Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 95
Filter
1.
Actual. nutr ; 24(3): 194-199, Jul-Sept 2023. tab
Article in Spanish | LILACS, ARGMSAL, BINACIS | ID: biblio-1511518

ABSTRACT

Introducción: El tratamiento mediante los distintos tipos de dietas cetogénicas ha demostrado en diversos trabajos efectividad en la reducción de las crisis convulsivas, de manera total o parcial. Sin embargo, se reportan tasas de deserción en la realización a largo plazo. Objetivo: Este trabajo tiene como objetivo identificar beneficios y dificultades que perciben las familias de niños en el tratamiento de Epilepsia resistente a fármacos que lleven a cabo la dieta cetogénica y que podrían influir en la adherencia o deserción. Materiales y métodos: Se realizó un estudio descriptivo transversal retrospectivo, en el Servicio de Neurología Infantil del HIBA, sección Dieta Cetogénica. Para el estudio, se realizó una encuesta para recabar características sociodemográficas de la población bajo estudio y también sobre dificultades y beneficios hallados en la terapia cetogénica. Se analizaron frecuencias, medias y chi cuadrado para establecer diferencias significativas con intervalo de confianza de 95%. Resultados: La muestra estuvo compuesta por 51 participantes, de 0 a 18 años. Al indagar sobre si percibían mejoras tras realizar terapia cetogénica, el 81% respondió que sí, el 11% no percibió mejoras y el 8% no sabía. Acerca de la presencia de dificultades para llevar a cabo el tratamiento, el 71% respondió que se encontraba con dificultades, el 23% no registró dificultades y el 6% manifestó que a veces. Al relacionar la presencia de dificultades con el nivel socioeconómico, se observaron diferencias significativas entre los grupos, siendo de mayor incidencia en familias de ingresos más bajos. Respecto de la variable edad, no se encontraron diferencias significativas en relación con las dificultades percibidas. Conclusiones: Es importante continuar trabajando con las familias en las dificultades que presentan para evitar deserción del tratamiento. Asimismo, resulta indispensable destacar el alto porcentaje de mejorías que perciben sus padres para lograr mayor adherencia


Introduction: Treatment using the different types of ketogenic diets has been shown in various studies to be effective in reducing seizures, which can be total or partial. However, dropout rates are reported in the long-term completion of it. Objetive: The objective of this work is to identify the benefits and difficulties perceived by the families of children undergoing treatment for drug-resistant epilepsy who follow the ketogenic diet and that could influence adherence or desertion. Materials and methods: A retrospective cross-sectional descriptive study was carried out at the HIBA Child Neurology Service, Ketogenic Diet section. For the study, a survey was carried out to collect sociodemographic characteristics of the population under study and also about difficulties and benefits found in ketogenic therapy. Frequencies, measures and chi square were analyzed to establish significant differences with a 95% confidence interval. Results: The sample consisted of 51 participants, from 0 to 18 years old. When asked if they perceived improvements after performing ketogenic therapy, 81% answered yes, 11% did not perceive improvements and 8% did not know. About the presence of difficulties to carry out the treatment, 71% answered that they had difficulties, 23% did not have them and 6% sometimes.When relating the presence of difficulties with the socioeconomic level, significant differences were observed between the groups, with a higher incidence in lower-income families. Regarding the age variable, no significant differences were found in relation to the perceived difficulties. Conclusion: It is important to continue working with families on the difficulties they present to avoid dropping out of treatment. Likewise, it is essential to highlight the high percentage of improvements that their parents perceive to achieve greater adherence


Subject(s)
Diet, Ketogenic , Drug Resistant Epilepsy , Quality of Life , Child
2.
Vive (El Alto) ; 6(16): 286-298, abr. 2023.
Article in Spanish | LILACS | ID: biblio-1442276

ABSTRACT

La dieta cetogénica durante muchos años utilizada como una alternativa en el tratamiento para la epilepsia refractaria infantil, que consiste en un alto consumo de grasas, reducidas cantidades de carbohidratos y las cantidades necesarias de proteína que permitan al paciente por medio de la producción de cetonas un correcto y adecuado aporte energético al cerebro y todo el SNC. Objetivo. Describir el uso de la dieta cetogénica en el tratamiento de la epilepsia refractaria infantil para determinar su efectividad en la reducción de convulsiones y mejora en la calidad de vida de los pacientes. Metodología. Se ha realizado una revisión sistemática de la literatura científica para examinar la relación entre la dieta cetogénica y su efecto en el tratamiento de la epilepsia refractaria infantil. Para identificar y seleccionar las fuentes de información, se aplicó la declaración PRISMA y se llevó a cabo una búsqueda bibliográfica exhaustiva en diversas bases de datos electrónicas, incluyendo PubMed, SCOPUS y SCIELO. Se utilizaron términos descriptores específicos como "dieta cetogénica", "influencia", "tratamiento", "epilepsia refractaria" y "niños", así como conectores como AND, OR o NOT para mejorar la precisión de la búsqueda. Conclusión. La dieta cetogénica ha demostrado ser efectiva en el tratamiento de la epilepsia refractaria al reducir en un 50% el número de crisis convulsivas y mejorar la cognición de los pacientes, lo que la convierte en una opción viable para el manejo de esta afección. Sin embargo, es importante tener en cuenta que la dieta cetogénica también puede tener efectos secundarios.


The ketogenic diet has been used for many years as an alternative in the treatment of refractory epilepsy in children, which consists of a high consumption of fats, reduced amounts of carbohydrates and the necessary amounts of protein to allow the patient, through the production of ketones, a correct and adequate energy supply to the brain and the entire CNS. Objective. To describe the use of the ketogenic diet in the treatment of refractory epilepsy in children to determine its effectiveness in reducing seizures and improving the quality of life of patients. Methodology. A systematic review of the scientific literature was conducted to examine the relationship between the ketogenic diet and its effect in the treatment of refractory epilepsy in children. To identify and select sources of information, the PRISMA statement was applied and a comprehensive literature search was conducted in various electronic databases, including PubMed, SCOPUS and SCIELO. Specific descriptor terms such as "ketogenic diet", "influence", "treatment", "refractory epilepsy" and "children" were used, as well as connectors such as AND, OR or NOT to improve search precision. Conclusion. The ketogenic diet has been shown to be effective in the treatment of refractory epilepsy by reducing the number of seizures by 50% and improving patients' cognition, making it a viable option for the management of this condition. However, it is important to keep in mind that the ketogenic diet can also have side effects.


A dieta cetogênica tem sido usada há muitos anos como um tratamento alternativo para epilepsia refratária em crianças, consistindo em um alto consumo de gorduras, quantidades reduzidas de carboidratos e as quantidades necessárias de proteínas para permitir ao paciente, por meio da produção de cetonas, um fornecimento correto e adequado de energia para o cérebro e todo o SNC. Objetivo. Descrever o uso da dieta cetogênica no tratamento da epilepsia refratária em crianças, a fim de determinar sua eficácia na redução das crises e na melhoria da qualidade de vida dos pacientes. Metodologia. Foi realizada uma revisão sistemática da literatura científica para examinar a relação entre a dieta cetogênica e seu efeito no tratamento da epilepsia refratária em crianças. Para identificar e selecionar as fontes de informação, foi aplicada a declaração PRISMA e realizada uma pesquisa abrangente da literatura em vários bancos de dados eletrônicos, incluindo PubMed, SCOPUS e SCIELO. Foram usados termos descritores específicos, como "dieta cetogênica", "influência", "tratamento", "epilepsia refratária" e "crianças", além de conectores como AND, OR ou NOT para melhorar a precisão da pesquisa. Conclusão. A dieta cetogênica demonstrou ser eficaz no tratamento da epilepsia refratária, reduzindo o número de convulsões em 50% e melhorando a cognição dos pacientes, o que a torna uma opção viável para o tratamento dessa condição. Entretanto, é importante observar que a dieta cetogênica também pode ter efeitos colaterais.


Subject(s)
Diet, Ketogenic
3.
Rev. Flum. Odontol. (Online) ; 1(60): 15-22, jan.-abr. 2023.
Article in Portuguese | LILACS, BBO | ID: biblio-1411181

ABSTRACT

A epilepsia configura-se como sendo uma patologia crónica oriunda de manifestação elétrica cerebral de caráter anormal, que ocasiona repercussões neurológicas. O tratamento da epilepsia emprega a administração medicamentosa e também pode utilizar o recurso da dieta cetogénica. Sabe-se que o recurso da utilização da dieta cetogênica para enfrentamento da epilepsia promove repercussões a nível da saúde bucal dos enfermos em tratamento. O objetivo deste artigo foi evidenciar como o emprego da dieta cetogênica na terapia utilizada para enfrentamento da epilepsia pode influenciar na saúde bucal dos indivíduos em tratamento. O tratamento medicamentoso da epilepsia emprega anticonvulsivantes e muitas vezes requer o uso de mais de um medicamento para tratamento, o que pode acarretar efeitos adversos a nível sistêmico e oral. Merecem atenção e cuidados odontológicos comumente o tratamento com fármacos por intermédio da administração da fenitoína, geralmente utilizada para tratamento da epilepsia, que pode trazer repercussões odontológicas e alterações periodontais, como a hiperplasia gengival. O conhecimento e a conscientização por parte dos cirurgiões dentistas acerca dos cuidados odontológicos que devem ser adotados para esses pacientes especiais portadores de epilepsia são de suma importância para realização de uma abordagem odontológica. Concluiu-se que as repercussões bucais oriundas da epilepsia devem ser identificadas e tratadas imediatamente, ao passo que o cirurgião dentista contata os pacientes enfermos, uma vez que caso contrário pode-se conviver com agravantes e piora no quadro odontológico apresentado, portanto deve-se primar por impedir a evolução desfavorável do estado de saúde bucal dos pacientes.


Epilepsy is a chronic pathology arising from an abnormal electrical brain manifestation, which causes neurological repercussions. The treatment of epilepsy employs drug administration and can also use the ketogenic diet. It is known that the use of the ketogenic diet to cope with epilepsy promotes repercussions in terms of the oral health of patients undergoing treatment. The objective of this article was to show how the use of the ketogenic diet in the therapy used to cope with epilepsy can influence the oral health of individuals undergoing treatment. Drug treatment of epilepsy uses anticonvulsants and often requires the use of more than one drug for treatment, which can lead to adverse systemic and oral effects. Treatment with drugs through the administration of phenytoin, generally used for the treatment of epilepsy, which can bring dental repercussions and periodontal changes, such as gingival hyperplasia, deserves attention and dental care. Knowledge and awareness on the part of dental surgeons about the dental care that should be adopted for these special patients with epilepsy are of paramount importance for carrying out a dental approach. It was concluded that the oral repercussions arising from epilepsy should be identified and treated immediately, while the dental surgeon contacts sick patients, since otherwise one can live with aggravating factors and worsening of the dental condition presented, therefore, one should excel in preventing the unfavorable evolution of the patients' oral health status.


Subject(s)
Oral Health , Dentistry , Epilepsy/therapy , Diet, Ketogenic
4.
Acta Physiologica Sinica ; (6): 171-178, 2023.
Article in Chinese | WPRIM | ID: wpr-980994

ABSTRACT

The aim of the present study was to investigate the effects of short-term ketogenic diet on the low temperature tolerance of mice and the involvement of peroxisome proliferator-activated receptor α (PPARα). C57BL/6J mice were divided into two groups: normal diet (WT+ND) group and ketogenic diet (WT+KD) group. After being fed with normal or ketogenic diet at room temperature for 2 d, the mice were exposed to 4 °C low temperature for 12 h. The changes in core temperature, blood glucose, blood pressure of mice under low temperature condition were detected, and the protein expression levels of PPARα and mitochondrial uncoupling protein 1 (UCP1) were detected by Western blot. PPARα knockout mice were divided into normal diet (PPARα-/-+ND) group and ketogenic diet (PPARα-/-+KD) group. After being fed with the normal or ketogenic diet at room temperature for 2 d, the mice were exposed to 4 °C low temperature for 12 h. The above indicators were also detected. The results showed that, at room temperature, the protein expression levels of PPARα and UCP1 in liver and brown adipose tissue of WT+KD group were significantly up-regulated, compared with those of WT+ND group. Under low temperature condition, compared with WT+ND, the core temperature and blood glucose of WT+KD group were increased, while mean arterial pressure was decreased; The ketogenic diet up-regulated PPARα protein expression in brown adipose tissue, as well as UCP1 protein expression in liver and brown adipose tissue of WT+KD group. Under low temperature condition, compared to WT+ND group, PPARα-/-+ND group exhibited decreased core temperature and down-regulated PPARα and UCP1 protein expression levels in liver, skeletal muscle, white and brown adipose tissue. Compared to the PPARα-/-+ND group, the PPARα-/-+KD group exhibited decreased core temperature and did not show any difference in the protein expression of UCP1 in liver, skeletal muscle, white and brown adipose tissue. These results suggest that the ketogenic diet promotes UCP1 expression by up-regulating PPARα, thus improving low temperature tolerance of mice. Therefore, short-term ketogenic diet can be used as a potential intervention to improve the low temperature tolerance.


Subject(s)
Animals , Mice , Adipose Tissue, Brown/metabolism , PPAR alpha/pharmacology , Diet, Ketogenic , Uncoupling Protein 1/metabolism , Blood Glucose/metabolism , Temperature , Mice, Inbred C57BL , Liver , Adipose Tissue/metabolism
5.
São Paulo; s.n; 2023. 115 p.
Thesis in Portuguese | LILACS | ID: biblio-1538391

ABSTRACT

Introdução - A dieta cetogênica (DC) tem sido utilizada como tratamento adjuvante da epilepsia fármaco resistente e tem se popularizado no manejo de outras doenças neurológicas e metabólicas (obesidade, diabetes e dislipidemias). Entretanto, também está associada a efeitos adversos que precisam ser melhor compreendidos. Objetivo - Avaliar o potencial efeito protetor de uma dieta cetogênica modificada (DCM), rica em ácidos graxos monoinsaturados (MUFAs) e ácidos graxos poli-insaturados (PUFAs), e suplementada com ácido docosahexaenóico (DHA), sobre a neuroinflamação e o estresse oxidativo e suas repercussões no comportamento de ratos. Materiais e Métodos - Estudo experimental com 18 ratos Wistar, alocados em 3 grupos de 6 animais. No grupo da dieta padrão (DP), os animais consumiram dieta comercial. No grupo da dieta cetogênica clássica (DCC), os animais consumiram uma dieta rica em gorduras saturadas. No grupo DCM, os animais consumiram dieta rica em MUFAs e PUFAs e enriquecida com DHA. Após 100 dias de intervenção foram realizados testes comportamentais e, após a eutanásia, foram feitos extratos lipídico e aquoso do lobo frontal e do hipocampo para análise de ácidos graxos e parâmetros oxidativos e inflamatórios. Resultados - Os animais DCC apresentaram um comportamento mais ansioso que ao animas DP, segundo os testes de Labirinto em Cruz Elevado e Medo ao Contexto. O grupo DCC teve mais incorporação de ácidos graxos saturados (AGs) no lobo frontal e no hipocampo em relação ao DCM. O grupo DCM teve maior incorporação de PUFAs, com destaque para o aumento de DHA no hipocampo. As citocinas inflamatórias IL1-ß e IL-6 tiveram menor concentração nos grupos DCM e DCC em relação ao grupo DP no lobo frontal, perfil semelhante ao observado com a IL-6 no hipocampo, e diferente da IL1-ß que foi reduzida significativamente apenas no DCM. Não houve diferença da concentração da Neuroprotectina D (NPD) e da enzima antioxidante Superóxido Dismutase (SOD) entre os grupos. A LDLox teve menor concentração nos grupos DCC e DCM em relação ao DP. A enzima catalase (CAT) foi menor no grupo DCM em relação ao grupo DP. Conclusão - Embora a modulação da composição de ácidos graxos da DC possa ser promissora, uma vez que a DCC induziu a um estado mais ansioso, não foi possível explicar essa diferença pelas vias inflamatória e antioxidante avaliadas.


Introduction - The ketogenic diet (KD) has been applied as an adjuvant treatment for drug-resistant epilepsy and has become popular in the management of other neurological and metabolic diseases (obesity, diabetes and dyslipidemia). However, it is also associated with adverse effects that need to be better understood. Objective - To evaluate the potential protective effect of a modified ketogenic diet (MKD), rich in monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs), and supplemented with docosahexaenoic acid (DHA), on neuroinflammation and oxidative stress and their repercussions on the behavior of rats. Materials and Methods - Experimental study with 18 Wistar rats, allocated into 3 groups of 6 animals. In the standard diet (SD) group, the animals consumed a commercial diet. In the classical ketogenic diet (CKD) group, the animals consumed a diet rich in saturated fats. In the MKD group, the animals consumed a diet rich in MUFAs and PUFAs and enriched with DHA. After 100 days of intervention, behavioral tests were carried out and, after euthanasia, lipid and aqueous extracts were made from the frontal lobe and hippocampus for analysis of fatty acids and oxidative and inflammatory parameters. Results - The CKD animals showed more anxious behavior than the DP animals, according to the Elevated Cross Maze and Context Fear tests. The CKD group had more incorporation of saturated fatty acids (SFAs) in the frontal lobe and hippocampus compared to MKD. The MKD group had greater incorporation of PUFAs, with emphasis on the increase in DHA in the hippocampus. The inflammatory cytokines IL1-ß and IL-6 had lower concentrations in the MKD and CKD groups compared to the PD group in the frontal lobe, a profile similar to that observed with IL-6 in the hippocampus, and different from IL1-ß, which was significantly reduced in the MKD. There was no difference in the concentration of Neuroprotectin D (NPD) and the antioxidant enzyme Superoxide Dismutase (SOD) between the groups. LDLox had a lower concentration in the CKD and MKD groups compared to the DP. The catalase enzyme was lower in the MKD group compared to the DP group. Conclusion - Although the modulation of the fatty acid composition of KD may be promising, since CKD induced a more anxious state, it was not possible to explain this difference through the inflammatory and antioxidant pathways evaluated.


Subject(s)
Behavior , Fatty Acids, Omega-3 , Docosahexaenoic Acids , Oxidative Stress , Diet, Ketogenic , Fatty Acids , Fatty Acids, Unsaturated , Inflammation
6.
Arch. argent. pediatr ; 120(5): e207-e209, oct. 2022.
Article in Spanish | LILACS, BINACIS | ID: biblio-1395677

ABSTRACT

El síndrome de deficiencia del transportador de glucosa cerebral de tipo 1 es una enfermedad neurometabólica rara en pediatría. Existe un fenotípico clásico (85 %) y otro no clásico (15 %). Ambos fenotipos se asocian con hipoglucorraquia. Se identifican múltiples mutaciones en el gen SLC2A1. El tratamiento es la terapia cetogénica. Se presenta un varón que comenzó a los cuatro años con hemicorea y hemidistonía medicado con anticonvulsivantes sin respuesta clínica, por lo que consultó nuevamente a los seis años. Con sospecha diagnóstica de síndrome de déficit de glut-1 atípico se realizó punción lumbar; el diagnóstico se confirmó por la presencia de hipoglucorraquia. Inmediatamente después de iniciar la dieta cetogénica, el paciente no presentó más movimientos anormales durante los siguientes 8 años hasta la actualidad, ya cumplidos los 14 años.


Glucose transporter type 1 deficiency syndrome is a rare pediatric neurometabolic disorder. There are two phenotypes: the classical phenotype (85%) and the non-classic (15%). Both phenotypes are associated with hypoglycorrhachia. Multiple mutations are described in the SCL2A1 gene. The treatment is the ketogenic diet. We report a case of a four-year-old male patient who started with hemichorea and hemidystonia and was medicated with drugs for seizures without clinical response, that's why his parents made another pediatric consultation at his six-year-old. With the suggestive clinical findings of glucose transporter type 1 deficiency syndrome the lumbar puncture was made confirming the diagnosis. Immediately after starting the ketogenic diet the patient stopped making abnormal movements up to the moment when he is fourteen years old, eight years after.


Subject(s)
Humans , Male , Adolescent , Carbohydrate Metabolism, Inborn Errors/complications , Carbohydrate Metabolism, Inborn Errors/diagnosis , Carbohydrate Metabolism, Inborn Errors/genetics , Diet, Ketogenic , Monosaccharide Transport Proteins/deficiency , Monosaccharide Transport Proteins/genetics , Glucose Transporter Type 1
8.
Rev. bras. ter. intensiva ; 33(4): 635-639, out.-dez. 2021. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1357187

ABSTRACT

RESUMO Define-se estado epiléptico super-refratário como ocorrência de crises epilépticas persistentes ou que ressurgem em condições de infusão endovenosa de anestésicos por mais de 24 horas. Nos últimos anos, chamou-se a atenção para os potenciais benefícios de uma dieta cetogênica para o controle de tais pacientes. Contudo, o papel específico dessa estratégia na população adulta, assim como o mecanismo de ação, a melhor ocasião para iniciar e o manejo das complicações, permanece como assunto amplamente debatível. Relatamos uma série de casos com três pacientes que foram internados em unidade de terapia intensiva em razão de estado epiléptico super-refratário e tratados com utilização de dieta cetogênica; também propomos uma abordagem clínica para início, transição e manejo das intercorrências clínicas desta intervenção.


Abstract Super-refractory status epilepticus is defined as seizures that persist or reemerge in the setting of an intravenous anesthetic infusion for more than 24 hours. In recent years, attention has been driven to the potential benefits of a ketogenic diet in the management of these patients. However, the specific role of this strategy in the adult population, as well as its underlying mechanism of action and optimal time for the initiation and management of complications, remain widely debatable. We report a case series of three patients admitted to an intensive care unit due to super-refractory status epilepticus who were managed with a ketogenic diet and propose a clinical approach to its initiation, transition, and management of clinical intercurrences.


Subject(s)
Humans , Adult , Status Epilepticus , Diet, Ketogenic , Seizures , Critical Care , Intensive Care Units
9.
Rev. Assoc. Med. Bras. (1992, Impr.) ; 67(10): 1415-1420, Oct. 2021. graf
Article in English | LILACS | ID: biblio-1351432

ABSTRACT

SUMMARY OBJECTIVE: This study evaluates the effects of a ketogenic diet on morphology and follicle reserve. METHOD: Sixteen Sprague-Dawley rats were randomized into two groups: standard diet group (n=8) and ketogenic diet group (n=8). Rats were time mated. Dams were permitted to deliver spontaneously. The animals were monitored for the onset of puberty. All the rats were weighed and anesthetized, serum anti-Müllerian hormone level was measured, and the oviducts were removed. The morphological characteristics of follicles were determined and total ovarian volumes were calculated. RESULTS: The mean ovarian volume was statistically significantly lower in the ketogenic diet group compared to the standard diet group (14.41±0.99 mm3 versus 18.89±1.28 mm3) (p=0.000). The mean number of antral follicles was 13.63±1.80 in the standard diet group and 4.462±0.760 in the ketogenic diet group. The mean ovarian weight of the ketogenic diet group was significantly lower than that of the standard diet group (0.42±0.06 g versus 0.815±107 g). The mean anti-Müllerian hormone levels were significantly higher in the standard diet group compared to the ketogenic diet group (1.023±4.75 ng/mL versus 0.69±0.07 ng/mL) (p=0.000). The mean percentage of staining of Ki-67 was 35.28±4.75 in the standard diet group and 16.98±3.33 in the ketogenic diet group (p=0.000). CONCLUSION: Maternal ketogenic diet reduces ovarian follicular reserve in female offspring and has important implications for maintaining reproductive potential at a population level.


Subject(s)
Humans , Animals , Female , Rats , Diet, Ketogenic/adverse effects , Ovarian Reserve , Ovary , Rats, Sprague-Dawley , Anti-Mullerian Hormone
10.
REVISA (Online) ; 10(1): 156-164, 2021.
Article in Portuguese | LILACS | ID: biblio-1177768

ABSTRACT

Objetivo: verificar alterações no consumo alimentar e hábitos de vida em pacientes com fibrose cística brasileiros durante o período de isolamento social devido a pandemia de COVID-19. Métodos: pesquisa transversal com levantamento de dados por meio de questionário elaborado pela equipe de nutricionistas especialistas no tratamento de pacientes com fibrose cística, com questões referentes às manifestações respiratórias recentes de pacientes ou familiares, alterações nos hábitos de aquisição e compras de alimentos e alterações quanto ao consumo de grupos alimentares e suplementos. Os dados foram tabulados e foi realizada uma análise descritiva. Resultados: 40,34% das famílias de pacientes com fibrose cística mudaram os hábitos de compras de alimentos, cerca de 40% dos pacientes diminuíram a prática de atividade física e aumentaram o tempo de uso de telas em mais de 50% durante o período da pandemia de COVID-19. Conclusões: Apesar de algumas dificuldades relacionadas à aquisição dos alimentos e alterações em hábitos de vida, houve manutenção do consumo alimentar da maioria dos grupos alimentares e suplementos pelos pacientes pediátricos com fibrose cística brasileiros durante o isolamento social devido a pandemia de COVID-19


Objective: This study describes the creation of the first ketogenic diet-teaching kitchen at a ketogenic reference center in Brazil aimed at developing ketogenic recipes and holding keto-culinary workshops with caregivers. Method: In this prospective study, 26 recipes were tested and assessed by sensory panel testing. Eighteen recipes were selected to be prepared in culinary workshops with parents or legal guardians of children with refractory epilepsy receiving the ketogenic diet as outpatients. All recipes were selected, calculated, and approved by registered dietitians. Results: Eight parents or legal guardians participated in four culinary workshops. The activities were extremely satisfactory: participants were able to clear out their doubts, learn, practice recipes, and develop new skills. In general, all participants enjoyed the prepared recipes and praised the culinary workshop. Conclusion: The ketogenic teaching kitchen enabled the development of ketogenic recipes adapted to Brazilian eating habits. Providing alternative meals to children is essential for enhancing compliance with the ketogenic diet because they contribute to expand the dietary repertoire of these patients. Future studies with high methodological quality should test the efficacy of the ketogenic kitchen in increasing compliance with the ketogenic diet in the long term.


Objetivo: Este estudio describe la creación de la primera cocina cetogénica para enseñar dieta cetogénica en un centro de referencia en Brasil, con el objetivo de desarrollar recetas cetogénicas y realizar talleres culinarios con los cuidadores. Método: En este estudio prospectivo, un panel sensorial probó y evaluó 26 recetas. Se seleccionaron dieciocho recetas para ser elaboradas en talleres de cocina con padres o tutores legales de niños con epilepsia refractaria que reciben una dieta cetogénica ambulatoria. Todas las recetas fueron seleccionadas, calculadas y aprobadas por nutricionistas. Resultados: Ocho padres o tutores participaron en cuatro talleres culinarios. Las actividades fueron sumamente satisfactorias: los participantes pudieron despejar sus dudas, aprender, practicar recetas y desarrollar nuevas habilidades. En general, a todos los participantes les gustaron las recetas elaboradas y elogiaron el taller de cocina. Conclusión: La cocina de enseñanza cetogénica permitió el desarrollo de recetas cetogénicas adaptadas a los hábitos alimentarios brasileños. Proporcionar comidas alternativas a los niños es fundamental para mejorar la adherencia a la dieta cetogénica, ya que contribuyen a ampliar el repertorio dietético de estos pacientes. Los estudios futuros con alta calidad metodológica deberían probar la efectividad de la cocina cetogénica para aumentar la adherencia a la dieta cetogénica a largo plazo.


Subject(s)
Food and Nutrition Education , Epilepsy , Diet, Ketogenic
11.
Rev. méd. Chile ; 148(11)nov. 2020.
Article in Spanish | LILACS | ID: biblio-1389241

ABSTRACT

With low carbohydrate diets glucose becomes unavailable as a source of energy for our body, leading to the production of ketones from fatty acids in the liver. The increase in plasma ketones is known as nutritional ketosis. The available evidence from basic and clinical studies indicates that both low carbohydrate and high fat low carbohydrate diets are effective for weight loss and are better than non-intervention. However, low carbohydrate diet and ketogenic diets induce unique metabolic changes and consistently improve some markers of cardiovascular risk, lowering elevated blood glucose, insulin, triglycerides, ApoB and saturated fat concentrations, reducing small dense LDL particle numbers, glycated hemoglobin levels, blood pressure and body weight while increasing HDL-cholesterol concentrations and reversing non-alcoholic fatty liver disease. Low carbohydrate diets are an efficient strategy for the management of obesity and metabolic syndrome. They may also benefit patients with polycystic ovary syndrome. They must be prescribed by trained professionals to balance the risks and benefits for each individual patient. Future research is required to improve the knowledge about individual responses to dietary interventions, their safety, tolerance, efficacy and long-term effects.


Subject(s)
Female , Humans , Diet, Ketogenic , Triglycerides , Blood Glucose , Dietary Carbohydrates , Dietary Fats , Weight Loss , Obesity
13.
Rev. chil. pediatr ; 91(5): 697-704, oct. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1144268

ABSTRACT

INTRODUCCIÓN: La epilepsia afecta a 0,5% a 1% de la población, iniciándose en la infancia en el 60% de los casos. El 25% de los niños que la presentan, tienen epilepsia refractaria (ER) a fármacos antiepilépticos (FAE) y en ellos la dieta cetogénica (DC) surge como un tratamiento no farmacológico efectivo. OBJETIVO: Evaluar el impacto de la DC en el número de crisis, en la calidad de vida y bienestar del paciente y su entorno. PACIENTES Y MÉTODO: Se revisaron los registros médicos de los pacientes con diagnóstico de ER que recibieron DC entre los años 2008 y 2018 registrando variables: edad, diagnóstico, número de crisis, número de FAE, respuesta y complicaciones. La DC se inició en todos los casos con el paciente hospitalizado durante un período no mayor a siete días, en el cual se realizó evaluación nutricional antropométrica con medición de peso y talla según condición clínica. RESULTADOS: Se analizaron 35 DC. La mediana de edad al inicio fue 4,8 años con rango intercuartil (RIC) de 2,3-6,8 años. Se utilizó DC clásica en 49% de los pacientes, Dieta Atkins Modificada en 37% y Dieta de Bajo Índice Glicémico en 14%. Su promedio de duración fue 13 meses + 11 DS meses. Luego de tres meses de iniciada la DC, la reducción de al menos un 50% de las crisis se observó en 82% de los casos, de los cuales 22,8% presentaron reducción de más de 90% y 20% quedó libre de crisis. Se registraron efectos secundarios en 21 pacientes, la mayoría gastrointestinales (62%) y dislipidemia (14%). Todos los efectos secundarios se resolvieron con manejo médico. CONCLUSIONES: La DC es un tratamiento efectivo en pacientes pediátricos con ER y las complicaciones asociadas fueron fácilmente controla das por un equipo multidisciplinario.


INTRODUCTION: Epilepsy affects 0.5 to 1% of the population. 25% of pediatric patients have drug-resistant epilepsy (DRE). Ketogenic Diet (KD) emerges as an effective, non-pharmacological treatment in this group. OBJECTIVE: To describe the effect of KD on seizure control and nutritional status in children whit DRE. PATIENTS AND METHOD: We reviewed the medical records of patients with DRE treated with KD, between 2008 and 2018, evaluating age, diagnosis, number of seizures, number of antiepileptic drugs used, clinical outcomes, and complications. The KD was initiated in all patients hospitalized for a period no longer than seven days, who were evaluated for their nutritional and anthropometric sta tus, with weight and height measurements according to the clinical condition. RESULTS: We analyzed 35 KD in 33 cases. The median age of KD initiation was 4.8 years with an interquartile range (IQR) of 2-3 to 6.8 years. Classical KD was used in 49% of patients, Modified Atkins Diet (MAD) in 37%, and Low-Glycemic Index Treatment (LGIT) in 14% of cases. The average duration was 13 months (SD 11 months). After three months of using KD, we observed at least 50% reduction of seizures in 82% (27/33) of the patients, out of these, 22.8% presented 90% or more reduction of seizures, and 20% ended up seizure-free. Adverse events were observed in 21 patients, mainly gastrointestinal (62%) and dyslipidemia (14%), without effect on height. All side effects resolved with medical ma nagement. CONCLUSIONS: KD is a useful treatment in pediatric patients with DRE without nutritional impact. The adverse events were easily controlled if the patients are evaluated by a multidisciplinary team, according to international guidelines.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Diet, Ketogenic/methods , Drug Resistant Epilepsy/diet therapy , Nutritional Status , Follow-Up Studies , Treatment Outcome , Diet, Ketogenic/adverse effects , Drug Resistant Epilepsy/diagnosis
14.
ARS med. (Santiago, En línea) ; 45(1): 51-56, mar. 2020. Revisión sistemática
Article in Spanish | LILACS | ID: biblio-1146576

ABSTRACT

Introducción: Existe un porcentaje relevante de pacientes con epilepsia que son refractarios al tratamiento con fármacos anticonvulsivan-tes. Este cuadro, se denomina epilepsia refractaria (ER), en el cual, la dieta cetogénica (DC), ha probado ser una alternativa efectiva. Existen diferentes versiones de la DC, y ciertos componentes de esta dieta han mostrado ser más efectivos que otros. Por otra parte, diferentes autores han propuesto hipótesis, de cómo, la DC podría actuar a nivel molecular y celular, para controlar estas crisis epilépticas. Los objetivos de esta revisión, son, explicar la DC, y analizar la evidencia existente, en relación con los mecanismos, a través de los cuales, la DC ejerce un control de las crisis convulsivas. Método y resultados: Se realizó una búsqueda avanzada en PubMed, considerando los términos «refrac-tory¼, «epilepsy¼, «ketogenic¼ y «diet¼, incluidos en el título y el resumen. La búsqueda, dio como resultado, 288 artículos publicados en los últimos 10 años. De estos artículos, se seleccionaron 134 potencialmente relevantes, posterior a la lectura de sus títulos. Se realizó la lectura del resumen para los 134 artículos, de los cuales, se seleccionaron 17, que fueron, a juicio de los autores, los que incluían la información pertinente para esta revisión. La búsqueda se centró en artículos originales y revisiones disponibles en inglés,con énfasis, en los artículos apropiados para comprender los conceptos generales de la DC y los mecanismos de acción, que podrían representar un rol relevante al momento de controlar la ER. Conclusiones: La DC ha probado ser efectiva en el tratamiento de la ER, sin embargo, hay pacientes que no la toleran adecuadamente. Existen ciertos compuestos asociados la DC que han probado ser más efectivos que otro como es el caso de los triglicéridos de cadena mediana (TCM). Finalmente, se han investigado numerosas hipótesis en relación con el mecanismo de acción de la DC, donde destacan las hipótesis de los cuerpos cetónicos, la adenosina y la del cortocircuito GABA.


Introduction: A percentage of epilepsy patients are refractory to treatment with anticonvulsant drugs. An effective alternative for treating this condition, known as refractory epilepsy (RE), is the ketogenic diet (KD). There are different variations of the KD, and certain components of this diet have been shown more effective than others. Various authors have proposed hypotheses for how the KD acts on the molecular and cellular levels in controlling seizures. The objectives of this review are to explain the KD and analyze existing evi-dence regarding the mechanisms through which the KD exercises control over seizures. Methods and results: PubMed was extensively searched using the terms «refractory¼, «epilepsy¼, «ketogenic¼, and«diet¼ included in the title and abstract. The search returned 288 published articles within the last ten years. Of these 288 manuscripts, 134 were selected as potentially relevant based on the title. After reading the abstract of each potentially relevant paper, 17 were finally included in the review. These manuscripts, per the judgement of the authors of this study, included information pertinent to the review. The search focused on original articles and reviews available in English, with an emphasis on texts appropriate for understanding the general concepts of the KD and the mechanisms of action that could play a relevant role in controlling RE. Conclusions: The KD has been proven effective in treating RE. However, some patients do not adequately tolerate this diet. There are certain compounds associated with the KD that are more effective than others, as is the case with medium-chain triglycerides. Finally, numerous hypotheses exist regarding the mechanisms of action for the KD. Notable among these hypotheses are ketone bodies, adenosine, and the GABA shunt.


Subject(s)
Humans , Diet, Ketogenic , Drug Resistant Epilepsy , PubMed , Literature
15.
Journal of Southern Medical University ; (12): 1155-1164, 2020.
Article in Chinese | WPRIM | ID: wpr-828913

ABSTRACT

OBJECTIVE@#To investigate the inhibitory effect of ketogenic diet (KD) on growth of neuroblastoma in mice.@*METHODS@#BALB/c-nu mouse models bearing neuroblastoma xenografts were established by subcutaneous injection of human neuroblastoma cell line (SH-SY5Y). When the tumor volume reached 250 mm3, the mice were randomized into SD group with standard diet and PBS treatment, KD group with ketogenic diet and PBS treatment, and CP+KD group with ketogenic diet and cyclophosphamide (60 mg·kg·day) treatment, =8. The tumor volume, body weight, blood glucose, ketone body (β-Hydroxybutyrate) levels, and hepatic steatosis in the mice were assessed. The expressions of caspase-3 and caspase-8 were detected by Western blotting, and Ki67 expresison was detected using immunohistochemistry (IHC). Transmission electron microscopy (TEM) was employed for the autophagosomes, and the autophagic protein Beclin1, LC3A/B and P62 were detected by IHC and Western blotting.@*RESULTS@#On day 28 post tumor cell injection, the mice in KD and CP+KD groups could prolong the overall survival rates than that in SD group ( < 0.001). On day 22 post the injection, the tumor volume in KD group was smaller than that in SD group ( < 0.05); on 16, 19, and 22 day post the injection, the tumor volume in CP+KD group was smaller than that in SD group ( < 0.01). The mice in SD group showed greater body weight on day 19 and higher blood glucose level on day 13 post the injection than those in the other two groups ( < 0.05). Blood ketone level and hepatic steatosis score were higher and glucose ketone index (GKI) was lower in KD and CP+KD groups than those in SD group (all < 0.05). The expressions of Ki67 and apoptotic proteins were detected in the tumor tissues of all groups. TEM revealed more autophagosomes in the tumor tissues of KD group than that of SD group. P62 expression was lowered ( < 0.01) and Beclin1 and LC3A/B expressions were up-regulated in the tumor tissues of KD group ( < 0.05), which is consisitent with IHC.@*CONCLUSIONS@#KD has a strong anti-tumor effect in the xenograft mouse model possibly by regulating cell autophagy.


Subject(s)
Animals , Humans , Mice , 3-Hydroxybutyric Acid , Blood Glucose , Cell Line, Tumor , Diet, Ketogenic , Mice, Inbred BALB C , Neuroblastoma
17.
Rev. chil. nutr ; 46(5): 606-613, oct. 2019. tab
Article in English | LILACS | ID: biblio-1042701

ABSTRACT

Countless strategies have been proposed to change dietary patterns to promote weight loss. Many of these strategies are controversial, with questions of effectiveness and possible negative consequences to health, even if weight loss effects are achieved. Ketogenic diets, with or without calorie restrictions, are framed in this context. In the present systematic review, evidence on ketogenic diets for weight loss was investigated. Studies on ketogenic diet with or without calorie restriction related to weight loss published between 2012 and 2017 were selected from MEDLINE, Scielo and Web of Science databases. Results show there is a lack of knowledge on specific physiological mechanisms involved in the ketogenic diet. Much of the evidence published, despite showing specific effects on weight loss, BMI and fat percentage reduction, did not precisely assess its effects on specific physiological and biochemical parameters, mainly on the hepatic, cardiac and renal tissues. We conclude that strategies to control overweight and obesity do not necessarily need to impose restrictions on certain nutrients, especially carbohydrates, or increase the intake of food groups whose excessive consumption has been associated with different pathologies.


Innumerables estrategias se han propuesto para cambiar el patrón de la dieta y así promover la pérdida de peso. Muchas de estas estrategias aún son controversiales con respecto a la efectividad y las consecuencias negativas para la salud. Las dietas cetogénicas, con o sin restricciones calóricas, se enmarcan en este contexto. En la presente revisión sistemática, se investigaron las evidencias sobre las dietas cetogénicas para la pérdida de peso. Para esto, se seleccionaron los estudios de dieta cetogénica con o sin restricción calórica relacionada con la pérdida de peso publicados entre 2012 y 2017 a través de las bases de datos MEDLINE, Scielo y Web of Science. Los resultados muestran falta de conocimiento sobre mecanismos fisiológicos específicos implicados en la dieta cetogénica. Gran parte de la evidencia publicada, a pesar de mostrar efectos específicos sobre la pérdida de peso, IMC y reducción del porcentaje de grasa, no evaluó con precisión sus efectos sobre parámetros fisiológicos y bioquímicos, principalmente en los tejidos hepático, cardíaco y renal. Concluimos que las estrategias para controlar el sobrepeso y la obesidad no necesariamente tienen que imponer restricciones sobre nutrientes, especialmente los carbohidratos, o aumentar la ingesta de grupos de alimentos cuyo consumo excesivo se ha asociado con diferentes patologías.


Subject(s)
Humans , Weight Loss/physiology , Diet, Ketogenic , Body Composition
18.
Medicina (B.Aires) ; 79(3): 225-231, June 2019. tab
Article in Spanish | LILACS | ID: biblio-1020065

ABSTRACT

La dieta cetogénica se considera un tratamiento eficaz y bien tolerado para la epilepsia refractaria. Nuestro trabajo suministra información práctica sobre el uso de la dieta cetogénica, realizando una revisión acerca de las indicaciones clásicas y las nuevas que permiten ampliar el uso de la misma. Detallamos cómo implementar la dieta, los controles médicos en el seguimiento y la forma de actuar en situaciones especiales, tales como la anestesia o la enfermedad aguda. Se enfatiza la i mportancia del trabajo de los profesionales de las distintas especialidades y la familia como equipo, detallando los roles que ocupa cada uno en este interesante pero laborioso tratamiento.


The ketogenic diet is an established, effective and well-tolerated treatment in refractory epilepsy. This paper provides practical information on the administration of ketogenic diet. It goes over the standardized protocols and the new ones that allow to broaden the scope regarding the clinical management of the ketogenic diet. It addresses issues such as the implementation, counseling and follow-up as well as the application and how to proceed in special situations such as anesthesia or acute illness. Finally, the aim of this paper is to highlight the relevance of the multidisciplinary teamwork and the family support throughout this laborious but interesting treatment.


Subject(s)
Humans , Diet, Ketogenic/classification , Diet, Ketogenic/adverse effects , Drug Resistant Epilepsy/diet therapy , Drug Resistant Epilepsy/therapy , Interdisciplinary Studies , Diet, High-Protein Low-Carbohydrate
19.
Medicina (Ribeiräo Preto) ; 52(1)jan.-mar.,2019.
Article in Portuguese | LILACS | ID: biblio-1024902

ABSTRACT

RESUMO: Importância do problema: A Síndrome da Deficiência do Transportador de Glicose tipo 1 (GLUT1DS), descrita pela primeira vez por De Vivo em 1991, é causada por um deficitário transporte de glicose na barreira hematoencefálica e nos astrócitos devido à mutações na maioria das vezes de novo heterozigóticas no gene SLC2A1, responsável pela codificação do transportador de glicose tipo 1 (GLUT-1). Essa mutação limita a disponibilidade de glicose cerebral, levando a sua deficiência energética, sendo o mecanismo gerador de suas manifestações clínicas. Os sintomas sugestivos são convulsões, atraso no desenvolvimento, microcefalia, hipotonia, espasticidade e complexas alterações no movimento, consistindo de ataxia e distonia. Em pacientes GLUT1DS, substratos energéticos alternativos são de fundamental importância. Inúmeros trabalhos recomendam a utilização da dieta cetogênica de maneira imperiosa como mecanismo padrão ouro de tratamento. Esta, nos primeiros anos de vida em pacientes com GLUT1DS, garante um melhor resultado cognitivo e melhora nos aspectos psicomotores. Comentários: A GLUT1DS, por ser uma doença de recente descoberta, ter poucos casos descritos na literatura, características clínicas heterogêneas e falta substancial de casuística é muitas vezes subdiagnosticada. Nesse sentido, critérios de suspeição e algoritmos diagnósticos se fazem necessários. Dessa maneira, o objetivo deste artigo é chamar a atenção da comunidade médica brasileira para essa síndrome, com vistas a incrementar seu diagnóstico e melhorar o prognóstico de epilepsias de difícil controle (AU)


ABSTRACT: Glut-1 deficiency syndrome (GLUT1DS), first described by De Vivo in 1991, is caused by a deficient glucose transport in the blood-brain barrier and astrocytes by heterozygous mutations, mostly de novo, in the gene SLC2A1 encoding the glucose transporter type 1 (GLUT-1). This mutation limits the availability of cerebral glucose leading to energy deficiency, which is the underlying mechanism of the clinical manifestations. The suggestive symptoms are convulsions, developmental delay, microcephaly, hypotonia, spasticity, and complex changes in movement consisting of ataxia and dystonia. In GLUT1DS patients, altern ative energy substrates are of fundamental importance. Numerous studies recommend the use of a ketogenic diet in an imperative manner as a gold standard therapy method. This diet, in the first years of life in patients with GLUT1DS, guarantees a better cognitive result and improvement in psychomotor aspects. Because GLUT1DS is a disease of recent discovery, with a few cases described in the literature, heterogeneous clinical features and a substantial lack of casuistry is often underdiagnosed. In this sense, suspicion criteria and diagnostic algorithms become necessary. Thus, the purpose of this article is to draw the attention of the Brazilian medical community to this syndrome to increase its diagnosis and improve the prognosis of difficult-to-control epilepsy (AU)


Subject(s)
Humans , Male , Child, Preschool , Epilepsy , Glucose Transport Proteins, Facilitative , Diet, Ketogenic
20.
Childhood Kidney Diseases ; : 48-52, 2019.
Article in English | WPRIM | ID: wpr-763263

ABSTRACT

The ketogenic diet (KD) has been used as an effective antiepileptic therapy for intractable childhood epilepsy. However, various adverse effects have been reported with use of the KD. We report a case of a child who developed acute tubular necrosis subsequent to therapy with KD. A 5-year-old girl had myoclonic epilepsy with developmental delay. She was under the treatment with antiepileptic drugs since the age of 3 months and on the KD during the past 18 months. Proteinuria persisted intermittently with the initiation of the KD and subsequently increased in the past 2 months. She was admitted with intermittent mild fever, vomiting, and lethargy for the past 3–4 weeks. At the time of admission, she presented with hypertriglyceridemia, heavy proteinuria, renal Fanconi syndrome, and acute kidney injury. Renal sonography showed a marked increase in the size and parenchymal echogenicity of both kidneys. A renal biopsy revealed acute tubular necrosis accompanied by early interstitial fibrosis. After the withdrawal of the KD and supportive therapy, without changing other anticonvulsants and their dosages, improvement of renal function was observed. Proteinuria had disappeared after 1 month and kidney size returned to normal after 8 months. It is hypothesized that the KD can induce and/or aggravate the renal tubulointerstitial injury in some patients who are under the treatment with anticonvulsants.


Subject(s)
Child , Child, Preschool , Female , Humans , Acute Kidney Injury , Anticonvulsants , Biopsy , Drug Resistant Epilepsy , Epilepsies, Myoclonic , Epilepsy , Fanconi Syndrome , Fever , Fibrosis , Hypertriglyceridemia , Diet, Ketogenic , Kidney , Lethargy , Necrosis , Proteinuria , Vomiting
SELECTION OF CITATIONS
SEARCH DETAIL