faustino Pérez Hernández, de Matanzas. Las técnicas aplicadas se basaron en las variables cuantitativas: área, perímetro y factor de forma nuclear de las células foliculares. Los resultados se expresaron en porcentajes; la media aritmética como medida de tendencia central; desviación típica, incluyéndose el cálculo de los valores máximo, mínimo y recorrido para cada variable comprendida en el estudio, reflejados en tablas y gráficos realizados a través del software Microsoft Office Excel. Resultados: se obtuvieron valores elevados de área y perímetro nuclear de las células foliculares del carcinoma papilar variante folicular con relación al adenoma folicular, mientras que el factor de forma no arrojó resultados significativos para la diferenciación de dichas enfermedades tiroideas. Conclusiones: la aplicación de técnicas morfométricas a variables cariométricas en el tiroides, para el diagnóstico diferencial entre el carcinoma papilar variante folicular y el adenoma folicular, ofrece resultados aplicables en estudios histopatológicos (AU).


ABSTRACT Introduction: differentiated thyroid carcinomas are originated in the follicular epithelium. Of them, the papillary carcinoma shows higher incidence. Follicular carcinoma, one of its variants, occasionally shows an architectural pattern imitating a follicular adenoma. Objective: to contribute to the differential diagnosis between the papillary carcinoma, follicular variant, and thyroid follicular adenoma, using karyometric variables of follicular cells. Materials and methods: morphometric techniques were applied to samples of biopsies of thyroids with papillary carcinoma, follicular variant, and follicular adenoma, and also to samples without any pathology, in the period from January 2013 to December 2016, gathered in the University Hospital Comandante Faustino Perez, of Matanzas. The applied techniques were based on quantitative variables: area, perimeter and nuclear form factor. Results were expressed in percentages; the arithmetic median as measure of central tendency; typical deviation, including the calculation of maximal, minimal values and the course for each variable included in the study, were drawn in tables and graphics using Microsoft Office Excel software. Results: highs values of area and nuclear perimeter of the follicular cells of the papillary carcinoma, follicular variant, were obtained, while the shape factor did not show significant results for those thyroidal diseases differentiation. Conclusions: the application of morphometric techniques to karyometric variables in the thyroids, for the differential diagnosis between the papillary carcinoma, follicular variant, in follicular carcinoma, offers results that can be applied in histopathological studies (AU).


Subject(s)
Humans , Male , Female , Adult , Diabetes Insipidus/diagnosis , Diabetes Mellitus, Type 2/epidemiology , Diabetes Insipidus/complications , Diabetes Insipidus/congenital , Diabetes Insipidus/pathology , Diabetes Mellitus, Type 2/diagnosis
5.
Rev. enferm. UERJ ; 28: e49109, jan.-dez. 2020.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1146588

ABSTRACT

Objetivo: verificar associação entre diabetes mellitus e doenças oculares em pessoas com deficiência visual. Método: estudo transversal com 51 pessoas com diabetes e deficiência visual, em um centro de reabilitação visual do interior paulista, que participaram de entrevista estruturada, em 2018. Utilizou-se os testes: Kolmogorov Smirnov, Regressão de Poisson, Regressão de Logística Binária, e Correlação de Spearman. Resultados: a maioria das pessoas era cega e relatou que a retinopatia diabética, o glaucoma e a catarata foram causa da deficiência visual; com tempo de diagnóstico do diabetes acima de 109 meses. A catarata apresentou um nível de correlação baixa (r=0,280 e p=0,047), e a retinopatia diabética um nível de correlação moderada (r=0,565 e p=0,000), considerando o tempo de diagnóstico do diabetes. Conclusão: associação estatisticamente significante entre o tipo de diabetes e a retinopatia, e correlação estatisticamente significante entre o tempo de diagnóstico do diabetes, a catarata e a retinopatia diabética.


Objective: to verify the association between diabetes mellitus and eye diseases in people with visual impairment. Method: this cross-sectional study involved 51 people with diabetes and visual impairment at a Visual Rehabilitation Center in São Paulo, who participated in a structured interview in 2018. The tests used were: Kolmogorov Smirnov, Poisson Regression, Binary Logistic Regression, and Spearman Correlation. Results: most participants were blind, reported that diabetic retinopathy, glaucoma and cataracts were the causes of their visual impairment, and had been diagnosed with diabetes over 109 months earlier. Cataract returned a low level of correlation with time with diagnosis of diabetes (r = 0.280 and p = 0.047), and diabetic retinopathy, moderate correlation (r = 0.565 and p = 0.000). Conclusion: a statistically significant association was found between type of diabetes and retinopathy, and statistically significant correlations between the time diagnosed with diabetes, cataracts and diabetic retinopathy.


Objetivo: verificar la asociación entre diabetes mellitus y enfermedades oculares en personas con discapacidad visual. Método: este estudio transversal involucró a 51 personas con diabetes y discapacidad visual en un Centro de Rehabilitación Visual en São Paulo, quienes participaron en una entrevista estructurada en 2018.Las pruebas utilizadas fueron: Kolmogorov Smirnov, Regresión de Poisson, Regresión Logística Binaria y Spearman Correlación. Resultados: la mayoría de los participantes eran ciegos, informaron que la retinopatía diabética, el glaucoma y las cataratas eran las causas de su discapacidad visual y habían sido diagnosticados con diabetes más de 109 meses antes. La catarata devolvió un bajo nivel de correlación con el tiempo con el diagnóstico de diabetes (r = 0,280 yp = 0,047) y la retinopatía diabética, correlación moderada (r = 0,565 yp = 0,000). Conclusión: se encontró asociación estadísticamente significativa entre tipo de diabetes y retinopatía, y correlaciones estadísticamente significativas entre el tiempo de diagnóstico de diabetes, cataratas y retinopatía diabética.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Vision Disorders/epidemiology , Cataract/epidemiology , Glaucoma/epidemiology , Diabetes Mellitus, Type 1/epidemiology , Diabetes Mellitus, Type 2/epidemiology , Diabetic Retinopathy/epidemiology , Brazil/epidemiology , Logistic Models , Poisson Distribution , Prevalence , Risk Factors , Statistics, Nonparametric , Visually Impaired Persons/statistics & numerical data , Diabetes Mellitus, Type 1/diagnosis , Diabetes Mellitus, Type 2/diagnosis
6.
Rev. bras. ativ. fís. saúde ; 25: 1-8, set. 2020. ilus, tab
Article in Portuguese | LILACS | ID: biblio-1141481

ABSTRACT

O objetivo desse estudo foi verificar a concordância na velocidade da marcha (VM) a partir dos testes de caminhada de seis minutos (6MWT) e de quatro metros (4MWT) em mulheres diabéticas tipo 2 (DM2). Os testes foram realizados antes e após intervenção de 12 semanas com exercícios físicos. O 4MWT foi realizado em espaço de quatro metros, sendo o resultado do teste medido como o tempo gasto (segundos) no percurso. O 6MWT foi realizado em modelo de ir e vir em uma distância de 15 metros e o resultado foi a distância total (metros) percorrida. Os resultados foram padronizados para velocidade de deslocamento (m/s). Para avaliar a concordância (6MWTpré x 4MWTpré) e (6MWTpósx 4MWTpós), utilizou-se o teste de Bland-Altman (B-A) e o coeficiente de concordância de correlação de Lin. O nível de significância aceito para o estudo foi α 5%. Foram medidas 39 mulheres, com idade média de 58,79 ± 10,03 anos e diagnóstico de DM2 a 8,64 ± 8,53 anos. Verificou-se, pelo teste de B-A, diferenças na VM dos testes de -0,001 ± 0,19 m/s (IC95%: -0,37 a 0,37 m/s) no início e 0,02 ± 0,21 m/s (IC95%: -0,39 a 0,42 m/s) ao final e concordância de 0,60 (IC95%: 0,41 a 0,79; p < 0,001) e 0,52 (IC95%: 0,31 a 0,73; p < 0,001) pré e pós, respectivamente, pelo coeficiente de concordância de correlação Lin. Através dos dados obtidos, sugere-se que os dois testes podem ser utilizados para avaliar a VM das mulheres DM2, porém o 6MWT apresentou maior reprodutibilidade para detectar mudanças na VM ao longo do tempo


This study aimed to test the agreement in the gait speed (GS) between the 6-minute walk test and the 4-me-ter gait speed (6MWT - 4MWT) in type 2 diabetic women (T2DM). The tests were performed before and after a 12-week physical exercise intervention. The 4MWT was performed in a space of four meters, with results based on the time spent (seconds) to complete a 4-meter distance. The 6MWT was carried out similar to a yo-yo test in 15 meters and the result was operationalized by the total distance (meters) covered. The results of the tests were standardized as speed (m/s). To evaluate agreements (6MWTbefore x 4MWTbefore) and (6MWTafter x 4MWTafter), Bland-Altman (B-A), and Lin's agreements were used. The level of significance was set at 5%. A total of 39 women were evaluated, mean age 58.79 ± 10.03 years, diagnosis of diabetes at 8.64 ± 8.53 years.The B-A test showed a mean difference in GS of -0.001 ± 0.19 m/s (95%CI: -0.37 to 0.37 m/s) before and 0.02 ± 0.21 m/s (95%CI: -0.39 to 0.42 m/s) after, and Lin's agreements of 0.60 (95%CI: 0.41 to 0.79; p < 0.001) and 0.52 (95%CI: 0.31 to 0.73; p < 0.001) before and after, respectively. Based on our data it is suggested that the two tests can be used to evaluate the GS of T2DM women, but the 6MWT was more reproductible to detect changes in GS over time


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Diabetes Mellitus, Type 2/diagnosis , Walk Test/methods , Gait Analysis/methods , Socioeconomic Factors , Fujita-Pearson Scale , Walking Speed
7.
Rev. cuba. angiol. cir. vasc ; 21(2): e113, mayo.-ago. 2020. tab, fig
Article in Spanish | LILACS, CUMED | ID: biblio-1126377

ABSTRACT

Objetivo: Caracterizar la enfermedad arterial periférica en pacientes con diabetes mellitus tipo 2 e identificar su relación con variables sociodemográficas y clínicas. Métodos: Estudio descriptivo en 252 pacientes con diabetes melltus tipo 2. A todos se les midió el índice de presiones tobillo-brazo, para caracterizar la enfermedad y se les aplicó el cuestionario de Edimburgo. Las variables: índice de presiones tobillo-brazo, edad, sexo, años de evolución de la diabetes, factores de riesgo cardiovascular, claudicación intermitente. Resultados: La frecuencia del índice de presiones tobillo-brazo bajo fue de 37,2 por ciento (n= 99). Los factores asociados fueron el sexo, la edad, la hipertensión arterial y los años de evolución de la diabetes. El cuestionario de Edimburgo presentó una sensibilidad de 44,4 por ciento y una especificidad de 71,9 por ciento para detectar enfermedad arterial periférica sintomática. Conclusiones: La enfermedad arterial periférica se encuentra infradiagnosticada a pesar de la elevada frecuencia del índice de presiones tobillo-brazo bajo en pacientes con diabetes mellitus tipo 2; en Honduras hay escasa información, dado que no se implementan los métodos diagnósticos de manera rutinaria en pacientes con factores de riesgo para desarrollar la enfermedad, hasta que se encuentra muy avanzada. Hay relación directa de esta enfermedad con la edad, el sexo femenino, el tiempo de evolución de la diabetes mellitus y la hipertensión arterial. El cribado sistemático a través del índice tobillo-brazo identifica más individuos de alto riesgo candidatos a un control intensivo de sus factores de riesgo cardiovascular y facilita la búsqueda activa de enfermedad vascular en otros territorios(AU)


Objective: To characterize the peripheral arterial disease in patients with diabetes mellitus type 2 and to identify its relation with socio-demographic and clinical variables. Methods: A descriptive study in 252 patients with diabetes mellitus type 2. To all of them it was measured the ankle-brachial pressure index to characterize the disease and it was applied the Edinburgh questionnaire. The variables were: ankle-brachial pressure index, age, sex, years of evolution of diabetes, cardiovascular risk factors, and intermittent claudication. Results: The frequency of the ankle- upper arm pressures index was 37.2% (n=99). The associated factors were sex, age, hypertension and the years of evolution of diabetes. The Edinburgh questionnaire had a sensitivity of 44.4 percent and a specificity of 71.9 percent to detect symptomatic peripheral arterial disease. Conclusions: Peripheral arterial disease is underdiagnosed in spite of the high frequency of the of ankle- upper arm pressure index in patients with diabetes mellitus type 2; in Honduras, there is scarce information since there are not routinely implemented the diagnostic methods in patients with risk factors for developing the disease, until it is very advanced. There is a direct relation of this disease with the age, the female sex, time of evolution of diabetes mellitus and hypertension. The systematic screening through the ankle-brachial index identifies more high-risk individuals which are candidates for intensive control of cardiovascular risk factors and it facilitates the active search of vascular disease in other territories(AU)


Subject(s)
Humans , Male , Female , Vascular Diseases/complications , Diabetes Mellitus, Type 2/diagnosis , Peripheral Arterial Disease/therapy , Epidemiology, Descriptive , Cross-Sectional Studies
8.
Rev. cuba. invest. bioméd ; 39(1): e361, ene.-mar. 2020. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1126569

ABSTRACT

Introducción: En la actualidad se hace imprescindible el estudio de la diabetes mellitus tipo 2 a partir de técnicas poco costosas en función de la carga sanitaria que representa, es entonces donde la prueba del peso sostenido gana valor como ejercicio isométrico estático cubano en el estudio de la variabilidad de la frecuencia cardíaca. Objetivo: Determinar las respuestas electrofisiológicas autonómicas y hemodinámicas en estado basal y durante la prueba del peso sostenido en pacientes sanos y con diabetes tipo 2. Métodos: Se realizó un estudio en la Universidad de Ciencias Médicas de Santiago de Cuba, no observacional, cuasi-experimental, de tipo antes-después con grupo control de 60 pacientes (30 sanos y 60 con diabetes mellitus tipo 2). Resultados: Los diabéticos presentaron mayor IMC (p = 0,004). En estado basal se experimentaron diferencias significativas entre pacientes sanos y diabéticos. En la mayoría, los parámetros de la variabilidad de la frecuencia cardíaca analizados y durante la prueba del peso sostenido, solo se observaron diferencias significativas en las variables TAS (p = 0,022), BF (p = 0,001) y AF (p = 0,015). Al realizar la prueba del peso sostenido se encontraron variaciones muy significativas (p < 0,001) de los parámetros hemodinámicos, y variaciones significativas de AF (p = 0,023) y BF/AF (p = 0,046) en pacientes sanos; y en diabéticos, diferencias significativas de las variables hemodinámicas. Conclusiones: Se determinó una menor respuesta en pacientes diabéticos con respecto a los sanos del sistema nervioso autónomo, lo que expresa un deterioro de este y una disminución de la actividad simpática y parasimpática(AU)


Introduction: At present it is indispensable to study type 2 diabetes mellitus with low-cost techniques due to the health load it represents. In this context the sustained weight test acquires great value as a Cuban static isometric exercise for the study of heart rate variability. Objective: Determine autonomic and hemodynamic electrophysiological responses at baseline state and during the sustained weight test in healthy subjects and type 2 diabetic patients. Methods: A non-observational quasi-experimental before-after study was conducted at the University of Medical Sciences of Santiago de Cuba based on a control group of 60 patients (30 healthy and 30 with type 2 diabetes mellitus). Results: Diabetics had a higher BMI (p = 0.004). At baseline state significant differences were found between healthy subjects and diabetic patients. In most of the heart rate variability parameters analyzed and during the sustained weight tests, the only variables that showed significant differences were SBP (p = 0.022), FB (p = 0.001) and FA (p = 0.015). The results obtained from the sustained weight test were the following: very significant variations of hemodynamic parameters (p < 0.001), significant FA (p = 0.023) and FB/FA (p = 0.046) variations in healthy subjects, and significant differences in hemodynamic variables in diabetic patients. Conclusions: A lower response by the autonomic nervous system was determined in diabetic patients versus healthy subjects, signaling deterioration of that system and reduced sympathetic and parasympathetic activity(AU)


Subject(s)
Humans , Exercise , Heart Rate , Electrophysiologic Techniques, Cardiac/methods , Diabetes Mellitus, Type 2/diagnosis , Healthy Volunteers , Non-Randomized Controlled Trials as Topic
9.
Revista Digital de Postgrado ; 9(1): e189, 2020. tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1095033

ABSTRACT

Evaluar el impacto educativo en pacientes con Diabetes Mellitus tipo 2 (DMT2) e Hipertensión arterial (HTA), y su efecto en la calidad de vida. Métodos: Se realizó un estudio intervención en comunidad, en pacientes con diagnóstico de DMT2 e HTA, en la consulta de Medicina Interna. Resultados: Participaron 314 pacientes, distribuidos en un grupo estudio (n = 160) y grupo control (n = 154). Sin diferencias en edad (p = 0,491) y sexo (p = 0,747). En la calidad de vida de pacientes DM entre pre y post charla, en cada grupo, sin diferencias entre grupos en pre-charla (p = 0,869), pero sí en post-charla (p = 0,001), siendo calidad de vida más alta en el grupo estudio (98,2%) que en grupo control (76,9%). Al evaluar los cambios entre pre y post charla, se observó que pre charla en el grupo estudio tuvo 86% de alta calidad de vida, posterior aumentó a 98,2%, cambio estadístico (p = 0,008), en grupo control en cambio, la calidad de vida pre charla fue 87% pasó a 76,9% posterior a ésta, aun así, fue un cambio significativo (p = 0,025) La calidad de vida en HTA, sin diferencias en pre y post charla. La comparación entre pre charla y post charla, en el grupo estudio, no tuvo cambios (p = 0,157) como igualmente en el grupo control (p = 0,317). Conclusiones: Se demostró el impacto positivo de un plan educativo en calidad de vida de los pacientes con diabetes, mas no en pacientes hipertensos(AU)


To evaluate the educational impact in patients with Type 2 Diabetes Mellitus (T2DM) and arterial hypertension (AHT), and its effect on quality of life. Methods: A community intervention study was carried out in patients diagnosed with T2DM and HBP in the Internal Medicine department. Results: 314 patients participated, distributed in a study group (n = 160) and control group (n = 154). No differences in age (p = 0.491) and sex (p = 0.747). In the quality of life of DM patients between pre and post talk, in each group, without differences between groups in pre-talk (p = 0.869), but in post-talk (p = 0.001), with higher quality of life in the study group (98.2%) than in the control group (76.9%). When evaluating the changes between pre and post talk, it was observed that pre-talk in the study group had 86% of high quality of life, later it increased to 98.2%, statistical change (p = 0.008), in control group instead, Pre-chat quality of life was 87%, after 76.9%, it was still a significant change (p = 0.025) Quality of life in HTA, without differences in pre and post talk. The comparison between pre-talk and post-talk, in the study group, did not change (p = 0.157) as well as in the control group (p = 0.317). Conclusions: The positive impact of an educational plan on the quality of life of diabetic patients was demonstrated, but not in hypertensive patients(AU)


Subject(s)
Quality of Life , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/diagnosis , Diabetes Mellitus, Type 2/prevention & control , Hypertension/complications , Hypertension/diagnosis , Hypertension/prevention & control , Health Programs and Plans , Patient Education as Topic , Control Groups , Surveys and Questionnaires/statistics & numerical data , Disease Progression
10.
Rev. bras. epidemiol ; 23: e200060, 2020. tab, graf
Article in English | LILACS | ID: biblio-1101590

ABSTRACT

ABSTRACT: Introduction: The Finnish Diabetes Risk Score (FINDRISC) is a tool that was initially developed to predict the risk of developing type 2 diabetes mellitus in adults. This tool is simple, quick to apply, non-invasive, and low-cost. The aims of this study were to perform a translation and cultural adaptation of the original version of FINDRISC into Brazilian Portuguese and to assess test-retest reliability. Methodology: This work was done following the ISPOR Principles of Good Practice for the Translation and Cultural Adaptation Process for Patient-Reported Outcomes Measures. Once the final Brazilian Portuguese version (FINDRISC-Br) was developed, the reliability assessment was performed using a non-random sample of 83 individuals attending a primary care health center. Each participant was interviewed by trained registered dieticians on two occasions with a mean interval of 14 days. The reliability assessment was performed by analyzing the level of agreement between the test-retest responses of FINDRISC-Br using Cohen's kappa coefficient and the intraclass correlation coefficient (ICC). Results: The steps of ISPOR guidelines were consecutively followed without major problems. Regarding the reliability assessment, the questionnaire as a whole presented adequate reliability (Cohen's kappa = 0.82, 95%CI 0.72 - 0.92 and ICC = 0.94, 95%CI 0.91 - 0.96). Conclusion: FINDRISC was translated into Brazilian Portuguese and culturally adapted following standard procedures. FINDRISC-Br has thus become available for use and has potential as a screening tool in different Brazilian settings and applications.


RESUMO: Introdução: O Escore Finlandês de Risco de Diabetes (FINDRISC) é um instrumento que inicialmente foi desenvolvido para predizer o risco de desenvolver diabetes mellitus tipo 2 em adultos. Esse instrumento é simples, rápido de aplicar, não invasivo e de baixo custo. Os objetivos deste estudo foram descrever o processo de tradução e adaptação transcultural do FINDRISC para o português do Brasil e avaliar a sua confiabilidade teste-reteste. Metodologia: O projeto foi conduzido de acordo com as recomendações dos Princípios de Boas Práticas para o Processo de Tradução e Adaptação Transcultural de Medidas de Resultados Relatados pelo Paciente desenvolvidas pela ISPOR. Uma vez desenvolvida a versão final em português brasileiro (FINDRISC-Br), realizou-se a avaliação da confiabilidade usando uma amostra não aleatória de 83 indivíduos atendidos em uma unidade de atenção básica. Cada participante foi entrevistado por nutricionistas registradas treinadas em duas ocasiões com intervalo médio de 14 dias. A avaliação da confiabilidade foi realizada por meio da análise do nível de concordância entre as respostas do teste-reteste, utilizando-se o coeficiente kappa de Cohen e o coeficiente de correlação intraclasse (CCI). Resultados: As etapas das diretrizes da ISPOR foram seguidas consecutivamente sem maiores problemas. Em relação à avaliação da confiabilidade do teste-reteste, o questionário como um todo apresentou confiabilidade adequada (kappa de Cohen = 0,82; IC95% 0,72 - 0,92 e CCI = 0,94; IC95% 0,91 - 0,96). Conclusão: O FINDRISC foi traduzido e adaptado transculturalmente para o português do Brasil seguindo procedimentos padronizados. O FINDRISC-Br já está disponível para uso e tem potencial para ser usado como ferramenta de rastreamento em diferentes cenários brasileiros.


Subject(s)
Humans , Male , Female , Adult , Aged , Translations , Surveys and Questionnaires/standards , Risk Assessment/standards , Diabetes Mellitus, Type 2/diagnosis , Translating , Brazil , Cross-Cultural Comparison , Reproducibility of Results , Risk Factors , Middle Aged
12.
Rev. Col. Bras. Cir ; 47: e20202394, 2020. tab, graf
Article in Portuguese | LILACS | ID: biblio-1136585

ABSTRACT

RESUMO Objetivo: avaliar as diferenças no perfil metabonômico de pacientes que atingiram remissão de diabetes mellitus tipo 2 (DM2) após cirurgia bariátrica em relação aos que apresentaram manutenção ou recidiva dessa condição após a cirurgia. Métodos: Participaram do estudo 33 pacientes obesos diabéticos tipo 2, dos quais 22 tiveram remissão completa da DM2 e 11 tiveram recidiva da DM2 ou não apresentaram remissão da doença no pós-operatório. Amostras de sangue foram coletadas para avaliação dos perfis metabonômicos séricos através de um estudo metabonômico baseado em RMN de 1H. Resultados: o modelo metabonômico para avaliação da recidiva da diabetes apresentou uma acurácia de 93,9%, sensibilidade de 81,8%, especificidade de 100%, valor preditivo positivo (VPP) igual a 100% e valor preditivo negativo (VPN) igual a 91,7%. Conclusão: a cirurgia bariátrica promove efeitos específicos na distribuição dos metabólitos de pacientes que atingiram remissão de DM2, e essa nova distribuição pode ser avaliada através de um modelo metabonômico.


ABSTRACT Purpose: To evaluate the differences in the metabonomic profile of patients who achieved remisison of Type 2 diabetes mellitus (T2DM) after bariatric surgery in relation to those who presented maintenance or recurrence of this condition after surgery. Methods: Thirthy-three patients with obesity and T2D were submitted to bariatric/metabolic surgery, among which, 22 experienced complete remission of T2D, and 11 did not experience remission in the postoperative period. Blood samples were taken in order to assess the serum profiles through a 1H NMR-based metabonomic study. Results: The metabonomic model for the assessment of T2D recurrence presented an accuracy of 93.9%, sensibility of 81.8%, specificity of 100%, positive predictive value of 100% and a negative predictive value of 91.7%. Conclusion: bariatric surgery provide specific effects on the distribution of metabolites in those patients who achieved remission of T2DM, and this new distribution can be assessed through a metabonomic model.


Subject(s)
Humans , Male , Female , Obesity, Morbid/surgery , Diabetes Mellitus, Type 2/diagnosis , Diabetes Mellitus, Type 2/metabolism , Bariatric Surgery , Time Factors , Blood Glucose/metabolism , Obesity, Morbid/metabolism , Remission Induction , Biomarkers/metabolism , Weight Loss , Cross-Sectional Studies , Predictive Value of Tests , Sensitivity and Specificity , Treatment Outcome , Middle Aged
13.
Braz. J. Pharm. Sci. (Online) ; 56: e18772, 2020. tab, graf
Article in English | LILACS | ID: biblio-1285509

ABSTRACT

There is emerging evidence for a dysregulation of insulin signaling in the brains of patients with Alzheimer's disease (AD) with overlapping molecular features to Type 2 Diabetes Mellitus (T2DM). In addition, T2DM is a known risk factor of AD. The goal of this study was to investigate the neurogenic and neuroprotective potential of rosmarinic acid (RA) in a streptozotocin (STZ)-induced combined with high fat diet (HFD) mouse model of diabetes. Animals were divided into four experimental groups (control, diabetic, diabetic + RA, RA only). Behavioral analysis was performed to assess spatial learning and anxiety levels of animals, whereas quantitative real time PCR was carried out to assess the gene expression levels of neuronal markers of neurogenesis (Ki67, DCX and NeuN). A significant decrease in memory and spatial learning was observed in the diabetic mice, which was substantially improved by RA treatment. RA also increased the gene expression of NeuN, DCX and Ki67, which were dysregulated in the diabetic model. This study proposes RA as a potential therapeutic agent to mitigate neuronal dysfunction associated with T2DM by promoting adult hippocampal neurogenesis.


Subject(s)
Animals , Male , Mice , Diabetes Mellitus, Type 2/diagnosis , Alzheimer Disease/diagnosis , Risk Factors , Streptozocin/pharmacokinetics , Neurogenesis/genetics , Real-Time Polymerase Chain Reaction/methods
14.
Article in English | LILACS, BBO | ID: biblio-1135545

ABSTRACT

Abstract Objective: To analyze whether the FokI polymorphism (rs228570) present in the vitamin D receptor gene in type 2 diabetics is related to chronic periodontitis's clinical status and evaluates the influence of chronic periodontitis on the perception of quality of life. Material and Methods: It is a clinical and laboratory study, composed of a sample of 59 individuals with previous diagnosis of type 2 Diabetes Mellitus and chronic periodontitis, of both sexes. On clinical examination, socio-epidemiological data and quality of life of patients with the Oral Health Impact Profile (OHIP-14) were recorded and a periogram was performed. Subsequently, saliva was collected spontaneously in sterile Falcon tubes (15 ml) and stored in the freezer at -20 °C. The purification of the genetic material was done with a PROMEGA kit (Wizard®), and the polymorphism studied was FokI (rs228570), found in the vitamin D receptor promoting region, with rs: 228570. After extraction of saliva DNA and purification, genotyping was performed by real-time PCR using specific allele probes (TaqMan® System). Results: The polymorphism of the vitamin D receptor gene was not positively associated with the severity and clinical characteristics of periodontitis, but suggested a relationship with the extent of the disease. Periodontitis also had no positive association with patients' perception of quality of life. Conclusion: The perception of quality of life of patients with chronic periodontitis and type 2 diabetes mellitus was compromised by the systemic condition, secondary to oral health, although some dimensions of OHIP-14 have been more frequently mentioned, such as psychological discomfort, physical pain and physical disability.


Subject(s)
Humans , Polymorphism, Genetic , Quality of Life , Receptors, Calcitriol , Diabetes Mellitus, Type 2/diagnosis , Chronic Periodontitis/pathology , Periodontitis/pathology , Brazil , Chi-Square Distribution , Oral Health , Statistics, Nonparametric , Real-Time Polymerase Chain Reaction/methods
16.
Rev. medica electron ; 41(4): 850-861, jul.-ago. 2019. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1094093

ABSTRACT

RESUMEN Introducción: la Organización Mundial de la Salud, estima que la enfermedad renal crónica estará incluida dentro de las principales causas de discapacidad para el 2020. La prevalencia en países desarrollados es aproximadamente de 500 a 1400 pacientes por millón de habitantes y la incidencia anual se encuentra alrededor de 350 pacientes por millón de población. Objetivo: determinar la prevalencia de la enfermedad renal oculta e identificar algunos factores de riesgos predisponentes en adultos mayores con diabetes mellitus tipo 2 pertenecientes al Policlínico Universitario "Jimmy Hirzel", Bayamo, Granma, en el período comprendido entre junio 2016 - junio 2017. Materiales y métodos: se realizó estudio observacional descriptivo, de corte transversal en el que se incluyeron 180 gerontes con diabetes mellitus tipo 2. Resultados: se estableció el diagnóstico de enfermedad renal oculta en 167 individuos de 180 sujetos estudiados, el grupo de 70 - 79 años de edad fue el más afectado por la nefropatía crónica, mientras que el sexo femenino y la raza blanca fueron los de mayor prevalencia. Los principales factores de riesgo predisponentes de enfermedad renal oculta fueron: cardiopatía isquémica crónica, dislipemias e hipertensión arterial. Conclusiones: existe una alta morbilidad de enfermedad renal oculta en los senescentes estudiados.


ABSTRACT Introduction: the World Health Organization (WHO) estimates that chronic hidden renal disease (ERC) will be included within the principal causes of disability by 2020. The prevalence in developed countries is around 500 to 1400 patients per million inhabitants, and the yearly incidence is around 350 patients per million people. Objective: to determine the prevalence of the hidden renal disease and to identify some predisposing risk factors in elder people with type II diabetes mellitus belonging to the University Policlinic "Jimmy Hirzel", Bayamo, Gramma, in the period between June 2016 and June 2017. Material and methods: an observational descriptive, cross-sectional study was carried out in 180 elder people with type 2 diabetes mellitus. Results: the chronic hidden renal disease was diagnosed in 167 individuals from the 180 studied subjects; the 70-79 years-old-group was the most affected one by chronic renal disease, while the female sex and white race showed the highest prevalence. The main risk factors predisposing to chronic hidden renal disease were: chronic ischemic heart disease, dyslipidemia and arterial hypertension. Conclusions: there is a high morbidity due to hidden renal disease in the studied senescent people.


Subject(s)
Humans , Female , Aged , Prevalence , Risk Factors , Morbidity , Myocardial Ischemia/etiology , Diabetes Mellitus, Type 2/diagnosis , Diabetes Mellitus, Type 2/etiology , Diabetes Mellitus, Type 2/epidemiology , Renal Insufficiency, Chronic/complications , Renal Insufficiency, Chronic/diagnosis , Renal Insufficiency, Chronic/prevention & control , Renal Insufficiency, Chronic/epidemiology , Dyslipidemias/etiology , Hypertension/etiology , Epidemiology, Descriptive , Cross-Sectional Studies , Diabetic Nephropathies/etiology , Observational Study , Kidney Diseases/etiology
17.
Rev. medica electron ; 41(3): 628-640, mayo.-jun. 2019. tab
Article in Spanish | LILACS | ID: biblio-1094072

ABSTRACT

RESUMEN Introducción: la prevalencia del síndrome metabólico, a nivel mundial, es muy elevada y continúa en aumento vertiginosamente en los últimos años. Por lo que se puede considerar una pandemia de la época contemporánea, se estima que el 25 % de la población adulta la padece. Objetivo: determinar la prevalencia del síndrome metabólico e identificar otras formas clínicas de enfermedad vascular ateroesclerótica, en gerontes hospitalizados en Servicios de Geriatría del Hospital Provincial Clínico Quirúrgico Docente "Celia Sánchez Manduley", Manzanillo, Granma; en el período comprendido entre junio 2015 a junio 2016. Materiales y métodos: se realizó estudio observacional, descriptivo, de corte transversal. Se incluyeron los 120 senescentes que ingresaron en los Servicios de Geriatría. Resultados: se estableció el diagnóstico de síndrome metabólico en 105 individuos de 120 sujetos estudiados. El grupo de 70-79 años de edad y el sexo masculino fueron los más afectados por la endocrinopatía. Las otras formas clínicas de enfermedad vascular ateroesclerótica que se identificaron en los senescentes estudiados, fueron: cardiopatía isquémica, enfermedad cerebrovascular y cardiopatía hipertensiva. Conclusiones: existe una alta prevalencia del síndrome metabólico en los adultos mayores estudiados.


ABSTRACT Introduction: the prevalence of the metabolic syndrome is very high around the world and is still vertiginously increasing in the last years. Therefore, it can be considered a pandemic of the current times. It is thought that 25 % of the adult population suffers it. Objective: to determine the prevalence of the metabolic syndrome and to identify other clinical forms of the atherosclerotic vascular disease in elder people who entered the Service of Geriatrics of the Provincial Teaching Clinical Surgical Hospital "Celia Sanchez Manduley", of Manzanillo, Granma, in the period from June 2015 to June 2016. Materials and methods: a cross-sectional, observational, descriptive study was carried out with the inclusion of the 120 elder people who the Service of Geriatrics. Results: 105 individuals of 129 studied were diagnosed with metabolic syndrome. The 79-79 age group and male sex were the most affected by endocrinopathy. Other clinical forms of the arteriosclerotic vascular disease identified in the studied elder people were ischemic heart disease, cerebrovascular disease and hypertensive heart disease. Conclusions: there is a high prevalence of the metabolic syndrome among the studied elder people.


Subject(s)
Humans , Aged , Aging , Cerebrovascular Disorders/diagnosis , Risk Factors , Myocardial Ischemia/diagnosis , Metabolic Syndrome/diagnosis , Metabolic Syndrome/etiology , Metabolic Syndrome/prevention & control , Metabolic Syndrome/therapy , Metabolic Syndrome/epidemiology , Diabetes Mellitus, Type 2/diagnosis , Geriatrics , Epidemiology, Descriptive , Cross-Sectional Studies , Hospital Care , Obesity, Abdominal/diagnosis , Early Medical Intervention , Observational Study , Hypertension/diagnosis
19.
Rev. Assoc. Med. Bras. (1992) ; 65(1): 56-60, Jan. 2019.
Article in English | LILACS | ID: biblio-985002

ABSTRACT

SUMMARY Diabetes is one of the most common chronic pathologies around the world, involving treatment with general clinicians, endocrinologists, cardiologists, ophthalmologists, nephrologists and a multidisciplinary team. Patients with type 2 Diabetes Mellitus (T2DM) can be affected by cardiac autonomic neuropathy, leading to increased mortality and morbidity. In this review, we will present current concepts, clinical features, diagnosis, prognosis, and possible treatment. New drugs recently developed to reduce glycemic level presented a pleiotropic effect of reducing sudden death, suggesting a potential use in patients at risk.


RESUMO Diabetes é uma das mais frequentes patologias crônicas em todo o mundo, cujo tratamento envolve uma equipe multidisciplinar, médicos generalistas, endocrinologistas, cardiologistas, nefrologistas e oftalmologistas. Pacientes com diabetes mellitus tipo 2 (DMT2) podem apresentar neuropatia autonômica cardíaca (NAC), levando a aumento de mortalidade e morbidade. Nesta revisão, apresentaremos atuais conceitos, características clínicas, diagnóstico, prognóstico e possíveis tratamentos. Novas drogas recentemente desenvolvidas para redução de níveis glicêmicos apresentaram efeito pleiotrópico de redução de morte súbita, sugerindo um potencial uso neste perfil de pacientes.


Subject(s)
Humans , Autonomic Nervous System Diseases/diagnosis , Diabetes Complications/diagnosis , Diabetes Mellitus, Type 2/diagnosis , Diabetic Neuropathies/diagnosis , Heart Diseases/diagnosis , Prognosis , Autonomic Nervous System Diseases/mortality , Autonomic Nervous System Diseases/therapy , Risk Factors , Death, Sudden , Diabetes Complications/mortality , Diabetes Complications/therapy , Diabetes Mellitus, Type 2/mortality , Diabetes Mellitus, Type 2/therapy , Diabetic Neuropathies/mortality , Diabetic Neuropathies/therapy , Heart Diseases/mortality , Heart Diseases/therapy
20.
Investig. enferm ; 21(1)2019. ilus
Article in Spanish | LILACS, BDENF, COLNAL | ID: biblio-995530

ABSTRACT

Introducción: La diabetes como enfermedad crónica es un evento catastrófico que origina comportamientos negativos hacia la adherencia terapéutica, lo que hace necesario usar teorías cognoscitivas y sociales para reorientar los cuidados de enfermería. Objetivo: Dar respuesta a las preguntas orientadoras de la investigación: ¿cuál es la representación social que la mujer tiene sobre la diabetes tipo 2? ¿Qué elementos integran el núcleo central y los sistemas periféricos de la representación social? Método: Revisión integrativa utilizando como guía el método prisma, de artículos cuyos descriptores primarios fueran "representaciones sociales", "diabetes tipo 2" y "mujeres" y secundarios "pacientes con diabetes tipo 2". La búsqueda se realizó en bases de datos informatizadas: Web of Science, Medline, PubMed, SciELO, LILACS, Bireme y CUIDEN. Resultados: Los hallazgos señalan que el fenómeno de la diabetes dio origen a una representación social irreversible. Este sistema de informaciones, actitudes y creencias se organizan y estructuran alrededor del padecimiento, alimentación, ejercicio y medicación, lo que dificulta la identidad social y, probablemente, la adherencia terapéutica a la enfermedad. Conclusión: El identificar la estructura de la representación social y elementos que integran el núcleo central les permite a los profesionales de la salud planear intervenciones que favorezcan la identidad social y la adherencia terapéutica de las mujeres en la diabetes tipo 2.


Introduction: As a chronic disease, diabetes is a disastrous event bringing about negative behaviors regarding the treatment adherence, which makes necessary the use of cognitive and social theories in order to redirect the nursing care. Objective: To answer the guiding research questions: What is the social representation that women have about Diabetes Type 2? What elements form the central core and the peripheral systems of the social representation? Method: This is a comprehensive review using the Prism Method as a guide. It includes articles whose primary descriptors are "social representations", "Diabetes Type 2" and "women"; and the secondary descriptor "type 2 diabetes patients". The search was carried out in systematized databases: Web of Science, Medline, PubMed, SciELO, LILACS, Bireme, and CUIDEN. Results: The findings indicate that diabetes phenomenon gave rise to an irreversible social representation. This system of data, attitudes and beliefs is organized and structured around the suffering, feeding, exercise and medication, which makes difficult to ascertain the social identity and, probably, the treatment adherence specific to this disease. Conclusion: To identify the structure of the social representation and elements forming the central core allows the health professionals to plan interventions intended to favor the social identity and treatment adherence among women with diabetes type 2.


Introdução: O diabete como urna doença crónica é um evento catastrófico que origina comportamentos negativos para a adesão terapêutica, o que faz preciso usar teorias cognoscitivas e sociais para reorientar os cuidados de enfermagem. Objetivo: Dar resposta às perguntas norteadoras da pesquisa: qual a representação social que a mulher possue sobre o diabete tipo 2? Quais elementos compõem o núcleo central e os sistemas periféricos da representação social? Método: Revisão integrativa utilizando como guia o método prisma, de artigos cujos descritores primarios foram "representações sociais", "diabete tipo 2" e "mulheres" e secundarios "pacientes com diabete tipo 2". A busca foi realizada em bases de dados informatizadas: Web of Science, Medline, PubMed, SciELO, LILACS, Birerne e CUIDEN. Resultados: Os achados apontam que o fenômeno da diabete deu origem a urna representação social irreversível. Esse sistema de informações, atitudes e crenças é organizado e estruturado em torno do padecimento, alimentação, exercício e medicação, o que dificulta a identidade social e, provavelmente, a adesão terapêutica à doença. Conclusão: Identificar a estrutura da representação social e elementos que integram o núcleo central permite os pro fissionais de a saúde planejarem intervenções favorecendo a identidade social e a adesão terapêutica das mulheres em diabetes tipo 2.


Subject(s)
Female , Chronic Disease , Diabetes Mellitus, Type 2/diagnosis , Treatment Adherence and Compliance/psychology
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